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Type I atherosclerotic lesion

MedGen UID:
1635748
Concept ID:
C4703474
Disease or Syndrome
HPO: HP:0031679

Definition

Type I lesions represent the very initial changes and are recognized as an increase in the number of intimal macrophages and the appearance of macrophages filled with lipid droplets (foam cells). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVType I atherosclerotic lesion

Professional guidelines

PubMed

Papadea P, Kalaitzopoulou E, Skipitari M, Varemmenou A, Papasotiriou M, Papachristou E, Goumenos D, Grune T, Georgiou CD
Redox Biol 2023 Aug;64:102762. Epub 2023 Jun 2 doi: 10.1016/j.redox.2023.102762. PMID: 37302344Free PMC Article
Vigario FL, Kuiper J, Slütter B
EBioMedicine 2020 Jul;57:102827. Epub 2020 Jun 20 doi: 10.1016/j.ebiom.2020.102827. PMID: 32574952Free PMC Article
Kumins NH, King AH, Ambani RN, Thomas JP, Kim AH, Augustin G, Wong VL, Harth KC, Cho JS, Colvard B, Kashyap VS
J Vasc Surg 2020 Oct;72(4):1395-1404. Epub 2020 Mar 4 doi: 10.1016/j.jvs.2020.01.041. PMID: 32145991

Recent clinical studies

Etiology

Libby P
Vascul Pharmacol 2024 Mar;154:107255. Epub 2023 Dec 28 doi: 10.1016/j.vph.2023.107255. PMID: 38157682
Kalayci A, Gibson CM, Ridker PM, Wright SD, Kingwell BA, Korjian S, Chi G, Lee JJ, Tricoci P, Kazmi SH, Fitzgerald C, Shaunik A, Berman G, Duffy D, Libby P
Curr Atheroscler Rep 2022 Jul;24(7):585-597. Epub 2022 May 7 doi: 10.1007/s11883-022-01025-7. PMID: 35524914Free PMC Article
Gisterå A, Hansson GK
Nat Rev Nephrol 2017 Jun;13(6):368-380. Epub 2017 Apr 10 doi: 10.1038/nrneph.2017.51. PMID: 28392564
Di Pietro N, Formoso G, Pandolfi A
Vascul Pharmacol 2016 Sep;84:1-7. Epub 2016 May 30 doi: 10.1016/j.vph.2016.05.013. PMID: 27256928
Bornfeldt KE, Tabas I
Cell Metab 2011 Nov 2;14(5):575-85. doi: 10.1016/j.cmet.2011.07.015. PMID: 22055501Free PMC Article

Diagnosis

Sniderman AD, Robinson JG
Atherosclerosis 2019 Mar;282:169-175. Epub 2018 Nov 10 doi: 10.1016/j.atherosclerosis.2018.11.001. PMID: 30463677
Domschke G, Gleissner CA
Cytokine 2019 Oct;122:154141. Epub 2017 Sep 10 doi: 10.1016/j.cyto.2017.08.021. PMID: 28899579
Fan J, Chen Y, Yan H, Liu B, Wang Y, Zhang J, Chen YE, Liu E, Liang J
Int J Mol Sci 2018 Nov 8;19(11) doi: 10.3390/ijms19113512. PMID: 30413026Free PMC Article
Cozzani E, Rosa GM, Burlando M, Parodi A
G Ital Dermatol Venereol 2018 Oct;153(5):659-665. Epub 2018 Apr 19 doi: 10.23736/S0392-0488.18.06040-6. PMID: 29683293
Plouin PF, Perdu J, La Batide-Alanore A, Boutouyrie P, Gimenez-Roqueplo AP, Jeunemaitre X
Orphanet J Rare Dis 2007 Jun 7;2:28. doi: 10.1186/1750-1172-2-28. PMID: 17555581Free PMC Article

Therapy

Kalayci A, Gibson CM, Ridker PM, Wright SD, Kingwell BA, Korjian S, Chi G, Lee JJ, Tricoci P, Kazmi SH, Fitzgerald C, Shaunik A, Berman G, Duffy D, Libby P
Curr Atheroscler Rep 2022 Jul;24(7):585-597. Epub 2022 May 7 doi: 10.1007/s11883-022-01025-7. PMID: 35524914Free PMC Article
Räber L, Ueki Y, Otsuka T, Losdat S, Häner JD, Lonborg J, Fahrni G, Iglesias JF, van Geuns RJ, Ondracek AS, Radu Juul Jensen MD, Zanchin C, Stortecky S, Spirk D, Siontis GCM, Saleh L, Matter CM, Daemen J, Mach F, Heg D, Windecker S, Engstrøm T, Lang IM, Koskinas KC; PACMAN-AMI collaborators
JAMA 2022 May 10;327(18):1771-1781. doi: 10.1001/jama.2022.5218. PMID: 35368058Free PMC Article
Hu D, Wang Z, Wang Y, Liang C
Curr Pharm Biotechnol 2021;22(15):2008-2018. doi: 10.2174/1389201022666210122142233. PMID: 33480337
Di Pietro N, Formoso G, Pandolfi A
Vascul Pharmacol 2016 Sep;84:1-7. Epub 2016 May 30 doi: 10.1016/j.vph.2016.05.013. PMID: 27256928
Kreisberg RA
Am J Cardiol 1998 Dec 17;82(12A):67U-73U; discussion 85U-86U. doi: 10.1016/s0002-9149(98)00848-0. PMID: 9915665

Prognosis

Libby P
Vascul Pharmacol 2024 Mar;154:107255. Epub 2023 Dec 28 doi: 10.1016/j.vph.2023.107255. PMID: 38157682
Schmit D, Fliser D, Speer T
Nephrol Dial Transplant 2019 Aug 1;34(8):1266-1271. doi: 10.1093/ndt/gfz122. PMID: 31190079
Yahagi K, Kolodgie FD, Lutter C, Mori H, Romero ME, Finn AV, Virmani R
Arterioscler Thromb Vasc Biol 2017 Feb;37(2):191-204. Epub 2016 Dec 1 doi: 10.1161/ATVBAHA.116.306256. PMID: 27908890Free PMC Article
Bulusu S, Sharma M
Ann Clin Biochem 2016 May;53(Pt 3):312-32. Epub 2015 Jul 2 doi: 10.1177/0004563215597010. PMID: 26139450
Kreisberg RA
Am J Cardiol 1998 Dec 17;82(12A):67U-73U; discussion 85U-86U. doi: 10.1016/s0002-9149(98)00848-0. PMID: 9915665

Clinical prediction guides

Libby P
Vascul Pharmacol 2024 Mar;154:107255. Epub 2023 Dec 28 doi: 10.1016/j.vph.2023.107255. PMID: 38157682
Benincasa G, Suades R, Padró T, Badimon L, Napoli C
Eur Heart J Cardiovasc Pharmacother 2023 Dec 14;9(8):758-769. doi: 10.1093/ehjcvp/pvad059. PMID: 37562936
Krishnaswamy A, Isogai T, Brilakis ES, Nanjundappa A, Ziada KM, Parikh SA, Rodés-Cabau J, Windecker S, Kapadia SR
JACC Cardiovasc Interv 2023 Jul 10;16(13):1561-1578. doi: 10.1016/j.jcin.2023.05.015. PMID: 37438024
Yahagi K, Kolodgie FD, Lutter C, Mori H, Romero ME, Finn AV, Virmani R
Arterioscler Thromb Vasc Biol 2017 Feb;37(2):191-204. Epub 2016 Dec 1 doi: 10.1161/ATVBAHA.116.306256. PMID: 27908890Free PMC Article
Breslow JL
Science 1996 May 3;272(5262):685-8. doi: 10.1126/science.272.5262.685. PMID: 8614828

Recent systematic reviews

Nikolic S, Dugic A, Steiner C, Tsolakis AV, Haugen Löfman IM, Löhr JM, Vujasinovic M
World J Gastroenterol 2019 Nov 28;25(44):6561-6570. doi: 10.3748/wjg.v25.i44.6561. PMID: 31802835Free PMC Article
Eiken FL, Pedersen BL, Bækgaard N, Eiberg JP
Int Angiol 2019 Feb;38(1):62-69. doi: 10.23736/S0392-9590.18.04051-8. PMID: 30860342
Touzé E, Southerland AM, Boulanger M, Labeyrie PE, Azizi M, Bouatia-Naji N, Debette S, Gornik HL, Hussain SM, Jeunemaitre X, Joux J, Kirton A, Le Hello C, Majersik JJ, Mocco J, Persu A, Sharma A, Worrall BB, Olin JW, Plouin PF
JAMA Neurol 2019 Feb 1;76(2):217-226. doi: 10.1001/jamaneurol.2018.2848. PMID: 30285053
Canas JA, Gidding SS, Mauras N
Curr Diabetes Rev 2017;13(6):544-554. doi: 10.2174/1573399813666170113142621. PMID: 28088892
Kayssi A, Al-Atassi T, Oreopoulos G, Roche-Nagle G, Tan KT, Rajan DK
Cochrane Database Syst Rev 2016 Aug 4;2016(8):CD011319. doi: 10.1002/14651858.CD011319.pub2. PMID: 27490003Free PMC Article

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