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Maternal Sepsis

MedGen UID:
1636613
•Concept ID:
C4704910
•
Disease or Syndrome
Synonyms: Sepsis during Pregnancy; Sepsis in Pregnancies; Sepsis in Pregnancy; Sepsis, Maternal

Definition

A pathologic response to infection in a mother or pregnant woman. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMaternal Sepsis

Professional guidelines

PubMed

Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Top 10 Pearls for the Recognition, Evaluation, and Management of Maternal Sepsis.
Shields A, de Assis V, Halscott T
Obstet Gynecol 2021 Aug 1;138(2):289-304. doi: 10.1097/AOG.0000000000004471. PMID: 34237760Free PMC Article
Early Recognition and Management of Maternal Sepsis.
Olvera L, Dutra D
Nurs Womens Health 2016 Apr-May;20(2):182-95; quiz 196. doi: 10.1016/j.nwh.2016.02.003. PMID: 27067934

Recent clinical studies

Etiology

Azithromycin to Prevent Sepsis or Death in Women Planning a Vaginal Birth.
Tita ATN, Carlo WA, McClure EM, Mwenechanya M, Chomba E, Hemingway-Foday JJ, Kavi A, Metgud MC, Goudar SS, Derman R, Lokangaka A, Tshefu A, Bauserman M, Bose C, Shivkumar P, Waikar M, Patel A, Hibberd PL, Nyongesa P, Esamai F, Ekhaguere OA, Bucher S, Jessani S, Tikmani SS, Saleem S, Goldenberg RL, Billah SM, Lennox R, Haque R, Petri W, Figueroa L, Mazariegos M, Krebs NF, Moore JL, Nolen TL, Koso-Thomas M; A-PLUS Trial Group
N Engl J Med 2023 Mar 30;388(13):1161-1170. Epub 2023 Feb 9 doi: 10.1056/NEJMoa2212111. PMID: 36757318Free PMC Article
Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Recent advances in the diagnosis and management of sepsis in pregnancy.
Ali A, Lamont RF
F1000Res 2019;8 Epub 2019 Aug 30 doi: 10.12688/f1000research.18736.1. PMID: 31508205Free PMC Article
Maternal sepsis is an evolving challenge.
Turner MJ
Int J Gynaecol Obstet 2019 Jul;146(1):39-42. Epub 2019 May 17 doi: 10.1002/ijgo.12833. PMID: 31037723
Sepsis in pregnancy and the puerperium.
Burlinson CEG, Sirounis D, Walley KR, Chau A
Int J Obstet Anesth 2018 Nov;36:96-107. Epub 2018 Jun 18 doi: 10.1016/j.ijoa.2018.04.010. PMID: 29921485

Diagnosis

Maternal sepsis.
Filetici N, Van de Velde M, Roofthooft E, Devroe S
Best Pract Res Clin Anaesthesiol 2022 May;36(1):165-177. Epub 2022 Mar 30 doi: 10.1016/j.bpa.2022.03.003. PMID: 35659952
Top 10 Pearls for the Recognition, Evaluation, and Management of Maternal Sepsis.
Shields A, de Assis V, Halscott T
Obstet Gynecol 2021 Aug 1;138(2):289-304. doi: 10.1097/AOG.0000000000004471. PMID: 34237760Free PMC Article
Maternal sepsis update.
Abir G, Bauer ME
Curr Opin Anaesthesiol 2021 Jun 1;34(3):254-259. doi: 10.1097/ACO.0000000000000997. PMID: 33927129
Maternal sepsis.
Escobar MF, Echavarría MP, Zambrano MA, Ramos I, Kusanovic JP
Am J Obstet Gynecol MFM 2020 Aug;2(3):100149. Epub 2020 Jun 29 doi: 10.1016/j.ajogmf.2020.100149. PMID: 33345880
Sepsis in pregnancy and the puerperium.
Burlinson CEG, Sirounis D, Walley KR, Chau A
Int J Obstet Anesth 2018 Nov;36:96-107. Epub 2018 Jun 18 doi: 10.1016/j.ijoa.2018.04.010. PMID: 29921485

Therapy

Azithromycin to Prevent Sepsis or Death in Women Planning a Vaginal Birth.
Tita ATN, Carlo WA, McClure EM, Mwenechanya M, Chomba E, Hemingway-Foday JJ, Kavi A, Metgud MC, Goudar SS, Derman R, Lokangaka A, Tshefu A, Bauserman M, Bose C, Shivkumar P, Waikar M, Patel A, Hibberd PL, Nyongesa P, Esamai F, Ekhaguere OA, Bucher S, Jessani S, Tikmani SS, Saleem S, Goldenberg RL, Billah SM, Lennox R, Haque R, Petri W, Figueroa L, Mazariegos M, Krebs NF, Moore JL, Nolen TL, Koso-Thomas M; A-PLUS Trial Group
N Engl J Med 2023 Mar 30;388(13):1161-1170. Epub 2023 Feb 9 doi: 10.1056/NEJMoa2212111. PMID: 36757318Free PMC Article
Top 10 Pearls for the Recognition, Evaluation, and Management of Maternal Sepsis.
Shields A, de Assis V, Halscott T
Obstet Gynecol 2021 Aug 1;138(2):289-304. doi: 10.1097/AOG.0000000000004471. PMID: 34237760Free PMC Article
Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Sepsis in pregnancy and the puerperium.
Burlinson CEG, Sirounis D, Walley KR, Chau A
Int J Obstet Anesth 2018 Nov;36:96-107. Epub 2018 Jun 18 doi: 10.1016/j.ijoa.2018.04.010. PMID: 29921485
Maternal sepsis.
Vaught AJ
Semin Perinatol 2018 Feb;42(1):9-12. doi: 10.1053/j.semperi.2017.11.003. PMID: 29463391Free PMC Article

Prognosis

Maternal Mortality in Low and Middle-Income Countries.
Lawrence ER, Klein TJ, Beyuo TK
Obstet Gynecol Clin North Am 2022 Dec;49(4):713-733. doi: 10.1016/j.ogc.2022.07.001. PMID: 36328676
Top 10 Pearls for the Recognition, Evaluation, and Management of Maternal Sepsis.
Shields A, de Assis V, Halscott T
Obstet Gynecol 2021 Aug 1;138(2):289-304. doi: 10.1097/AOG.0000000000004471. PMID: 34237760Free PMC Article
Maternal sepsis update.
Abir G, Bauer ME
Curr Opin Anaesthesiol 2021 Jun 1;34(3):254-259. doi: 10.1097/ACO.0000000000000997. PMID: 33927129
Maternal sepsis.
Escobar MF, Echavarría MP, Zambrano MA, Ramos I, Kusanovic JP
Am J Obstet Gynecol MFM 2020 Aug;2(3):100149. Epub 2020 Jun 29 doi: 10.1016/j.ajogmf.2020.100149. PMID: 33345880
Sepsis in pregnancy and the puerperium.
Burlinson CEG, Sirounis D, Walley KR, Chau A
Int J Obstet Anesth 2018 Nov;36:96-107. Epub 2018 Jun 18 doi: 10.1016/j.ijoa.2018.04.010. PMID: 29921485

Clinical prediction guides

Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis.
Sharma S, Rodrigues PRS, Zaher S, Davies LC, Ghazal P
EBioMedicine 2022 Dec;86:104337. Epub 2022 Dec 2 doi: 10.1016/j.ebiom.2022.104337. PMID: 36470829Free PMC Article
Incidence and determinants of maternal sepsis in Ghana in the midst of a pandemic.
Noora CL, Manu A, Addo-Lartey A, Mohammed AG, Ameme DK, Kenu E, Torpey K, Adanu R
BMC Pregnancy Childbirth 2022 Nov 23;22(1):864. doi: 10.1186/s12884-022-05182-0. PMID: 36424531Free PMC Article
Maternal sepsis is an evolving challenge.
Turner MJ
Int J Gynaecol Obstet 2019 Jul;146(1):39-42. Epub 2019 May 17 doi: 10.1002/ijgo.12833. PMID: 31037723
Maternal sepsis: new concepts, new practices.
Foeller ME, Gibbs RS
Curr Opin Obstet Gynecol 2019 Apr;31(2):90-96. doi: 10.1097/GCO.0000000000000523. PMID: 30789841
Maternal Sepsis and Septic Shock.
Chebbo A, Tan S, Kassis C, Tamura L, Carlson RW
Crit Care Clin 2016 Jan;32(1):119-35. Epub 2015 Oct 19 doi: 10.1016/j.ccc.2015.08.010. PMID: 26600449

Recent systematic reviews

Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Maternal Disease With Group B Streptococcus and Serotype Distribution Worldwide: Systematic Review and Meta-analyses.
Hall J, Adams NH, Bartlett L, Seale AC, Lamagni T, Bianchi-Jassir F, Lawn JE, Baker CJ, Cutland C, Heath PT, Ip M, Le Doare K, Madhi SA, Rubens CE, Saha SK, Schrag S, Sobanjo-Ter Meulen A, Vekemans J, Gravett MG
Clin Infect Dis 2017 Nov 6;65(suppl_2):S112-S124. doi: 10.1093/cid/cix660. PMID: 29117328Free PMC Article
Towards a consensus definition of maternal sepsis: results of a systematic review and expert consultation.
Bonet M, Nogueira Pileggi V, Rijken MJ, Coomarasamy A, Lissauer D, Souza JP, Gülmezoglu AM
Reprod Health 2017 May 30;14(1):67. doi: 10.1186/s12978-017-0321-6. PMID: 28558733Free PMC Article
Different classes of antibiotics given to women routinely for preventing infection at caesarean section.
Gyte GM, Dou L, Vazquez JC
Cochrane Database Syst Rev 2014 Nov 17;2014(11):CD008726. doi: 10.1002/14651858.CD008726.pub2. PMID: 25402227Free PMC Article
Maternal physiologic parameters in relationship to systemic inflammatory response syndrome criteria: a systematic review and meta-analysis.
Bauer ME, Bauer ST, Rajala B, MacEachern MP, Polley LS, Childers D, Aronoff DM
Obstet Gynecol 2014 Sep;124(3):535-541. doi: 10.1097/AOG.0000000000000423. PMID: 25162253

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