U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Posterior leukoencephalopathy syndrome

MedGen UID:
163898
Concept ID:
C0878576
Disease or Syndrome
Synonyms: Leukoencephalopathy Syndrome, Posterior; Leukoencephalopathy Syndromes, Posterior; Posterior Leukoencephalopathy Syndrome; Syndrome, Posterior Leukoencephalopathy; Syndromes, Posterior Leukoencephalopathy
 
Monarch Initiative: MONDO:0044033

Definition

An acute or subacute reversible condition characterized by headaches, mental status changes, visual disturbances, and seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPosterior leukoencephalopathy syndrome

Professional guidelines

PubMed

Ghali MGZ, Davanzo J, Leo M, Rizk E
Leuk Lymphoma 2019 Oct;60(10):2365-2372. Epub 2019 Sep 26 doi: 10.1080/10428194.2019.1594210. PMID: 31556774
Grewal J, Grewal HK, Forman AD
Curr Oncol Rep 2008 Jan;10(1):63-71. doi: 10.1007/s11912-008-0010-2. PMID: 18366962
Vázquez E, Lucaya J, Castellote A, Piqueras J, Sainz P, Olivé T, Sánchez-Toledo J, Ortega JJ
Radiographics 2002 Nov-Dec;22(6):1411-28. doi: 10.1148/rg.226025029. PMID: 12432112

Recent clinical studies

Etiology

Perillo T, Paolella C, Perrotta G, Serino A, Caranci F, Manto A
Radiol Med 2022 Sep;127(9):981-990. Epub 2022 Aug 6 doi: 10.1007/s11547-022-01532-2. PMID: 35932443Free PMC Article
Ando Y, Ono Y, Sano A, Fujita N, Ono S
Intern Med 2022 Jan 15;61(2):135-141. Epub 2021 Jul 17 doi: 10.2169/internalmedicine.7520-21. PMID: 34275982Free PMC Article
Singhal AB
Continuum (Minneap Minn) 2021 Oct 1;27(5):1301-1320. doi: 10.1212/CON.0000000000001037. PMID: 34618761
Gewirtz AN, Gao V, Parauda SC, Robbins MS
Curr Pain Headache Rep 2021 Feb 25;25(3):19. doi: 10.1007/s11916-020-00932-1. PMID: 33630183Free PMC Article
Zambrano MD, Miller EC
Curr Atheroscler Rep 2019 Jun 22;21(9):33. doi: 10.1007/s11883-019-0798-2. PMID: 31230137Free PMC Article

Diagnosis

Triplett JD, Kutlubaev MA, Kermode AG, Hardy T
Pract Neurol 2022 Jun;22(3):183-189. Epub 2022 Jan 19 doi: 10.1136/practneurol-2021-003194. PMID: 35046115
Gewirtz AN, Gao V, Parauda SC, Robbins MS
Curr Pain Headache Rep 2021 Feb 25;25(3):19. doi: 10.1007/s11916-020-00932-1. PMID: 33630183Free PMC Article
Horkovičová K, Hájková E, Krásnik V
Cesk Slov Oftalmol 2020 Spring;76(3):135-138. doi: 10.31348/2020/23. PMID: 33126810
Fischer M, Schmutzhard E
J Neurol 2017 Aug;264(8):1608-1616. Epub 2017 Jan 4 doi: 10.1007/s00415-016-8377-8. PMID: 28054130Free PMC Article
Fugate JE, Rabinstein AA
Lancet Neurol 2015 Sep;14(9):914-925. Epub 2015 Jul 13 doi: 10.1016/S1474-4422(15)00111-8. PMID: 26184985

Therapy

Triplett JD, Kutlubaev MA, Kermode AG, Hardy T
Pract Neurol 2022 Jun;22(3):183-189. Epub 2022 Jan 19 doi: 10.1136/practneurol-2021-003194. PMID: 35046115
Parasher A, Jhamb R
Postgrad Med J 2020 Oct;96(1140):623-628. Epub 2020 May 28 doi: 10.1136/postgradmedj-2020-137706. PMID: 32467104
Peixoto AJ
N Engl J Med 2019 Nov 7;381(19):1843-1852. doi: 10.1056/NEJMcp1901117. PMID: 31693807
Fittro K, Dizon R
JAAPA 2018 Jul;31(7):31-34. doi: 10.1097/01.JAA.0000534980.69236.81. PMID: 29957604
Tormoehlen LM
Psychiatr Clin North Am 2013 Jun;36(2):277-92. Epub 2013 Apr 12 doi: 10.1016/j.psc.2013.02.006. PMID: 23688692

Prognosis

Trivedi S, Chakravarty A
Curr Neurol Neurosci Rep 2022 Aug;22(8):515-529. Epub 2022 Jun 21 doi: 10.1007/s11910-022-01213-7. PMID: 35727463Free PMC Article
Ando Y, Ono Y, Sano A, Fujita N, Ono S
Intern Med 2022 Jan 15;61(2):135-141. Epub 2021 Jul 17 doi: 10.2169/internalmedicine.7520-21. PMID: 34275982Free PMC Article
Gewirtz AN, Gao V, Parauda SC, Robbins MS
Curr Pain Headache Rep 2021 Feb 25;25(3):19. doi: 10.1007/s11916-020-00932-1. PMID: 33630183Free PMC Article
Parasher A, Jhamb R
Postgrad Med J 2020 Oct;96(1140):623-628. Epub 2020 May 28 doi: 10.1136/postgradmedj-2020-137706. PMID: 32467104
Fischer M, Schmutzhard E
J Neurol 2017 Aug;264(8):1608-1616. Epub 2017 Jan 4 doi: 10.1007/s00415-016-8377-8. PMID: 28054130Free PMC Article

Clinical prediction guides

Trivedi S, Chakravarty A
Curr Neurol Neurosci Rep 2022 Aug;22(8):515-529. Epub 2022 Jun 21 doi: 10.1007/s11910-022-01213-7. PMID: 35727463Free PMC Article
Harapan BN, Yoo HJ
J Neurol 2021 Sep;268(9):3059-3071. Epub 2021 Jan 23 doi: 10.1007/s00415-021-10406-y. PMID: 33486564Free PMC Article
Chakraborty T, Kramer CL, Wijdicks EFM, Rabinstein AA
Neurocrit Care 2020 Feb;32(1):113-120. doi: 10.1007/s12028-019-00781-w. PMID: 31297663
Zambrano MD, Miller EC
Curr Atheroscler Rep 2019 Jun 22;21(9):33. doi: 10.1007/s11883-019-0798-2. PMID: 31230137Free PMC Article
Liman TG, Siebert E, Endres M
Curr Opin Neurol 2019 Feb;32(1):25-35. doi: 10.1097/WCO.0000000000000640. PMID: 30531559

Recent systematic reviews

Yeahia R, Schefflein J, Chiarolanzio P, Rozenstein A, Gomes W, Ali S, Mehta H, Al-Mufti F, McClelland A, Gulko E
Clin Imaging 2022 Jan;81:107-113. Epub 2021 Oct 16 doi: 10.1016/j.clinimag.2021.10.003. PMID: 34700172Free PMC Article
Orlando C, Milani GP, Simonetti GD, Goeggel Simonetti B, Lava SAG, Wyttenbach R, Bianchetti MG, Cristallo Lacalamita M
Pediatr Nephrol 2022 Apr;37(4):833-841. Epub 2021 Sep 21 doi: 10.1007/s00467-021-05244-z. PMID: 34546419Free PMC Article
Jaramillo-Calle DA, Solano JM, Rabinstein AA, Bonkovsky HL
Mol Genet Metab 2019 Nov;128(3):242-253. Epub 2019 Nov 1 doi: 10.1016/j.ymgme.2019.10.011. PMID: 31706631
Racchiusa S, Mormina E, Ax A, Musumeci O, Longo M, Granata F
Neurol Sci 2019 May;40(5):915-922. Epub 2019 Jan 2 doi: 10.1007/s10072-018-3651-4. PMID: 30604335
How J, Blattner M, Fowler S, Wang-Gillam A, Schindler SE
Neurologist 2016 Nov;21(6):112-117. doi: 10.1097/NRL.0000000000000105. PMID: 27801773Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...