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Moderate hypermetropia

MedGen UID:
1637815
Concept ID:
C4703504
Disease or Syndrome
Synonym: Moderate hyperopia
 
HPO: HP:0031729

Definition

A form of hypermetropia with more than +2.00 diopters but not more than +5.00 diopters. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerate hypermetropia

Conditions with this feature

Hermansky-Pudlak syndrome 8
MedGen UID:
854728
Concept ID:
C3888026
Disease or Syndrome
Hermansky-Pudlak syndrome (HPS) is characterized by oculocutaneous albinism, a bleeding diathesis, and, in some individuals, pulmonary fibrosis, granulomatous colitis, or immunodeficiency. Ocular findings include reduced iris pigment with iris transillumination, reduced retinal pigment, foveal hypoplasia with significant reduction in visual acuity (usually in the range of 20/50 to 20/400), nystagmus, and increased crossing of the optic nerve fibers. Hair color ranges from white to brown; skin color ranges from white to olive and is usually a shade lighter than that of other family members. The bleeding diathesis can result in variable bruising, epistaxis, gingival bleeding, postpartum hemorrhage, colonic bleeding, and prolonged bleeding with menses or after tooth extraction, circumcision, and other surgeries. Pulmonary fibrosis, a restrictive lung disease, typically causes symptoms in the early thirties and can progress to death within a decade. Granulomatous colitis is severe in about 15% of affected individuals. Neutropenia and/or immune defects occur primarily in individuals with pathogenic variants in AP3B1 and AP3D1.

Professional guidelines

PubMed

Alió Del Barrio JL, Milán-Castillo R, Canto-Cerdan M, Molina-Lespron A, Alió JL
J Cataract Refract Surg 2023 Jun 1;49(6):558-564. doi: 10.1097/j.jcrs.0000000000001153. PMID: 36745850
Zhang Y, Huang L, Cao C, Li Y
Eye Sci 2012 Jun;27(2):85-8. doi: 10.3969/j.issn.1000-4432.2012.02.007. PMID: 22678871
Williams WR, Latif AH, Hannington L, Watkins DR
Arch Dis Child 2005 Feb;90(2):150-3. doi: 10.1136/adc.2003.046755. PMID: 15665167Free PMC Article

Recent clinical studies

Etiology

Tsao WS, Hsieh HP, Chuang YT, Sheu MM
J Formos Med Assoc 2017 May;116(5):345-350. Epub 2016 Oct 11 doi: 10.1016/j.jfma.2016.06.013. PMID: 27742159
Birch EE, Stager DR Sr, Wang J, O'Connor A
Eye (Lond) 2010 Dec;24(12):1814-21. Epub 2010 Oct 8 doi: 10.1038/eye.2010.129. PMID: 20930854Free PMC Article
Snir M, Friling R, Weinberger D, Sherf I, Axer-Siegel R
Br J Ophthalmol 2004 Jul;88(7):900-4. doi: 10.1136/bjo.2003.037499. PMID: 15205234Free PMC Article

Diagnosis

Sturm V, Menke MN, Töteberg M, Jaggi GP, Schoeffler C
Klin Monbl Augenheilkd 2012 Apr;229(4):357-61. Epub 2012 Apr 11 doi: 10.1055/s-0031-1299237. PMID: 22496003
Campos EC
J AAPOS 2008 Aug;12(4):326-31. Epub 2008 Jun 11 doi: 10.1016/j.jaapos.2008.03.013. PMID: 18550403
Gutteridge IF
Am J Optom Physiol Opt 1981 Aug;58(8):671-6. PMID: 6169281

Therapy

Gutteridge IF
Am J Optom Physiol Opt 1981 Aug;58(8):671-6. PMID: 6169281

Prognosis

Birch EE, Stager DR Sr, Wang J, O'Connor A
Eye (Lond) 2010 Dec;24(12):1814-21. Epub 2010 Oct 8 doi: 10.1038/eye.2010.129. PMID: 20930854Free PMC Article
Campos EC
J AAPOS 2008 Aug;12(4):326-31. Epub 2008 Jun 11 doi: 10.1016/j.jaapos.2008.03.013. PMID: 18550403

Clinical prediction guides

Sturm V, Menke MN, Töteberg M, Jaggi GP, Schoeffler C
Klin Monbl Augenheilkd 2012 Apr;229(4):357-61. Epub 2012 Apr 11 doi: 10.1055/s-0031-1299237. PMID: 22496003
Birch EE, Stager DR Sr, Wang J, O'Connor A
Eye (Lond) 2010 Dec;24(12):1814-21. Epub 2010 Oct 8 doi: 10.1038/eye.2010.129. PMID: 20930854Free PMC Article

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