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Adenosquamous bile duct carcinoma

MedGen UID:
163666
•Concept ID:
C0861854
•
Neoplastic Process
Synonyms: Adenosquamous Bile Duct Carcinoma; adenosquamous bile duct carcinoma; Adenosquamous Carcinoma of Bile Duct; adenosquamous carcinoma of bile duct; Adenosquamous Carcinoma of the Bile Duct; adenosquamous carcinoma of the bile duct; Bile Duct Adenosquamous Carcinoma; bile duct adenosquamous carcinoma; Extrahepatic Bile Duct Adenosquamous Carcinoma
 
Monarch Initiative: MONDO:0003549

Definition

A carcinoma that arises from the extrahepatic bile ducts. It is characterized by the presence of glandular and squamous malignant epithelial components. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenosquamous bile duct carcinoma

Professional guidelines

PubMed

Adenosquamous Carcinoma of Extrahepatic Bile Duct in Primary Sclerosing Cholangitis.
Chiang TH, Kumar A, Desai CS
J Gastrointest Surg 2022 Nov;26(11):2399-2401. Epub 2022 Aug 26 doi: 10.1007/s11605-022-05442-6. PMID: 36028730

Recent clinical studies

Etiology

Randomized clinical trial of adjuvant gemcitabine chemotherapy versus observation in resected bile duct cancer.
Ebata T, Hirano S, Konishi M, Uesaka K, Tsuchiya Y, Ohtsuka M, Kaneoka Y, Yamamoto M, Ambo Y, Shimizu Y, Ozawa F, Fukutomi A, Ando M, Nimura Y, Nagino M; Bile Duct Cancer Adjuvant Trial (BCAT) Study Group
Br J Surg 2018 Feb;105(3):192-202. doi: 10.1002/bjs.10776. PMID: 29405274
Nivolumab treatment for oesophageal squamous-cell carcinoma: an open-label, multicentre, phase 2 trial.
Kudo T, Hamamoto Y, Kato K, Ura T, Kojima T, Tsushima T, Hironaka S, Hara H, Satoh T, Iwasa S, Muro K, Yasui H, Minashi K, Yamaguchi K, Ohtsu A, Doki Y, Kitagawa Y
Lancet Oncol 2017 May;18(5):631-639. Epub 2017 Mar 15 doi: 10.1016/S1470-2045(17)30181-X. PMID: 28314688
Adenosquamous carcinoma in the biliary tract: association of the proliferative ability of the squamous component with its proportion and tumor progression.
Hoshimoto S, Hoshi S, Hishinuma S, Tomikawa M, Shirakawa H, Ozawa I, Wakamatsu S, Hoshi N, Hirabayashi K, Ogata Y
Scand J Gastroenterol 2017 Apr;52(4):425-430. Epub 2016 Dec 30 doi: 10.1080/00365521.2016.1273383. PMID: 28034323
Adenosquamous carcinoma of the pancreas: multidetector-row computed tomographic manifestations and tumor characteristics.
Yin Q, Wang C, Wu Z, Wang M, Cheng K, Zhao X, Yuan F, Tang Y, Miao F
J Comput Assist Tomogr 2013 Mar-Apr;37(2):125-33. doi: 10.1097/RCT.0b013e31827bc452. PMID: 23493198
Adenosquamous carcinoma of the extrahepatic bile duct: clinicopathologic and radiologic features.
Kim KW, Kim SH, Kim MA, Lee JM, Park HS, Kim JY, Lee JY, Han JK, Choi BI
Abdom Imaging 2009 Mar-Apr;34(2):217-24. doi: 10.1007/s00261-008-9363-0. PMID: 18204917

Diagnosis

Adenosquamous carcinoma of the liver: The challenge of diagnosis.
Liu YM, Lei YL, Liu F
Liver Int 2023 Oct;43(10):2320-2322. Epub 2023 Aug 25 doi: 10.1111/liv.15708. PMID: 37622287
Rare histotypes of epithelial biliary tract tumors: A literature review.
Sapuppo E, Brunetti O, Tessitore D, Brandi G, Di Giovanni N, Fadda G, Luchini C, Martini M, Quaresmini D, Russo A, Santarpia M, Scarpa A, Scartozzi M, Tuccari G, Franchina T, Silvestris N
Crit Rev Oncol Hematol 2023 Jan;181:103892. Epub 2022 Dec 5 doi: 10.1016/j.critrevonc.2022.103892. PMID: 36481306
The epidemiology of rare types of hepatobiliary and pancreatic cancer from national cancer registry.
Satake T, Morizane C, Rikitake R, Higashi T, Okusaka T, Kawai A
J Gastroenterol 2022 Nov;57(11):890-901. Epub 2022 Sep 26 doi: 10.1007/s00535-022-01920-5. PMID: 36161533Free PMC Article
Adenosquamous carcinoma of the ampulla of Vater: a case report and literature review.
Hoshimoto S, Aiura K, Shito M, Kakefuda T, Sugiura H
World J Surg Oncol 2015 Sep 29;13:287. doi: 10.1186/s12957-015-0709-0. PMID: 26420726Free PMC Article
Adenosquamous carcinoma of extrahepatic bile duct: a case report.
Lim SH, Yang HW, Kim A, Cha SW, Jung SH, Go H, Lee WC
Korean J Intern Med 2007 Sep;22(3):206-10. doi: 10.3904/kjim.2007.22.3.206. PMID: 17939340Free PMC Article

Therapy

Synchronous Adeno-squamous Carcinoma of Gallbladder and Adenocarcinoma of Common Bile Duct: Twin Trouble.
Varshney VK, Rao M, Soni SC, Sureka B
J Gastrointest Cancer 2019 Dec;50(4):1014-1017. doi: 10.1007/s12029-018-0177-1. PMID: 30397857
Randomized clinical trial of adjuvant gemcitabine chemotherapy versus observation in resected bile duct cancer.
Ebata T, Hirano S, Konishi M, Uesaka K, Tsuchiya Y, Ohtsuka M, Kaneoka Y, Yamamoto M, Ambo Y, Shimizu Y, Ozawa F, Fukutomi A, Ando M, Nimura Y, Nagino M; Bile Duct Cancer Adjuvant Trial (BCAT) Study Group
Br J Surg 2018 Feb;105(3):192-202. doi: 10.1002/bjs.10776. PMID: 29405274
Nivolumab treatment for oesophageal squamous-cell carcinoma: an open-label, multicentre, phase 2 trial.
Kudo T, Hamamoto Y, Kato K, Ura T, Kojima T, Tsushima T, Hironaka S, Hara H, Satoh T, Iwasa S, Muro K, Yasui H, Minashi K, Yamaguchi K, Ohtsu A, Doki Y, Kitagawa Y
Lancet Oncol 2017 May;18(5):631-639. Epub 2017 Mar 15 doi: 10.1016/S1470-2045(17)30181-X. PMID: 28314688
Outcome of adjuvant therapy in biliary tract cancers.
McNamara MG, Walter T, Horgan AM, Amir E, Cleary S, McKeever EL, Min T, Wallace E, Hedley D, Krzyzanowska M, Moore M, Gallinger S, Greig P, Serra S, Dawson LA, Knox JJ
Am J Clin Oncol 2015 Aug;38(4):382-7. doi: 10.1097/COC.0b013e31829e19fb. PMID: 24572429
Primary adenosquamous carcinoma of the liver: case report.
Suzuki E, Hirai R, Ota T, Shimizu N
J Hepatobiliary Pancreat Surg 2002;9(6):769-73. doi: 10.1007/s005340200108. PMID: 12658415

Prognosis

Pathologic classification of "pancreatic cancers": current concepts and challenges.
Mostafa ME, Erbarut-Seven I, Pehlivanoglu B, Adsay V
Chin Clin Oncol 2017 Dec;6(6):59. doi: 10.21037/cco.2017.12.01. PMID: 29307199
Adenosquamous carcinoma in the biliary tract: association of the proliferative ability of the squamous component with its proportion and tumor progression.
Hoshimoto S, Hoshi S, Hishinuma S, Tomikawa M, Shirakawa H, Ozawa I, Wakamatsu S, Hoshi N, Hirabayashi K, Ogata Y
Scand J Gastroenterol 2017 Apr;52(4):425-430. Epub 2016 Dec 30 doi: 10.1080/00365521.2016.1273383. PMID: 28034323
Adenosquamous carcinoma of the ampulla of Vater: a case report and literature review.
Hoshimoto S, Aiura K, Shito M, Kakefuda T, Sugiura H
World J Surg Oncol 2015 Sep 29;13:287. doi: 10.1186/s12957-015-0709-0. PMID: 26420726Free PMC Article
CDX2 and MUC2 protein expression in extrahepatic bile duct carcinoma.
Hong SM, Cho H, Moskaluk CA, Frierson HF Jr, Yu E, Ro JY
Am J Clin Pathol 2005 Sep;124(3):361-70. doi: 10.1309/GTU1-Y77M-VR4D-X5A2. PMID: 16191504
Primary adenosquamous carcinoma of the liver: case report.
Suzuki E, Hirai R, Ota T, Shimizu N
J Hepatobiliary Pancreat Surg 2002;9(6):769-73. doi: 10.1007/s005340200108. PMID: 12658415

Clinical prediction guides

Randomized clinical trial of adjuvant gemcitabine chemotherapy versus observation in resected bile duct cancer.
Ebata T, Hirano S, Konishi M, Uesaka K, Tsuchiya Y, Ohtsuka M, Kaneoka Y, Yamamoto M, Ambo Y, Shimizu Y, Ozawa F, Fukutomi A, Ando M, Nimura Y, Nagino M; Bile Duct Cancer Adjuvant Trial (BCAT) Study Group
Br J Surg 2018 Feb;105(3):192-202. doi: 10.1002/bjs.10776. PMID: 29405274
Adenosquamous carcinoma in the biliary tract: association of the proliferative ability of the squamous component with its proportion and tumor progression.
Hoshimoto S, Hoshi S, Hishinuma S, Tomikawa M, Shirakawa H, Ozawa I, Wakamatsu S, Hoshi N, Hirabayashi K, Ogata Y
Scand J Gastroenterol 2017 Apr;52(4):425-430. Epub 2016 Dec 30 doi: 10.1080/00365521.2016.1273383. PMID: 28034323
Adenosquamous carcinoma of the ampulla of Vater: a case report and literature review.
Hoshimoto S, Aiura K, Shito M, Kakefuda T, Sugiura H
World J Surg Oncol 2015 Sep 29;13:287. doi: 10.1186/s12957-015-0709-0. PMID: 26420726Free PMC Article
Adenosquamous carcinoma of the pancreas: multidetector-row computed tomographic manifestations and tumor characteristics.
Yin Q, Wang C, Wu Z, Wang M, Cheng K, Zhao X, Yuan F, Tang Y, Miao F
J Comput Assist Tomogr 2013 Mar-Apr;37(2):125-33. doi: 10.1097/RCT.0b013e31827bc452. PMID: 23493198
CDX2 and MUC2 protein expression in extrahepatic bile duct carcinoma.
Hong SM, Cho H, Moskaluk CA, Frierson HF Jr, Yu E, Ro JY
Am J Clin Pathol 2005 Sep;124(3):361-70. doi: 10.1309/GTU1-Y77M-VR4D-X5A2. PMID: 16191504

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