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Increased circulating troponin I concentration

MedGen UID:
1636885
Concept ID:
C4703660
Finding
Synonym: Increased troponin I level in blood
 
HPO: HP:0410173

Definition

An increased concentration of tropnin I in the blood, which is a cardiac regulatory protein that controls the calcium mediated interaction between actin and myosin. Raised cardiac troponin concentrations are now accepted as the standard biochemical marker for the diagnosis of myocardial infarction. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating troponin I concentration

Conditions with this feature

Arrhythmogenic right ventricular dysplasia 10
MedGen UID:
347543
Concept ID:
C1857777
Disease or Syndrome
Arrhythmogenic right ventricular cardiomyopathy (ARVC) – previously referred to as arrhythmogenic right ventricular dysplasia (ARVD) – is characterized by progressive fibrofatty replacement of the myocardium that predisposes to ventricular tachycardia and sudden death in young individuals and athletes. It primarily affects the right ventricle, and it may also involve the left ventricle. The presentation of disease is highly variable even within families, and some affected individuals may not meet established clinical criteria. The mean age at diagnosis is 31 years (±13; range: 4-64 years).
Myofibrillar myopathy 10
MedGen UID:
1769385
Concept ID:
C5436656
Disease or Syndrome
Myofibrillar myopathy-10 (MFM10) is an autosomal recessive structural muscle disorder characterized by onset of muscle pain, cramping, and exercise fatigue in the first or second decades of life. Some patients have mild contractures of the large joints apparent in early childhood. Affected individuals have a characteristic appearance of a thick neck and prominent shoulder girdle with anteverted shoulders and a tendency toward kyphosis. There is no apparent muscle weakness, but some affected individuals show progressive muscle rigidity leading to limited mobility. There is variable cardiac involvement, ranging from chest pain with left ventricular hypertrophy to subclinical signs such as abnormal EKG or elevated cardiac enzymes. Skeletal muscle biopsy shows structural abnormalities with myofibrillar disorganization and accumulation of autophagocytic vacuoles (summary by Hedberg-Oldfors et al., 2020). For a general phenotypic description and a discussion of genetic heterogeneity of myofibrillar myopathy, see MFM1 (601419).

Professional guidelines

PubMed

Pokrzywinski KL, Biel TG, Rosen ET, Bonanno JL, Aryal B, Mascia F, Moshkelani D, Mog S, Rao VA
Biol Sex Differ 2018 Jun 15;9(1):25. doi: 10.1186/s13293-018-0183-9. PMID: 29907135Free PMC Article
Zhong Y, Yu K, Wang X, Wang X, Ji Q, Zeng Q
Mediators Inflamm 2015;2015:490120. Epub 2015 Dec 24 doi: 10.1155/2015/490120. PMID: 26819499Free PMC Article
Leistner DM, Klotsche J, Pieper L, Stalla GK, Lehnert H, Silber S, März W, Wittchen HU, Zeiher AM; DETECT Study Group
Clin Chem 2012 Jan;58(1):200-8. Epub 2011 Dec 7 doi: 10.1373/clinchem.2011.174292. PMID: 22156668

Recent clinical studies

Etiology

de Bakker M, Anand A, Shipley M, Fujisawa T, Shah ASV, Kardys I, Boersma E, Brunner EJ, Mills NL, Kimenai DM
Circulation 2023 Jun 13;147(24):1798-1808. Epub 2023 Apr 28 doi: 10.1161/CIRCULATIONAHA.123.064386. PMID: 37114498Free PMC Article
du Fay de Lavallaz J, Prepoudis A, Wendebourg MJ, Kesenheimer E, Kyburz D, Daikeler T, Haaf P, Wanschitz J, Löscher WN, Schreiner B, Katan M, Jung HH, Maurer B, Hammerer-Lercher A, Mayr A, Gualandro DM, Acket A, Puelacher C, Boeddinghaus J, Nestelberger T, Lopez-Ayala P, Glarner N, Shrestha S, Manka R, Gawinecka J, Piscuoglio S, Gallon J, Wiedemann S, Sinnreich M, Mueller C; BASEL XII Investigators
Circulation 2022 Jun 14;145(24):1764-1779. Epub 2022 Apr 7 doi: 10.1161/CIRCULATIONAHA.121.058489. PMID: 35389756Free PMC Article
Camen S, Palosaari T, Reinikainen J, Sprünker NA, Niiranen T, Gianfagna F, Vishram-Nielsen JKK, Costanzo S, Söderberg S, Palmieri L, Ferrario M, Peters A, Vartiainen E, Donati MB, Donfrancesco C, Borchini R, Börschel CS, Giampaoli S, Di Castelnuovo A, Magnussen C, Kee F, Koenig W, Blankenberg S, de Gaetano G, Tunstall-Pedoe H, Rospleszcz S, Jørgensen T, Zeller T, Kuulasmaa K, Linneberg A, Salomaa V, Iacoviello L, Schnabel RB; BiomarCaRE Consortium
Stroke 2020 Sep;51(9):2770-2777. Epub 2020 Aug 19 doi: 10.1161/STROKEAHA.120.029452. PMID: 32811388Free PMC Article
Liu L, Liu S, Shen L, Tu B, Hu Z, Hu F, Zheng L, Ding L, Fan X, Yao Y
Clin Cardiol 2020 Oct;43(10):1150-1159. Epub 2020 Aug 18 doi: 10.1002/clc.23425. PMID: 32810305Free PMC Article
Aengevaeren VL, Hopman MTE, Thompson PD, Bakker EA, George KP, Thijssen DHJ, Eijsvogels TMH
Circulation 2019 Sep 9;140(10):804-814. Epub 2019 Aug 12 doi: 10.1161/CIRCULATIONAHA.119.041627. PMID: 31401842

Diagnosis

de Bakker M, Anand A, Shipley M, Fujisawa T, Shah ASV, Kardys I, Boersma E, Brunner EJ, Mills NL, Kimenai DM
Circulation 2023 Jun 13;147(24):1798-1808. Epub 2023 Apr 28 doi: 10.1161/CIRCULATIONAHA.123.064386. PMID: 37114498Free PMC Article
du Fay de Lavallaz J, Prepoudis A, Wendebourg MJ, Kesenheimer E, Kyburz D, Daikeler T, Haaf P, Wanschitz J, Löscher WN, Schreiner B, Katan M, Jung HH, Maurer B, Hammerer-Lercher A, Mayr A, Gualandro DM, Acket A, Puelacher C, Boeddinghaus J, Nestelberger T, Lopez-Ayala P, Glarner N, Shrestha S, Manka R, Gawinecka J, Piscuoglio S, Gallon J, Wiedemann S, Sinnreich M, Mueller C; BASEL XII Investigators
Circulation 2022 Jun 14;145(24):1764-1779. Epub 2022 Apr 7 doi: 10.1161/CIRCULATIONAHA.121.058489. PMID: 35389756Free PMC Article
Katrukha IA, Katrukha AG
Clin Chem 2021 Jan 8;67(1):124-130. doi: 10.1093/clinchem/hvaa281. PMID: 33418589
Aengevaeren VL, Hopman MTE, Thompson PD, Bakker EA, George KP, Thijssen DHJ, Eijsvogels TMH
Circulation 2019 Sep 9;140(10):804-814. Epub 2019 Aug 12 doi: 10.1161/CIRCULATIONAHA.119.041627. PMID: 31401842
Mair J, Lindahl B, Hammarsten O, Müller C, Giannitsis E, Huber K, Möckel M, Plebani M, Thygesen K, Jaffe AS
Eur Heart J Acute Cardiovasc Care 2018 Sep;7(6):553-560. Epub 2017 Dec 27 doi: 10.1177/2048872617748553. PMID: 29278915

Therapy

Árnadóttir Á, Pedersen S, Bo Hasselbalch R, Goetze JP, Friis-Hansen LJ, Bloch-Münster AM, Skov Jensen J, Bundgaard H, Iversen K
Circulation 2021 Mar 16;143(11):1095-1104. Epub 2020 Dec 10 doi: 10.1161/CIRCULATIONAHA.120.046574. PMID: 33297742
Tan ESJ, Chan SP, Liew OW, Chong JPC, Leong GKT, Yeo DPS, Ong HY, Jaufeerally F, Yap J, Sim D, Ng TP, Ling LH, Lam CSP, Richards AM
Clin Chem 2021 Jan 8;67(1):216-226. doi: 10.1093/clinchem/hvaa287. PMID: 33279970
van der Linden N, Wildi K, Twerenbold R, Pickering JW, Than M, Cullen L, Greenslade J, Parsonage W, Nestelberger T, Boeddinghaus J, Badertscher P, Rubini Giménez M, Klinkenberg LJJ, Bekers O, Schöni A, Keller DI, Sabti Z, Puelacher C, Cupa J, Schumacher L, Kozhuharov N, Grimm K, Shrestha S, Flores D, Freese M, Stelzig C, Strebel I, Miró Ò, Rentsch K, Morawiec B, Kawecki D, Kloos W, Lohrmann J, Richards AM, Troughton R, Pemberton C, Osswald S, van Dieijen-Visser MP, Mingels AM, Reichlin T, Meex SJR, Mueller C
Circulation 2018 Sep 4;138(10):989-999. doi: 10.1161/CIRCULATIONAHA.117.032003. PMID: 29691270
Hunter AL, Shah AS, Langrish JP, Raftis JB, Lucking AJ, Brittan M, Venkatasubramanian S, Stables CL, Stelzle D, Marshall J, Graveling R, Flapan AD, Newby DE, Mills NL
Circulation 2017 Apr 4;135(14):1284-1295. doi: 10.1161/CIRCULATIONAHA.116.025711. PMID: 28373523Free PMC Article
Klinkenberg LJ, Luyten P, van der Linden N, Urgel K, Snijders DP, Knackstedt C, Dennert R, Kietselaer BL, Mingels AM, Cardinaels EP, Peeters FE, van Suijlen JD, Ten Kate J, Marsch E, Theelen TL, Sluimer JC, Wouters K, Bekers O, Bekkers SC, van Loon LJ, van Dieijen-Visser MP, Meex SJ
Am J Cardiol 2016 Jul 15;118(2):281-7. Epub 2016 May 4 doi: 10.1016/j.amjcard.2016.04.030. PMID: 27282835

Prognosis

de Bakker M, Anand A, Shipley M, Fujisawa T, Shah ASV, Kardys I, Boersma E, Brunner EJ, Mills NL, Kimenai DM
Circulation 2023 Jun 13;147(24):1798-1808. Epub 2023 Apr 28 doi: 10.1161/CIRCULATIONAHA.123.064386. PMID: 37114498Free PMC Article
Camen S, Palosaari T, Reinikainen J, Sprünker NA, Niiranen T, Gianfagna F, Vishram-Nielsen JKK, Costanzo S, Söderberg S, Palmieri L, Ferrario M, Peters A, Vartiainen E, Donati MB, Donfrancesco C, Borchini R, Börschel CS, Giampaoli S, Di Castelnuovo A, Magnussen C, Kee F, Koenig W, Blankenberg S, de Gaetano G, Tunstall-Pedoe H, Rospleszcz S, Jørgensen T, Zeller T, Kuulasmaa K, Linneberg A, Salomaa V, Iacoviello L, Schnabel RB; BiomarCaRE Consortium
Stroke 2020 Sep;51(9):2770-2777. Epub 2020 Aug 19 doi: 10.1161/STROKEAHA.120.029452. PMID: 32811388Free PMC Article
Liu L, Liu S, Shen L, Tu B, Hu Z, Hu F, Zheng L, Ding L, Fan X, Yao Y
Clin Cardiol 2020 Oct;43(10):1150-1159. Epub 2020 Aug 18 doi: 10.1002/clc.23425. PMID: 32810305Free PMC Article
Aengevaeren VL, Hopman MTE, Thompson PD, Bakker EA, George KP, Thijssen DHJ, Eijsvogels TMH
Circulation 2019 Sep 9;140(10):804-814. Epub 2019 Aug 12 doi: 10.1161/CIRCULATIONAHA.119.041627. PMID: 31401842
Giannoni A, Giovannini S, Clerico A
Clin Chem Lab Med 2009;47(10):1167-77. doi: 10.1515/CCLM.2009.320. PMID: 19803806

Clinical prediction guides

de Bakker M, Anand A, Shipley M, Fujisawa T, Shah ASV, Kardys I, Boersma E, Brunner EJ, Mills NL, Kimenai DM
Circulation 2023 Jun 13;147(24):1798-1808. Epub 2023 Apr 28 doi: 10.1161/CIRCULATIONAHA.123.064386. PMID: 37114498Free PMC Article
du Fay de Lavallaz J, Prepoudis A, Wendebourg MJ, Kesenheimer E, Kyburz D, Daikeler T, Haaf P, Wanschitz J, Löscher WN, Schreiner B, Katan M, Jung HH, Maurer B, Hammerer-Lercher A, Mayr A, Gualandro DM, Acket A, Puelacher C, Boeddinghaus J, Nestelberger T, Lopez-Ayala P, Glarner N, Shrestha S, Manka R, Gawinecka J, Piscuoglio S, Gallon J, Wiedemann S, Sinnreich M, Mueller C; BASEL XII Investigators
Circulation 2022 Jun 14;145(24):1764-1779. Epub 2022 Apr 7 doi: 10.1161/CIRCULATIONAHA.121.058489. PMID: 35389756Free PMC Article
Camen S, Palosaari T, Reinikainen J, Sprünker NA, Niiranen T, Gianfagna F, Vishram-Nielsen JKK, Costanzo S, Söderberg S, Palmieri L, Ferrario M, Peters A, Vartiainen E, Donati MB, Donfrancesco C, Borchini R, Börschel CS, Giampaoli S, Di Castelnuovo A, Magnussen C, Kee F, Koenig W, Blankenberg S, de Gaetano G, Tunstall-Pedoe H, Rospleszcz S, Jørgensen T, Zeller T, Kuulasmaa K, Linneberg A, Salomaa V, Iacoviello L, Schnabel RB; BiomarCaRE Consortium
Stroke 2020 Sep;51(9):2770-2777. Epub 2020 Aug 19 doi: 10.1161/STROKEAHA.120.029452. PMID: 32811388Free PMC Article
Liu L, Liu S, Shen L, Tu B, Hu Z, Hu F, Zheng L, Ding L, Fan X, Yao Y
Clin Cardiol 2020 Oct;43(10):1150-1159. Epub 2020 Aug 18 doi: 10.1002/clc.23425. PMID: 32810305Free PMC Article
Aengevaeren VL, Hopman MTE, Thompson PD, Bakker EA, George KP, Thijssen DHJ, Eijsvogels TMH
Circulation 2019 Sep 9;140(10):804-814. Epub 2019 Aug 12 doi: 10.1161/CIRCULATIONAHA.119.041627. PMID: 31401842

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