U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Plasma Cell Myeloma by RISS Stage

MedGen UID:
1638206
•Concept ID:
C4683782
•
Neoplastic Process
Synonym: Plasma Cell Myeloma by Revised International Staging System Stage

Definition

A staging system for plasma cell myeloma based on the Revised International Staging System (RISS) criteria. This staging system does not apply to smoldering multiple myeloma (no AJCC staging system), monoclonal gammopathy of undetermined significance (no AJCC staging system), and Waldenstrom macroglobulinemia (no AJCC staging system). (from AJCC 8th Ed.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlasma Cell Myeloma by RISS Stage

Professional guidelines

PubMed

Comparison of clinical characteristics, treatment efficacy and survival in patients with newly diagnosed multiple myeloma with single- versus multi-site extramedullary invasion.
Zhao Y, Zhou F
J Cancer Res Clin Oncol 2023 Mar;149(3):995-1006. Epub 2022 Feb 25 doi: 10.1007/s00432-022-03948-9. PMID: 35212816
Pomalidomide Treatment in Relapsed/Refractory Multiple Myeloma Patients-Real-World Data From Hungary.
Lovas S, Obajed Al-Ali N, Varga G, Szita V, Alizadeh H, Plander M, Rajnics P, Illés Á, Szemlaky Z, Mikala G, Váróczy L
Pathol Oncol Res 2022;28:1610645. Epub 2022 Oct 3 doi: 10.3389/pore.2022.1610645. PMID: 36262875Free PMC Article
Diagnosis and treatment of multiple myeloma in Hunan Province.
Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article

Recent clinical studies

Etiology

The progress in multiple myeloma.
Hatjiharissi P
Hell J Nucl Med 2023 May-Aug;26 Suppl:30-35. PMID: 37658559
High-risk disease in newly diagnosed multiple myeloma: beyond the R-ISS and IMWG definitions.
Hagen P, Zhang J, Barton K
Blood Cancer J 2022 May 30;12(5):83. doi: 10.1038/s41408-022-00679-5. PMID: 35637223Free PMC Article
Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Risk Stratification in Multiple Myeloma.
Ooi MG, de Mel S, Chng WJ
Curr Hematol Malig Rep 2016 Apr;11(2):137-47. doi: 10.1007/s11899-016-0307-4. PMID: 26883334
Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P
J Clin Oncol 2015 Sep 10;33(26):2863-9. Epub 2015 Aug 3 doi: 10.1200/JCO.2015.61.2267. PMID: 26240224Free PMC Article

Diagnosis

The progress in multiple myeloma.
Hatjiharissi P
Hell J Nucl Med 2023 May-Aug;26 Suppl:30-35. PMID: 37658559
High-risk disease in newly diagnosed multiple myeloma: beyond the R-ISS and IMWG definitions.
Hagen P, Zhang J, Barton K
Blood Cancer J 2022 May 30;12(5):83. doi: 10.1038/s41408-022-00679-5. PMID: 35637223Free PMC Article
Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Risk Stratification in Multiple Myeloma.
Ooi MG, de Mel S, Chng WJ
Curr Hematol Malig Rep 2016 Apr;11(2):137-47. doi: 10.1007/s11899-016-0307-4. PMID: 26883334
Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P
J Clin Oncol 2015 Sep 10;33(26):2863-9. Epub 2015 Aug 3 doi: 10.1200/JCO.2015.61.2267. PMID: 26240224Free PMC Article

Therapy

Real-life experiences with CAR T-cell therapy with idecabtagene vicleucel (ide-cel) for triple-class exposed relapsed/refractory multiple myeloma patients.
Sanoyan DA, Seipel K, Bacher U, Kronig MN, Porret N, Wiedemann G, Daskalakis M, Pabst T
BMC Cancer 2023 Apr 15;23(1):345. doi: 10.1186/s12885-023-10824-3. PMID: 37061680Free PMC Article
Isatuximab Plus Carfilzomib and Dexamethasone Versus Carfilzomib and Dexamethasone in Patients with Relapsed Multiple Myeloma: IKEMA Subgroup Analysis by Prior Transplantation.
Martin TG, Capra M, Mohty M, Suzuki K, Quach H, Cavo M, Moreau P, Dimopoulos M, Yong K, Tekle C, Foster MC, Barnes Y, Risse ML, Mikhael J
Transplant Cell Ther 2023 Feb;29(2):134.e1-134.e7. Epub 2022 Nov 11 doi: 10.1016/j.jtct.2022.11.005. PMID: 36372355
Pomalidomide Treatment in Relapsed/Refractory Multiple Myeloma Patients-Real-World Data From Hungary.
Lovas S, Obajed Al-Ali N, Varga G, Szita V, Alizadeh H, Plander M, Rajnics P, Illés Á, Szemlaky Z, Mikala G, Váróczy L
Pathol Oncol Res 2022;28:1610645. Epub 2022 Oct 3 doi: 10.3389/pore.2022.1610645. PMID: 36262875Free PMC Article
Current Approach to Managing Patients with Newly Diagnosed High-Risk Multiple Myeloma.
Marneni N, Chakraborty R
Curr Hematol Malig Rep 2021 Apr;16(2):148-161. Epub 2021 Apr 19 doi: 10.1007/s11899-021-00631-7. PMID: 33876390
Metaphase cytogenetics and plasma cell proliferation index for risk stratification in newly diagnosed multiple myeloma.
Mellors PW, Binder M, Ketterling RP, Greipp PT, Baughn LB, Peterson JF, Jevremovic D, Pearce KE, Buadi FK, Lacy MQ, Gertz MA, Dispenzieri A, Hayman SR, Kapoor P, Gonsalves WI, Hwa YL, Fonder A, Hobbs M, Kourelis T, Warsame R, Lust JA, Leung N, Go RS, Kyle RA, Rajkumar SV, Kumar SK
Blood Adv 2020 May 26;4(10):2236-2244. doi: 10.1182/bloodadvances.2019001275. PMID: 32442300Free PMC Article

Prognosis

The progress in multiple myeloma.
Hatjiharissi P
Hell J Nucl Med 2023 May-Aug;26 Suppl:30-35. PMID: 37658559
High-risk disease in newly diagnosed multiple myeloma: beyond the R-ISS and IMWG definitions.
Hagen P, Zhang J, Barton K
Blood Cancer J 2022 May 30;12(5):83. doi: 10.1038/s41408-022-00679-5. PMID: 35637223Free PMC Article
Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Risk Stratification in Multiple Myeloma.
Ooi MG, de Mel S, Chng WJ
Curr Hematol Malig Rep 2016 Apr;11(2):137-47. doi: 10.1007/s11899-016-0307-4. PMID: 26883334
Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P
J Clin Oncol 2015 Sep 10;33(26):2863-9. Epub 2015 Aug 3 doi: 10.1200/JCO.2015.61.2267. PMID: 26240224Free PMC Article

Clinical prediction guides

Development of a Semiquantitative Whole-Body MRI Scoring System for Multiple Myeloma.
Kim DK, Jung JY, Kim H, Lee S, Lee SY, Lee S, Park SS, Min CK
Radiology 2023 Sep;308(3):e230667. doi: 10.1148/radiol.230667. PMID: 37668524
Integrated analysis of next generation sequencing minimal residual disease (MRD) and PET scan in transplant eligible myeloma patients.
Fonseca R, Arribas M, Wiedmeier-Nutor JE, Kusne YN, González Vélez M, Kosiorek HE, Butterfield RDJ, Kirsch IR, Mikhael JR, Stewart AK, Reeder C, Larsen J, Bergsagel PL, Fonseca R
Blood Cancer J 2023 Mar 6;13(1):32. doi: 10.1038/s41408-023-00794-x. PMID: 36878906Free PMC Article
CCL18 promotes migration and invasion of multiple myeloma cells and is associated with poor prognosis.
Qiao B, Chen L, Cheng Q, Wang G, Li Q, Zhang B, Li J, Hu Y, Sun C
Carcinogenesis 2023 May 15;44(1):38-45. doi: 10.1093/carcin/bgac097. PMID: 36455232
Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Risk Stratification in Multiple Myeloma.
Ooi MG, de Mel S, Chng WJ
Curr Hematol Malig Rep 2016 Apr;11(2):137-47. doi: 10.1007/s11899-016-0307-4. PMID: 26883334

Recent systematic reviews

Circulating plasma cells as a predictive biomarker in Multiple myeloma: an updated systematic review and meta-analysis.
Li Q, Ai L, Zuo L, Li J, Zhao F, Xu A, Zhang B, Cai L, Hu Y, Sun C
Ann Med 2024 Dec;56(1):2338604. Epub 2024 Apr 10 doi: 10.1080/07853890.2024.2338604. PMID: 38599340Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...