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Grade 2 Pulmonary Fibrosis, CTCAE

MedGen UID:
1638087
•Concept ID:
C4685899
•
Finding

Definition

Evidence of pulmonary hypertension; radiographic pulmonary fibrosis 25-50% associated with hypoxia [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 2 Pulmonary Fibrosis, CTCAE

Professional guidelines

PubMed

Management, risk factors and prognostic impact of checkpoint-inhibitor pneumonitis (CIP) in lung cancer - A multicenter observational analysis.
Frost N, Unger K, Blum TG, Misch D, Kurz S, Lüders H, Olive E, Raspe M, Hilbrandt M, Koch M, Böhmer D, Senger C, Witzenrath M, Grohé C, Bauer T, Modest DP, Kollmeier J
Lung Cancer 2023 May;179:107184. Epub 2023 Mar 31 doi: 10.1016/j.lungcan.2023.107184. PMID: 37040677
Early CT findings of tomotherapy-induced radiation pneumonitis after treatment of lung malignancy.
Park HJ, Kim KJ, Park SH, Kay CS, Oh JS
AJR Am J Roentgenol 2009 Sep;193(3):W209-13. doi: 10.2214/AJR.08.2298. PMID: 19696261

Recent clinical studies

Etiology

Management, risk factors and prognostic impact of checkpoint-inhibitor pneumonitis (CIP) in lung cancer - A multicenter observational analysis.
Frost N, Unger K, Blum TG, Misch D, Kurz S, Lüders H, Olive E, Raspe M, Hilbrandt M, Koch M, Böhmer D, Senger C, Witzenrath M, Grohé C, Bauer T, Modest DP, Kollmeier J
Lung Cancer 2023 May;179:107184. Epub 2023 Mar 31 doi: 10.1016/j.lungcan.2023.107184. PMID: 37040677
Weight loss in nintedanib-treated patients with idiopathic pulmonary fibrosis.
Tomioka H, Iwabayashi M, Yokota M, Hashimoto R, Amimoto H
Pulm Pharmacol Ther 2023 Jun;80:102213. Epub 2023 Mar 29 doi: 10.1016/j.pupt.2023.102213. PMID: 37001796
Abnormal pulmonary function tests predict the development of radiation-induced pneumonitis in advanced non-small cell lung Cancer.
Torre-Bouscoulet L, Muñoz-Montaño WR, Martínez-Briseño D, Lozano-Ruiz FJ, Fernández-Plata R, Beck-Magaña JA, García-Sancho C, Guzmán-Barragán A, Vergara E, Blake-Cerda M, Gochicoa-Rangel L, Maldonado F, Arroyo-Hernández M, Arrieta O
Respir Res 2018 Apr 24;19(1):72. doi: 10.1186/s12931-018-0775-2. PMID: 29690880Free PMC Article
Low body surface area predicts hepatotoxicity of nintedanib in patients with idiopathic pulmonary fibrosis.
Ikeda S, Sekine A, Baba T, Yamanaka Y, Sadoyama S, Yamakawa H, Oda T, Okuda R, Kitamura H, Okudela K, Iwasawa T, Ohashi K, Takemura T, Ogura T
Sci Rep 2017 Sep 7;7(1):10811. doi: 10.1038/s41598-017-11321-x. PMID: 28883482Free PMC Article
Chemotherapy with BCNU in recurrent glioma: Analysis of clinical outcome and side effects in chemotherapy-naïve patients.
Jungk C, Chatziaslanidou D, Ahmadi R, Capper D, Bermejo JL, Exner J, von Deimling A, Herold-Mende C, Unterberg A
BMC Cancer 2016 Feb 10;16:81. doi: 10.1186/s12885-016-2131-6. PMID: 26865253Free PMC Article

Diagnosis

Abnormal pulmonary function tests predict the development of radiation-induced pneumonitis in advanced non-small cell lung Cancer.
Torre-Bouscoulet L, Muñoz-Montaño WR, Martínez-Briseño D, Lozano-Ruiz FJ, Fernández-Plata R, Beck-Magaña JA, García-Sancho C, Guzmán-Barragán A, Vergara E, Blake-Cerda M, Gochicoa-Rangel L, Maldonado F, Arroyo-Hernández M, Arrieta O
Respir Res 2018 Apr 24;19(1):72. doi: 10.1186/s12931-018-0775-2. PMID: 29690880Free PMC Article
Early CT findings of tomotherapy-induced radiation pneumonitis after treatment of lung malignancy.
Park HJ, Kim KJ, Park SH, Kay CS, Oh JS
AJR Am J Roentgenol 2009 Sep;193(3):W209-13. doi: 10.2214/AJR.08.2298. PMID: 19696261

Therapy

Low body surface area predicts hepatotoxicity of nintedanib in patients with idiopathic pulmonary fibrosis.
Ikeda S, Sekine A, Baba T, Yamanaka Y, Sadoyama S, Yamakawa H, Oda T, Okuda R, Kitamura H, Okudela K, Iwasawa T, Ohashi K, Takemura T, Ogura T
Sci Rep 2017 Sep 7;7(1):10811. doi: 10.1038/s41598-017-11321-x. PMID: 28883482Free PMC Article
Chemotherapy with BCNU in recurrent glioma: Analysis of clinical outcome and side effects in chemotherapy-naïve patients.
Jungk C, Chatziaslanidou D, Ahmadi R, Capper D, Bermejo JL, Exner J, von Deimling A, Herold-Mende C, Unterberg A
BMC Cancer 2016 Feb 10;16:81. doi: 10.1186/s12885-016-2131-6. PMID: 26865253Free PMC Article

Prognosis

Management, risk factors and prognostic impact of checkpoint-inhibitor pneumonitis (CIP) in lung cancer - A multicenter observational analysis.
Frost N, Unger K, Blum TG, Misch D, Kurz S, Lüders H, Olive E, Raspe M, Hilbrandt M, Koch M, Böhmer D, Senger C, Witzenrath M, Grohé C, Bauer T, Modest DP, Kollmeier J
Lung Cancer 2023 May;179:107184. Epub 2023 Mar 31 doi: 10.1016/j.lungcan.2023.107184. PMID: 37040677
Weight loss in nintedanib-treated patients with idiopathic pulmonary fibrosis.
Tomioka H, Iwabayashi M, Yokota M, Hashimoto R, Amimoto H
Pulm Pharmacol Ther 2023 Jun;80:102213. Epub 2023 Mar 29 doi: 10.1016/j.pupt.2023.102213. PMID: 37001796
Abnormal pulmonary function tests predict the development of radiation-induced pneumonitis in advanced non-small cell lung Cancer.
Torre-Bouscoulet L, Muñoz-Montaño WR, Martínez-Briseño D, Lozano-Ruiz FJ, Fernández-Plata R, Beck-Magaña JA, García-Sancho C, Guzmán-Barragán A, Vergara E, Blake-Cerda M, Gochicoa-Rangel L, Maldonado F, Arroyo-Hernández M, Arrieta O
Respir Res 2018 Apr 24;19(1):72. doi: 10.1186/s12931-018-0775-2. PMID: 29690880Free PMC Article
Low body surface area predicts hepatotoxicity of nintedanib in patients with idiopathic pulmonary fibrosis.
Ikeda S, Sekine A, Baba T, Yamanaka Y, Sadoyama S, Yamakawa H, Oda T, Okuda R, Kitamura H, Okudela K, Iwasawa T, Ohashi K, Takemura T, Ogura T
Sci Rep 2017 Sep 7;7(1):10811. doi: 10.1038/s41598-017-11321-x. PMID: 28883482Free PMC Article
Chemotherapy with BCNU in recurrent glioma: Analysis of clinical outcome and side effects in chemotherapy-naïve patients.
Jungk C, Chatziaslanidou D, Ahmadi R, Capper D, Bermejo JL, Exner J, von Deimling A, Herold-Mende C, Unterberg A
BMC Cancer 2016 Feb 10;16:81. doi: 10.1186/s12885-016-2131-6. PMID: 26865253Free PMC Article

Clinical prediction guides

Management, risk factors and prognostic impact of checkpoint-inhibitor pneumonitis (CIP) in lung cancer - A multicenter observational analysis.
Frost N, Unger K, Blum TG, Misch D, Kurz S, Lüders H, Olive E, Raspe M, Hilbrandt M, Koch M, Böhmer D, Senger C, Witzenrath M, Grohé C, Bauer T, Modest DP, Kollmeier J
Lung Cancer 2023 May;179:107184. Epub 2023 Mar 31 doi: 10.1016/j.lungcan.2023.107184. PMID: 37040677
Weight loss in nintedanib-treated patients with idiopathic pulmonary fibrosis.
Tomioka H, Iwabayashi M, Yokota M, Hashimoto R, Amimoto H
Pulm Pharmacol Ther 2023 Jun;80:102213. Epub 2023 Mar 29 doi: 10.1016/j.pupt.2023.102213. PMID: 37001796
Abnormal pulmonary function tests predict the development of radiation-induced pneumonitis in advanced non-small cell lung Cancer.
Torre-Bouscoulet L, Muñoz-Montaño WR, Martínez-Briseño D, Lozano-Ruiz FJ, Fernández-Plata R, Beck-Magaña JA, García-Sancho C, Guzmán-Barragán A, Vergara E, Blake-Cerda M, Gochicoa-Rangel L, Maldonado F, Arroyo-Hernández M, Arrieta O
Respir Res 2018 Apr 24;19(1):72. doi: 10.1186/s12931-018-0775-2. PMID: 29690880Free PMC Article
Low body surface area predicts hepatotoxicity of nintedanib in patients with idiopathic pulmonary fibrosis.
Ikeda S, Sekine A, Baba T, Yamanaka Y, Sadoyama S, Yamakawa H, Oda T, Okuda R, Kitamura H, Okudela K, Iwasawa T, Ohashi K, Takemura T, Ogura T
Sci Rep 2017 Sep 7;7(1):10811. doi: 10.1038/s41598-017-11321-x. PMID: 28883482Free PMC Article
Chemotherapy with BCNU in recurrent glioma: Analysis of clinical outcome and side effects in chemotherapy-naïve patients.
Jungk C, Chatziaslanidou D, Ahmadi R, Capper D, Bermejo JL, Exner J, von Deimling A, Herold-Mende C, Unterberg A
BMC Cancer 2016 Feb 10;16:81. doi: 10.1186/s12885-016-2131-6. PMID: 26865253Free PMC Article

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