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Type V atherosclerotic lesion

MedGen UID:
1638264
Concept ID:
C4703477
Disease or Syndrome
HPO: HP:0031682

Definition

Type V lesions are defined as lesions in which prominent new fibrous connective tissue has formed. When the new tissue is part of a lesion with a lipid core (type IV), this type of morphology may be referred to as fibroatheroma or type Va lesion. A type V lesion in which the lipid core and other parts of the lesion are calcified may be referred to as type Vb. A type V lesion in which a lipid core is absent and lipid in general is minimal may be referred to as type Vc. With these lesions, arteries are variously narrowed, generally more than with type IV. Importantly, as with type IV lesions, type V lesions may develop fissures, hematoma, and/or thrombus (type VI lesion), and for this reason too they are clinically relevant. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVType V atherosclerotic lesion

Recent clinical studies

Etiology

Kothari V, Ho TWW, Cabodevilla AG, He Y, Kramer F, Shimizu-Albergine M, Kanter JE, Snell-Bergeon J, Fisher EA, Shao B, Heinecke JW, Wobbrock JO, Lee WL, Goldberg IJ, Vaisar T, Bornfeldt KE
Circ Res 2024 Jul 5;135(2):335-349. Epub 2024 Jun 3 doi: 10.1161/CIRCRESAHA.123.323100. PMID: 38828596Free PMC Article
Belov YV, Kazantsev AN, Kravchuk VN, Vinogradov RA, Korotkikh AV, Shmatov DV, Chernykh KP, Zakeryaev AB, Sukhoruchkin PV, Matusevich VV, Yu Lider R, Kazantseva EG, Zakharova CL, Sh Bagdavadze G, Zharova AS, Artyukhov SV, Lutsenko VA, Sultanov RV
Curr Probl Cardiol 2022 Sep;47(9):101272. Epub 2022 May 27 doi: 10.1016/j.cpcardiol.2022.101272. PMID: 35644499
Westerterp M, Fotakis P, Ouimet M, Bochem AE, Zhang H, Molusky MM, Wang W, Abramowicz S, la Bastide-van Gemert S, Wang N, Welch CL, Reilly MP, Stroes ES, Moore KJ, Tall AR
Circulation 2018 Aug 28;138(9):898-912. doi: 10.1161/CIRCULATIONAHA.117.032636. PMID: 29588315Free PMC Article
Yahagi K, Kolodgie FD, Lutter C, Mori H, Romero ME, Finn AV, Virmani R
Arterioscler Thromb Vasc Biol 2017 Feb;37(2):191-204. Epub 2016 Dec 1 doi: 10.1161/ATVBAHA.116.306256. PMID: 27908890Free PMC Article
Ye YX, Calcagno C, Binderup T, Courties G, Keliher EJ, Wojtkiewicz GR, Iwamoto Y, Tang J, Pérez-Medina C, Mani V, Ishino S, Johnbeck CB, Knigge U, Fayad ZA, Libby P, Weissleder R, Tawakol A, Dubey S, Belanger AP, Di Carli MF, Swirski FK, Kjaer A, Mulder WJ, Nahrendorf M
Circ Res 2015 Oct 23;117(10):835-45. Epub 2015 Sep 22 doi: 10.1161/CIRCRESAHA.115.307024. PMID: 26394773Free PMC Article

Diagnosis

Nogales P, Velasco C, Mota-Cobián A, González-Cintado L, Mota RA, España S, Mateo J, Bentzon JF
Arterioscler Thromb Vasc Biol 2021 Oct;41(10):e480-e490. Epub 2021 Jul 22 doi: 10.1161/ATVBAHA.121.316075. PMID: 34289703
Ge X, Zhou Z, Zhao H, Li X, Sun B, Suo S, Hackett ML, Wan J, Xu J, Liu X
J Magn Reson Imaging 2017 Sep;46(3):870-876. Epub 2017 Jan 24 doi: 10.1002/jmri.25637. PMID: 28120364
Vos A, Van Hecke W, Spliet WG, Goldschmeding R, Isgum I, Kockelkoren R, Bleys RL, Mali WP, de Jong PA, Vink A
Stroke 2016 Jan;47(1):221-3. Epub 2015 Oct 29 doi: 10.1161/STROKEAHA.115.011196. PMID: 26514193
Ye YX, Calcagno C, Binderup T, Courties G, Keliher EJ, Wojtkiewicz GR, Iwamoto Y, Tang J, Pérez-Medina C, Mani V, Ishino S, Johnbeck CB, Knigge U, Fayad ZA, Libby P, Weissleder R, Tawakol A, Dubey S, Belanger AP, Di Carli MF, Swirski FK, Kjaer A, Mulder WJ, Nahrendorf M
Circ Res 2015 Oct 23;117(10):835-45. Epub 2015 Sep 22 doi: 10.1161/CIRCRESAHA.115.307024. PMID: 26394773Free PMC Article
Pflederer T, Marwan M, Schepis T, Ropers D, Seltmann M, Muschiol G, Daniel WG, Achenbach S
Atherosclerosis 2010 Aug;211(2):437-44. Epub 2010 Feb 10 doi: 10.1016/j.atherosclerosis.2010.02.001. PMID: 20189568

Therapy

Belov YV, Kazantsev AN, Kravchuk VN, Vinogradov RA, Korotkikh AV, Shmatov DV, Chernykh KP, Zakeryaev AB, Sukhoruchkin PV, Matusevich VV, Yu Lider R, Kazantseva EG, Zakharova CL, Sh Bagdavadze G, Zharova AS, Artyukhov SV, Lutsenko VA, Sultanov RV
Curr Probl Cardiol 2022 Sep;47(9):101272. Epub 2022 May 27 doi: 10.1016/j.cpcardiol.2022.101272. PMID: 35644499
Räber L, Ueki Y, Otsuka T, Losdat S, Häner JD, Lonborg J, Fahrni G, Iglesias JF, van Geuns RJ, Ondracek AS, Radu Juul Jensen MD, Zanchin C, Stortecky S, Spirk D, Siontis GCM, Saleh L, Matter CM, Daemen J, Mach F, Heg D, Windecker S, Engstrøm T, Lang IM, Koskinas KC; PACMAN-AMI collaborators
JAMA 2022 May 10;327(18):1771-1781. doi: 10.1001/jama.2022.5218. PMID: 35368058Free PMC Article
Rinne P, Rami M, Nuutinen S, Santovito D, van der Vorst EPC, Guillamat-Prats R, Lyytikäinen LP, Raitoharju E, Oksala N, Ring L, Cai M, Hruby VJ, Lehtimäki T, Weber C, Steffens S
Circulation 2017 Jul 4;136(1):83-97. Epub 2017 Apr 27 doi: 10.1161/CIRCULATIONAHA.116.025889. PMID: 28450348Free PMC Article
Koniari I, Apostolakis E, Diamantopoulos A, Papadaki H, Papadimitriou E, Poimenidi E, Karnabatidis D, Karahaliou A, Costaridou L, Papalois A, Siablis D, Dougenis D, Alexopoulos D
Lipids Health Dis 2014 Feb 15;13:33. doi: 10.1186/1476-511X-13-33. PMID: 24529182Free PMC Article
Hansson GK, Zhou X, Törnquist E, Paulsson G
Ann N Y Acad Sci 2000 May;902:53-62; discussion 62-4. doi: 10.1111/j.1749-6632.2000.tb06300.x. PMID: 10865825

Prognosis

Kothari V, Ho TWW, Cabodevilla AG, He Y, Kramer F, Shimizu-Albergine M, Kanter JE, Snell-Bergeon J, Fisher EA, Shao B, Heinecke JW, Wobbrock JO, Lee WL, Goldberg IJ, Vaisar T, Bornfeldt KE
Circ Res 2024 Jul 5;135(2):335-349. Epub 2024 Jun 3 doi: 10.1161/CIRCRESAHA.123.323100. PMID: 38828596Free PMC Article
Winkels H, Ehinger E, Vassallo M, Buscher K, Dinh HQ, Kobiyama K, Hamers AAJ, Cochain C, Vafadarnejad E, Saliba AE, Zernecke A, Pramod AB, Ghosh AK, Anto Michel N, Hoppe N, Hilgendorf I, Zirlik A, Hedrick CC, Ley K, Wolf D
Circ Res 2018 Jun 8;122(12):1675-1688. Epub 2018 Mar 15 doi: 10.1161/CIRCRESAHA.117.312513. PMID: 29545366Free PMC Article
Parenti A, Pala L, Paccosi S, Rotella CM
Curr Pharm Des 2017;23(10):1435-1444. doi: 10.2174/1381612823666170124125826. PMID: 28120714
Yahagi K, Kolodgie FD, Lutter C, Mori H, Romero ME, Finn AV, Virmani R
Arterioscler Thromb Vasc Biol 2017 Feb;37(2):191-204. Epub 2016 Dec 1 doi: 10.1161/ATVBAHA.116.306256. PMID: 27908890Free PMC Article
Ye YX, Calcagno C, Binderup T, Courties G, Keliher EJ, Wojtkiewicz GR, Iwamoto Y, Tang J, Pérez-Medina C, Mani V, Ishino S, Johnbeck CB, Knigge U, Fayad ZA, Libby P, Weissleder R, Tawakol A, Dubey S, Belanger AP, Di Carli MF, Swirski FK, Kjaer A, Mulder WJ, Nahrendorf M
Circ Res 2015 Oct 23;117(10):835-45. Epub 2015 Sep 22 doi: 10.1161/CIRCRESAHA.115.307024. PMID: 26394773Free PMC Article

Clinical prediction guides

Kobo O, Saada M, von Birgelen C, Tonino PAL, Íñiguez-Romo A, Fröbert O, Halabi M, Oemrawsingh RM, Polad J, IJsselmuiden AJJ, Roffi M, Aminian A, Mamas MA, Roguin A
Eur Heart J Qual Care Clin Outcomes 2023 Jun 21;9(4):417-426. doi: 10.1093/ehjqcco/qcac043. PMID: 35876646Free PMC Article
Winkels H, Ehinger E, Vassallo M, Buscher K, Dinh HQ, Kobiyama K, Hamers AAJ, Cochain C, Vafadarnejad E, Saliba AE, Zernecke A, Pramod AB, Ghosh AK, Anto Michel N, Hoppe N, Hilgendorf I, Zirlik A, Hedrick CC, Ley K, Wolf D
Circ Res 2018 Jun 8;122(12):1675-1688. Epub 2018 Mar 15 doi: 10.1161/CIRCRESAHA.117.312513. PMID: 29545366Free PMC Article
Rinne P, Rami M, Nuutinen S, Santovito D, van der Vorst EPC, Guillamat-Prats R, Lyytikäinen LP, Raitoharju E, Oksala N, Ring L, Cai M, Hruby VJ, Lehtimäki T, Weber C, Steffens S
Circulation 2017 Jul 4;136(1):83-97. Epub 2017 Apr 27 doi: 10.1161/CIRCULATIONAHA.116.025889. PMID: 28450348Free PMC Article
Parenti A, Pala L, Paccosi S, Rotella CM
Curr Pharm Des 2017;23(10):1435-1444. doi: 10.2174/1381612823666170124125826. PMID: 28120714
Yahagi K, Kolodgie FD, Lutter C, Mori H, Romero ME, Finn AV, Virmani R
Arterioscler Thromb Vasc Biol 2017 Feb;37(2):191-204. Epub 2016 Dec 1 doi: 10.1161/ATVBAHA.116.306256. PMID: 27908890Free PMC Article

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