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Refractory Nasal Type Extranodal NK/T-Cell Lymphoma

MedGen UID:
163470
•Concept ID:
C0854832
•
Neoplastic Process
Synonyms: Angiocentric Lymphoma Refractory; Refractory Angiocentric Lymphoma; Refractory Nasal/Nasal Type T/NK-Cell Lymphoma

Definition

Nasal type extranodal NK/T-cell lymphoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Nasal Type Extranodal NK/T-Cell Lymphoma

Professional guidelines

PubMed

The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article
NK/T-cell lymphomas: pathobiology, prognosis and treatment paradigm.
Suzuki R
Curr Oncol Rep 2012 Oct;14(5):395-402. doi: 10.1007/s11912-012-0245-9. PMID: 22639106
Treatment of advanced extranodal NK/T cell lymphoma, nasal-type and aggressive NK-cell leukemia.
Suzuki R
Int J Hematol 2010 Dec;92(5):697-701. Epub 2010 Dec 1 doi: 10.1007/s12185-010-0726-2. PMID: 21116747

Recent clinical studies

Etiology

First-line sintilimab with pegaspargase, gemcitabine, and oxaliplatin in advanced extranodal natural killer/T cell lymphoma (SPIRIT): a multicentre, single-arm, phase 2 trial.
Tian XP, Cai J, Xia Y, Zhang YC, Wang L, Liu PP, Huang HQ, Li YJ, Zhou H, Li ZM, Yang J, Wei LQ, Zou QH, Huang Y, Li J, Ling L, Zhong WL, Cai QQ
Lancet Haematol 2024 May;11(5):e336-e344. Epub 2024 Mar 27 doi: 10.1016/S2352-3026(24)00066-8. PMID: 38554717
T- and NK-cell lymphoproliferative disorders of the gastrointestinal tract: review and update.
van Vliet C, Spagnolo DV
Pathology 2020 Jan;52(1):128-141. Epub 2019 Nov 11 doi: 10.1016/j.pathol.2019.10.001. PMID: 31727264
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article
Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study.
Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R
J Clin Oncol 2011 Nov 20;29(33):4410-6. Epub 2011 Oct 11 doi: 10.1200/JCO.2011.35.6287. PMID: 21990393
Extranodal natural killer/T-cell lymphoma: advances in the management.
Jaccard A, Hermine O
Curr Opin Oncol 2011 Sep;23(5):429-35. doi: 10.1097/CCO.0b013e328349aba6. PMID: 21743325

Diagnosis

Review on natural killer/T-cell lymphoma.
He X, Gao Y, Li Z, Huang H
Hematol Oncol 2023 Apr;41(2):221-229. Epub 2021 Dec 9 doi: 10.1002/hon.2944. PMID: 34731509
NK-Cell Lymphomas.
Chihara D, Oki Y
Cancer Treat Res 2019;176:163-184. doi: 10.1007/978-3-319-99716-2_8. PMID: 30596218
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article
Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study.
Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R
J Clin Oncol 2011 Nov 20;29(33):4410-6. Epub 2011 Oct 11 doi: 10.1200/JCO.2011.35.6287. PMID: 21990393
The diagnosis and management of extranodal NK/T-cell lymphoma, nasal-type and aggressive NK-cell leukemia.
Kwong YL
J Clin Exp Hematop 2011;51(1):21-8. doi: 10.3960/jslrt.51.21. PMID: 21628857

Therapy

NK/T Cell Lymphoma: Updates in Therapy.
Suzuki R
Curr Hematol Malig Rep 2018 Feb;13(1):7-12. doi: 10.1007/s11899-018-0430-5. PMID: 29368155
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article
NK/T-cell lymphomas: pathobiology, prognosis and treatment paradigm.
Suzuki R
Curr Oncol Rep 2012 Oct;14(5):395-402. doi: 10.1007/s11912-012-0245-9. PMID: 22639106
Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study.
Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R
J Clin Oncol 2011 Nov 20;29(33):4410-6. Epub 2011 Oct 11 doi: 10.1200/JCO.2011.35.6287. PMID: 21990393
Treatment of advanced extranodal NK/T cell lymphoma, nasal-type and aggressive NK-cell leukemia.
Suzuki R
Int J Hematol 2010 Dec;92(5):697-701. Epub 2010 Dec 1 doi: 10.1007/s12185-010-0726-2. PMID: 21116747

Prognosis

Review on natural killer/T-cell lymphoma.
He X, Gao Y, Li Z, Huang H
Hematol Oncol 2023 Apr;41(2):221-229. Epub 2021 Dec 9 doi: 10.1002/hon.2944. PMID: 34731509
Molecular pathogenic pathways in extranodal NK/T cell lymphoma.
de Mel S, Hue SS, Jeyasekharan AD, Chng WJ, Ng SB
J Hematol Oncol 2019 Apr 2;12(1):33. doi: 10.1186/s13045-019-0716-7. PMID: 30935402Free PMC Article
NK/T Cell Lymphoma: Updates in Therapy.
Suzuki R
Curr Hematol Malig Rep 2018 Feb;13(1):7-12. doi: 10.1007/s11899-018-0430-5. PMID: 29368155
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article
NK/T-cell lymphomas: pathobiology, prognosis and treatment paradigm.
Suzuki R
Curr Oncol Rep 2012 Oct;14(5):395-402. doi: 10.1007/s11912-012-0245-9. PMID: 22639106

Clinical prediction guides

First-line sintilimab with pegaspargase, gemcitabine, and oxaliplatin in advanced extranodal natural killer/T cell lymphoma (SPIRIT): a multicentre, single-arm, phase 2 trial.
Tian XP, Cai J, Xia Y, Zhang YC, Wang L, Liu PP, Huang HQ, Li YJ, Zhou H, Li ZM, Yang J, Wei LQ, Zou QH, Huang Y, Li J, Ling L, Zhong WL, Cai QQ
Lancet Haematol 2024 May;11(5):e336-e344. Epub 2024 Mar 27 doi: 10.1016/S2352-3026(24)00066-8. PMID: 38554717
DDGP vs. SMILE in Relapsed/Refractory Extranodal Natural Killer/T-cell Lymphoma, Nasal Type: A Retrospective Study of 54 Patients.
Wang X, Hu J, Dong M, Ding M, Zhu L, Wu J, Sun Z, Li X, Zhang L, Li L, Wang X, Fu X, Wang G, Chen Q, Zhang M, Zhang X
Clin Transl Sci 2021 Jan;14(1):405-411. Epub 2020 Oct 12 doi: 10.1111/cts.12893. PMID: 33045134Free PMC Article
Using etoposide + dexamethasone-based regimens to treat nasal type extranodal natural killer/T-cell lymphoma-associated hemophagocytic lymphohistiocytosis.
Wei L, Yang L, Cong J, Ye J, Li X, Yao N, Yang J, Ding J, Wang J
J Cancer Res Clin Oncol 2021 Mar;147(3):863-869. Epub 2020 Oct 6 doi: 10.1007/s00432-020-03376-7. PMID: 33025280Free PMC Article
Frequent expression of CD30 in extranodal NK/T-cell lymphoma: Potential therapeutic target for anti-CD30 antibody-based therapy.
Kawamoto K, Miyoshi H, Suzuki T, Sasaki Y, Yamada K, Yanagida E, Muto R, Kiryu M, Sone H, Seto M, Ohshima K, Takizawa J
Hematol Oncol 2018 Feb;36(1):166-173. Epub 2017 Oct 20 doi: 10.1002/hon.2482. PMID: 29052238
Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study.
Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R
J Clin Oncol 2011 Nov 20;29(33):4410-6. Epub 2011 Oct 11 doi: 10.1200/JCO.2011.35.6287. PMID: 21990393

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