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Physiological polycythemia

MedGen UID:
163545
•Concept ID:
C0856817
•
Disease or Syndrome
Synonyms: Physiological Polycythemia; physiological polycythemia
 
Monarch Initiative: MONDO:0004563

Definition

Polycythemia that is not pathologic. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPhysiological polycythemia

Professional guidelines

PubMed

Childhood polycythemias/erythrocytoses: classification, diagnosis, clinical presentation, and treatment.
Cario H
Ann Hematol 2005 Mar;84(3):137-45. Epub 2004 Dec 15 doi: 10.1007/s00277-004-0985-1. PMID: 15599750
Idiopathic erythrocytosis, diagnosis and clinical management.
Pearson TC, Messinezy M
Pathol Biol (Paris) 2001 Mar;49(2):170-7. doi: 10.1016/s0369-8114(00)00025-0. PMID: 11317965
Polycythemia: mechanisms and management.
Golde DW, Hocking WG, Koeffler HP, Adamson JW
Ann Intern Med 1981 Jul;95(1):71-87. doi: 10.7326/0003-4819-95-1-71. PMID: 7018337

Recent clinical studies

Etiology

Stroke at Moderate and High Altitude.
Syed MJ, Khatri IA, Alamgir W, Wasay M
High Alt Med Biol 2022 Mar;23(1):1-7. Epub 2021 Oct 11 doi: 10.1089/ham.2021.0043. PMID: 34637624
Dysregulated iron metabolism in polycythemia vera: etiology and consequences.
Ginzburg YZ, Feola M, Zimran E, Varkonyi J, Ganz T, Hoffman R
Leukemia 2018 Oct;32(10):2105-2116. Epub 2018 Jul 24 doi: 10.1038/s41375-018-0207-9. PMID: 30042411Free PMC Article
Thrombocytosis in children.
Chiarello P, Magnolia M, Rubino M, Liguori SA, Miniero R
Minerva Pediatr 2011 Dec;63(6):507-13. PMID: 22075805
Polycythemia and chorea.
Marvi MM, Lew MF
Handb Clin Neurol 2011;100:271-6. doi: 10.1016/B978-0-444-52014-2.00019-7. PMID: 21496586
Physiological adaptation of the cardiovascular system to high altitude.
Naeije R
Prog Cardiovasc Dis 2010 May-Jun;52(6):456-66. doi: 10.1016/j.pcad.2010.03.004. PMID: 20417339

Diagnosis

Testosterone Therapy: Review of Clinical Applications.
Petering RC, Brooks NA
Am Fam Physician 2017 Oct 1;96(7):441-449. PMID: 29094914
Male hypogonadism.
Basaria S
Lancet 2014 Apr 5;383(9924):1250-63. Epub 2013 Oct 10 doi: 10.1016/S0140-6736(13)61126-5. PMID: 24119423
Thrombocytosis in children.
Chiarello P, Magnolia M, Rubino M, Liguori SA, Miniero R
Minerva Pediatr 2011 Dec;63(6):507-13. PMID: 22075805
Polycythemia and chorea.
Marvi MM, Lew MF
Handb Clin Neurol 2011;100:271-6. doi: 10.1016/B978-0-444-52014-2.00019-7. PMID: 21496586
Spurious polycythemia.
Weinreb NJ, Shih CF
Semin Hematol 1975 Oct;12(4):397-407. PMID: 1198127

Therapy

Effects of an Aqueous Extract of Withania somnifera on Strength Training Adaptations and Recovery: The STAR Trial.
Ziegenfuss TN, Kedia AW, Sandrock JE, Raub BJ, Kerksick CM, Lopez HL
Nutrients 2018 Nov 20;10(11) doi: 10.3390/nu10111807. PMID: 30463324Free PMC Article
Testosterone Therapy: Review of Clinical Applications.
Petering RC, Brooks NA
Am Fam Physician 2017 Oct 1;96(7):441-449. PMID: 29094914
Male hypogonadism.
Basaria S
Lancet 2014 Apr 5;383(9924):1250-63. Epub 2013 Oct 10 doi: 10.1016/S0140-6736(13)61126-5. PMID: 24119423
Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells.
Mullally A, Lane SW, Ball B, Megerdichian C, Okabe R, Al-Shahrour F, Paktinat M, Haydu JE, Housman E, Lord AM, Wernig G, Kharas MG, Mercher T, Kutok JL, Gilliland DG, Ebert BL
Cancer Cell 2010 Jun 15;17(6):584-96. doi: 10.1016/j.ccr.2010.05.015. PMID: 20541703Free PMC Article
Hematologic disorders in the elderly.
Walsh JR
West J Med 1981 Dec;135(6):446-54. PMID: 6801866Free PMC Article

Prognosis

Dysregulated iron metabolism in polycythemia vera: etiology and consequences.
Ginzburg YZ, Feola M, Zimran E, Varkonyi J, Ganz T, Hoffman R
Leukemia 2018 Oct;32(10):2105-2116. Epub 2018 Jul 24 doi: 10.1038/s41375-018-0207-9. PMID: 30042411Free PMC Article
"Benign erythrocytosis" and other familial and congenital polycythemias.
Prchal JT, Sokol L
Eur J Haematol 1996 Oct;57(4):263-8. PMID: 8982288
Chronic myeloproliferative disorders (CMPD).
Burkhardt R, Bartl R, Jäger K, Frisch B, Kettner G, Mahl G, Sund M
Pathol Res Pract 1984 Nov;179(2):131-86. doi: 10.1016/S0344-0338(84)80124-7. PMID: 6395125
Hematologic disorders in the elderly.
Walsh JR
West J Med 1981 Dec;135(6):446-54. PMID: 6801866Free PMC Article
Spurious polycythemia.
Weinreb NJ, Shih CF
Semin Hematol 1975 Oct;12(4):397-407. PMID: 1198127

Clinical prediction guides

Newborns physiological differences in low- and high-altitude settings of Ecuador.
Asas-Jinde M, González-Andrade F
J Dev Orig Health Dis 2022 Aug;13(4):494-499. Epub 2021 Sep 21 doi: 10.1017/S2040174421000532. PMID: 34544515
Effects of an Aqueous Extract of Withania somnifera on Strength Training Adaptations and Recovery: The STAR Trial.
Ziegenfuss TN, Kedia AW, Sandrock JE, Raub BJ, Kerksick CM, Lopez HL
Nutrients 2018 Nov 20;10(11) doi: 10.3390/nu10111807. PMID: 30463324Free PMC Article
Dysregulated iron metabolism in polycythemia vera: etiology and consequences.
Ginzburg YZ, Feola M, Zimran E, Varkonyi J, Ganz T, Hoffman R
Leukemia 2018 Oct;32(10):2105-2116. Epub 2018 Jul 24 doi: 10.1038/s41375-018-0207-9. PMID: 30042411Free PMC Article
Care of the infant of the diabetic mother.
Hay WW Jr
Curr Diab Rep 2012 Feb;12(1):4-15. doi: 10.1007/s11892-011-0243-6. PMID: 22094826
Chronic myeloproliferative disorders (CMPD).
Burkhardt R, Bartl R, Jäger K, Frisch B, Kettner G, Mahl G, Sund M
Pathol Res Pract 1984 Nov;179(2):131-86. doi: 10.1016/S0344-0338(84)80124-7. PMID: 6395125

Recent systematic reviews

The heart and pulmonary circulation at high altitudes: healthy highlanders and chronic mountain sickness.
Penaloza D, Arias-Stella J
Circulation 2007 Mar 6;115(9):1132-46. doi: 10.1161/CIRCULATIONAHA.106.624544. PMID: 17339571
Crystalloid or colloid for partial exchange transfusion in neonatal polycythemia: a systematic review and meta-analysis.
Dempsey EM, Barrington K
Acta Paediatr 2005 Nov;94(11):1650-5. doi: 10.1080/08035250500192748. PMID: 16303705

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