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Type I atherosclerotic lesion

MedGen UID:
1635748
•Concept ID:
C4703474
•
Disease or Syndrome
HPO: HP:0031679

Definition

Type I lesions represent the very initial changes and are recognized as an increase in the number of intimal macrophages and the appearance of macrophages filled with lipid droplets (foam cells). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVType I atherosclerotic lesion

Professional guidelines

PubMed

Low-density lipoprotein cholesterol lowering treatment: the current approach.
Crismaru I, Pantea Stoian A, Bratu OG, Gaman MA, Stanescu AMA, Bacalbasa N, Diaconu CC
Lipids Health Dis 2020 May 6;19(1):85. doi: 10.1186/s12944-020-01275-x. PMID: 32375792Free PMC Article
Newly approved devices for endovascular treatment of femoropopliteal disease: a review of clinical evidence.
Giannopoulos S, Armstrong EJ
Expert Rev Cardiovasc Ther 2019 Oct;17(10):729-740. Epub 2019 Oct 28 doi: 10.1080/14779072.2019.1675512. PMID: 31575289
Assessment and management of intermittent claudication: importance of secondary prevention.
Donnelly R
Int J Clin Pract Suppl 2001 Apr;(119):2-9. PMID: 11355275

Recent clinical studies

Etiology

ApoA-I Infusion Therapies Following Acute Coronary Syndrome: Past, Present, and Future.
Kalayci A, Gibson CM, Ridker PM, Wright SD, Kingwell BA, Korjian S, Chi G, Lee JJ, Tricoci P, Kazmi SH, Fitzgerald C, Shaunik A, Berman G, Duffy D, Libby P
Curr Atheroscler Rep 2022 Jul;24(7):585-597. Epub 2022 May 7 doi: 10.1007/s11883-022-01025-7. PMID: 35524914Free PMC Article
Clock Gene Bmal1 Disruption in Vascular Smooth Muscle Cells Worsens Carotid Atherosclerotic Lesions.
Lin C, Xu L, Tang X, Li X, Lu C, Cheng Q, Jiang J, Shen Y, Yan D, Qian R, Fu W, Guo D
Arterioscler Thromb Vasc Biol 2022 May;42(5):565-579. Epub 2022 Mar 3 doi: 10.1161/ATVBAHA.121.316480. PMID: 35236106
Updated Clinical and Radiological Classification of Lower Limb Atherosclerotic Disease.
Cannavale A, Santoni M, Gazzetti M, Catalano C, Fanelli F
Ann Vasc Surg 2019 Feb;55:272-284. Epub 2018 Aug 13 doi: 10.1016/j.avsg.2018.06.011. PMID: 30114503
The immunology of atherosclerosis.
Gisterå A, Hansson GK
Nat Rev Nephrol 2017 Jun;13(6):368-380. Epub 2017 Apr 10 doi: 10.1038/nrneph.2017.51. PMID: 28392564
Pathology of Human Coronary and Carotid Artery Atherosclerosis and Vascular Calcification in Diabetes Mellitus.
Yahagi K, Kolodgie FD, Lutter C, Mori H, Romero ME, Finn AV, Virmani R
Arterioscler Thromb Vasc Biol 2017 Feb;37(2):191-204. Epub 2016 Dec 1 doi: 10.1161/ATVBAHA.116.306256. PMID: 27908890Free PMC Article

Diagnosis

Targeting Macrophages in Atherosclerosis.
Hu D, Wang Z, Wang Y, Liang C
Curr Pharm Biotechnol 2021;22(15):2008-2018. doi: 10.2174/1389201022666210122142233. PMID: 33480337
ApoB in clinical care: Pro and Con.
Sniderman AD, Robinson JG
Atherosclerosis 2019 Mar;282:169-175. Epub 2018 Nov 10 doi: 10.1016/j.atherosclerosis.2018.11.001. PMID: 30463677
CXCL4-induced macrophages in human atherosclerosis.
Domschke G, Gleissner CA
Cytokine 2019 Oct;122:154141. Epub 2017 Sep 10 doi: 10.1016/j.cyto.2017.08.021. PMID: 28899579
Psoriasis as a cardiovascular risk factor: updates and algorithmic approach.
Cozzani E, Rosa GM, Burlando M, Parodi A
G Ital Dermatol Venereol 2018 Oct;153(5):659-665. Epub 2018 Apr 19 doi: 10.23736/S0392-0488.18.06040-6. PMID: 29683293
Fibromuscular dysplasia.
Plouin PF, Perdu J, La Batide-Alanore A, Boutouyrie P, Gimenez-Roqueplo AP, Jeunemaitre X
Orphanet J Rare Dis 2007 Jun 7;2:28. doi: 10.1186/1750-1172-2-28. PMID: 17555581Free PMC Article

Therapy

Effect of Alirocumab Added to High-Intensity Statin Therapy on Coronary Atherosclerosis in Patients With Acute Myocardial Infarction: The PACMAN-AMI Randomized Clinical Trial.
Räber L, Ueki Y, Otsuka T, Losdat S, Häner JD, Lonborg J, Fahrni G, Iglesias JF, van Geuns RJ, Ondracek AS, Radu Juul Jensen MD, Zanchin C, Stortecky S, Spirk D, Siontis GCM, Saleh L, Matter CM, Daemen J, Mach F, Heg D, Windecker S, Engstrøm T, Lang IM, Koskinas KC; PACMAN-AMI collaborators
JAMA 2022 May 10;327(18):1771-1781. doi: 10.1001/jama.2022.5218. PMID: 35368058Free PMC Article
Targeting Macrophages in Atherosclerosis.
Hu D, Wang Z, Wang Y, Liang C
Curr Pharm Biotechnol 2021;22(15):2008-2018. doi: 10.2174/1389201022666210122142233. PMID: 33480337
PCSK9 and inflammation: a review of experimental and clinical evidence.
Momtazi-Borojeni AA, Sabouri-Rad S, Gotto AM, Pirro M, Banach M, Awan Z, Barreto GE, Sahebkar A
Eur Heart J Cardiovasc Pharmacother 2019 Oct 1;5(4):237-245. doi: 10.1093/ehjcvp/pvz022. PMID: 31236571
Fibromuscular dysplasia.
Plouin PF, Perdu J, La Batide-Alanore A, Boutouyrie P, Gimenez-Roqueplo AP, Jeunemaitre X
Orphanet J Rare Dis 2007 Jun 7;2:28. doi: 10.1186/1750-1172-2-28. PMID: 17555581Free PMC Article
Diabetic dyslipidemia.
Kreisberg RA
Am J Cardiol 1998 Dec 17;82(12A):67U-73U; discussion 85U-86U. doi: 10.1016/s0002-9149(98)00848-0. PMID: 9915665

Prognosis

Updated Clinical and Radiological Classification of Lower Limb Atherosclerotic Disease.
Cannavale A, Santoni M, Gazzetti M, Catalano C, Fanelli F
Ann Vasc Surg 2019 Feb;55:272-284. Epub 2018 Aug 13 doi: 10.1016/j.avsg.2018.06.011. PMID: 30114503
Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry.
Winkels H, Ehinger E, Vassallo M, Buscher K, Dinh HQ, Kobiyama K, Hamers AAJ, Cochain C, Vafadarnejad E, Saliba AE, Zernecke A, Pramod AB, Ghosh AK, Anto Michel N, Hoppe N, Hilgendorf I, Zirlik A, Hedrick CC, Ley K, Wolf D
Circ Res 2018 Jun 8;122(12):1675-1688. Epub 2018 Mar 15 doi: 10.1161/CIRCRESAHA.117.312513. PMID: 29545366Free PMC Article
Pathology of Human Coronary and Carotid Artery Atherosclerosis and Vascular Calcification in Diabetes Mellitus.
Yahagi K, Kolodgie FD, Lutter C, Mori H, Romero ME, Finn AV, Virmani R
Arterioscler Thromb Vasc Biol 2017 Feb;37(2):191-204. Epub 2016 Dec 1 doi: 10.1161/ATVBAHA.116.306256. PMID: 27908890Free PMC Article
Fibromuscular dysplasia.
Plouin PF, Perdu J, La Batide-Alanore A, Boutouyrie P, Gimenez-Roqueplo AP, Jeunemaitre X
Orphanet J Rare Dis 2007 Jun 7;2:28. doi: 10.1186/1750-1172-2-28. PMID: 17555581Free PMC Article
Diabetic dyslipidemia.
Kreisberg RA
Am J Cardiol 1998 Dec 17;82(12A):67U-73U; discussion 85U-86U. doi: 10.1016/s0002-9149(98)00848-0. PMID: 9915665

Clinical prediction guides

PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Triggers Vascular Smooth Muscle Cell Senescence and Apoptosis: Implication of Its Direct Role in Degenerative Vascular Disease.
Guo Y, Tang Z, Yan B, Yin H, Tai S, Peng J, Cui Y, Gui Y, Belke D, Zhou S, Zheng XL
Arterioscler Thromb Vasc Biol 2022 Jan;42(1):67-86. Epub 2021 Nov 23 doi: 10.1161/ATVBAHA.121.316902. PMID: 34809446
Calcium deposition within coronary atherosclerotic lesion: Implications for plaque stability.
Jinnouchi H, Sato Y, Sakamoto A, Cornelissen A, Mori M, Kawakami R, Gadhoke NV, Kolodgie FD, Virmani R, Finn AV
Atherosclerosis 2020 Aug;306:85-95. Epub 2020 Jun 14 doi: 10.1016/j.atherosclerosis.2020.05.017. PMID: 32654790
Pathology of Human Coronary and Carotid Artery Atherosclerosis and Vascular Calcification in Diabetes Mellitus.
Yahagi K, Kolodgie FD, Lutter C, Mori H, Romero ME, Finn AV, Virmani R
Arterioscler Thromb Vasc Biol 2017 Feb;37(2):191-204. Epub 2016 Dec 1 doi: 10.1161/ATVBAHA.116.306256. PMID: 27908890Free PMC Article
Lipoprotein(a) in cardiovascular diseases.
Malaguarnera M, Vacante M, Russo C, Malaguarnera G, Antic T, Malaguarnera L, Bella R, Pennisi G, Galvano F, Frigiola A
Biomed Res Int 2013;2013:650989. Epub 2012 Dec 30 doi: 10.1155/2013/650989. PMID: 23484137Free PMC Article
Fibromuscular dysplasia.
Plouin PF, Perdu J, La Batide-Alanore A, Boutouyrie P, Gimenez-Roqueplo AP, Jeunemaitre X
Orphanet J Rare Dis 2007 Jun 7;2:28. doi: 10.1186/1750-1172-2-28. PMID: 17555581Free PMC Article

Recent systematic reviews

Chronic pancreatitis and the heart disease: Still terra incognita?
Nikolic S, Dugic A, Steiner C, Tsolakis AV, Haugen Löfman IM, Löhr JM, Vujasinovic M
World J Gastroenterol 2019 Nov 28;25(44):6561-6570. doi: 10.3748/wjg.v25.i44.6561. PMID: 31802835Free PMC Article
Diagnostic methods for measurement of peripheral blood flow during exercise in patients with type 2 diabetes and peripheral artery disease: a systematic review.
Eiken FL, Pedersen BL, Bækgaard N, Eiberg JP
Int Angiol 2019 Feb;38(1):62-69. doi: 10.23736/S0392-9590.18.04051-8. PMID: 30860342
Fibromuscular Dysplasia and Its Neurologic Manifestations: A Systematic Review.
Touzé E, Southerland AM, Boulanger M, Labeyrie PE, Azizi M, Bouatia-Naji N, Debette S, Gornik HL, Hussain SM, Jeunemaitre X, Joux J, Kirton A, Le Hello C, Majersik JJ, Mocco J, Persu A, Sharma A, Worrall BB, Olin JW, Plouin PF
JAMA Neurol 2019 Feb 1;76(2):217-226. doi: 10.1001/jamaneurol.2018.2848. PMID: 30285053
Interventions to Reduce Cardiovascular Risk in Children with Type 1 Diabetes.
Canas JA, Gidding SS, Mauras N
Curr Diabetes Rev 2017;13(6):544-554. doi: 10.2174/1573399813666170113142621. PMID: 28088892
Drug-eluting balloon angioplasty versus uncoated balloon angioplasty for peripheral arterial disease of the lower limbs.
Kayssi A, Al-Atassi T, Oreopoulos G, Roche-Nagle G, Tan KT, Rajan DK
Cochrane Database Syst Rev 2016 Aug 4;2016(8):CD011319. doi: 10.1002/14651858.CD011319.pub2. PMID: 27490003Free PMC Article

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