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Increased level of propylene glycol in blood

MedGen UID:
1639186
•Concept ID:
C4703635
•
Finding
Synonym: Increased level of propane-1,2-diol in blood
 
HPO: HP:0410069

Definition

An increase in the level of propylene glycol in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased level of propylene glycol in blood

Conditions with this feature

Cirrhosis, familial
MedGen UID:
350049
•Concept ID:
C1861556
•
Disease or Syndrome
Cirrhosis in which no causative agent can be identified.
See: Condition Record
Cirrhosis, familial

Recent clinical studies

Etiology

Considerations for deriving a safe intake of propylene glycol.
Lewis AS, Boomhower SR, Marsh CM, Jack MM
Food Chem Toxicol 2024 Apr;186:114460. Epub 2024 Feb 5 doi: 10.1016/j.fct.2024.114460. PMID: 38325632
Toxicity of Propylene Glycol Extract of Propolis on Central Nervous System and Liver in Pregnant and Neonatal Rats.
Silici S, Okan A, Köklü B, Demiray S, Doğanyiğit Z
Z Geburtshilfe Neonatol 2023 Aug;227(4):261-268. Epub 2023 Mar 8 doi: 10.1055/a-2010-4009. PMID: 36889342
The Health Risks of Electronic Cigarette Use to Bystanders.
Visser WF, Klerx WN, Cremers HWJM, Ramlal R, Schwillens PL, Talhout R
Int J Environ Res Public Health 2019 Apr 30;16(9) doi: 10.3390/ijerph16091525. PMID: 31052162Free PMC Article
Assessing Propylene Glycol Toxicity in Alcohol Withdrawal Patients Receiving Intravenous Benzodiazepines: A One-Compartment Pharmacokinetic Model.
Jahn A, Bodreau C, Farthing K, Elbarbry F
Eur J Drug Metab Pharmacokinet 2018 Aug;43(4):423-430. doi: 10.1007/s13318-018-0462-1. PMID: 29392569
Electronic cigarettes: human health effects.
Callahan-Lyon P
Tob Control 2014 May;23 Suppl 2(Suppl 2):ii36-40. doi: 10.1136/tobaccocontrol-2013-051470. PMID: 24732161Free PMC Article

Diagnosis

Development and Validation of an HPLC-UV Assay to Quantify Plasma Levels of Sulfametrol: A Preferential Antibiotic in Children.
Koch BC, Zabirova SR, van der Nagel BC, Hanff LM
Ther Drug Monit 2015 Oct;37(5):670-4. doi: 10.1097/FTD.0000000000000208. PMID: 25830929
A modified cryopreservation method increases the survival of human biopsied cleavage stage embryos.
Jericho H, Wilton L, Gook DA, Edgar DH
Hum Reprod 2003 Mar;18(3):568-71. doi: 10.1093/humrep/deg106. PMID: 12615826
A biological monitoring study of 1-methoxy-2-propanol: analytical method development and a human volunteer study.
Jones K, Dyne D, Cocker J, Wilson HK
Sci Total Environ 1997 Jun 20;199(1-2):23-30. doi: 10.1016/s0048-9697(97)05478-8. PMID: 9200844
Dietary effects of propylene glycol alginate in humans.
Anderson DM, Brydon WG, Eastwood MA, Sedgwick DM
Food Addit Contam 1991 May-Jun;8(3):225-36. doi: 10.1080/02652039109373973. PMID: 1778262

Therapy

Differential responses to e-cig generated aerosols from humectants and different forms of nicotine in epithelial cells from nonsmokers and smokers.
Escobar YH, Morrison CB, Chen Y, Hickman E, Love CA, Rebuli ME, Surratt JD, Ehre C, Jaspers I
Am J Physiol Lung Cell Mol Physiol 2021 Jun 1;320(6):L1064-L1073. Epub 2021 Apr 7 doi: 10.1152/ajplung.00525.2020. PMID: 33825493Free PMC Article
The Health Risks of Electronic Cigarette Use to Bystanders.
Visser WF, Klerx WN, Cremers HWJM, Ramlal R, Schwillens PL, Talhout R
Int J Environ Res Public Health 2019 Apr 30;16(9) doi: 10.3390/ijerph16091525. PMID: 31052162Free PMC Article
Assessing Propylene Glycol Toxicity in Alcohol Withdrawal Patients Receiving Intravenous Benzodiazepines: A One-Compartment Pharmacokinetic Model.
Jahn A, Bodreau C, Farthing K, Elbarbry F
Eur J Drug Metab Pharmacokinet 2018 Aug;43(4):423-430. doi: 10.1007/s13318-018-0462-1. PMID: 29392569
Nicotine delivery, retention and pharmacokinetics from various electronic cigarettes.
St Helen G, Havel C, Dempsey DA, Jacob P 3rd, Benowitz NL
Addiction 2016 Mar;111(3):535-44. Epub 2015 Nov 11 doi: 10.1111/add.13183. PMID: 26430813Free PMC Article
Electronic cigarettes: human health effects.
Callahan-Lyon P
Tob Control 2014 May;23 Suppl 2(Suppl 2):ii36-40. doi: 10.1136/tobaccocontrol-2013-051470. PMID: 24732161Free PMC Article

Prognosis

Assessing Propylene Glycol Toxicity in Alcohol Withdrawal Patients Receiving Intravenous Benzodiazepines: A One-Compartment Pharmacokinetic Model.
Jahn A, Bodreau C, Farthing K, Elbarbry F
Eur J Drug Metab Pharmacokinet 2018 Aug;43(4):423-430. doi: 10.1007/s13318-018-0462-1. PMID: 29392569
Acute tubular necrosis associated with propylene glycol from concomitant administration of intravenous lorazepam and trimethoprim-sulfamethoxazole.
Hayman M, Seidl EC, Ali M, Malik K
Pharmacotherapy 2003 Sep;23(9):1190-4. doi: 10.1592/phco.23.10.1190.32753. PMID: 14524651

Clinical prediction guides

Toxicity of Propylene Glycol Extract of Propolis on Central Nervous System and Liver in Pregnant and Neonatal Rats.
Silici S, Okan A, Köklü B, Demiray S, Doğanyiğit Z
Z Geburtshilfe Neonatol 2023 Aug;227(4):261-268. Epub 2023 Mar 8 doi: 10.1055/a-2010-4009. PMID: 36889342
Assessing Propylene Glycol Toxicity in Alcohol Withdrawal Patients Receiving Intravenous Benzodiazepines: A One-Compartment Pharmacokinetic Model.
Jahn A, Bodreau C, Farthing K, Elbarbry F
Eur J Drug Metab Pharmacokinet 2018 Aug;43(4):423-430. doi: 10.1007/s13318-018-0462-1. PMID: 29392569
Effect of diazepam on adenosine 3',5'-cyclic monophosphate (cAMP) plasma levels in anesthetized patients.
Carceles MD, Ribó AR, Dávalos R, Martinez T, Hernández J
Clin Ther 2004 May;26(5):737-43. doi: 10.1016/s0149-2918(04)90073-2. PMID: 15220017
Absorption of hydrocortisone from the skin reservoir in atopic dermatitis.
Turpeinen M
Br J Dermatol 1991 Apr;124(4):358-60. doi: 10.1111/j.1365-2133.1991.tb00597.x. PMID: 2025556
Dietary effects of propylene glycol alginate in humans.
Anderson DM, Brydon WG, Eastwood MA, Sedgwick DM
Food Addit Contam 1991 May-Jun;8(3):225-36. doi: 10.1080/02652039109373973. PMID: 1778262

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