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Refractory Pancreatic Carcinoma

MedGen UID:
1638265
Concept ID:
C4684831
Neoplastic Process

Definition

Pancreatic carcinoma that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A
Nat Genet 2022 Aug;54(8):1178-1191. Epub 2022 Jul 28 doi: 10.1038/s41588-022-01134-8. PMID: 35902743Free PMC Article
Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article
Brown E, Watkin D, Evans J, Yip V, Cuthbertson DJ
Clin Endocrinol (Oxf) 2018 May;88(5):615-624. Epub 2018 Mar 2 doi: 10.1111/cen.13528. PMID: 29205458

Recent clinical studies

Etiology

Kaur J, Vijayvergia N
Curr Oncol 2023 Sep 21;30(9):8653-8664. doi: 10.3390/curroncol30090627. PMID: 37754542Free PMC Article
Schoenfeld JD, Giobbie-Hurder A, Ranasinghe S, Kao KZ, Lako A, Tsuji J, Liu Y, Brennick RC, Gentzler RD, Lee C, Hubbard J, Arnold SM, Abbruzzese JL, Jabbour SK, Uboha NV, Stephans KL, Johnson JM, Park H, Villaruz LC, Sharon E, Streicher H, Ahmed MM, Lyon H, Cibuskis C, Lennon N, Jhaveri A, Yang L, Altreuter J, Gunasti L, Weirather JL, Mak RH, Awad MM, Rodig SJ, Chen HX, Wu CJ, Monjazeb AM, Hodi FS
Lancet Oncol 2022 Feb;23(2):279-291. Epub 2022 Jan 13 doi: 10.1016/S1470-2045(21)00658-6. PMID: 35033226Free PMC Article
Qin S, Li Q, Gu S, Chen X, Lin L, Wang Z, Xu A, Chen X, Zhou C, Ren Z, Yang L, Xu L, Bai Y, Chen L, Li J, Pan H, Cao B, Fang W, Wu W, Wang G, Cheng Y, Yu Z, Zhu X, Jiang D, Lu Y, Wang H, Xu J, Bai L, Liu Y, Lin H, Wu C, Zhang Y, Yan P, Jin C, Zou J
Lancet Gastroenterol Hepatol 2021 Jul;6(7):559-568. Epub 2021 May 8 doi: 10.1016/S2468-1253(21)00109-6. PMID: 33971141
Chin RI, Wu FS, Menda Y, Kim H
Semin Radiat Oncol 2021 Jan;31(1):60-70. doi: 10.1016/j.semradonc.2020.07.007. PMID: 33246637
Hasskarl J
Recent Results Cancer Res 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. PMID: 30069763

Diagnosis

Stossel C, Raitses-Gurevich M, Atias D, Beller T, Glick Gorman Y, Halperin S, Peer E, Denroche RE, Zhang A, Notta F, Wilson JM, O'Kane GM, Haimov Talmoud E, Amison N, Schvimer M, Salpeter SJ, Bar V, Zundelevich A, Tirosh I, Tal R, Dinstag G, Kinar Y, Eliezer Y, Ben-David U, Gavert NS, Straussman R, Gallinger SJ, Berger R, Golan T
Cancer Discov 2023 Aug 4;13(8):1826-1843. doi: 10.1158/2159-8290.CD-22-0412. PMID: 37449843Free PMC Article
Qin S, Li Q, Gu S, Chen X, Lin L, Wang Z, Xu A, Chen X, Zhou C, Ren Z, Yang L, Xu L, Bai Y, Chen L, Li J, Pan H, Cao B, Fang W, Wu W, Wang G, Cheng Y, Yu Z, Zhu X, Jiang D, Lu Y, Wang H, Xu J, Bai L, Liu Y, Lin H, Wu C, Zhang Y, Yan P, Jin C, Zou J
Lancet Gastroenterol Hepatol 2021 Jul;6(7):559-568. Epub 2021 May 8 doi: 10.1016/S2468-1253(21)00109-6. PMID: 33971141
Xu J, Shen J, Gu S, Zhang Y, Wu L, Wu J, Shao G, Zhang Y, Xu L, Yin T, Liu J, Ren Z, Xiong J, Mao X, Zhang L, Yang J, Li L, Chen X, Wang Z, Gu K, Chen X, Pan Z, Ma K, Zhou X, Yu Z, Li E, Yin G, Zhang X, Wang S, Wang Q
Clin Cancer Res 2021 Feb 15;27(4):1003-1011. Epub 2020 Oct 21 doi: 10.1158/1078-0432.CCR-20-2571. PMID: 33087333
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article
Haas AR, Tanyi JL, O'Hara MH, Gladney WL, Lacey SF, Torigian DA, Soulen MC, Tian L, McGarvey M, Nelson AM, Farabaugh CS, Moon E, Levine BL, Melenhorst JJ, Plesa G, June CH, Albelda SM, Beatty GL
Mol Ther 2019 Nov 6;27(11):1919-1929. Epub 2019 Jul 30 doi: 10.1016/j.ymthe.2019.07.015. PMID: 31420241Free PMC Article

Therapy

Singhal A, Li BT, O'Reilly EM
Nat Med 2024 Apr;30(4):969-983. Epub 2024 Apr 18 doi: 10.1038/s41591-024-02903-0. PMID: 38637634
Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article
Katoh M, Katoh M
Int J Mol Med 2020 Feb;45(2):279-297. Epub 2019 Dec 4 doi: 10.3892/ijmm.2019.4418. PMID: 31894255Free PMC Article
Morello A, Sadelain M, Adusumilli PS
Cancer Discov 2016 Feb;6(2):133-46. Epub 2015 Oct 26 doi: 10.1158/2159-8290.CD-15-0583. PMID: 26503962Free PMC Article

Prognosis

Singhal A, Li BT, O'Reilly EM
Nat Med 2024 Apr;30(4):969-983. Epub 2024 Apr 18 doi: 10.1038/s41591-024-02903-0. PMID: 38637634
Stossel C, Raitses-Gurevich M, Atias D, Beller T, Glick Gorman Y, Halperin S, Peer E, Denroche RE, Zhang A, Notta F, Wilson JM, O'Kane GM, Haimov Talmoud E, Amison N, Schvimer M, Salpeter SJ, Bar V, Zundelevich A, Tirosh I, Tal R, Dinstag G, Kinar Y, Eliezer Y, Ben-David U, Gavert NS, Straussman R, Gallinger SJ, Berger R, Golan T
Cancer Discov 2023 Aug 4;13(8):1826-1843. doi: 10.1158/2159-8290.CD-22-0412. PMID: 37449843Free PMC Article
Yamamoto Y, Kasashima H, Fukui Y, Tsujio G, Yashiro M, Maeda K
Cancer Sci 2023 Jan;114(1):16-24. Epub 2022 Oct 19 doi: 10.1111/cas.15609. PMID: 36197901Free PMC Article
Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A
Nat Genet 2022 Aug;54(8):1178-1191. Epub 2022 Jul 28 doi: 10.1038/s41588-022-01134-8. PMID: 35902743Free PMC Article
Chen F, Zou Z, Du J, Su S, Shao J, Meng F, Yang J, Xu Q, Ding N, Yang Y, Liu Q, Wang Q, Sun Z, Zhou S, Du S, Wei J, Liu B
J Clin Invest 2019 May 1;129(5):2056-2070. Epub 2019 Mar 5 doi: 10.1172/JCI99538. PMID: 30835255Free PMC Article

Clinical prediction guides

Stossel C, Raitses-Gurevich M, Atias D, Beller T, Glick Gorman Y, Halperin S, Peer E, Denroche RE, Zhang A, Notta F, Wilson JM, O'Kane GM, Haimov Talmoud E, Amison N, Schvimer M, Salpeter SJ, Bar V, Zundelevich A, Tirosh I, Tal R, Dinstag G, Kinar Y, Eliezer Y, Ben-David U, Gavert NS, Straussman R, Gallinger SJ, Berger R, Golan T
Cancer Discov 2023 Aug 4;13(8):1826-1843. doi: 10.1158/2159-8290.CD-22-0412. PMID: 37449843Free PMC Article
Pradat Y, Viot J, Yurchenko AA, Gunbin K, Cerbone L, Deloger M, Grisay G, Verlingue L, Scott V, Padioleau I, Panunzi L, Michiels S, Hollebecque A, Jules-Clément G, Mezquita L, Lainé A, Loriot Y, Besse B, Friboulet L, André F, Cournède PH, Gautheret D, Nikolaev SI
Cancer Discov 2023 May 4;13(5):1116-1143. doi: 10.1158/2159-8290.CD-22-0966. PMID: 36862804Free PMC Article
Schoenfeld JD, Giobbie-Hurder A, Ranasinghe S, Kao KZ, Lako A, Tsuji J, Liu Y, Brennick RC, Gentzler RD, Lee C, Hubbard J, Arnold SM, Abbruzzese JL, Jabbour SK, Uboha NV, Stephans KL, Johnson JM, Park H, Villaruz LC, Sharon E, Streicher H, Ahmed MM, Lyon H, Cibuskis C, Lennon N, Jhaveri A, Yang L, Altreuter J, Gunasti L, Weirather JL, Mak RH, Awad MM, Rodig SJ, Chen HX, Wu CJ, Monjazeb AM, Hodi FS
Lancet Oncol 2022 Feb;23(2):279-291. Epub 2022 Jan 13 doi: 10.1016/S1470-2045(21)00658-6. PMID: 35033226Free PMC Article
Chen F, Zou Z, Du J, Su S, Shao J, Meng F, Yang J, Xu Q, Ding N, Yang Y, Liu Q, Wang Q, Sun Z, Zhou S, Du S, Wei J, Liu B
J Clin Invest 2019 May 1;129(5):2056-2070. Epub 2019 Mar 5 doi: 10.1172/JCI99538. PMID: 30835255Free PMC Article
Durand F, Antoine C, Soubrane O
Liver Transpl 2019 May;25(5):763-770. Epub 2019 Apr 1 doi: 10.1002/lt.25419. PMID: 30697904

Recent systematic reviews

Vouros D, Bramis K, Alexakis N, Kotsarinis V, Antonakis P, Memos N, Konstadoulakis M, Toutouzas K
Am Surg 2023 Dec;89(12):6134-6146. Epub 2023 Jun 9 doi: 10.1177/00031348231183121. PMID: 37295804
Schizas D, Mastoraki A, Bagias G, Patras R, Moris D, Lazaridis II, Arkadopoulos N, Felekouras E
J BUON 2019 Mar-Apr;24(2):415-423. PMID: 31127985
Tian G, Zhao Q, Chen F, Jiang T, Wang W
Oncotarget 2017 Jan 24;8(4):5853-5860. doi: 10.18632/oncotarget.14030. PMID: 28009979Free PMC Article
Gurusamy KS, Pallari E
Cochrane Database Syst Rev 2016 Mar 29;3(3):CD011523. doi: 10.1002/14651858.CD011523.pub2. PMID: 27025289Free PMC Article
Vayne-Bossert P, Afsharimani B, Good P, Gray P, Hardy J
Support Care Cancer 2016 Mar;24(3):1429-38. Epub 2015 Dec 11 doi: 10.1007/s00520-015-3047-4. PMID: 26660344

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