U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Acute myeloid leukemia and myelodysplastic syndromes related to radiation

MedGen UID:
1637827
Concept ID:
C4707660
Neoplastic Process
Synonyms: Acute myeloid leukemia and myelodysplastic syndrome related to radiation; acute myeloid leukemia and myelodysplastic syndromes related to radiation; AML and myelodysplastic syndromes related to radiation
SNOMED CT: Acute myeloid leukemia and myelodysplastic syndrome related to radiation (766048008)
 
Monarch Initiative: MONDO:0015608
Orphanet: ORPHA164726

Definition

A subgroup of therapy-related myeloid neoplasms (t-MN), associated with treatment of an unrelated neoplastic disease with radiation. The neoplastic cells typically harbor unbalanced aberrations of chromosomes 5 and 7 (monosomy 5/del(5q) and monosomy 7/del(7q)) or a complex karyotype. Patients frequently present with multilineage dysplasia and cytopenias 5-10 years after exposure. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute myeloid leukemia and myelodysplastic syndromes related to radiation

Professional guidelines

PubMed

Moreno Berggren D, Garelius H, Willner Hjelm P, Nilsson L, Rasmussen B, Weibull CE, Lambe M, Lehmann S, Hellström-Lindberg E, Jädersten M, Ejerblad E
Leukemia 2023 May;37(5):1103-1112. Epub 2023 Mar 17 doi: 10.1038/s41375-023-01864-6. PMID: 36928008Free PMC Article
Armitage JO, Carbone PP, Connors JM, Levine A, Bennett JM, Kroll S
J Clin Oncol 2003 Mar 1;21(5):897-906. doi: 10.1200/JCO.2003.07.113. PMID: 12610191
van Leeuwen FE
Baillieres Clin Haematol 1996 Mar;9(1):57-85. doi: 10.1016/s0950-3536(96)80037-0. PMID: 8730551

Recent clinical studies

Etiology

Morton LM, Dores GM, Schonfeld SJ, Linet MS, Sigel BS, Lam CJK, Tucker MA, Curtis RE
JAMA Oncol 2019 Mar 1;5(3):318-325. doi: 10.1001/jamaoncol.2018.5625. PMID: 30570657Free PMC Article
Mehta PA, Davies SM, Leemhuis T, Myers K, Kernan NA, Prockop SE, Scaradavou A, O'Reilly RJ, Williams DA, Lehmann L, Guinan E, Margolis D, Baker KS, Lane A, Boulad F
Blood 2017 Apr 20;129(16):2308-2315. Epub 2017 Feb 8 doi: 10.1182/blood-2016-09-743112. PMID: 28179273Free PMC Article
Candelaria M, Dueñas-Gonzalez A
Expert Opin Drug Saf 2015 May;14(5):655-65. Epub 2015 Feb 12 doi: 10.1517/14740338.2015.1014340. PMID: 25675961
Leone G, Mele L, Pulsoni A, Equitani F, Pagano L
Haematologica 1999 Oct;84(10):937-45. PMID: 10509043
van Leeuwen FE
Baillieres Clin Haematol 1996 Mar;9(1):57-85. doi: 10.1016/s0950-3536(96)80037-0. PMID: 8730551

Diagnosis

Morton LM, Dores GM, Schonfeld SJ, Linet MS, Sigel BS, Lam CJK, Tucker MA, Curtis RE
JAMA Oncol 2019 Mar 1;5(3):318-325. doi: 10.1001/jamaoncol.2018.5625. PMID: 30570657Free PMC Article
Davidsson J, Puschmann A, Tedgård U, Bryder D, Nilsson L, Cammenga J
Leukemia 2018 May;32(5):1106-1115. Epub 2018 Feb 25 doi: 10.1038/s41375-018-0074-4. PMID: 29535429Free PMC Article
Jhanwar SC
Adv Biol Regul 2015 May;58:28-37. Epub 2014 Nov 20 doi: 10.1016/j.jbior.2014.11.002. PMID: 25499150
Niemeyer CM, Baumann I
Semin Hematol 2008 Jan;45(1):60-70. doi: 10.1053/j.seminhematol.2007.10.006. PMID: 18179970
Merlat A, Lai JL, Sterkers Y, Demory JL, Bauters F, Preudhomme C, Fenaux P
Leukemia 1999 Feb;13(2):250-7. doi: 10.1038/sj.leu.2401298. PMID: 10025899

Therapy

Morton LM, Dores GM, Schonfeld SJ, Linet MS, Sigel BS, Lam CJK, Tucker MA, Curtis RE
JAMA Oncol 2019 Mar 1;5(3):318-325. doi: 10.1001/jamaoncol.2018.5625. PMID: 30570657Free PMC Article
Mehta PA, Davies SM, Leemhuis T, Myers K, Kernan NA, Prockop SE, Scaradavou A, O'Reilly RJ, Williams DA, Lehmann L, Guinan E, Margolis D, Baker KS, Lane A, Boulad F
Blood 2017 Apr 20;129(16):2308-2315. Epub 2017 Feb 8 doi: 10.1182/blood-2016-09-743112. PMID: 28179273Free PMC Article
Visani G, Pagano L, Pulsoni A, Tosi P, Piccaluga PP, Pastano R, Grafone T, Malagola M, Isidori A, Tura S
Leuk Lymphoma 2000 May;37(5-6):543-9. doi: 10.3109/10428190009058506. PMID: 11042514
Merlat A, Lai JL, Sterkers Y, Demory JL, Bauters F, Preudhomme C, Fenaux P
Leukemia 1999 Feb;13(2):250-7. doi: 10.1038/sj.leu.2401298. PMID: 10025899
van Leeuwen FE
Baillieres Clin Haematol 1996 Mar;9(1):57-85. doi: 10.1016/s0950-3536(96)80037-0. PMID: 8730551

Prognosis

McNerney ME, Godley LA, Le Beau MM
Nat Rev Cancer 2017 Aug 24;17(9):513-527. doi: 10.1038/nrc.2017.60. PMID: 28835720Free PMC Article
Candelaria M, Dueñas-Gonzalez A
Expert Opin Drug Saf 2015 May;14(5):655-65. Epub 2015 Feb 12 doi: 10.1517/14740338.2015.1014340. PMID: 25675961
Descatha A, Jenabian A, Conso F, Ameille J
Cancer Causes Control 2005 Oct;16(8):939-53. doi: 10.1007/s10552-005-2301-3. PMID: 16132803
Visani G, Pagano L, Pulsoni A, Tosi P, Piccaluga PP, Pastano R, Grafone T, Malagola M, Isidori A, Tura S
Leuk Lymphoma 2000 May;37(5-6):543-9. doi: 10.3109/10428190009058506. PMID: 11042514
Leone G, Mele L, Pulsoni A, Equitani F, Pagano L
Haematologica 1999 Oct;84(10):937-45. PMID: 10509043

Clinical prediction guides

Vo P, Gooley TA, Rajendran JG, Fisher DR, Orozco JJ, Green DJ, Gopal AK, Haaf R, Nartea M, Storb R, Appelbaum FR, Press OW, Pagel JM, Sandmaier BM
Haematologica 2020 Jun;105(6):1731-1737. Epub 2019 Oct 3 doi: 10.3324/haematol.2019.229492. PMID: 31582553Free PMC Article
Bhatia S
Semin Oncol 2013 Dec;40(6):666-75. doi: 10.1053/j.seminoncol.2013.09.013. PMID: 24331189Free PMC Article
Sill H, Olipitz W, Zebisch A, Schulz E, Wölfler A
Br J Pharmacol 2011 Feb;162(4):792-805. doi: 10.1111/j.1476-5381.2010.01100.x. PMID: 21039422Free PMC Article
Merlat A, Lai JL, Sterkers Y, Demory JL, Bauters F, Preudhomme C, Fenaux P
Leukemia 1999 Feb;13(2):250-7. doi: 10.1038/sj.leu.2401298. PMID: 10025899
van Leeuwen FE
Baillieres Clin Haematol 1996 Mar;9(1):57-85. doi: 10.1016/s0950-3536(96)80037-0. PMID: 8730551

Recent systematic reviews

Eichenauer DA, Becker I, Monsef I, Chadwick N, de Sanctis V, Federico M, Fortpied C, Gianni AM, Henry-Amar M, Hoskin P, Johnson P, Luminari S, Bellei M, Pulsoni A, Sydes MR, Valagussa P, Viviani S, Engert A, Franklin J
Haematologica 2017 Oct;102(10):1748-1757. Epub 2017 Sep 14 doi: 10.3324/haematol.2017.167478. PMID: 28912173Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...