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Peripartum cardiomyopathy

MedGen UID:
163756
•Concept ID:
C0877208
•
Disease or Syndrome
Synonyms: antepartum peripartum cardiomyopathy; Meadows' syndrome; Peripartum Cardiomyopathy; peripartum cardiomyopathy; Postpartum cardiomyopathy; postpartum cardiomyopathy; postpartum peripartum cardiomyopathy
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
Monarch Initiative: MONDO:0018920
Orphanet: ORPHA563

Definition

Peripartum cardiomyopathy (PPCM) is an idiopathic, potentially fatal form of dilated cardiomyopathy that develops during the final month of pregnancy or within five months after delivery. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeripartum cardiomyopathy

Professional guidelines

PubMed

Peripartum cardiomyopathy: from genetics to management.
Sliwa K, Bauersachs J, Arany Z, Spracklen TF, Hilfiker-Kleiner D
Eur Heart J 2021 Aug 21;42(32):3094-3102. doi: 10.1093/eurheartj/ehab458. PMID: 34322694
Pathophysiology, diagnosis and management of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathy.
Bauersachs J, König T, van der Meer P, Petrie MC, Hilfiker-Kleiner D, Mbakwem A, Hamdan R, Jackson AM, Forsyth P, de Boer RA, Mueller C, Lyon AR, Lund LH, Piepoli MF, Heymans S, Chioncel O, Anker SD, Ponikowski P, Seferovic PM, Johnson MR, Mebazaa A, Sliwa K
Eur J Heart Fail 2019 Jul;21(7):827-843. Epub 2019 Jun 27 doi: 10.1002/ejhf.1493. PMID: 31243866
Peripartum cardiomyopathy: approach to management.
Goland S, Elkayam U
Curr Opin Cardiol 2018 May;33(3):347-353. doi: 10.1097/HCO.0000000000000516. PMID: 29601327

Recent clinical studies

Etiology

Obstetric Disorders and Critical Illness.
Griffin KM, Oxford-Horrey C, Bourjeily G
Clin Chest Med 2022 Sep;43(3):471-488. doi: 10.1016/j.ccm.2022.04.008. PMID: 36116815Free PMC Article
Peripartum Cardiomyopathy: JACC State-of-the-Art Review.
Davis MB, Arany Z, McNamara DM, Goland S, Elkayam U
J Am Coll Cardiol 2020 Jan 21;75(2):207-221. doi: 10.1016/j.jacc.2019.11.014. PMID: 31948651
Sex differences in heart failure.
Lam CSP, Arnott C, Beale AL, Chandramouli C, Hilfiker-Kleiner D, Kaye DM, Ky B, Santema BT, Sliwa K, Voors AA
Eur Heart J 2019 Dec 14;40(47):3859-3868c. doi: 10.1093/eurheartj/ehz835. PMID: 31800034
Cardiomyopathy and pregnancy.
Schaufelberger M
Heart 2019 Oct;105(20):1543-1551. Epub 2019 Jul 15 doi: 10.1136/heartjnl-2018-313476. PMID: 31308064Free PMC Article
Peripartum cardiomyopathy.
Honigberg MC, Givertz MM
BMJ 2019 Jan 30;364:k5287. doi: 10.1136/bmj.k5287. PMID: 30700415

Diagnosis

Peripartum Cardiomyopathy.
Arany Z
N Engl J Med 2024 Jan 11;390(2):154-164. doi: 10.1056/NEJMra2306667. PMID: 38197818
Obstetric Disorders and Critical Illness.
Griffin KM, Oxford-Horrey C, Bourjeily G
Clin Chest Med 2022 Sep;43(3):471-488. doi: 10.1016/j.ccm.2022.04.008. PMID: 36116815Free PMC Article
Peripartum cardiomyopathy: a review.
Iorgoveanu C, Zaghloul A, Ashwath M
Heart Fail Rev 2021 Nov;26(6):1287-1296. Epub 2021 Jun 17 doi: 10.1007/s10741-020-10061-x. PMID: 34138401Free PMC Article
Peripartum Cardiomyopathy: JACC State-of-the-Art Review.
Davis MB, Arany Z, McNamara DM, Goland S, Elkayam U
J Am Coll Cardiol 2020 Jan 21;75(2):207-221. doi: 10.1016/j.jacc.2019.11.014. PMID: 31948651
Peripartum cardiomyopathy.
Honigberg MC, Givertz MM
BMJ 2019 Jan 30;364:k5287. doi: 10.1136/bmj.k5287. PMID: 30700415

Therapy

Peripartum Cardiomyopathy: JACC State-of-the-Art Review.
Davis MB, Arany Z, McNamara DM, Goland S, Elkayam U
J Am Coll Cardiol 2020 Jan 21;75(2):207-221. doi: 10.1016/j.jacc.2019.11.014. PMID: 31948651
Anthracycline and Peripartum Cardiomyopathies.
Cowgill JA, Francis SA, Sawyer DB
Circ Res 2019 May 24;124(11):1633-1646. doi: 10.1161/CIRCRESAHA.119.313577. PMID: 31120822
Understanding Peripartum Cardiomyopathy.
Arany Z
Annu Rev Med 2018 Jan 29;69:165-176. Epub 2017 Aug 16 doi: 10.1146/annurev-med-041316-090545. PMID: 28813232
Peripartum Cardiomyopathy.
Arany Z, Elkayam U
Circulation 2016 Apr 5;133(14):1397-409. doi: 10.1161/CIRCULATIONAHA.115.020491. PMID: 27045128
Peripartum cardiomyopathy.
Murali S, Baldisseri MR
Crit Care Med 2005 Oct;33(10 Suppl):S340-6. doi: 10.1097/01.ccm.0000183500.47273.8e. PMID: 16215357

Prognosis

Recent Findings Related to Cardiomyopathy and Genetics.
Yamada T, Nomura S
Int J Mol Sci 2021 Nov 20;22(22) doi: 10.3390/ijms222212522. PMID: 34830403Free PMC Article
Peripartum cardiomyopathy: a review.
Iorgoveanu C, Zaghloul A, Ashwath M
Heart Fail Rev 2021 Nov;26(6):1287-1296. Epub 2021 Jun 17 doi: 10.1007/s10741-020-10061-x. PMID: 34138401Free PMC Article
Sex differences in heart failure.
Lam CSP, Arnott C, Beale AL, Chandramouli C, Hilfiker-Kleiner D, Kaye DM, Ky B, Santema BT, Sliwa K, Voors AA
Eur Heart J 2019 Dec 14;40(47):3859-3868c. doi: 10.1093/eurheartj/ehz835. PMID: 31800034
Cardiomyopathy and pregnancy.
Schaufelberger M
Heart 2019 Oct;105(20):1543-1551. Epub 2019 Jul 15 doi: 10.1136/heartjnl-2018-313476. PMID: 31308064Free PMC Article
Peripartum cardiomyopathy.
Honigberg MC, Givertz MM
BMJ 2019 Jan 30;364:k5287. doi: 10.1136/bmj.k5287. PMID: 30700415

Clinical prediction guides

Genetic and Phenotypic Landscape of Peripartum Cardiomyopathy.
Goli R, Li J, Brandimarto J, Levine LD, Riis V, McAfee Q, DePalma S, Haghighi A, Seidman JG, Seidman CE, Jacoby D, Macones G, Judge DP, Rana S, Margulies KB, Cappola TP, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Alexis JD, Boehmer J, Kamiya C, Gustafsson F, Damm P, Ersbøll AS, Goland S, Hilfiker-Kleiner D, McNamara DM; IMAC-2 and IPAC Investigators, Arany Z
Circulation 2021 May 11;143(19):1852-1862. Epub 2021 Apr 20 doi: 10.1161/CIRCULATIONAHA.120.052395. PMID: 33874732Free PMC Article
Genetics of Peripartum Cardiomyopathy: Current Knowledge, Future Directions and Clinical Implications.
Spracklen TF, Chakafana G, Schwartz PJ, Kotta MC, Shaboodien G, Ntusi NAB, Sliwa K
Genes (Basel) 2021 Jan 15;12(1) doi: 10.3390/genes12010103. PMID: 33467574Free PMC Article
Cardiomyopathy and pregnancy.
Schaufelberger M
Heart 2019 Oct;105(20):1543-1551. Epub 2019 Jul 15 doi: 10.1136/heartjnl-2018-313476. PMID: 31308064Free PMC Article
Anthracycline and Peripartum Cardiomyopathies.
Cowgill JA, Francis SA, Sawyer DB
Circ Res 2019 May 24;124(11):1633-1646. doi: 10.1161/CIRCRESAHA.119.313577. PMID: 31120822
Cardiomyopathy and Preeclampsia.
Gammill HS, Chettier R, Brewer A, Roberts JM, Shree R, Tsigas E, Ward K
Circulation 2018 Nov 20;138(21):2359-2366. doi: 10.1161/CIRCULATIONAHA.117.031527. PMID: 30021846

Recent systematic reviews

Prolactin Inhibition in Peripartum Cardiomyopathy: Systematic Review and Meta-analysis.
Kumar A, Ravi R, Sivakumar RK, Chidambaram V, Majella MG, Sinha S, Adamo L, Lau ES, Al'Aref SJ, Asnani A, Sharma G, Mehta JL
Curr Probl Cardiol 2023 Feb;48(2):101461. Epub 2022 Oct 17 doi: 10.1016/j.cpcardiol.2022.101461. PMID: 36261102Free PMC Article
Effects of bromocriptine in peripartum cardiomyopathy: a systematic review and meta-analysis.
Trongtorsak A, Kittipibul V, Mahabir S, Ibrahim M, Saint Croix GR, Hernandez GA, Chaparro S
Heart Fail Rev 2022 Mar;27(2):533-543. Epub 2021 Nov 1 doi: 10.1007/s10741-021-10185-8. PMID: 34725781
Peripartum cardiomyopathy: A systematic review of the literature.
Asad ZUA, Maiwand M, Farah F, Dasari TW
Clin Cardiol 2018 May;41(5):693-697. Epub 2018 May 11 doi: 10.1002/clc.22932. PMID: 29749620Free PMC Article
Peripartum cardiomyopathy: a systematic literature review.
Ersbøll AS, Damm P, Gustafsson F, Vejlstrup NG, Johansen M
Acta Obstet Gynecol Scand 2016 Nov;95(11):1205-1219. doi: 10.1111/aogs.13005. PMID: 27545093
The relationship between pre-eclampsia and peripartum cardiomyopathy: a systematic review and meta-analysis.
Bello N, Rendon ISH, Arany Z
J Am Coll Cardiol 2013 Oct 29;62(18):1715-1723. Epub 2013 Sep 4 doi: 10.1016/j.jacc.2013.08.717. PMID: 24013055Free PMC Article

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