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Decreased glucose-6-phosphate dehydrogenase level in red blood cells

MedGen UID:
1634509
•Concept ID:
C4703674
•
Finding
Synonyms: Decreased G6PD level in RBCs; Decreased G6PD level in red blood cells
 
HPO: HP:0410188

Definition

A decrease in the level of glucose-6-phosphate dehydrogenase in red blood cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased glucose-6-phosphate dehydrogenase level in red blood cells

Professional guidelines

PubMed

Does vitamin E have a role in treatment and prevention of anemia?
Jilani T, Iqbal MP
Pak J Pharm Sci 2011 Apr;24(2):237-42. PMID: 21454177
Correlations between treatment outcome and both anti-MSP119 antibody response and erythrocyte-related genetic factors in Plasmodium falciparum malaria.
Aubouy A, Migot-Nabias F, Deloron P
Infect Genet Evol 2007 Mar;7(2):147-54. Epub 2006 Aug 4 doi: 10.1016/j.meegid.2006.07.001. PMID: 16890498
Metabolic and cellular basis of 2-butoxyethanol-induced hemolytic anemia in rats and assessment of human risk in vitro.
Ghanayem BI
Biochem Pharmacol 1989 May 15;38(10):1679-84. doi: 10.1016/0006-2952(89)90317-1. PMID: 2730682

Recent clinical studies

Etiology

The potential role of vitamin E in patients with glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis.
Abdelwahab OA, Akil K, Seif A, Allam M, Sherif ME, Al-Alfy MN
Medicine (Baltimore) 2023 Feb 10;102(6):e32937. doi: 10.1097/MD.0000000000032937. PMID: 36820534Free PMC Article
Laboratory Approach to Hemolytic Anemia.
Jamwal M, Sharma P, Das R
Indian J Pediatr 2020 Jan;87(1):66-74. Epub 2019 Dec 10 doi: 10.1007/s12098-019-03119-8. PMID: 31823208
Erythrocyte Glucose-6-Phosphate Dehydrogenase Level in Type 2 Diabetes Male.
Khanam A, Akter QS, Karim F, Zannat MR
Mymensingh Med J 2018 Jan;27(1):103-107. PMID: 29459599
Study of Glucose-6-Phosphate Dehydrogenase Deficiency: 5 Years Retrospective Egyptian Study.
Hagag AA, Badraia IM, Elfarargy MS, Abd Elmageed MM, Abo-Ali EA
Endocr Metab Immune Disord Drug Targets 2018 Feb 13;18(2):155-162. doi: 10.2174/1871530317666171003160350. PMID: 28982343
Glucose-6-phosphate dehydrogenase deficiency in retinal vein occlusion.
Pinna A, Carru C, Solinas G, Zinellu A, Carta F
Invest Ophthalmol Vis Sci 2007 Jun;48(6):2747-52. doi: 10.1167/iovs.06-1064. PMID: 17525208

Diagnosis

Hemolysis and Metabolic Lesion of G6PD Deficient RBCs in Response to Dapsone Hydroxylamine in a Humanized Mouse Model.
Dziewulska KH, Reisz JA, Hay AM, D'Alessandro A, Zimring JC
J Pharmacol Exp Ther 2023 Sep;386(3):323-330. Epub 2023 Jun 22 doi: 10.1124/jpet.123.001634. PMID: 37348965
Laboratory Approach to Hemolytic Anemia.
Jamwal M, Sharma P, Das R
Indian J Pediatr 2020 Jan;87(1):66-74. Epub 2019 Dec 10 doi: 10.1007/s12098-019-03119-8. PMID: 31823208
Decreased glucose-6-phosphate dehydrogenase activity along with oxidative stress affects visual contrast sensitivity in alcoholics.
Pramanik S, Ganguly U, Khemka VK, Banerjee A
Alcohol 2018 Dec;73:17-24. Epub 2018 Mar 21 doi: 10.1016/j.alcohol.2018.03.007. PMID: 30172164
New cases of Glucose-6-Phosphate Dehydrogenase deficiency in Pulmonary Arterial Hypertension.
Kurdyukov S, Eccles CA, Desai AA, Gonzalez-Garay M, Yuan JX, Garcia JGN, Rafikova O, Rafikov R
PLoS One 2018;13(8):e0203493. Epub 2018 Aug 30 doi: 10.1371/journal.pone.0203493. PMID: 30161219Free PMC Article
Membrane characteristics and metabolic properties of glucose-6-phosphate dehydrogenase deficient red cells.
Jansson SE, Hekali R, Gripenberg J, Härkönen M, Vuopio P
Br J Haematol 1980 Sep;46(1):79-87. doi: 10.1111/j.1365-2141.1980.tb05937.x. PMID: 6252945

Therapy

The potential role of vitamin E in patients with glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis.
Abdelwahab OA, Akil K, Seif A, Allam M, Sherif ME, Al-Alfy MN
Medicine (Baltimore) 2023 Feb 10;102(6):e32937. doi: 10.1097/MD.0000000000032937. PMID: 36820534Free PMC Article
Erythrocyte Glucose-6-Phosphate Dehydrogenase Level in Type 2 Diabetes Male.
Khanam A, Akter QS, Karim F, Zannat MR
Mymensingh Med J 2018 Jan;27(1):103-107. PMID: 29459599
Study of Glucose-6-Phosphate Dehydrogenase Deficiency: 5 Years Retrospective Egyptian Study.
Hagag AA, Badraia IM, Elfarargy MS, Abd Elmageed MM, Abo-Ali EA
Endocr Metab Immune Disord Drug Targets 2018 Feb 13;18(2):155-162. doi: 10.2174/1871530317666171003160350. PMID: 28982343
Does vitamin E have a role in treatment and prevention of anemia?
Jilani T, Iqbal MP
Pak J Pharm Sci 2011 Apr;24(2):237-42. PMID: 21454177
Changes in antioxidant enzymes in humans with long-term exposure to pesticides.
López O, Hernández AF, Rodrigo L, Gil F, Pena G, Serrano JL, Parrón T, Villanueva E, Pla A
Toxicol Lett 2007 Jul 10;171(3):146-53. Epub 2007 May 21 doi: 10.1016/j.toxlet.2007.05.004. PMID: 17590542

Prognosis

Hematologic and systemic metabolic alterations due to Mediterranean class II G6PD deficiency in mice.
D'Alessandro A, Howie HL, Hay AM, Dziewulska KH, Brown BC, Wither MJ, Karafin M, Stone EF, Spitalnik SL, Hod EA, Francis RO, Fu X, Thomas T, Zimring JC
JCI Insight 2021 Jul 22;6(14) doi: 10.1172/jci.insight.147056. PMID: 34138756Free PMC Article
The G6PD flow-cytometric assay is a reliable tool for diagnosis of G6PD deficiency in women and anaemic subjects.
Bancone G, Kalnoky M, Chu CS, Chowwiwat N, Kahn M, Malleret B, Wilaisrisak P, Rénia L, Domingo GJ, Nosten F
Sci Rep 2017 Aug 29;7(1):9822. doi: 10.1038/s41598-017-10045-2. PMID: 28852037Free PMC Article
Changes in antioxidant enzymes in humans with long-term exposure to pesticides.
López O, Hernández AF, Rodrigo L, Gil F, Pena G, Serrano JL, Parrón T, Villanueva E, Pla A
Toxicol Lett 2007 Jul 10;171(3):146-53. Epub 2007 May 21 doi: 10.1016/j.toxlet.2007.05.004. PMID: 17590542
Deletion of leucine 61 in glucose-6-phosphate dehydrogenase leads to chronic nonspherocytic anemia, granulocyte dysfunction, and increased susceptibility to infections.
van Bruggen R, Bautista JM, Petropoulou T, de Boer M, van Zwieten R, Gómez-Gallego F, Belohradsky BH, Hartwig NG, Stevens D, Mason PJ, Roos D
Blood 2002 Aug 1;100(3):1026-30. doi: 10.1182/blood.v100.3.1026. PMID: 12130518
Interplay between glutathione-S-transferase and glucose-6-phosphate dehydrogenase in neonatal cord blood.
Hunaiti AA, al-Shareef M
Biol Neonate 1997;72(5):273-8. doi: 10.1159/000244493. PMID: 9395837

Clinical prediction guides

Red cell proteasome modulation by storage, redox metabolism and transfusion.
Tzounakas VL, Dzieciatkowska M, Anastasiadi AT, Karadimas DG, Vergaki A, Siourounis P, Stamoulis K, Papassideri IS, Kriebardis AG, D'Alessandro A, Antonelou MH
Blood Transfus 2022 Jan;20(1):27-39. Epub 2020 Nov 27 doi: 10.2450/2020.0179-20. PMID: 33263521Free PMC Article
Hematologic and systemic metabolic alterations due to Mediterranean class II G6PD deficiency in mice.
D'Alessandro A, Howie HL, Hay AM, Dziewulska KH, Brown BC, Wither MJ, Karafin M, Stone EF, Spitalnik SL, Hod EA, Francis RO, Fu X, Thomas T, Zimring JC
JCI Insight 2021 Jul 22;6(14) doi: 10.1172/jci.insight.147056. PMID: 34138756Free PMC Article
Decreased glucose-6-phosphate dehydrogenase activity along with oxidative stress affects visual contrast sensitivity in alcoholics.
Pramanik S, Ganguly U, Khemka VK, Banerjee A
Alcohol 2018 Dec;73:17-24. Epub 2018 Mar 21 doi: 10.1016/j.alcohol.2018.03.007. PMID: 30172164
Erythrocyte Glucose-6-Phosphate Dehydrogenase Level in Type 2 Diabetes Male.
Khanam A, Akter QS, Karim F, Zannat MR
Mymensingh Med J 2018 Jan;27(1):103-107. PMID: 29459599
Ozone and human blood.
Buckley RD, Hackney JD, Clark K, Posin C
Arch Environ Health 1975 Jan;30(1):40-3. doi: 10.1080/00039896.1975.10666631. PMID: 1109271

Recent systematic reviews

The potential role of vitamin E in patients with glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis.
Abdelwahab OA, Akil K, Seif A, Allam M, Sherif ME, Al-Alfy MN
Medicine (Baltimore) 2023 Feb 10;102(6):e32937. doi: 10.1097/MD.0000000000032937. PMID: 36820534Free PMC Article

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