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Increased glucose-6-phosphate dehydrogenase level in red blood cells

MedGen UID:
1637238
•Concept ID:
C4703675
•
Finding
Synonyms: Increased G6PD level in RBCs; Increased G6PD level in red blood cells
 
HPO: HP:0410189

Definition

An increase in the level of glucose-6-phosphate dehydrogenase in red blood cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased glucose-6-phosphate dehydrogenase level in red blood cells

Professional guidelines

PubMed

Does vitamin E have a role in treatment and prevention of anemia?
Jilani T, Iqbal MP
Pak J Pharm Sci 2011 Apr;24(2):237-42. PMID: 21454177
Drug-induced methaemoglobinaemia. Treatment issues.
Coleman MD, Coleman NA
Drug Saf 1996 Jun;14(6):394-405. doi: 10.2165/00002018-199614060-00005. PMID: 8828017
Effect of phenobarbital treatment on erythrocyte glucose-6-phosphate dehydrogenase in human newborns.
Laconi E, Dessì S, Batetta B, Pani P, Pirisi L, Andria C, Macciotta A
Pediatr Pharmacol (New York) 1983;3(2):59-62. PMID: 6674910

Recent clinical studies

Etiology

The potential role of vitamin E in patients with glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis.
Abdelwahab OA, Akil K, Seif A, Allam M, Sherif ME, Al-Alfy MN
Medicine (Baltimore) 2023 Feb 10;102(6):e32937. doi: 10.1097/MD.0000000000032937. PMID: 36820534Free PMC Article
Laboratory Approach to Hemolytic Anemia.
Jamwal M, Sharma P, Das R
Indian J Pediatr 2020 Jan;87(1):66-74. Epub 2019 Dec 10 doi: 10.1007/s12098-019-03119-8. PMID: 31823208
Periodontal disease and hemolysis in glucose-6-phosphate dehydrogenase deficiency: Is there a nexus?
Singh N, Uppoor A, Rajendran V, Naik DG
J Oral Biosci 2019 Jun;61(2):129-133. Epub 2019 Mar 22 doi: 10.1016/j.job.2019.03.001. PMID: 31235029
Erythrocyte Glucose-6-Phosphate Dehydrogenase Level in Type 2 Diabetes Male.
Khanam A, Akter QS, Karim F, Zannat MR
Mymensingh Med J 2018 Jan;27(1):103-107. PMID: 29459599
Gene-nutrient interactions in G6PD-deficient subjects--implications for cardiovascular disease susceptibility.
Muntoni S, Muntoni S
J Nutrigenet Nutrigenomics 2008;1(1-2):49-54. Epub 2007 Oct 16 doi: 10.1159/000109874. PMID: 19918114

Diagnosis

Enzymatic Changes in Red Blood Cells of Diamond-Blackfan Anemia.
Utsugisawa T, Uchiyama T, Toki T, Shimojima-Yamamoto K, Ohga S, Ito E, Kanno H
Tohoku J Exp Med 2021 Sep;255(1):49-55. doi: 10.1620/tjem.255.49. PMID: 34526430
Laboratory Approach to Hemolytic Anemia.
Jamwal M, Sharma P, Das R
Indian J Pediatr 2020 Jan;87(1):66-74. Epub 2019 Dec 10 doi: 10.1007/s12098-019-03119-8. PMID: 31823208
Mechanisms and significance of eryptosis.
Lang F, Lang KS, Lang PA, Huber SM, Wieder T
Antioxid Redox Signal 2006 Jul-Aug;8(7-8):1183-92. doi: 10.1089/ars.2006.8.1183. PMID: 16910766
Drug-induced methaemoglobinaemia. Treatment issues.
Coleman MD, Coleman NA
Drug Saf 1996 Jun;14(6):394-405. doi: 10.2165/00002018-199614060-00005. PMID: 8828017
Chemical toxicity of red cells.
Piomelli S
Environ Health Perspect 1981 Jun;39:65-70. doi: 10.1289/ehp.813965. PMID: 7016524Free PMC Article

Therapy

The potential role of vitamin E in patients with glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis.
Abdelwahab OA, Akil K, Seif A, Allam M, Sherif ME, Al-Alfy MN
Medicine (Baltimore) 2023 Feb 10;102(6):e32937. doi: 10.1097/MD.0000000000032937. PMID: 36820534Free PMC Article
Randomised controlled trial of glucose-6-phosphate dehydrogenase deficient versus non-deficient red blood cell transfusion in patients with hypoproliferative anaemia.
Krajibthong S, Sahntipurna V, Parnsamut C, Pitakpolrat P, Pattanapongsak W, Watanaboonyongcharoen P, Rojnuckarin P
Transfus Med 2022 Aug;32(4):293-298. Epub 2022 May 9 doi: 10.1111/tme.12871. PMID: 35534916
Erythrocyte Glucose-6-Phosphate Dehydrogenase Level in Type 2 Diabetes Male.
Khanam A, Akter QS, Karim F, Zannat MR
Mymensingh Med J 2018 Jan;27(1):103-107. PMID: 29459599
Does vitamin E have a role in treatment and prevention of anemia?
Jilani T, Iqbal MP
Pak J Pharm Sci 2011 Apr;24(2):237-42. PMID: 21454177
Drug-induced methaemoglobinaemia. Treatment issues.
Coleman MD, Coleman NA
Drug Saf 1996 Jun;14(6):394-405. doi: 10.2165/00002018-199614060-00005. PMID: 8828017

Prognosis

Hematologic and systemic metabolic alterations due to Mediterranean class II G6PD deficiency in mice.
D'Alessandro A, Howie HL, Hay AM, Dziewulska KH, Brown BC, Wither MJ, Karafin M, Stone EF, Spitalnik SL, Hod EA, Francis RO, Fu X, Thomas T, Zimring JC
JCI Insight 2021 Jul 22;6(14) doi: 10.1172/jci.insight.147056. PMID: 34138756Free PMC Article
Exploring the role of glucose‑6‑phosphate dehydrogenase in cancer (Review).
Li R, Wang W, Yang Y, Gu C
Oncol Rep 2020 Dec;44(6):2325-2336. Epub 2020 Oct 12 doi: 10.3892/or.2020.7803. PMID: 33125150
Oxidative markers in spontaneous intracerebral hemorrhage: leukocyte 8-hydroxy-2'-deoxyguanosine as an independent predictor of the 30-day outcome.
Chen YC, Chen CM, Liu JL, Chen ST, Cheng ML, Chiu DT
J Neurosurg 2011 Dec;115(6):1184-90. Epub 2011 Aug 26 doi: 10.3171/2011.7.JNS11718. PMID: 21962000
Deletion of leucine 61 in glucose-6-phosphate dehydrogenase leads to chronic nonspherocytic anemia, granulocyte dysfunction, and increased susceptibility to infections.
van Bruggen R, Bautista JM, Petropoulou T, de Boer M, van Zwieten R, Gómez-Gallego F, Belohradsky BH, Hartwig NG, Stevens D, Mason PJ, Roos D
Blood 2002 Aug 1;100(3):1026-30. doi: 10.1182/blood.v100.3.1026. PMID: 12130518
Favism: impairment of proteolytic systems in red blood cells.
Morelli A, Grasso M, Meloni T, Forteleoni G, Zocchi E, De Flora A
Blood 1987 Jun;69(6):1753-8. PMID: 3034353

Clinical prediction guides

Enzymatic Changes in Red Blood Cells of Diamond-Blackfan Anemia.
Utsugisawa T, Uchiyama T, Toki T, Shimojima-Yamamoto K, Ohga S, Ito E, Kanno H
Tohoku J Exp Med 2021 Sep;255(1):49-55. doi: 10.1620/tjem.255.49. PMID: 34526430
Exploring the role of glucose‑6‑phosphate dehydrogenase in cancer (Review).
Li R, Wang W, Yang Y, Gu C
Oncol Rep 2020 Dec;44(6):2325-2336. Epub 2020 Oct 12 doi: 10.3892/or.2020.7803. PMID: 33125150
The clinical impact of glucose-6-phosphate dehydrogenase deficiency in patients with sickle cell disease.
Karafin MS, Fu X, D'Alessandro A, Thomas T, Hod EA, Zimring JC, Field JJ, Francis RO
Curr Opin Hematol 2018 Nov;25(6):494-499. doi: 10.1097/MOH.0000000000000455. PMID: 30239377
Erythrocyte Glucose-6-Phosphate Dehydrogenase Level in Type 2 Diabetes Male.
Khanam A, Akter QS, Karim F, Zannat MR
Mymensingh Med J 2018 Jan;27(1):103-107. PMID: 29459599
Chemical toxicity of red cells.
Piomelli S
Environ Health Perspect 1981 Jun;39:65-70. doi: 10.1289/ehp.813965. PMID: 7016524Free PMC Article

Recent systematic reviews

The potential role of vitamin E in patients with glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis.
Abdelwahab OA, Akil K, Seif A, Allam M, Sherif ME, Al-Alfy MN
Medicine (Baltimore) 2023 Feb 10;102(6):e32937. doi: 10.1097/MD.0000000000032937. PMID: 36820534Free PMC Article

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