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Multifocal hyperintensity of cerebral white matter on MRI

MedGen UID:
1639379
Concept ID:
C4703611
Finding
HPO: HP:0040329

Definition

An abnormal area of increased brightness (hyperintensity) that occurs in several distinct areas. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultifocal hyperintensity of cerebral white matter on MRI

Recent clinical studies

Etiology

McKeon A, Shelly S, Zivelonghi C, Basal E, Dubey D, Flanagan E, Madhavan AA, Mariotto S, Toledano M, Tracy JA, Zekeridou A, Pittock SJ
Ann Clin Transl Neurol 2021 Feb;8(2):425-439. Epub 2020 Dec 28 doi: 10.1002/acn3.51284. PMID: 33369283Free PMC Article
Kremer S, Lersy F, de Sèze J, Ferré JC, Maamar A, Carsin-Nicol B, Collange O, Bonneville F, Adam G, Martin-Blondel G, Rafiq M, Geeraerts T, Delamarre L, Grand S, Krainik A, Caillard S, Constans JM, Metanbou S, Heintz A, Helms J, Schenck M, Lefèbvre N, Boutet C, Fabre X, Forestier G, de Beaurepaire I, Bornet G, Lacalm A, Oesterlé H, Bolognini F, Messié J, Hmeydia G, Benzakoun J, Oppenheim C, Bapst B, Megdiche I, Henry Feugeas MC, Khalil A, Gaudemer A, Jager L, Nesser P, Talla Mba Y, Hemmert C, Feuerstein P, Sebag N, Carré S, Alleg M, Lecocq C, Schmitt E, Anxionnat R, Zhu F, Comby PO, Ricolfi F, Thouant P, Desal H, Boulouis G, Berge J, Kazémi A, Pyatigorskaya N, Lecler A, Saleme S, Edjlali-Goujon M, Kerleroux B, Zorn PE, Matthieu M, Baloglu S, Ardellier FD, Willaume T, Brisset JC, Boulay C, Mutschler V, Hansmann Y, Mertes PM, Schneider F, Fafi-Kremer S, Ohana M, Meziani F, David JS, Meyer N, Anheim M, Cotton F
Radiology 2020 Nov;297(2):E242-E251. Epub 2020 Jun 16 doi: 10.1148/radiol.2020202222. PMID: 32544034Free PMC Article
Patel JB, Wilson SH, Oakes TR, Santhanam P, Weaver LK
AJNR Am J Neuroradiol 2020 Jan;41(1):92-99. Epub 2020 Jan 2 doi: 10.3174/ajnr.A6346. PMID: 31896572Free PMC Article
Xu N, Zhou W, Li S, Zhou G, Zhang N, Liang J
J Neuroimaging 2009 Oct;19(4):326-31. Epub 2009 Jan 29 doi: 10.1111/j.1552-6569.2008.00344.x. PMID: 19187474
Gladstone JP, Dodick DW
Neurologist 2005 Jan;11(1):19-29. doi: 10.1097/01.nrl.0000149973.61810.21. PMID: 15631641

Diagnosis

Adra N, Goodheart AE, Rapalino O, Caruso P, Mukerji SS, González RG, Venna N, Schmahmann JD
AJNR Am J Neuroradiol 2021 Jun;42(6):1073-1079. Epub 2021 May 13 doi: 10.3174/ajnr.A7145. PMID: 33985948Free PMC Article
Mascalchi M, Vella A
Int Rev Neurobiol 2018;143:109-162. Epub 2018 Oct 29 doi: 10.1016/bs.irn.2018.09.011. PMID: 30473193
Weber T
Neurol Clin 2008 Aug;26(3):833-54, x-xi. doi: 10.1016/j.ncl.2008.03.007. PMID: 18657729
Berger JR, Major EO
Semin Neurol 1999;19(2):193-200. doi: 10.1055/s-2008-1040837. PMID: 10718540
Papo T, Biousse V, Lehoang P, Fardeau C, N'Guyen N, Huong DL, Aumaitre O, Bousser MG, Godeau P, Piette JC
Medicine (Baltimore) 1998 Jan;77(1):3-11. doi: 10.1097/00005792-199801000-00002. PMID: 9465860

Therapy

Wang RJ, Chen BD, Qi D
BMC Neurol 2015 Jul 8;15:107. doi: 10.1186/s12883-015-0366-5. PMID: 26152327Free PMC Article
Ekici B, Aydınlı N, Aydın K, Çalışkan M, Eraslan E, Özmen M
Clin Neurol Neurosurg 2013 Oct;115(10):2046-8. Epub 2013 Jul 23 doi: 10.1016/j.clineuro.2013.06.014. PMID: 23891141
Calabrese L
Cleve Clin J Med 2011 Nov;78 Suppl 2:S38-41. doi: 10.3949/ccjm.78.s2.09. PMID: 22123934
Xu N, Zhou W, Li S, Zhou G, Zhang N, Liang J
J Neuroimaging 2009 Oct;19(4):326-31. Epub 2009 Jan 29 doi: 10.1111/j.1552-6569.2008.00344.x. PMID: 19187474
Papo T, Biousse V, Lehoang P, Fardeau C, N'Guyen N, Huong DL, Aumaitre O, Bousser MG, Godeau P, Piette JC
Medicine (Baltimore) 1998 Jan;77(1):3-11. doi: 10.1097/00005792-199801000-00002. PMID: 9465860

Prognosis

Adra N, Goodheart AE, Rapalino O, Caruso P, Mukerji SS, González RG, Venna N, Schmahmann JD
AJNR Am J Neuroradiol 2021 Jun;42(6):1073-1079. Epub 2021 May 13 doi: 10.3174/ajnr.A7145. PMID: 33985948Free PMC Article
Varadan B, Shankar A, Rajakumar A, Subramanian S, Sathya AC, Hakeem AR, Kalyanasundaram S
Neuroradiology 2021 May;63(5):653-661. Epub 2021 Feb 11 doi: 10.1007/s00234-021-02667-1. PMID: 33575849Free PMC Article
Datta G, Colasanti A, Rabiner EA, Gunn RN, Malik O, Ciccarelli O, Nicholas R, Van Vlierberghe E, Van Hecke W, Searle G, Santos-Ribeiro A, Matthews PM
Brain 2017 Nov 1;140(11):2927-2938. doi: 10.1093/brain/awx228. PMID: 29053775
Weber T
Neurol Clin 2008 Aug;26(3):833-54, x-xi. doi: 10.1016/j.ncl.2008.03.007. PMID: 18657729
Papo T, Biousse V, Lehoang P, Fardeau C, N'Guyen N, Huong DL, Aumaitre O, Bousser MG, Godeau P, Piette JC
Medicine (Baltimore) 1998 Jan;77(1):3-11. doi: 10.1097/00005792-199801000-00002. PMID: 9465860

Clinical prediction guides

Adra N, Goodheart AE, Rapalino O, Caruso P, Mukerji SS, González RG, Venna N, Schmahmann JD
AJNR Am J Neuroradiol 2021 Jun;42(6):1073-1079. Epub 2021 May 13 doi: 10.3174/ajnr.A7145. PMID: 33985948Free PMC Article
Kremer S, Lersy F, de Sèze J, Ferré JC, Maamar A, Carsin-Nicol B, Collange O, Bonneville F, Adam G, Martin-Blondel G, Rafiq M, Geeraerts T, Delamarre L, Grand S, Krainik A, Caillard S, Constans JM, Metanbou S, Heintz A, Helms J, Schenck M, Lefèbvre N, Boutet C, Fabre X, Forestier G, de Beaurepaire I, Bornet G, Lacalm A, Oesterlé H, Bolognini F, Messié J, Hmeydia G, Benzakoun J, Oppenheim C, Bapst B, Megdiche I, Henry Feugeas MC, Khalil A, Gaudemer A, Jager L, Nesser P, Talla Mba Y, Hemmert C, Feuerstein P, Sebag N, Carré S, Alleg M, Lecocq C, Schmitt E, Anxionnat R, Zhu F, Comby PO, Ricolfi F, Thouant P, Desal H, Boulouis G, Berge J, Kazémi A, Pyatigorskaya N, Lecler A, Saleme S, Edjlali-Goujon M, Kerleroux B, Zorn PE, Matthieu M, Baloglu S, Ardellier FD, Willaume T, Brisset JC, Boulay C, Mutschler V, Hansmann Y, Mertes PM, Schneider F, Fafi-Kremer S, Ohana M, Meziani F, David JS, Meyer N, Anheim M, Cotton F
Radiology 2020 Nov;297(2):E242-E251. Epub 2020 Jun 16 doi: 10.1148/radiol.2020202222. PMID: 32544034Free PMC Article
Mascalchi M, Vella A
Int Rev Neurobiol 2018;143:109-162. Epub 2018 Oct 29 doi: 10.1016/bs.irn.2018.09.011. PMID: 30473193
Gladstone JP, Dodick DW
Neurologist 2005 Jan;11(1):19-29. doi: 10.1097/01.nrl.0000149973.61810.21. PMID: 15631641
Berger JR, Major EO
Semin Neurol 1999;19(2):193-200. doi: 10.1055/s-2008-1040837. PMID: 10718540

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