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DDIT3 Gene Rearrangement

MedGen UID:
1639057
•Concept ID:
C4683790
•
Cell or Molecular Dysfunction
Synonyms: C/EBPzeta Gene Rearrangement; CEBPZ Gene Rearrangement; CHOP-10 Gene Rearrangement; CHOP10 Gene Rearrangement; DDIT3 Rearrangement; DNA Damage Inducible Transcript 3 Gene Rearrangement; DNA-Damage-Inducible Transcript 3 Gene Rearrangement; GADD153 Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the DDIT3 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDDIT3 Gene Rearrangement

Professional guidelines

PubMed

Primary subcutaneous myxoid liposarcoma: a clinicopathologic review of three cases with molecular confirmation and discussion of the differential diagnosis.
Buehler D, Marburger TB, Billings SD
J Cutan Pathol 2014 Dec;41(12):907-15. Epub 2014 Dec 5 doi: 10.1111/cup.12428. PMID: 25376660

Recent clinical studies

Diagnosis

Expression of CTAG1B clone EPR13780 versus DDIT3 gene rearrangement distinguishes myxoid liposarcoma from its mimics with detection of novel DDIT3 gene copy number variations.
Abdelaziz MM, Tayel HY, Abdel-Bary A, Badawy OM
J Histotechnol 2022 Jun;45(2):56-65. Epub 2021 Nov 30 doi: 10.1080/01478885.2021.2004294. PMID: 34845972
Well-Differentiated Liposarcoma of the Hypopharynx Exhibiting Myxoid Liposarcoma-like Morphology with MDM2 and DDIT3 Co-Amplification.
Murshed KA, Abo Samra H, Ammar A
Head Neck Pathol 2022 Mar;16(1):288-293. Epub 2021 Jun 4 doi: 10.1007/s12105-021-01341-5. PMID: 34089125Free PMC Article
Lipoblastoma-like tumor of the vulva: further characterization in 8 new cases.
Mirkovic J, Fletcher CD
Am J Surg Pathol 2015 Sep;39(9):1290-5. doi: 10.1097/PAS.0000000000000448. PMID: 25929353
Primary myxoid liposarcoma of the ovary in a postpartum female: a case report and review of literature.
Liang SX, Howitt B, Blitz MJ, Bhuiya T, Thamasebi F, Sternchos J, Shih K
Int J Gynecol Pathol 2015 May;34(3):298-302. doi: 10.1097/PGP.0000000000000145. PMID: 25760901

Clinical prediction guides

Myxoid pleomorphic liposarcoma-a clinicopathologic, immunohistochemical, molecular genetic and epigenetic study of 12 cases, suggesting a possible relationship with conventional pleomorphic liposarcoma.
Creytens D, Folpe AL, Koelsche C, Mentzel T, Ferdinande L, van Gorp JM, Van der Linden M, Raman L, Menten B, Fritchie K, von Deimling A, Van Dorpe J, Flucke U
Mod Pathol 2021 Nov;34(11):2043-2049. Epub 2021 Jun 24 doi: 10.1038/s41379-021-00862-2. PMID: 34168281

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