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Superficial Basal Cell Carcinoma

MedGen UID:
163678
•Concept ID:
C0862889
•
Neoplastic Process
Synonyms: Multifocal basal cell carcinoma; Superficial basal cell carcinoma
SNOMED CT: Superficial basal cell carcinoma (403914000); Multifocal basal cell carcinoma (403914000)

Definition

A variant of basal cell carcinoma of the skin presenting as erythematous, often multiple patches. Morphologically, it is characterized by the presence of superficial lobules of basaloid cells projecting into the dermis. The basaloid cell lobules are surrounded by myxoid stroma and are usually confined to the papillary dermis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSuperficial Basal Cell Carcinoma

Professional guidelines

PubMed

Basal Cell and Cutaneous Squamous Cell Carcinomas: Diagnosis and Treatment.
Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Photodynamic therapy in superficial basal cell carcinoma treatment.
de Albuquerque IO, Nunes J, Figueiró Longo JP, Muehlmann LA, Azevedo RB
Photodiagnosis Photodyn Ther 2019 Sep;27:428-432. Epub 2019 Jul 23 doi: 10.1016/j.pdpdt.2019.07.017. PMID: 31349099
Current diagnosis and treatment of basal cell carcinoma.
Alter M, Hillen U, Leiter U, Sachse M, Gutzmer R
J Dtsch Dermatol Ges 2015 Sep;13(9):863-74; quiz 875. doi: 10.1111/ddg.12798. PMID: 26882375

Recent clinical studies

Etiology

Diagnosis and treatment of low-risk superficial basal cell carcinoma in a single visit.
Hattier GA, Duffy RF, Finkelstein MJ, Beggs SM, Lee JB
J Dermatolog Treat 2022 Feb;33(1):191-194. Epub 2020 Mar 11 doi: 10.1080/09546634.2020.1737637. PMID: 32116084
A review of emerging and non-US FDA-approved topical agents for the treatment of basal cell carcinoma.
Kash N, Silapunt S
Future Oncol 2021 Aug;17(23):3111-3132. Epub 2021 Jun 22 doi: 10.2217/fon-2020-1147. PMID: 34156307
Basal Cell and Cutaneous Squamous Cell Carcinomas: Diagnosis and Treatment.
Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Photodynamic therapy in superficial basal cell carcinoma treatment.
de Albuquerque IO, Nunes J, Figueiró Longo JP, Muehlmann LA, Azevedo RB
Photodiagnosis Photodyn Ther 2019 Sep;27:428-432. Epub 2019 Jul 23 doi: 10.1016/j.pdpdt.2019.07.017. PMID: 31349099
Imiquimod: in superficial basal cell carcinoma.
Oldfield V, Keating GM, Perry CM
Am J Clin Dermatol 2005;6(3):195-200; discussion 201-2. doi: 10.2165/00128071-200506030-00006. PMID: 15943496

Diagnosis

Diagnosis and treatment of low-risk superficial basal cell carcinoma in a single visit.
Hattier GA, Duffy RF, Finkelstein MJ, Beggs SM, Lee JB
J Dermatolog Treat 2022 Feb;33(1):191-194. Epub 2020 Mar 11 doi: 10.1080/09546634.2020.1737637. PMID: 32116084
Basal Cell and Cutaneous Squamous Cell Carcinomas: Diagnosis and Treatment.
Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Current diagnosis and treatment of basal cell carcinoma.
Alter M, Hillen U, Leiter U, Sachse M, Gutzmer R
J Dtsch Dermatol Ges 2015 Sep;13(9):863-74; quiz 875. doi: 10.1111/ddg.12798. PMID: 26882375
Optical coherence tomography in the diagnosis of basal cell carcinoma.
Hussain AA, Themstrup L, Jemec GB
Arch Dermatol Res 2015 Jan;307(1):1-10. Epub 2014 Sep 16 doi: 10.1007/s00403-014-1498-y. PMID: 25223745
Cryosurgery in dermatology.
Zouboulis CC
Eur J Dermatol 1998 Oct-Nov;8(7):466-74. PMID: 9854156

Therapy

A review of emerging and non-US FDA-approved topical agents for the treatment of basal cell carcinoma.
Kash N, Silapunt S
Future Oncol 2021 Aug;17(23):3111-3132. Epub 2021 Jun 22 doi: 10.2217/fon-2020-1147. PMID: 34156307
Dermoscopic features of basal cell carcinoma and its subtypes: A systematic review.
Reiter O, Mimouni I, Dusza S, Halpern AC, Leshem YA, Marghoob AA
J Am Acad Dermatol 2021 Sep;85(3):653-664. Epub 2019 Nov 7 doi: 10.1016/j.jaad.2019.11.008. PMID: 31706938Free PMC Article
Photodynamic therapy in superficial basal cell carcinoma treatment.
de Albuquerque IO, Nunes J, Figueiró Longo JP, Muehlmann LA, Azevedo RB
Photodiagnosis Photodyn Ther 2019 Sep;27:428-432. Epub 2019 Jul 23 doi: 10.1016/j.pdpdt.2019.07.017. PMID: 31349099
Topical 5-fluorouracil in dermatologic disease.
Prince GT, Cameron MC, Fathi R, Alkousakis T
Int J Dermatol 2018 Oct;57(10):1259-1264. Epub 2018 Jun 25 doi: 10.1111/ijd.14106. PMID: 30187924
Current diagnosis and treatment of basal cell carcinoma.
Alter M, Hillen U, Leiter U, Sachse M, Gutzmer R
J Dtsch Dermatol Ges 2015 Sep;13(9):863-74; quiz 875. doi: 10.1111/ddg.12798. PMID: 26882375

Prognosis

Implementing structured pathology reporting protocol for non-melanocytic skin cancers: practical considerations.
Gupta R, Selinger CI, Ashford B, Chua MST, Clark JR, Damian DL, Jackett LA, James C, Johnson S, Ladwa R, Lambie D, McKenzie C, Tan ST, Scolyer RA
Pathology 2023 Oct;55(6):743-759. Epub 2023 Jul 28 doi: 10.1016/j.pathol.2023.07.003. PMID: 37573165
Immunocryosurgery for non-superficial basal cell carcinomas ≤ 20 mm in maximal diameter: Five-year follow-up.
Gaitanis G, Bassukas ID
J Geriatr Oncol 2019 May;10(3):475-478. Epub 2018 Sep 12 doi: 10.1016/j.jgo.2018.08.012. PMID: 30219274
Simple 3-criteria-based ex vivo confocal diagnosis of basal cell carcinoma.
Hartmann D, Krammer S, Bachmann MR, Mathemeier L, Ruzicka T, von Braunmühl T
J Biophotonics 2018 Jul;11(7):e201800062. Epub 2018 May 24 doi: 10.1002/jbio.201800062. PMID: 29726112
Optical coherence tomography in the diagnosis of basal cell carcinoma.
Hussain AA, Themstrup L, Jemec GB
Arch Dermatol Res 2015 Jan;307(1):1-10. Epub 2014 Sep 16 doi: 10.1007/s00403-014-1498-y. PMID: 25223745
Cryosurgery in dermatology.
Zouboulis CC
Eur J Dermatol 1998 Oct-Nov;8(7):466-74. PMID: 9854156

Clinical prediction guides

Diagnosis and treatment of low-risk superficial basal cell carcinoma in a single visit.
Hattier GA, Duffy RF, Finkelstein MJ, Beggs SM, Lee JB
J Dermatolog Treat 2022 Feb;33(1):191-194. Epub 2020 Mar 11 doi: 10.1080/09546634.2020.1737637. PMID: 32116084
Treatment of superficial basal cell carcinoma with photodynamic therapy. Observational study in 22 patients with 5-aminolaevulinic acid and methyl aminolaevulinate.
Alique-García S, Company-Quiroga J, Sánchez Campos A, Hernández Núñez A, Borbujo J
Photodiagnosis Photodyn Ther 2019 Jun;26:190-192. Epub 2019 Mar 23 doi: 10.1016/j.pdpdt.2019.03.018. PMID: 30914392
Immunocryosurgery for non-superficial basal cell carcinomas ≤ 20 mm in maximal diameter: Five-year follow-up.
Gaitanis G, Bassukas ID
J Geriatr Oncol 2019 May;10(3):475-478. Epub 2018 Sep 12 doi: 10.1016/j.jgo.2018.08.012. PMID: 30219274
Accuracy of dermoscopic criteria for the differentiation between superficial basal cell carcinoma and Bowen's disease.
Papageorgiou C, Apalla Z, Variaah G, Matiaki FC, Sotiriou E, Vakirlis E, Lazaridou E, Ioannides D, Lallas A
J Eur Acad Dermatol Venereol 2018 Nov;32(11):1914-1919. Epub 2018 Jul 15 doi: 10.1111/jdv.14995. PMID: 29633377
Optical coherence tomography in the diagnosis of basal cell carcinoma.
Hussain AA, Themstrup L, Jemec GB
Arch Dermatol Res 2015 Jan;307(1):1-10. Epub 2014 Sep 16 doi: 10.1007/s00403-014-1498-y. PMID: 25223745

Recent systematic reviews

Dermoscopic features of basal cell carcinoma and its subtypes: A systematic review.
Reiter O, Mimouni I, Dusza S, Halpern AC, Leshem YA, Marghoob AA
J Am Acad Dermatol 2021 Sep;85(3):653-664. Epub 2019 Nov 7 doi: 10.1016/j.jaad.2019.11.008. PMID: 31706938Free PMC Article
Intralesional and Laser-Assisted 5-Fluorouracil in Dermatologic Disease: A Systematic Review.
Prince GT, Cameron MC, Fathi R, Alkousakis T
J Drugs Dermatol 2018 Mar 1;17(3):274-280. PMID: 29537445
Application of intense pulsed light in the treatment of dermatologic disease: a systematic review.
Wat H, Wu DC, Rao J, Goldman MP
Dermatol Surg 2014 Apr;40(4):359-77. Epub 2014 Feb 4 doi: 10.1111/dsu.12424. PMID: 24495252
Overall treatment success after treatment of primary superficial basal cell carcinoma: a systematic review and meta-analysis of randomized and nonrandomized trials.
Roozeboom MH, Arits AH, Nelemans PJ, Kelleners-Smeets NW
Br J Dermatol 2012 Oct;167(4):733-56. Epub 2012 Sep 7 doi: 10.1111/j.1365-2133.2012.11061.x. PMID: 22612571
Interventions for basal cell carcinoma of the skin: systematic review.
Bath-Hextall F, Bong J, Perkins W, Williams H
BMJ 2004 Sep 25;329(7468):705. Epub 2004 Sep 13 doi: 10.1136/bmj.38219.515266.AE. PMID: 15364703Free PMC Article

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