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Resectable Hepatocellular Carcinoma

MedGen UID:
163587
•Concept ID:
C0863194
•
Neoplastic Process
Synonyms: Hepatocellular Carcinoma, Resectable; Resectable Carcinoma of Liver Cell; Resectable Carcinoma of the Liver Cell; Resectable Hepatoma; Resectable Liver Cell Carcinoma

Definition

A hepatocellular carcinoma that is amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVResectable Hepatocellular Carcinoma

Professional guidelines

PubMed

An Overview of Clinical Trials in the Treatment of Resectable Hepatocellular Carcinoma.
Nevarez NM, Chang GY, Yopp AC
Surg Oncol Clin N Am 2023 Jan;32(1):101-117. Epub 2022 Nov 3 doi: 10.1016/j.soc.2022.07.008. PMID: 36410911
Adjuvant treatment strategy after curative resection for hepatocellular carcinoma.
Zhang W, Zhang B, Chen XP
Front Med 2021 Apr;15(2):155-169. Epub 2021 Mar 23 doi: 10.1007/s11684-021-0848-3. PMID: 33754281
State of the ablation nation: a review of ablative therapies for cure in the treatment of hepatocellular carcinoma.
Salati U, Barry A, Chou FY, Ma R, Liu DM
Future Oncol 2017 Jul;13(16):1437-1448. Epub 2017 Jul 7 doi: 10.2217/fon-2017-0061. PMID: 28685607

Recent clinical studies

Etiology

Real-world efficacy and prognostic factors of lenvatinib plus PD-1 inhibitors in 378 unresectable hepatocellular carcinoma patients.
Yang X, Chen B, Wang Y, Wang Y, Long J, Zhang N, Xue J, Xun Z, Zhang L, Cheng J, Lei J, Sun H, Li Y, Lin J, Xie F, Wang D, Pan J, Hu K, Guan M, Huo L, Shi J, Yu L, Zhou L, Zhou J, Lu Z, Yang X, Mao Y, Sang X, Lu Y, Zhao H
Hepatol Int 2023 Jun;17(3):709-719. Epub 2023 Feb 8 doi: 10.1007/s12072-022-10480-y. PMID: 36753026Free PMC Article
Neoadjuvant cemiplimab for resectable hepatocellular carcinoma: a single-arm, open-label, phase 2 trial.
Marron TU, Fiel MI, Hamon P, Fiaschi N, Kim E, Ward SC, Zhao Z, Kim J, Kennedy P, Gunasekaran G, Tabrizian P, Doroshow D, Legg M, Hammad A, Magen A, Kamphorst AO, Shareef M, Gupta NT, Deering R, Wang W, Wang F, Thanigaimani P, Mani J, Troncoso L, Tabachnikova A, Chang C, Akturk G, Buckup M, Hamel S, Ioannou G, Hennequin C, Jamal H, Brown H, Bonaccorso A, Labow D, Sarpel U, Rosenbloom T, Sung MW, Kou B, Li S, Jankovic V, James N, Hamon SC, Cheung HK, Sims JS, Miller E, Bhardwaj N, Thurston G, Lowy I, Gnjatic S, Taouli B, Schwartz ME, Merad M
Lancet Gastroenterol Hepatol 2022 Mar;7(3):219-229. Epub 2022 Jan 20 doi: 10.1016/S2468-1253(21)00385-X. PMID: 35065058Free PMC Article
Perioperative nivolumab monotherapy versus nivolumab plus ipilimumab in resectable hepatocellular carcinoma: a randomised, open-label, phase 2 trial.
Kaseb AO, Hasanov E, Cao HST, Xiao L, Vauthey JN, Lee SS, Yavuz BG, Mohamed YI, Qayyum A, Jindal S, Duan F, Basu S, Yadav SS, Nicholas C, Sun JJ, Singh Raghav KP, Rashid A, Carter K, Chun YS, Tzeng CD, Sakamuri D, Xu L, Sun R, Cristini V, Beretta L, Yao JC, Wolff RA, Allison JP, Sharma P
Lancet Gastroenterol Hepatol 2022 Mar;7(3):208-218. Epub 2022 Jan 20 doi: 10.1016/S2468-1253(21)00427-1. PMID: 35065057Free PMC Article
Adjuvant treatment strategy after curative resection for hepatocellular carcinoma.
Zhang W, Zhang B, Chen XP
Front Med 2021 Apr;15(2):155-169. Epub 2021 Mar 23 doi: 10.1007/s11684-021-0848-3. PMID: 33754281
Neoadjuvant Three-Dimensional Conformal Radiotherapy for Resectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Randomized, Open-Label, Multicenter Controlled Study.
Wei X, Jiang Y, Zhang X, Feng S, Zhou B, Ye X, Xing H, Xu Y, Shi J, Guo W, Zhou D, Zhang H, Sun H, Huang C, Lu C, Zheng Y, Meng Y, Huang B, Cong W, Lau WY, Cheng S
J Clin Oncol 2019 Aug 20;37(24):2141-2151. Epub 2019 Jul 8 doi: 10.1200/JCO.18.02184. PMID: 31283409Free PMC Article

Diagnosis

Contrast-enhanced ultrasound for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease.
Fraquelli M, Nadarevic T, Colli A, Manzotti C, Giljaca V, Miletic D, Štimac D, Casazza G
Cochrane Database Syst Rev 2022 Sep 2;9(9):CD013483. doi: 10.1002/14651858.CD013483.pub2. PMID: 36053210Free PMC Article
Magnetic resonance imaging for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease.
Nadarevic T, Colli A, Giljaca V, Fraquelli M, Casazza G, Manzotti C, Štimac D, Miletic D
Cochrane Database Syst Rev 2022 May 6;5(5):CD014798. doi: 10.1002/14651858.CD014798.pub2. PMID: 35521901Free PMC Article
Efficacy and safety of camrelizumab plus apatinib during the perioperative period in resectable hepatocellular carcinoma: a single-arm, open label, phase II clinical trial.
Xia Y, Tang W, Qian X, Li X, Cheng F, Wang K, Zhang F, Zhang C, Li D, Song J, Zhang H, Zhao J, Yao A, Wu X, Wu C, Ji G, Liu X, Zhu F, Qin L, Xiao X, Deng Z, Kong X, Li S, Yu Y, Xi W, Deng W, Qi C, Liu H, Pu L, Wang P, Wang X
J Immunother Cancer 2022 Apr;10(4) doi: 10.1136/jitc-2022-004656. PMID: 35379737Free PMC Article
Computed tomography for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease.
Nadarevic T, Giljaca V, Colli A, Fraquelli M, Casazza G, Miletic D, Štimac D
Cochrane Database Syst Rev 2021 Oct 6;10(10):CD013362. doi: 10.1002/14651858.CD013362.pub2. PMID: 34611889Free PMC Article
Neoadjuvant Three-Dimensional Conformal Radiotherapy for Resectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Randomized, Open-Label, Multicenter Controlled Study.
Wei X, Jiang Y, Zhang X, Feng S, Zhou B, Ye X, Xing H, Xu Y, Shi J, Guo W, Zhou D, Zhang H, Sun H, Huang C, Lu C, Zheng Y, Meng Y, Huang B, Cong W, Lau WY, Cheng S
J Clin Oncol 2019 Aug 20;37(24):2141-2151. Epub 2019 Jul 8 doi: 10.1200/JCO.18.02184. PMID: 31283409Free PMC Article

Therapy

Efficacy and safety of camrelizumab plus apatinib during the perioperative period in resectable hepatocellular carcinoma: a single-arm, open label, phase II clinical trial.
Xia Y, Tang W, Qian X, Li X, Cheng F, Wang K, Zhang F, Zhang C, Li D, Song J, Zhang H, Zhao J, Yao A, Wu X, Wu C, Ji G, Liu X, Zhu F, Qin L, Xiao X, Deng Z, Kong X, Li S, Yu Y, Xi W, Deng W, Qi C, Liu H, Pu L, Wang P, Wang X
J Immunother Cancer 2022 Apr;10(4) doi: 10.1136/jitc-2022-004656. PMID: 35379737Free PMC Article
Neoadjuvant cemiplimab for resectable hepatocellular carcinoma: a single-arm, open-label, phase 2 trial.
Marron TU, Fiel MI, Hamon P, Fiaschi N, Kim E, Ward SC, Zhao Z, Kim J, Kennedy P, Gunasekaran G, Tabrizian P, Doroshow D, Legg M, Hammad A, Magen A, Kamphorst AO, Shareef M, Gupta NT, Deering R, Wang W, Wang F, Thanigaimani P, Mani J, Troncoso L, Tabachnikova A, Chang C, Akturk G, Buckup M, Hamel S, Ioannou G, Hennequin C, Jamal H, Brown H, Bonaccorso A, Labow D, Sarpel U, Rosenbloom T, Sung MW, Kou B, Li S, Jankovic V, James N, Hamon SC, Cheung HK, Sims JS, Miller E, Bhardwaj N, Thurston G, Lowy I, Gnjatic S, Taouli B, Schwartz ME, Merad M
Lancet Gastroenterol Hepatol 2022 Mar;7(3):219-229. Epub 2022 Jan 20 doi: 10.1016/S2468-1253(21)00385-X. PMID: 35065058Free PMC Article
Perioperative nivolumab monotherapy versus nivolumab plus ipilimumab in resectable hepatocellular carcinoma: a randomised, open-label, phase 2 trial.
Kaseb AO, Hasanov E, Cao HST, Xiao L, Vauthey JN, Lee SS, Yavuz BG, Mohamed YI, Qayyum A, Jindal S, Duan F, Basu S, Yadav SS, Nicholas C, Sun JJ, Singh Raghav KP, Rashid A, Carter K, Chun YS, Tzeng CD, Sakamuri D, Xu L, Sun R, Cristini V, Beretta L, Yao JC, Wolff RA, Allison JP, Sharma P
Lancet Gastroenterol Hepatol 2022 Mar;7(3):208-218. Epub 2022 Jan 20 doi: 10.1016/S2468-1253(21)00427-1. PMID: 35065057Free PMC Article
Adjuvant treatment strategy after curative resection for hepatocellular carcinoma.
Zhang W, Zhang B, Chen XP
Front Med 2021 Apr;15(2):155-169. Epub 2021 Mar 23 doi: 10.1007/s11684-021-0848-3. PMID: 33754281
Neoadjuvant Three-Dimensional Conformal Radiotherapy for Resectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Randomized, Open-Label, Multicenter Controlled Study.
Wei X, Jiang Y, Zhang X, Feng S, Zhou B, Ye X, Xing H, Xu Y, Shi J, Guo W, Zhou D, Zhang H, Sun H, Huang C, Lu C, Zheng Y, Meng Y, Huang B, Cong W, Lau WY, Cheng S
J Clin Oncol 2019 Aug 20;37(24):2141-2151. Epub 2019 Jul 8 doi: 10.1200/JCO.18.02184. PMID: 31283409Free PMC Article

Prognosis

Neoadjuvant immunotherapy for resectable hepatocellular carcinoma: a systematic review and meta-analysis.
Han YH, Bo JQ, Liu LX
Eur Rev Med Pharmacol Sci 2023 Aug;27(15):7134-7147. doi: 10.26355/eurrev_202308_33287. PMID: 37606124
Real-world efficacy and prognostic factors of lenvatinib plus PD-1 inhibitors in 378 unresectable hepatocellular carcinoma patients.
Yang X, Chen B, Wang Y, Wang Y, Long J, Zhang N, Xue J, Xun Z, Zhang L, Cheng J, Lei J, Sun H, Li Y, Lin J, Xie F, Wang D, Pan J, Hu K, Guan M, Huo L, Shi J, Yu L, Zhou L, Zhou J, Lu Z, Yang X, Mao Y, Sang X, Lu Y, Zhao H
Hepatol Int 2023 Jun;17(3):709-719. Epub 2023 Feb 8 doi: 10.1007/s12072-022-10480-y. PMID: 36753026Free PMC Article
Efficacy and safety of camrelizumab plus apatinib during the perioperative period in resectable hepatocellular carcinoma: a single-arm, open label, phase II clinical trial.
Xia Y, Tang W, Qian X, Li X, Cheng F, Wang K, Zhang F, Zhang C, Li D, Song J, Zhang H, Zhao J, Yao A, Wu X, Wu C, Ji G, Liu X, Zhu F, Qin L, Xiao X, Deng Z, Kong X, Li S, Yu Y, Xi W, Deng W, Qi C, Liu H, Pu L, Wang P, Wang X
J Immunother Cancer 2022 Apr;10(4) doi: 10.1136/jitc-2022-004656. PMID: 35379737Free PMC Article
Adjuvant treatment strategy after curative resection for hepatocellular carcinoma.
Zhang W, Zhang B, Chen XP
Front Med 2021 Apr;15(2):155-169. Epub 2021 Mar 23 doi: 10.1007/s11684-021-0848-3. PMID: 33754281
Neoadjuvant Three-Dimensional Conformal Radiotherapy for Resectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Randomized, Open-Label, Multicenter Controlled Study.
Wei X, Jiang Y, Zhang X, Feng S, Zhou B, Ye X, Xing H, Xu Y, Shi J, Guo W, Zhou D, Zhang H, Sun H, Huang C, Lu C, Zheng Y, Meng Y, Huang B, Cong W, Lau WY, Cheng S
J Clin Oncol 2019 Aug 20;37(24):2141-2151. Epub 2019 Jul 8 doi: 10.1200/JCO.18.02184. PMID: 31283409Free PMC Article

Clinical prediction guides

Serum osteopontin predicts the response to atezolizumab plus bevacizumab in patients with hepatocellular carcinoma.
Yamauchi R, Ito T, Yoshio S, Yamamoto T, Mizuno K, Ishigami M, Kawashima H, Yasuda S, Shimose S, Iwamoto H, Yamazoe T, Mori T, Kakazu E, Kawaguchi T, Toyoda H, Kanto T
J Gastroenterol 2023 Jun;58(6):565-574. Epub 2023 Mar 30 doi: 10.1007/s00535-023-01985-w. PMID: 36991155
Real-world efficacy and prognostic factors of lenvatinib plus PD-1 inhibitors in 378 unresectable hepatocellular carcinoma patients.
Yang X, Chen B, Wang Y, Wang Y, Long J, Zhang N, Xue J, Xun Z, Zhang L, Cheng J, Lei J, Sun H, Li Y, Lin J, Xie F, Wang D, Pan J, Hu K, Guan M, Huo L, Shi J, Yu L, Zhou L, Zhou J, Lu Z, Yang X, Mao Y, Sang X, Lu Y, Zhao H
Hepatol Int 2023 Jun;17(3):709-719. Epub 2023 Feb 8 doi: 10.1007/s12072-022-10480-y. PMID: 36753026Free PMC Article
Efficacy and safety of camrelizumab plus apatinib during the perioperative period in resectable hepatocellular carcinoma: a single-arm, open label, phase II clinical trial.
Xia Y, Tang W, Qian X, Li X, Cheng F, Wang K, Zhang F, Zhang C, Li D, Song J, Zhang H, Zhao J, Yao A, Wu X, Wu C, Ji G, Liu X, Zhu F, Qin L, Xiao X, Deng Z, Kong X, Li S, Yu Y, Xi W, Deng W, Qi C, Liu H, Pu L, Wang P, Wang X
J Immunother Cancer 2022 Apr;10(4) doi: 10.1136/jitc-2022-004656. PMID: 35379737Free PMC Article
Neoadjuvant cemiplimab for resectable hepatocellular carcinoma: a single-arm, open-label, phase 2 trial.
Marron TU, Fiel MI, Hamon P, Fiaschi N, Kim E, Ward SC, Zhao Z, Kim J, Kennedy P, Gunasekaran G, Tabrizian P, Doroshow D, Legg M, Hammad A, Magen A, Kamphorst AO, Shareef M, Gupta NT, Deering R, Wang W, Wang F, Thanigaimani P, Mani J, Troncoso L, Tabachnikova A, Chang C, Akturk G, Buckup M, Hamel S, Ioannou G, Hennequin C, Jamal H, Brown H, Bonaccorso A, Labow D, Sarpel U, Rosenbloom T, Sung MW, Kou B, Li S, Jankovic V, James N, Hamon SC, Cheung HK, Sims JS, Miller E, Bhardwaj N, Thurston G, Lowy I, Gnjatic S, Taouli B, Schwartz ME, Merad M
Lancet Gastroenterol Hepatol 2022 Mar;7(3):219-229. Epub 2022 Jan 20 doi: 10.1016/S2468-1253(21)00385-X. PMID: 35065058Free PMC Article
Neoadjuvant Three-Dimensional Conformal Radiotherapy for Resectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Randomized, Open-Label, Multicenter Controlled Study.
Wei X, Jiang Y, Zhang X, Feng S, Zhou B, Ye X, Xing H, Xu Y, Shi J, Guo W, Zhou D, Zhang H, Sun H, Huang C, Lu C, Zheng Y, Meng Y, Huang B, Cong W, Lau WY, Cheng S
J Clin Oncol 2019 Aug 20;37(24):2141-2151. Epub 2019 Jul 8 doi: 10.1200/JCO.18.02184. PMID: 31283409Free PMC Article

Recent systematic reviews

Neoadjuvant immunotherapy for resectable hepatocellular carcinoma: a systematic review and meta-analysis.
Han YH, Bo JQ, Liu LX
Eur Rev Med Pharmacol Sci 2023 Aug;27(15):7134-7147. doi: 10.26355/eurrev_202308_33287. PMID: 37606124
Contrast-enhanced ultrasound for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease.
Fraquelli M, Nadarevic T, Colli A, Manzotti C, Giljaca V, Miletic D, Štimac D, Casazza G
Cochrane Database Syst Rev 2022 Sep 2;9(9):CD013483. doi: 10.1002/14651858.CD013483.pub2. PMID: 36053210Free PMC Article
Magnetic resonance imaging for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease.
Nadarevic T, Colli A, Giljaca V, Fraquelli M, Casazza G, Manzotti C, Štimac D, Miletic D
Cochrane Database Syst Rev 2022 May 6;5(5):CD014798. doi: 10.1002/14651858.CD014798.pub2. PMID: 35521901Free PMC Article
Computed tomography for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease.
Nadarevic T, Giljaca V, Colli A, Fraquelli M, Casazza G, Miletic D, Štimac D
Cochrane Database Syst Rev 2021 Oct 6;10(10):CD013362. doi: 10.1002/14651858.CD013362.pub2. PMID: 34611889Free PMC Article
Systematic review of neoadjuvant transarterial chemoembolization for resectable hepatocellular carcinoma.
Chua TC, Liauw W, Saxena A, Chu F, Glenn D, Chai A, Morris DL
Liver Int 2010 Feb;30(2):166-74. Epub 2009 Nov 13 doi: 10.1111/j.1478-3231.2009.02166.x. PMID: 19912531

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