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Abnormal aortic valve physiology

MedGen UID:
1637769
•Concept ID:
C4703464
•
Disease or Syndrome
HPO: HP:0031652

Professional guidelines

PubMed

Calcific aortic valve disease: mechanisms, prevention and treatment.
Moncla LM, Briend M, Bossé Y, Mathieu P
Nat Rev Cardiol 2023 Aug;20(8):546-559. Epub 2023 Feb 24 doi: 10.1038/s41569-023-00845-7. PMID: 36829083
Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes.
Bossone E, Eagle KA
Nat Rev Cardiol 2021 May;18(5):331-348. Epub 2020 Dec 22 doi: 10.1038/s41569-020-00472-6. PMID: 33353985
2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC).
Erbel R, Aboyans V, Boileau C, Bossone E, Bartolomeo RD, Eggebrecht H, Evangelista A, Falk V, Frank H, Gaemperli O, Grabenwöger M, Haverich A, Iung B, Manolis AJ, Meijboom F, Nienaber CA, Roffi M, Rousseau H, Sechtem U, Sirnes PA, Allmen RS, Vrints CJ; ESC Committee for Practice Guidelines
Eur Heart J 2014 Nov 1;35(41):2873-926. Epub 2014 Aug 29 doi: 10.1093/eurheartj/ehu281. PMID: 25173340

Recent clinical studies

Etiology

Bicuspid aortic valve and its ascending aortopathy.
Dunne EC, Lacro RV, Flyer JN
Curr Opin Pediatr 2023 Oct 1;35(5):538-545. Epub 2023 Jul 26 doi: 10.1097/MOP.0000000000001276. PMID: 37497761
Genetics in bicuspid aortic valve disease: Where are we?
Bravo-Jaimes K, Prakash SK
Prog Cardiovasc Dis 2020 Jul-Aug;63(4):398-406. Epub 2020 Jun 27 doi: 10.1016/j.pcad.2020.06.005. PMID: 32599026Free PMC Article
Polyamines and microbiota in bicuspid and tricuspid aortic valve aortopathy.
Forte A, Balistreri CR, De Feo M, Della Corte A, Hellstrand P, Persson L, Nilsson BO
J Mol Cell Cardiol 2019 Apr;129:179-187. Epub 2019 Feb 28 doi: 10.1016/j.yjmcc.2019.02.014. PMID: 30825483
Clinical and pathophysiological aspects of bicuspid aortic valve disease.
Pedersen MW, Groth KA, Mortensen KH, Brodersen J, Gravholt CH, Andersen NH
Cardiol Young 2019 Jan;29(1):1-10. Epub 2018 Oct 30 doi: 10.1017/S1047951118001658. PMID: 30375310
Acute aortic dissection: pathogenesis, risk factors and diagnosis.
Gawinecka J, Schönrath F, von Eckardstein A
Swiss Med Wkly 2017;147:w14489. Epub 2017 Aug 25 doi: 10.4414/smw.2017.14489. PMID: 28871571

Diagnosis

Bicuspid aortic valve and its ascending aortopathy.
Dunne EC, Lacro RV, Flyer JN
Curr Opin Pediatr 2023 Oct 1;35(5):538-545. Epub 2023 Jul 26 doi: 10.1097/MOP.0000000000001276. PMID: 37497761
Genetics in bicuspid aortic valve disease: Where are we?
Bravo-Jaimes K, Prakash SK
Prog Cardiovasc Dis 2020 Jul-Aug;63(4):398-406. Epub 2020 Jun 27 doi: 10.1016/j.pcad.2020.06.005. PMID: 32599026Free PMC Article
Acute aortic dissection: pathogenesis, risk factors and diagnosis.
Gawinecka J, Schönrath F, von Eckardstein A
Swiss Med Wkly 2017;147:w14489. Epub 2017 Aug 25 doi: 10.4414/smw.2017.14489. PMID: 28871571
Reexamining remodeling.
Schäfers HJ, Raddatz A, Schmied W, Takahashi H, Miura Y, Kunihara T, Aicher D
J Thorac Cardiovasc Surg 2015 Feb;149(2 Suppl):S30-6. Epub 2014 Sep 18 doi: 10.1016/j.jtcvs.2014.09.048. PMID: 25439784
What is aortic overriding?
Anderson RH, Spicer DE, Henry GW, Rigsby C, Hlavacek AM, Mohun TJ
Cardiol Young 2015 Apr;25(4):612-25. Epub 2014 Jul 1 doi: 10.1017/S1047951114001139. PMID: 24983250

Therapy

Aortic Valve Bioprostheses: Leaflet Immobility and Valve Thrombosis.
Holmes DR, Mack MJ
Circulation 2017 May 2;135(18):1749-1756. doi: 10.1161/CIRCULATIONAHA.116.025429. PMID: 28461416
Calcific aortic stenosis.
Lindman BR, Clavel MA, Mathieu P, Iung B, Lancellotti P, Otto CM, Pibarot P
Nat Rev Dis Primers 2016 Mar 3;2:16006. doi: 10.1038/nrdp.2016.6. PMID: 27188578Free PMC Article
Reexamining remodeling.
Schäfers HJ, Raddatz A, Schmied W, Takahashi H, Miura Y, Kunihara T, Aicher D
J Thorac Cardiovasc Surg 2015 Feb;149(2 Suppl):S30-6. Epub 2014 Sep 18 doi: 10.1016/j.jtcvs.2014.09.048. PMID: 25439784
2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC).
Erbel R, Aboyans V, Boileau C, Bossone E, Bartolomeo RD, Eggebrecht H, Evangelista A, Falk V, Frank H, Gaemperli O, Grabenwöger M, Haverich A, Iung B, Manolis AJ, Meijboom F, Nienaber CA, Roffi M, Rousseau H, Sechtem U, Sirnes PA, Allmen RS, Vrints CJ; ESC Committee for Practice Guidelines
Eur Heart J 2014 Nov 1;35(41):2873-926. Epub 2014 Aug 29 doi: 10.1093/eurheartj/ehu281. PMID: 25173340
Turner syndrome: diagnosis and management.
Morgan T
Am Fam Physician 2007 Aug 1;76(3):405-10. PMID: 17708142

Prognosis

Circulating microRNAs vs. aortic diameter in bicuspid aortic valve aortopathy.
Naito S, Petersen J, Sequeira-Gross T, Zeller T, Reichenspurner H, Girdauskas E
Asian Cardiovasc Thorac Ann 2022 Oct;30(8):947-953. Epub 2020 Jun 4 doi: 10.1177/0218492320927233. PMID: 32498553
The science of BAV aortopathy.
Lo Presti F, Guzzardi DG, Bancone C, Fedak PWM, Della Corte A
Prog Cardiovasc Dis 2020 Jul-Aug;63(4):465-474. Epub 2020 Jun 26 doi: 10.1016/j.pcad.2020.06.009. PMID: 32599028
Diagnosis of major heart defects by routine first-trimester ultrasound examination: association with increased nuchal translucency, tricuspid regurgitation and abnormal flow in ductus venosus.
Minnella GP, Crupano FM, Syngelaki A, Zidere V, Akolekar R, Nicolaides KH
Ultrasound Obstet Gynecol 2020 May;55(5):637-644. doi: 10.1002/uog.21956. PMID: 31875326
Aortic Valve Bioprostheses: Leaflet Immobility and Valve Thrombosis.
Holmes DR, Mack MJ
Circulation 2017 May 2;135(18):1749-1756. doi: 10.1161/CIRCULATIONAHA.116.025429. PMID: 28461416
Reexamining remodeling.
Schäfers HJ, Raddatz A, Schmied W, Takahashi H, Miura Y, Kunihara T, Aicher D
J Thorac Cardiovasc Surg 2015 Feb;149(2 Suppl):S30-6. Epub 2014 Sep 18 doi: 10.1016/j.jtcvs.2014.09.048. PMID: 25439784

Clinical prediction guides

Circulating microRNAs vs. aortic diameter in bicuspid aortic valve aortopathy.
Naito S, Petersen J, Sequeira-Gross T, Zeller T, Reichenspurner H, Girdauskas E
Asian Cardiovasc Thorac Ann 2022 Oct;30(8):947-953. Epub 2020 Jun 4 doi: 10.1177/0218492320927233. PMID: 32498553
Diagnosis of major heart defects by routine first-trimester ultrasound examination: association with increased nuchal translucency, tricuspid regurgitation and abnormal flow in ductus venosus.
Minnella GP, Crupano FM, Syngelaki A, Zidere V, Akolekar R, Nicolaides KH
Ultrasound Obstet Gynecol 2020 May;55(5):637-644. doi: 10.1002/uog.21956. PMID: 31875326
MicroRNAs fingerprint of bicuspid aortic valve.
Sabatino J, Wicik Z, De Rosa S, Eyileten C, Jakubik D, Spaccarotella C, Mongiardo A, Postula M, Indolfi C
J Mol Cell Cardiol 2019 Sep;134:98-106. Epub 2019 Jul 3 doi: 10.1016/j.yjmcc.2019.07.001. PMID: 31278905
Aortic Valve Bioprostheses: Leaflet Immobility and Valve Thrombosis.
Holmes DR, Mack MJ
Circulation 2017 May 2;135(18):1749-1756. doi: 10.1161/CIRCULATIONAHA.116.025429. PMID: 28461416
Reexamining remodeling.
Schäfers HJ, Raddatz A, Schmied W, Takahashi H, Miura Y, Kunihara T, Aicher D
J Thorac Cardiovasc Surg 2015 Feb;149(2 Suppl):S30-6. Epub 2014 Sep 18 doi: 10.1016/j.jtcvs.2014.09.048. PMID: 25439784

Recent systematic reviews

Family screening for bicuspid aortic valve and aortic dilatation: a meta-analysis.
Bray JJH, Freer R, Pitcher A, Kharbanda R
Eur Heart J 2023 Sep 1;44(33):3152-3164. doi: 10.1093/eurheartj/ehad320. PMID: 37288540Free PMC Article
Clinical features and complications of Loeys-Dietz syndrome: A systematic review.
Gouda P, Kay R, Habib M, Aziz A, Aziza E, Welsh R
Int J Cardiol 2022 Sep 1;362:158-167. Epub 2022 Jun 1 doi: 10.1016/j.ijcard.2022.05.065. PMID: 35662564
The freestyle aortic bioprosthesis: a systematic review.
Sherrah AG, Edelman JJ, Thomas SR, Brady PW, Wilson MK, Jeremy RW, Bannon PG, Vallely MP
Heart Lung Circ 2014 Dec;23(12):1110-7. Epub 2014 Jun 25 doi: 10.1016/j.hlc.2014.04.262. PMID: 25047283
Echocardiographic aortic root dilatation in hypertensive patients: a systematic review and meta-analysis.
Covella M, Milan A, Totaro S, Cuspidi C, Re A, Rabbia F, Veglio F
J Hypertens 2014 Oct;32(10):1928-35; discussion 1935. doi: 10.1097/HJH.0000000000000286. PMID: 24979304
Bicuspid aortic valve aortopathy: genetics, pathophysiology and medical therapy.
Abdulkareem N, Smelt J, Jahangiri M
Interact Cardiovasc Thorac Surg 2013 Sep;17(3):554-9. Epub 2013 May 31 doi: 10.1093/icvts/ivt196. PMID: 23728086Free PMC Article

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