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Activating NRAS Mutation

MedGen UID:
1636959
•Concept ID:
C4682499
•
Cell or Molecular Dysfunction
Synonyms: N-RAS Activating Mutation; Neuroblastoma RAS Viral Oncogene Homolog Activating Mutation; NRAS Activating Mutation; NRAS Proto-Oncogene, GTPase Activating Mutation; NRAS1 Activating Mutation

Definition

A change in the nucleotide sequence of the NRAS gene that that results in constitutive activation of both oncogene N-Ras protein and its downstream signaling pathways. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVActivating NRAS Mutation

Professional guidelines

PubMed

Treatment of severe Kaposiform lymphangiomatosis positive for NRAS mutation by MEK inhibition.
Chowers G, Abebe-Campino G, Golan H, Vivante A, Greenberger S, Soudack M, Barkai G, Fox-Fisher I, Li D, March M, Battig MR, Hakonarson H, Adams D, Dori Y, Dagan A
Pediatr Res 2023 Dec;94(6):1911-1915. Epub 2022 Mar 4 doi: 10.1038/s41390-022-01986-0. PMID: 35246606Free PMC Article

Recent clinical studies

Diagnosis

Lack of distinct molecular profile of Primary Dermal Melanoma.
Shaigany S, Tessier-Cloutier B, Busam KJ, Horst BA
Hum Pathol 2020 Dec;106:32-38. Epub 2020 Sep 15 doi: 10.1016/j.humpath.2020.09.002. PMID: 32946880Free PMC Article
Functional and genetic screening of acute myeloid leukemia associated with mediastinal germ cell tumor identifies MEK inhibitor as an active clinical agent.
Leonard JT, Raess PW, Dunlap J, Hayes-Lattin B, Tyner JW, Traer E
J Hematol Oncol 2016 Mar 31;9:31. doi: 10.1186/s13045-016-0258-1. PMID: 27036514Free PMC Article
Oncogenic codon 13 NRAS mutation in a primary mesenchymal brain neoplasm and nevus of a child with neurocutaneous melanosis.
Shih F, Yip S, McDonald PJ, Chudley AE, Del Bigio MR
Acta Neuropathol Commun 2014 Oct 21;2:140. doi: 10.1186/s40478-014-0140-8. PMID: 25330907Free PMC Article

Therapy

Functional and genetic screening of acute myeloid leukemia associated with mediastinal germ cell tumor identifies MEK inhibitor as an active clinical agent.
Leonard JT, Raess PW, Dunlap J, Hayes-Lattin B, Tyner JW, Traer E
J Hematol Oncol 2016 Mar 31;9:31. doi: 10.1186/s13045-016-0258-1. PMID: 27036514Free PMC Article

Prognosis

Treatment of severe Kaposiform lymphangiomatosis positive for NRAS mutation by MEK inhibition.
Chowers G, Abebe-Campino G, Golan H, Vivante A, Greenberger S, Soudack M, Barkai G, Fox-Fisher I, Li D, March M, Battig MR, Hakonarson H, Adams D, Dori Y, Dagan A
Pediatr Res 2023 Dec;94(6):1911-1915. Epub 2022 Mar 4 doi: 10.1038/s41390-022-01986-0. PMID: 35246606Free PMC Article
Lack of distinct molecular profile of Primary Dermal Melanoma.
Shaigany S, Tessier-Cloutier B, Busam KJ, Horst BA
Hum Pathol 2020 Dec;106:32-38. Epub 2020 Sep 15 doi: 10.1016/j.humpath.2020.09.002. PMID: 32946880Free PMC Article
Functional and genetic screening of acute myeloid leukemia associated with mediastinal germ cell tumor identifies MEK inhibitor as an active clinical agent.
Leonard JT, Raess PW, Dunlap J, Hayes-Lattin B, Tyner JW, Traer E
J Hematol Oncol 2016 Mar 31;9:31. doi: 10.1186/s13045-016-0258-1. PMID: 27036514Free PMC Article

Clinical prediction guides

Lack of distinct molecular profile of Primary Dermal Melanoma.
Shaigany S, Tessier-Cloutier B, Busam KJ, Horst BA
Hum Pathol 2020 Dec;106:32-38. Epub 2020 Sep 15 doi: 10.1016/j.humpath.2020.09.002. PMID: 32946880Free PMC Article
Radiosensitization and downregulation of heterogeneous nuclear ribonucleoprotein K (hnRNP K) upon inhibition of mitogen/extracellular signal-regulated kinase (MEK) in malignant melanoma cells.
Eder S, Lamkowski A, Priller M, Port M, Steinestel K
Oncotarget 2015 Jul 10;6(19):17178-91. doi: 10.18632/oncotarget.3935. PMID: 26136337Free PMC Article

Supplemental Content

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