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Adenocarcinoma of penis

MedGen UID:
1637360
Concept ID:
C2212153
Neoplastic Process
Synonyms: Adenocarcinoma of the penis; Penile adenocarcinoma
SNOMED CT: Adenocarcinoma of penis (764846009); Penile adenocarcinoma (764846009)
 
Orphanet: ORPHA398053

Definition

An extremely rare penile epithelial neoplasm, histologically composed of nests of epithelial cells floating in lakes of extracellular, PAS-positive mucin, with clinical characteristics of a nonhealing ulcer or soft mass in the preputium or glans area, with itching and burning often preceding appearance of the lesion. Lymphadenopathy may indicate dissemination. Mucinous metaplasia of the penis may be a risk factor. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma of penis

Professional guidelines

PubMed

Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Christodoulidou M, Alnajjar HM, Parnham A, Khetrapal P, Freeman A, Haider A, Mitra AV, Bunker CB, Muneer A
Urol Oncol 2021 Aug;39(8):501.e1-501.e10. Epub 2021 Jun 27 doi: 10.1016/j.urolonc.2021.05.018. PMID: 34193377
Janisch F, Abufaraj M, Fajkovic H, Kimura S, Iwata T, Nyirady P, Rink M, Shariat SF
Eur Urol Focus 2019 Sep;5(5):722-734. Epub 2019 Jul 13 doi: 10.1016/j.euf.2019.07.001. PMID: 31307949

Recent clinical studies

Etiology

Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769
Zhao T, Chuang HW, Cornejo KM, Crotty RK, Dahl DM, Wszolek MF, Zlatev DV, Zietman AL, Wu CL
Hum Pathol 2022 Oct;128:101-109. Epub 2022 Aug 1 doi: 10.1016/j.humpath.2022.07.018. PMID: 35926810
Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
Acosta AM, Sholl LM, Fanelli GN, Gordetsky JB, Baniak N, Barletta JA, Lindeman NI, Hirsch MS
Mod Pathol 2021 Feb;34(2):457-468. Epub 2020 Aug 28 doi: 10.1038/s41379-020-00655-z. PMID: 32860003
Algaba F
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):23-8. PMID: 26072631

Diagnosis

Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Dauendorffer JN, Herms F, Baroudjian B, Basset-Seguin N, Cavelier-Balloy B, Fouéré S, Bagot M, Lebbé C
Ann Dermatol Venereol 2021 Jun;148(2):71-76. Epub 2021 Jan 16 doi: 10.1016/j.annder.2020.08.051. PMID: 33461789
Barbosa JABA, Ribeiro CTA, Grinblat B, Cardoso APG, Weltmann E, de Oliveira EC, Yorioka MAW, Borges LL
Urology 2019 Nov;133:e13-e14. Epub 2019 Jul 11 doi: 10.1016/j.urology.2019.07.002. PMID: 31302136
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904

Therapy

Wang D, Wang P, Li C, Zhou Z, Zhang L, Zhang G, Wang X
Photodiagnosis Photodyn Ther 2022 Mar;37:102670. Epub 2021 Dec 7 doi: 10.1016/j.pdpdt.2021.102670. PMID: 34883272
Padilla-Ansala C, García-Fernández E, González-Peramato P
Int J Surg Pathol 2021 Aug;29(5):488-495. Epub 2021 Jan 19 doi: 10.1177/1066896920988348. PMID: 33463392
Tran THT, Melamed J, Deng FM
Urology 2021 Feb;148:270-273. Epub 2020 Jul 16 doi: 10.1016/j.urology.2020.07.003. PMID: 32683064
Gao Y, Zhang XC, Wang WS, Yang Y, Wang HL, Lu YG, Fan DL
Photodiagnosis Photodyn Ther 2015 Mar;12(1):92-7. Epub 2014 Dec 3 doi: 10.1016/j.pdpdt.2014.11.004. PMID: 25479094
Bugeja S, Andrich DE, Mundy AR
Arch Esp Urol 2014 Jan-Feb;67(1):77-91. PMID: 24531675

Prognosis

Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Seipel AH, Delahunt B, Samaratunga H, Egevad L
Pathology 2016 Aug;48(5):398-405. Epub 2016 Jun 16 doi: 10.1016/j.pathol.2016.04.001. PMID: 27321992
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article
Chaux A, Cubilla AL
Semin Diagn Pathol 2012 May;29(2):72-82. doi: 10.1053/j.semdp.2011.08.002. PMID: 22641956

Clinical prediction guides

Padilla-Ansala C, García-Fernández E, González-Peramato P
Int J Surg Pathol 2021 Aug;29(5):488-495. Epub 2021 Jan 19 doi: 10.1177/1066896920988348. PMID: 33463392
Liu Y, Wang Y, Qi R, Mao X, Jin F
Medicine (Baltimore) 2020 Dec 18;99(51):e23443. doi: 10.1097/MD.0000000000023443. PMID: 33371071Free PMC Article
Piras A, Sanfratello A, Boldrini L, La Vecchia M, Venuti V, Amari ML, Orlando M, Zichichi L, Angileri T, Daidone A
Dermatol Ther 2020 Nov;33(6):e13890. Epub 2020 Jul 25 doi: 10.1111/dth.13890. PMID: 32584449
Janisch F, Abufaraj M, Fajkovic H, Kimura S, Iwata T, Nyirady P, Rink M, Shariat SF
Eur Urol Focus 2019 Sep;5(5):722-734. Epub 2019 Jul 13 doi: 10.1016/j.euf.2019.07.001. PMID: 31307949
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904

Recent systematic reviews

Janisch F, Abufaraj M, Fajkovic H, Kimura S, Iwata T, Nyirady P, Rink M, Shariat SF
Eur Urol Focus 2019 Sep;5(5):722-734. Epub 2019 Jul 13 doi: 10.1016/j.euf.2019.07.001. PMID: 31307949

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