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Abnormal extraocular muscle physiology

MedGen UID:: 1639027
•Concept ID:: C4703401
•: Pathologic Function

HPO:	HP:0025590

Definition

A functional anomaly of the muscles of the eye. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal extraocular muscle physiology

Phenotypic abnormality
- Abnormality of the eye
  - Abnormal eye physiology
    - Abnormal extraocular muscle physiology
      - Abnormal oblique muscle physiology
        Abnormal inferior oblique muscle physiology
        Inferior oblique muscle overaction
        Inferior oblique muscle weakness
        Abnormal superior oblique muscle physiology
        Superior oblique muscle overaction
        Superior oblique muscle weakness
      - Abnormal rectus muscle physiology
        Abnormal horizontal rectus muscle physiology
        Abnormal lateral rectus muscle physiology
        Abnormal medial rectus muscle physiology
        Abnormal vertical rectus muscle physiology
        Abnormal inferior rectus muscle physiology
        Abnormal superior rectus muscle physiology

Professional guidelines

PubMed

The diagnosis and treatment of infantile nystagmus syndrome (INS).

Khanna S, Dell'Osso LF
ScientificWorldJournal 2006 Oct 30;6:1385-97. doi: 10.1100/tsw.2006.248. PMID: 17086344 Free PMC Article

Extraocular mitochondrial myopathies and their differential diagnoses.

Schoser BG, Pongratz D
Strabismus 2006 Jun;14(2):107-13. doi: 10.1080/09273970600701218. PMID: 16760117

The diagnosis and treatment of bilateral masked superior oblique palsy.

Kushner BJ
Am J Ophthalmol 1988 Feb 15;105(2):186-94. doi: 10.1016/0002-9394(88)90184-5. PMID: 3277437

See all (11)

Recent clinical studies

Etiology

Congenital myasthenic syndromes.

Finsterer J
Orphanet J Rare Dis 2019 Feb 26;14(1):57. doi: 10.1186/s13023-019-1025-5. PMID: 30808424 Free PMC Article

Ophthalmoplegia in Mitochondrial Disease.

Lee SJ, Na JH, Han J, Lee YM
Yonsei Med J 2018 Dec;59(10):1190-1196. doi: 10.3349/ymj.2018.59.10.1190. PMID: 30450853 Free PMC Article

Congenital cranial dysinnervation disorders.

Singh A, Pandey PK, Agrawal A, Mittal SK, Rana KM, Bahuguna C
Int Ophthalmol 2017 Dec;37(6):1369-1381. Epub 2016 Nov 11 doi: 10.1007/s10792-016-0388-z. PMID: 27837354

The Role of Extraocular Muscle Pulleys in Incomitant Non-Paralytic Strabismus.

Clark RA
Middle East Afr J Ophthalmol 2015 Jul-Sep;22(3):279-85. doi: 10.4103/0974-9233.159698. PMID: 26180464 Free PMC Article

Ocular choristomas.

Mansour AM, Barber JC, Reinecke RD, Wang FM
Surv Ophthalmol 1989 Mar-Apr;33(5):339-58. doi: 10.1016/0039-6257(89)90011-8. PMID: 2655139

See all (286)

Diagnosis

Congenital myasthenic syndromes.

Finsterer J
Orphanet J Rare Dis 2019 Feb 26;14(1):57. doi: 10.1186/s13023-019-1025-5. PMID: 30808424 Free PMC Article

Ophthalmoplegia in Mitochondrial Disease.

Lee SJ, Na JH, Han J, Lee YM
Yonsei Med J 2018 Dec;59(10):1190-1196. doi: 10.3349/ymj.2018.59.10.1190. PMID: 30450853 Free PMC Article

Pearls: myasthenia.

Benatar M
Semin Neurol 2010 Feb;30(1):35-7. Epub 2010 Feb 1 doi: 10.1055/s-0029-1244999. PMID: 20127579

Infantile exotropia.

Biglan AW, Davis JS, Cheng KP, Pettapiece MC
J Pediatr Ophthalmol Strabismus 1996 Mar-Apr;33(2):79-84. doi: 10.3928/0191-3913-19960301-04. PMID: 8965243

Ocular myopathies.

Tomé FM, Fardeau M
Pathol Res Pract 1985 Jul;180(1):19-27. doi: 10.1016/S0344-0338(85)80070-4. PMID: 4034429

See all (303)

Therapy

Newly developed abnormal head position and secondary esotropia after strabismus surgery for children with intermittent exotropia.

Shen T, Kang Y, Lin X, Wu H, Yan J
Int Ophthalmol 2022 Oct;42(10):2965-2972. Epub 2022 Jan 27 doi: 10.1007/s10792-021-02173-6. PMID: 35083599

Congenital myasthenic syndromes.

Finsterer J
Orphanet J Rare Dis 2019 Feb 26;14(1):57. doi: 10.1186/s13023-019-1025-5. PMID: 30808424 Free PMC Article

Concentric or monopolar electrode for jitter determination in orbicularis oculi.

Oliveira Santos M, Swash M, de Carvalho M
Clin Neurophysiol 2018 Dec;129(12):2552-2556. Epub 2018 Oct 26 doi: 10.1016/j.clinph.2018.09.024. PMID: 30388614

PD-1 Inhibitor-associated Myopathies: Emerging Immune-mediated Myopathies.

Liewluck T, Kao JC, Mauermann ML
J Immunother 2018 May;41(4):208-211. doi: 10.1097/CJI.0000000000000196. PMID: 29200081

Ocular myasthenia gravis. A critical review of clinical and pathophysiological aspects.

Sommer N, Melms A, Weller M, Dichgans J
Doc Ophthalmol 1993;84(4):309-33. doi: 10.1007/BF01215447. PMID: 8156854

See all (92)

Prognosis

Ophthalmoplegia in Mitochondrial Disease.

Lee SJ, Na JH, Han J, Lee YM
Yonsei Med J 2018 Dec;59(10):1190-1196. doi: 10.3349/ymj.2018.59.10.1190. PMID: 30450853 Free PMC Article

Congenital cranial dysinnervation disorders.

Singh A, Pandey PK, Agrawal A, Mittal SK, Rana KM, Bahuguna C
Int Ophthalmol 2017 Dec;37(6):1369-1381. Epub 2016 Nov 11 doi: 10.1007/s10792-016-0388-z. PMID: 27837354

Strabismus in craniosynostosis.

Rosenberg JB, Tepper OM, Medow NB
J Pediatr Ophthalmol Strabismus 2013 May-Jun;50(3):140-8. Epub 2012 Nov 20 doi: 10.3928/01913913-20121113-02. PMID: 23163259

The anatomy and physiology of the ocular motor system.

Horn AK, Leigh RJ
Handb Clin Neurol 2011;102:21-69. doi: 10.1016/B978-0-444-52903-9.00008-X. PMID: 21601062

Guillain-Barré syndrome.

Gurwood AS, Drake J
Optometry 2006 Nov;77(11):540-6. doi: 10.1016/j.optm.2006.06.014. PMID: 17145565

See all (137)

Clinical prediction guides

The Role of Extraocular Muscle Pulleys in Incomitant Non-Paralytic Strabismus.

Clark RA
Middle East Afr J Ophthalmol 2015 Jul-Sep;22(3):279-85. doi: 10.4103/0974-9233.159698. PMID: 26180464 Free PMC Article

The anatomy and physiology of the ocular motor system.

Horn AK, Leigh RJ
Handb Clin Neurol 2011;102:21-69. doi: 10.1016/B978-0-444-52903-9.00008-X. PMID: 21601062

Strabismus and eye muscle function.

Lennerstrand G
Acta Ophthalmol Scand 2007 Nov;85(7):711-23. doi: 10.1111/j.1600-0420.2007.00853.x. PMID: 17944625

Oculonasal synkinesis.

Guyuron B, Bokhari F, Galloway DV, Thomas T
Plast Reconstr Surg 1994 Aug;94(2):251-3. doi: 10.1097/00006534-199408000-00005. PMID: 8041815

Ocular myopathies.

Tomé FM, Fardeau M
Pathol Res Pract 1985 Jul;180(1):19-27. doi: 10.1016/S0344-0338(85)80070-4. PMID: 4034429

See all (159)

Recent systematic reviews

Oculomotor functions in focal dystonias: A systematic review.

Hirsig A, Barbey C, Schüpbach MWM, Bargiotas P
Acta Neurol Scand 2020 May;141(5):359-367. Epub 2020 Feb 12 doi: 10.1111/ane.13224. PMID: 31990980

Congenital myasthenic syndromes.

Finsterer J
Orphanet J Rare Dis 2019 Feb 26;14(1):57. doi: 10.1186/s13023-019-1025-5. PMID: 30808424 Free PMC Article

Clinical and histologic ocular findings in pompe disease.

Yanovitch TL, Banugaria SG, Proia AD, Kishnani PS
J Pediatr Ophthalmol Strabismus 2010 Jan-Feb;47(1):34-40. Epub 2010 Jan 21 doi: 10.3928/01913913-20100106-08. PMID: 20128552

See all (3)

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Abnormal extraocular muscle physiology

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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