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Ectopic Chorionic Gonadotropin Secretion Syndrome

MedGen UID:
163683
•Concept ID:
C0863185
•
Disease or Syndrome
Synonym: Ectopic Chorionic Gonadotropin Secretion

Definition

A syndrome characterized by abnormal secretion of chorionic gonadotropin in conjunction with neoplastic growth occurring anywhere in the body. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEctopic Chorionic Gonadotropin Secretion Syndrome

Recent clinical studies

Etiology

TSH receptor antibodies (TRAb) - A potential new biomarker for endometriosis.
Svensson A, Roth B, Kronvall L, Ohlsson B
Eur J Obstet Gynecol Reprod Biol 2022 Nov;278:115-121. Epub 2022 Sep 17 doi: 10.1016/j.ejogrb.2022.09.013. PMID: 36152376
Reproductive outcomes of dual trigger with combination GnRH agonist and hCG versus trigger with hCG alone in women undergoing IVF/ICSI cycles: a retrospective cohort study with propensity score matching.
Dong L, Lian F, Wu H, Xiang S, Li Y, Wei C, Yu X, Xin X
BMC Pregnancy Childbirth 2022 Jul 22;22(1):583. doi: 10.1186/s12884-022-04899-2. PMID: 35869444Free PMC Article
Endocrine paraneoplastic syndromes in patients with neuroendocrine neoplasms.
Daskalakis K, Chatzelis E, Tsoli M, Papadopoulou-Marketou N, Dimitriadis GK, Tsolakis AV, Kaltsas G
Endocrine 2019 May;64(2):384-392. Epub 2018 Oct 2 doi: 10.1007/s12020-018-1773-3. PMID: 30280284Free PMC Article
Familial hCG syndrome: production of variable, degraded or mutant forms of hCG.
Cole LA, Butler S
J Reprod Med 2014 Sep-Oct;59(9-10):435-42. PMID: 25330684
Role of inhibin in normal and high-risk pregnancy.
Muttukrishna S
Semin Reprod Med 2004 Aug;22(3):227-34. doi: 10.1055/s-2004-831898. PMID: 15319825

Diagnosis

One Case of Pituitary Stalk Interruption Syndrome Associated with Liver Cirrhosis.
He H, Li DM
Endocr Metab Immune Disord Drug Targets 2023;23(9):1229-1234. doi: 10.2174/1871530323666230228110650. PMID: 36852803
TSH receptor antibodies (TRAb) - A potential new biomarker for endometriosis.
Svensson A, Roth B, Kronvall L, Ohlsson B
Eur J Obstet Gynecol Reprod Biol 2022 Nov;278:115-121. Epub 2022 Sep 17 doi: 10.1016/j.ejogrb.2022.09.013. PMID: 36152376
Pituitary stalk interruption syndrome: A rare case report and literature review.
Zhang W, Qian F, Lu G, Wu Y, Li R, Xia L, Zhao R, Lin Y, Gu M, Chen W
Medicine (Baltimore) 2020 Dec 11;99(50):e23266. doi: 10.1097/MD.0000000000023266. PMID: 33327247Free PMC Article
Endocrine paraneoplastic syndromes in patients with neuroendocrine neoplasms.
Daskalakis K, Chatzelis E, Tsoli M, Papadopoulou-Marketou N, Dimitriadis GK, Tsolakis AV, Kaltsas G
Endocrine 2019 May;64(2):384-392. Epub 2018 Oct 2 doi: 10.1007/s12020-018-1773-3. PMID: 30280284Free PMC Article
Tumor- and pregnancy-derived isoforms of human chorionic gonadotropin: biological and diagnostic relevance.
Lottersberger C, Hoermann R, Mann K, Schwarz S, Berger P
Horm Res 2003;59(3):125-34. doi: 10.1159/000069070. PMID: 12637792

Therapy

One Case of Pituitary Stalk Interruption Syndrome Associated with Liver Cirrhosis.
He H, Li DM
Endocr Metab Immune Disord Drug Targets 2023;23(9):1229-1234. doi: 10.2174/1871530323666230228110650. PMID: 36852803
Reproductive outcomes of dual trigger with combination GnRH agonist and hCG versus trigger with hCG alone in women undergoing IVF/ICSI cycles: a retrospective cohort study with propensity score matching.
Dong L, Lian F, Wu H, Xiang S, Li Y, Wei C, Yu X, Xin X
BMC Pregnancy Childbirth 2022 Jul 22;22(1):583. doi: 10.1186/s12884-022-04899-2. PMID: 35869444Free PMC Article
Ovarian hyperstimulation syndrome following GnRH agonist trigger-think ectopic.
Orvieto R, Vanni VS
J Assist Reprod Genet 2017 Sep;34(9):1161-1165. Epub 2017 Jun 9 doi: 10.1007/s10815-017-0960-0. PMID: 28600619Free PMC Article
Ectopic secretion of chorionic gonadotropin by a lung carcinoma. Pituitary gonadotropin and subunit secretion and prolonged chemotherapeutic remission.
Metz SA, Weintraub B, Rosen SW, Singer J, Robertson RP
Am J Med 1978 Aug;65(2):325-33. doi: 10.1016/0002-9343(78)90827-6. PMID: 210665
Cushing's syndrome complicating pregnancy. A case report.
Wieland RG, Shaffer MB Jr, Glove RP
Obstet Gynecol 1971 Dec;38(6):841-3. PMID: 5125430

Prognosis

Reproductive outcomes of dual trigger with combination GnRH agonist and hCG versus trigger with hCG alone in women undergoing IVF/ICSI cycles: a retrospective cohort study with propensity score matching.
Dong L, Lian F, Wu H, Xiang S, Li Y, Wei C, Yu X, Xin X
BMC Pregnancy Childbirth 2022 Jul 22;22(1):583. doi: 10.1186/s12884-022-04899-2. PMID: 35869444Free PMC Article
Pituitary stalk interruption syndrome: A rare case report and literature review.
Zhang W, Qian F, Lu G, Wu Y, Li R, Xia L, Zhao R, Lin Y, Gu M, Chen W
Medicine (Baltimore) 2020 Dec 11;99(50):e23266. doi: 10.1097/MD.0000000000023266. PMID: 33327247Free PMC Article
Role of inhibin in normal and high-risk pregnancy.
Muttukrishna S
Semin Reprod Med 2004 Aug;22(3):227-34. doi: 10.1055/s-2004-831898. PMID: 15319825
Usefulness of inferior petrosal sinus venous endocrine markers in Cushing's disease.
Zovickian J, Oldfield EH, Doppman JL, Cutler GB Jr, Loriaux DL
J Neurosurg 1988 Feb;68(2):205-10. doi: 10.3171/jns.1988.68.2.0205. PMID: 2828570
Aberrant hormone activity by tumors of gynecologic importance.
Shane JM, Naftolin F
Am J Obstet Gynecol 1975 Jan 1;121(1):133-43. doi: 10.1016/0002-9378(75)90991-6. PMID: 163584

Clinical prediction guides

Reproductive outcomes of dual trigger with combination GnRH agonist and hCG versus trigger with hCG alone in women undergoing IVF/ICSI cycles: a retrospective cohort study with propensity score matching.
Dong L, Lian F, Wu H, Xiang S, Li Y, Wei C, Yu X, Xin X
BMC Pregnancy Childbirth 2022 Jul 22;22(1):583. doi: 10.1186/s12884-022-04899-2. PMID: 35869444Free PMC Article
Is the adrenal cortex a target for gonadotropins?
Bernichtein S, Alevizaki M, Huhtaniemi I
Trends Endocrinol Metab 2008 Sep;19(7):231-8. Epub 2008 Aug 6 doi: 10.1016/j.tem.2008.06.003. PMID: 18691899
Role of inhibin in normal and high-risk pregnancy.
Muttukrishna S
Semin Reprod Med 2004 Aug;22(3):227-34. doi: 10.1055/s-2004-831898. PMID: 15319825
Ectopic secretion of chorionic gonadotropin by a lung carcinoma. Pituitary gonadotropin and subunit secretion and prolonged chemotherapeutic remission.
Metz SA, Weintraub B, Rosen SW, Singer J, Robertson RP
Am J Med 1978 Aug;65(2):325-33. doi: 10.1016/0002-9343(78)90827-6. PMID: 210665
Aberrant hormone activity by tumors of gynecologic importance.
Shane JM, Naftolin F
Am J Obstet Gynecol 1975 Jan 1;121(1):133-43. doi: 10.1016/0002-9378(75)90991-6. PMID: 163584

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