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Multifocal hyperintensity of cerebral white matter on MRI

MedGen UID:
1639379
•Concept ID:
C4703611
•
Finding
HPO: HP:0040329

Definition

An abnormal area of increased brightness (hyperintensity) that occurs in several distinct areas. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultifocal hyperintensity of cerebral white matter on MRI

Recent clinical studies

Etiology

Diagnostic Performance of Cortical Lesions and the Central Vein Sign in Multiple Sclerosis.
Cagol A, Cortese R, Barakovic M, Schaedelin S, Ruberte E, Absinta M, Barkhof F, Calabrese M, Castellaro M, Ciccarelli O, Cocozza S, De Stefano N, Enzinger C, Filippi M, Jurynczyk M, Maggi P, Mahmoudi N, Messina S, Montalban X, Palace J, Pontillo G, Pröbstel AK, Rocca MA, Ropele S, Rovira À, Schoonheim MM, Sowa P, Strijbis E, Wattjes MP, Sormani MP, Kappos L, Granziera C; MAGNIMS Study Group
JAMA Neurol 2024 Feb 1;81(2):143-153. doi: 10.1001/jamaneurol.2023.4737. PMID: 38079177Free PMC Article
Neuronal intermediate filament IgGs in CSF: Autoimmune Axonopathy Biomarkers.
McKeon A, Shelly S, Zivelonghi C, Basal E, Dubey D, Flanagan E, Madhavan AA, Mariotto S, Toledano M, Tracy JA, Zekeridou A, Pittock SJ
Ann Clin Transl Neurol 2021 Feb;8(2):425-439. Epub 2020 Dec 28 doi: 10.1002/acn3.51284. PMID: 33369283Free PMC Article
Structural and Volumetric Brain MRI Findings in Mild Traumatic Brain Injury.
Patel JB, Wilson SH, Oakes TR, Santhanam P, Weaver LK
AJNR Am J Neuroradiol 2020 Jan;41(1):92-99. Epub 2020 Jan 2 doi: 10.3174/ajnr.A6346. PMID: 31896572Free PMC Article
Clinical and MRI characteristics of levamisole-induced leukoencephalopathy in 16 patients.
Xu N, Zhou W, Li S, Zhou G, Zhang N, Liang J
J Neuroimaging 2009 Oct;19(4):326-31. Epub 2009 Jan 29 doi: 10.1111/j.1552-6569.2008.00344.x. PMID: 19187474
Migraine and cerebral white matter lesions: when to suspect cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Gladstone JP, Dodick DW
Neurologist 2005 Jan;11(1):19-29. doi: 10.1097/01.nrl.0000149973.61810.21. PMID: 15631641

Diagnosis

Diagnostic Performance of Cortical Lesions and the Central Vein Sign in Multiple Sclerosis.
Cagol A, Cortese R, Barakovic M, Schaedelin S, Ruberte E, Absinta M, Barkhof F, Calabrese M, Castellaro M, Ciccarelli O, Cocozza S, De Stefano N, Enzinger C, Filippi M, Jurynczyk M, Maggi P, Mahmoudi N, Messina S, Montalban X, Palace J, Pontillo G, Pröbstel AK, Rocca MA, Ropele S, Rovira À, Schoonheim MM, Sowa P, Strijbis E, Wattjes MP, Sormani MP, Kappos L, Granziera C; MAGNIMS Study Group
JAMA Neurol 2024 Feb 1;81(2):143-153. doi: 10.1001/jamaneurol.2023.4737. PMID: 38079177Free PMC Article
Neuroimaging Applications in Chronic Ataxias.
Mascalchi M, Vella A
Int Rev Neurobiol 2018;143:109-162. Epub 2018 Oct 29 doi: 10.1016/bs.irn.2018.09.011. PMID: 30473193
Progressive multifocal leukoencephalopathy.
Weber T
Neurol Clin 2008 Aug;26(3):833-54, x-xi. doi: 10.1016/j.ncl.2008.03.007. PMID: 18657729
Progressive multifocal leukoencephalopathy.
Berger JR, Major EO
Semin Neurol 1999;19(2):193-200. doi: 10.1055/s-2008-1040837. PMID: 10718540
Susac syndrome.
Papo T, Biousse V, Lehoang P, Fardeau C, N'Guyen N, Huong DL, Aumaitre O, Bousser MG, Godeau P, Piette JC
Medicine (Baltimore) 1998 Jan;77(1):3-11. doi: 10.1097/00005792-199801000-00002. PMID: 9465860

Therapy

Diagnostic Performance of Cortical Lesions and the Central Vein Sign in Multiple Sclerosis.
Cagol A, Cortese R, Barakovic M, Schaedelin S, Ruberte E, Absinta M, Barkhof F, Calabrese M, Castellaro M, Ciccarelli O, Cocozza S, De Stefano N, Enzinger C, Filippi M, Jurynczyk M, Maggi P, Mahmoudi N, Messina S, Montalban X, Palace J, Pontillo G, Pröbstel AK, Rocca MA, Ropele S, Rovira À, Schoonheim MM, Sowa P, Strijbis E, Wattjes MP, Sormani MP, Kappos L, Granziera C; MAGNIMS Study Group
JAMA Neurol 2024 Feb 1;81(2):143-153. doi: 10.1001/jamaneurol.2023.4737. PMID: 38079177Free PMC Article
The black swan: a case of central nervous system graft-versus-host disease.
Butera S, Tavarozzi R, Brunello L, Rivela P, Sofia A, Viero L, Salvio M, Ladetto M, Zallio F
J Basic Clin Physiol Pharmacol 2023 Nov 1;34(6):805-809. Epub 2023 Oct 17 doi: 10.1515/jbcpp-2023-0194. PMID: 37843253
A rational approach to PML for the clinician.
Calabrese L
Cleve Clin J Med 2011 Nov;78 Suppl 2:S38-41. doi: 10.3949/ccjm.78.s2.09. PMID: 22123934
Clinical and MRI characteristics of levamisole-induced leukoencephalopathy in 16 patients.
Xu N, Zhou W, Li S, Zhou G, Zhang N, Liang J
J Neuroimaging 2009 Oct;19(4):326-31. Epub 2009 Jan 29 doi: 10.1111/j.1552-6569.2008.00344.x. PMID: 19187474
Susac syndrome.
Papo T, Biousse V, Lehoang P, Fardeau C, N'Guyen N, Huong DL, Aumaitre O, Bousser MG, Godeau P, Piette JC
Medicine (Baltimore) 1998 Jan;77(1):3-11. doi: 10.1097/00005792-199801000-00002. PMID: 9465860

Prognosis

MRI Shrimp Sign in Cerebellar Progressive Multifocal Leukoencephalopathy: Description and Validation of a Novel Observation.
Adra N, Goodheart AE, Rapalino O, Caruso P, Mukerji SS, González RG, Venna N, Schmahmann JD
AJNR Am J Neuroradiol 2021 Jun;42(6):1073-1079. Epub 2021 May 13 doi: 10.3174/ajnr.A7145. PMID: 33985948Free PMC Article
Structural and Volumetric Brain MRI Findings in Mild Traumatic Brain Injury.
Patel JB, Wilson SH, Oakes TR, Santhanam P, Weaver LK
AJNR Am J Neuroradiol 2020 Jan;41(1):92-99. Epub 2020 Jan 2 doi: 10.3174/ajnr.A6346. PMID: 31896572Free PMC Article
A rational approach to PML for the clinician.
Calabrese L
Cleve Clin J Med 2011 Nov;78 Suppl 2:S38-41. doi: 10.3949/ccjm.78.s2.09. PMID: 22123934
Progressive multifocal leukoencephalopathy.
Weber T
Neurol Clin 2008 Aug;26(3):833-54, x-xi. doi: 10.1016/j.ncl.2008.03.007. PMID: 18657729
Susac syndrome.
Papo T, Biousse V, Lehoang P, Fardeau C, N'Guyen N, Huong DL, Aumaitre O, Bousser MG, Godeau P, Piette JC
Medicine (Baltimore) 1998 Jan;77(1):3-11. doi: 10.1097/00005792-199801000-00002. PMID: 9465860

Clinical prediction guides

MRI Shrimp Sign in Cerebellar Progressive Multifocal Leukoencephalopathy: Description and Validation of a Novel Observation.
Adra N, Goodheart AE, Rapalino O, Caruso P, Mukerji SS, González RG, Venna N, Schmahmann JD
AJNR Am J Neuroradiol 2021 Jun;42(6):1073-1079. Epub 2021 May 13 doi: 10.3174/ajnr.A7145. PMID: 33985948Free PMC Article
Structural and Volumetric Brain MRI Findings in Mild Traumatic Brain Injury.
Patel JB, Wilson SH, Oakes TR, Santhanam P, Weaver LK
AJNR Am J Neuroradiol 2020 Jan;41(1):92-99. Epub 2020 Jan 2 doi: 10.3174/ajnr.A6346. PMID: 31896572Free PMC Article
Neuroimaging Applications in Chronic Ataxias.
Mascalchi M, Vella A
Int Rev Neurobiol 2018;143:109-162. Epub 2018 Oct 29 doi: 10.1016/bs.irn.2018.09.011. PMID: 30473193
Migraine and cerebral white matter lesions: when to suspect cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Gladstone JP, Dodick DW
Neurologist 2005 Jan;11(1):19-29. doi: 10.1097/01.nrl.0000149973.61810.21. PMID: 15631641
Progressive multifocal leukoencephalopathy.
Berger JR, Major EO
Semin Neurol 1999;19(2):193-200. doi: 10.1055/s-2008-1040837. PMID: 10718540

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