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Multiple Myeloma by RISS Stage

MedGen UID:
1638206
•Concept ID:
C4683782
•
Neoplastic Process
Synonyms: Plasma Cell Myeloma by Revised International Staging System Stage; Plasma Cell Myeloma by RISS Stage

Definition

A staging system for multiple myeloma based on the Revised International Staging System (RISS) criteria. This staging system does not apply to smoldering multiple myeloma (no AJCC staging system), monoclonal gammopathy of undetermined significance (no AJCC staging system), and Waldenstrom macroglobulinemia (no AJCC staging system). (from AJCC 8th Ed.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultiple Myeloma by RISS Stage

Professional guidelines

PubMed

Pomalidomide Treatment in Relapsed/Refractory Multiple Myeloma Patients-Real-World Data From Hungary.
Lovas S, Obajed Al-Ali N, Varga G, Szita V, Alizadeh H, Plander M, Rajnics P, Illés Á, Szemlaky Z, Mikala G, Váróczy L
Pathol Oncol Res 2022;28:1610645. Epub 2022 Oct 3 doi: 10.3389/pore.2022.1610645. PMID: 36262875Free PMC Article
Diagnosis and treatment of multiple myeloma in Hunan Province.
Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article
Treatment and outcome of newly diagnosed multiple myeloma patients > 75 years old: a retrospective analysis.
Al Saleh AS, Visram A, Parmar H, Muchtar E, Buadi FK, Dispenzieri A, Warsame R, Lacy MQ, Dingli D, Leung N, Go RS, Gonsalves WI, Kourelis TV, Hayman SR, Kapoor P, Gertz MA, Kyle RA, Rajkumar SV, Kumar SK
Leuk Lymphoma 2021 Dec;62(12):3011-3018. Epub 2021 Jul 15 doi: 10.1080/10428194.2021.1950708. PMID: 34263694

Recent clinical studies

Therapy

Real-life experiences with CAR T-cell therapy with idecabtagene vicleucel (ide-cel) for triple-class exposed relapsed/refractory multiple myeloma patients.
Sanoyan DA, Seipel K, Bacher U, Kronig MN, Porret N, Wiedemann G, Daskalakis M, Pabst T
BMC Cancer 2023 Apr 15;23(1):345. doi: 10.1186/s12885-023-10824-3. PMID: 37061680Free PMC Article
Pomalidomide Treatment in Relapsed/Refractory Multiple Myeloma Patients-Real-World Data From Hungary.
Lovas S, Obajed Al-Ali N, Varga G, Szita V, Alizadeh H, Plander M, Rajnics P, Illés Á, Szemlaky Z, Mikala G, Váróczy L
Pathol Oncol Res 2022;28:1610645. Epub 2022 Oct 3 doi: 10.3389/pore.2022.1610645. PMID: 36262875Free PMC Article
Diagnosis and treatment of multiple myeloma in Hunan Province.
Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article
Current Approach to Managing Patients with Newly Diagnosed High-Risk Multiple Myeloma.
Marneni N, Chakraborty R
Curr Hematol Malig Rep 2021 Apr;16(2):148-161. Epub 2021 Apr 19 doi: 10.1007/s11899-021-00631-7. PMID: 33876390
Recognition of early mortality in multiple myeloma by a prediction matrix.
Terebelo H, Srinivasan S, Narang M, Abonour R, Gasparetto C, Toomey K, Hardin JW, Larkins G, Kitali A, Rifkin RM, Shah JJ
Am J Hematol 2017 Sep;92(9):915-923. Epub 2017 Jul 19 doi: 10.1002/ajh.24796. PMID: 28543165Free PMC Article

Prognosis

The progress in multiple myeloma.
Hatjiharissi P
Hell J Nucl Med 2023 May-Aug;26 Suppl:30-35. PMID: 37658559
High-risk disease in newly diagnosed multiple myeloma: beyond the R-ISS and IMWG definitions.
Hagen P, Zhang J, Barton K
Blood Cancer J 2022 May 30;12(5):83. doi: 10.1038/s41408-022-00679-5. PMID: 35637223Free PMC Article
Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Risk Stratification in Multiple Myeloma.
Ooi MG, de Mel S, Chng WJ
Curr Hematol Malig Rep 2016 Apr;11(2):137-47. doi: 10.1007/s11899-016-0307-4. PMID: 26883334
Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P
J Clin Oncol 2015 Sep 10;33(26):2863-9. Epub 2015 Aug 3 doi: 10.1200/JCO.2015.61.2267. PMID: 26240224Free PMC Article

Clinical prediction guides

Circulating plasma cells as a predictive biomarker in Multiple myeloma: an updated systematic review and meta-analysis.
Li Q, Ai L, Zuo L, Li J, Zhao F, Xu A, Zhang B, Cai L, Hu Y, Sun C
Ann Med 2024 Dec;56(1):2338604. Epub 2024 Apr 10 doi: 10.1080/07853890.2024.2338604. PMID: 38599340Free PMC Article
Enhancing prognostic power in multiple myeloma using a plasma cell signature derived from single-cell RNA sequencing.
Li JR, Arsang-Jang S, Cheng Y, Sun F, D'Souza A, Dhakal B, Hari P, Huang Q, Auer P, Li Y, Urrutia R, Zhan F, Shaughnessy JD Jr, Janz S, Dong J, Cheng C
Blood Cancer J 2024 Mar 6;14(1):38. doi: 10.1038/s41408-024-01024-8. PMID: 38443358Free PMC Article
Development of a Semiquantitative Whole-Body MRI Scoring System for Multiple Myeloma.
Kim DK, Jung JY, Kim H, Lee S, Lee SY, Lee S, Park SS, Min CK
Radiology 2023 Sep;308(3):e230667. doi: 10.1148/radiol.230667. PMID: 37668524
Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Risk Stratification in Multiple Myeloma.
Ooi MG, de Mel S, Chng WJ
Curr Hematol Malig Rep 2016 Apr;11(2):137-47. doi: 10.1007/s11899-016-0307-4. PMID: 26883334

Recent systematic reviews

Circulating plasma cells as a predictive biomarker in Multiple myeloma: an updated systematic review and meta-analysis.
Li Q, Ai L, Zuo L, Li J, Zhao F, Xu A, Zhang B, Cai L, Hu Y, Sun C
Ann Med 2024 Dec;56(1):2338604. Epub 2024 Apr 10 doi: 10.1080/07853890.2024.2338604. PMID: 38599340Free PMC Article

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