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Recurrent Primary Mediastinal (Thymic) Large B-Cell Lymphoma

MedGen UID:
163527
•Concept ID:
C0855153
•
Neoplastic Process
Synonyms: Recurrent Primary Mediastinal Large B-Cell Lymphoma; Relapsed Primary Mediastinal (Thymic) Large B-Cell Lymphoma; Relapsed Primary Mediastinal Large B-Cell Lymphoma

Definition

The reemergence of primary mediastinal (thymic) large B-cell lymphoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Primary Mediastinal (Thymic) Large B-Cell Lymphoma

Professional guidelines

PubMed

Relapsed/refractory primary mediastinal large B-cell lymphoma: a structured review of epidemiology, treatment guidelines and real-world treatment practices.
Takyar J, Raut M, Borse R, Balakumaran A, Sehgal M
Expert Rev Hematol 2020 Mar;13(3):275-287. Epub 2020 Jan 28 doi: 10.1080/17474086.2020.1716725. PMID: 31951774
R-CHOP versus dose-adjusted R-EPOCH in frontline management of primary mediastinal B-cell lymphoma: a multi-centre analysis.
Shah NN, Szabo A, Huntington SF, Epperla N, Reddy N, Ganguly S, Vose J, Obiozor C, Faruqi F, Kovach AE, Costa LJ, Xavier AC, Okal R, Kanate AS, Ghosh N, Kharfan-Dabaja MA, Strelec L, Hamadani M, Fenske TS, Calzada O, Cohen JB, Chavez J, Svoboda J
Br J Haematol 2018 Feb;180(4):534-544. Epub 2017 Dec 19 doi: 10.1111/bjh.15051. PMID: 29265182

Recent clinical studies

Etiology

Phase 2 Study of Dose-Reduced Consolidation Radiation Therapy in Diffuse Large B-Cell Lymphoma.
Kelsey CR, Broadwater G, James O, Chino J, Diehl L, Beaven AW, Chang C, Koontz BF, Prosnitz LR
Int J Radiat Oncol Biol Phys 2019 Sep 1;105(1):96-101. Epub 2019 Mar 8 doi: 10.1016/j.ijrobp.2019.02.055. PMID: 30858144Free PMC Article
Outcomes of Relapsed and Refractory Primary Mediastinal (Thymic) Large B Cell Lymphoma Treated with Second-Line Therapy and Intent to Transplant.
Vardhana S, Hamlin PA, Yang J, Zelenetz A, Sauter CS, Matasar MJ, Ni A, Yahalom J, Moskowitz CH
Biol Blood Marrow Transplant 2018 Oct;24(10):2133-2138. Epub 2018 Jun 15 doi: 10.1016/j.bbmt.2018.06.009. PMID: 29909154Free PMC Article
R-CHOP versus dose-adjusted R-EPOCH in frontline management of primary mediastinal B-cell lymphoma: a multi-centre analysis.
Shah NN, Szabo A, Huntington SF, Epperla N, Reddy N, Ganguly S, Vose J, Obiozor C, Faruqi F, Kovach AE, Costa LJ, Xavier AC, Okal R, Kanate AS, Ghosh N, Kharfan-Dabaja MA, Strelec L, Hamadani M, Fenske TS, Calzada O, Cohen JB, Chavez J, Svoboda J
Br J Haematol 2018 Feb;180(4):534-544. Epub 2017 Dec 19 doi: 10.1111/bjh.15051. PMID: 29265182
Primary mediastinal large B-cell lymphoma arising from thyroid in a renal recipient with Hashimoto's thyroiditis.
Wu F, Qu L, Li DQ, Hu CH
Int J Clin Exp Pathol 2015;8(5):5944-6. Epub 2015 May 1 PMID: 26191324Free PMC Article

Diagnosis

R-CHOP versus dose-adjusted R-EPOCH in frontline management of primary mediastinal B-cell lymphoma: a multi-centre analysis.
Shah NN, Szabo A, Huntington SF, Epperla N, Reddy N, Ganguly S, Vose J, Obiozor C, Faruqi F, Kovach AE, Costa LJ, Xavier AC, Okal R, Kanate AS, Ghosh N, Kharfan-Dabaja MA, Strelec L, Hamadani M, Fenske TS, Calzada O, Cohen JB, Chavez J, Svoboda J
Br J Haematol 2018 Feb;180(4):534-544. Epub 2017 Dec 19 doi: 10.1111/bjh.15051. PMID: 29265182
Primary mediastinal large B-cell lymphoma arising from thyroid in a renal recipient with Hashimoto's thyroiditis.
Wu F, Qu L, Li DQ, Hu CH
Int J Clin Exp Pathol 2015;8(5):5944-6. Epub 2015 May 1 PMID: 26191324Free PMC Article
Primary mediastinal large B-cell lymphoma.
Martelli M, Ferreri AJ, Johnson P
Crit Rev Oncol Hematol 2008 Dec;68(3):256-63. Epub 2008 Sep 7 doi: 10.1016/j.critrevonc.2008.07.020. PMID: 18774728
Primary large cell lymphoma of the mediastinum.
Aisenberg AC
Semin Oncol 1999 Jun;26(3):251-8. PMID: 10375082

Therapy

Phase 2 Study of Dose-Reduced Consolidation Radiation Therapy in Diffuse Large B-Cell Lymphoma.
Kelsey CR, Broadwater G, James O, Chino J, Diehl L, Beaven AW, Chang C, Koontz BF, Prosnitz LR
Int J Radiat Oncol Biol Phys 2019 Sep 1;105(1):96-101. Epub 2019 Mar 8 doi: 10.1016/j.ijrobp.2019.02.055. PMID: 30858144Free PMC Article
R-CHOP versus dose-adjusted R-EPOCH in frontline management of primary mediastinal B-cell lymphoma: a multi-centre analysis.
Shah NN, Szabo A, Huntington SF, Epperla N, Reddy N, Ganguly S, Vose J, Obiozor C, Faruqi F, Kovach AE, Costa LJ, Xavier AC, Okal R, Kanate AS, Ghosh N, Kharfan-Dabaja MA, Strelec L, Hamadani M, Fenske TS, Calzada O, Cohen JB, Chavez J, Svoboda J
Br J Haematol 2018 Feb;180(4):534-544. Epub 2017 Dec 19 doi: 10.1111/bjh.15051. PMID: 29265182
Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach?
Dunleavy K, Wilson WH
Blood 2015 Jan 1;125(1):33-9. Epub 2014 Dec 11 doi: 10.1182/blood-2014-05-575092. PMID: 25499450Free PMC Article
Primary mediastinal large B-cell lymphoma.
Martelli M, Ferreri AJ, Johnson P
Crit Rev Oncol Hematol 2008 Dec;68(3):256-63. Epub 2008 Sep 7 doi: 10.1016/j.critrevonc.2008.07.020. PMID: 18774728
Primary large cell lymphoma of the mediastinum.
Aisenberg AC
Semin Oncol 1999 Jun;26(3):251-8. PMID: 10375082

Prognosis

Outcomes of Relapsed and Refractory Primary Mediastinal (Thymic) Large B Cell Lymphoma Treated with Second-Line Therapy and Intent to Transplant.
Vardhana S, Hamlin PA, Yang J, Zelenetz A, Sauter CS, Matasar MJ, Ni A, Yahalom J, Moskowitz CH
Biol Blood Marrow Transplant 2018 Oct;24(10):2133-2138. Epub 2018 Jun 15 doi: 10.1016/j.bbmt.2018.06.009. PMID: 29909154Free PMC Article
Primary mediastinal large B-cell lymphoma.
Martelli M, Ferreri AJ, Johnson P
Crit Rev Oncol Hematol 2008 Dec;68(3):256-63. Epub 2008 Sep 7 doi: 10.1016/j.critrevonc.2008.07.020. PMID: 18774728
Primary large cell lymphoma of the mediastinum.
Aisenberg AC
Semin Oncol 1999 Jun;26(3):251-8. PMID: 10375082

Clinical prediction guides

Outcomes of Relapsed and Refractory Primary Mediastinal (Thymic) Large B Cell Lymphoma Treated with Second-Line Therapy and Intent to Transplant.
Vardhana S, Hamlin PA, Yang J, Zelenetz A, Sauter CS, Matasar MJ, Ni A, Yahalom J, Moskowitz CH
Biol Blood Marrow Transplant 2018 Oct;24(10):2133-2138. Epub 2018 Jun 15 doi: 10.1016/j.bbmt.2018.06.009. PMID: 29909154Free PMC Article
Primary mediastinal large B-cell lymphoma.
Martelli M, Ferreri AJ, Johnson P
Crit Rev Oncol Hematol 2008 Dec;68(3):256-63. Epub 2008 Sep 7 doi: 10.1016/j.critrevonc.2008.07.020. PMID: 18774728

Recent systematic reviews

Relapsed/refractory primary mediastinal large B-cell lymphoma: a structured review of epidemiology, treatment guidelines and real-world treatment practices.
Takyar J, Raut M, Borse R, Balakumaran A, Sehgal M
Expert Rev Hematol 2020 Mar;13(3):275-287. Epub 2020 Jan 28 doi: 10.1080/17474086.2020.1716725. PMID: 31951774

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