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Progressive Ependymoma

MedGen UID:
1639898
•Concept ID:
C4687712
•
Neoplastic Process

Definition

Ependymoma that is increasing in scope or severity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProgressive Ependymoma

Professional guidelines

PubMed

Childhood brain tumors: current management, biological insights, and future directions.
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article
Diagnosis, Management, and New Therapeutic Options in Childhood Neurofibromatosis Type 2 and Related Forms.
Ruggieri M, Praticò AD, Evans DG
Semin Pediatr Neurol 2015 Dec;22(4):240-58. Epub 2015 Oct 28 doi: 10.1016/j.spen.2015.10.008. PMID: 26706012
Current Management and Treatment Modalities for Intramedullary Spinal Cord Tumors.
Juthani RG, Bilsky MH, Vogelbaum MA
Curr Treat Options Oncol 2015 Aug;16(8):39. doi: 10.1007/s11864-015-0358-0. PMID: 26143269

Recent clinical studies

Etiology

A phase II study of dose-dense temozolomide and lapatinib for recurrent low-grade and anaplastic supratentorial, infratentorial, and spinal cord ependymoma.
Gilbert MR, Yuan Y, Wu J, Mendoza T, Vera E, Omuro A, Lieberman F, Robins HI, Gerstner ER, Wu J, Wen PY, Mikkelsen T, Aldape K, Armstrong TS
Neuro Oncol 2021 Mar 25;23(3):468-477. doi: 10.1093/neuonc/noaa240. PMID: 33085768Free PMC Article
Extent of re-excision, sequence/timing of salvage re-irradiation, and disease-free interval impact upon clinical outcomes in recurrent/progressive ependymoma.
Gupta T, Maitre M, Gupta P, Krishnatry R, Chatterjee A, Moiyadi A, Shetty P, Singh V, Chinnaswamy G, Epari S, Sahay A, Patil V, GodaSastri J
J Neurooncol 2020 Apr;147(2):405-415. Epub 2020 Feb 18 doi: 10.1007/s11060-020-03434-7. PMID: 32072441
Leksell Radiosurgery for Ependymomas and Oligodendrogliomas.
Kano H, Lunsford LD
Prog Neurol Surg 2019;34:200-206. Epub 2019 May 16 doi: 10.1159/000493065. PMID: 31096227

Diagnosis

Extent of re-excision, sequence/timing of salvage re-irradiation, and disease-free interval impact upon clinical outcomes in recurrent/progressive ependymoma.
Gupta T, Maitre M, Gupta P, Krishnatry R, Chatterjee A, Moiyadi A, Shetty P, Singh V, Chinnaswamy G, Epari S, Sahay A, Patil V, GodaSastri J
J Neurooncol 2020 Apr;147(2):405-415. Epub 2020 Feb 18 doi: 10.1007/s11060-020-03434-7. PMID: 32072441
Leksell Radiosurgery for Ependymomas and Oligodendrogliomas.
Kano H, Lunsford LD
Prog Neurol Surg 2019;34:200-206. Epub 2019 May 16 doi: 10.1159/000493065. PMID: 31096227
mTORC1 activation in childhood ependymoma and response to sirolimus.
Bowers DC, Kucejova B, Margraf L, Gargan L, Brugarolas J
J Neurooncol 2011 Jul;103(3):797-801. Epub 2010 Nov 13 doi: 10.1007/s11060-010-0455-7. PMID: 21076853

Therapy

A phase II study of dose-dense temozolomide and lapatinib for recurrent low-grade and anaplastic supratentorial, infratentorial, and spinal cord ependymoma.
Gilbert MR, Yuan Y, Wu J, Mendoza T, Vera E, Omuro A, Lieberman F, Robins HI, Gerstner ER, Wu J, Wen PY, Mikkelsen T, Aldape K, Armstrong TS
Neuro Oncol 2021 Mar 25;23(3):468-477. doi: 10.1093/neuonc/noaa240. PMID: 33085768Free PMC Article
mTORC1 activation in childhood ependymoma and response to sirolimus.
Bowers DC, Kucejova B, Margraf L, Gargan L, Brugarolas J
J Neurooncol 2011 Jul;103(3):797-801. Epub 2010 Nov 13 doi: 10.1007/s11060-010-0455-7. PMID: 21076853

Prognosis

Extent of re-excision, sequence/timing of salvage re-irradiation, and disease-free interval impact upon clinical outcomes in recurrent/progressive ependymoma.
Gupta T, Maitre M, Gupta P, Krishnatry R, Chatterjee A, Moiyadi A, Shetty P, Singh V, Chinnaswamy G, Epari S, Sahay A, Patil V, GodaSastri J
J Neurooncol 2020 Apr;147(2):405-415. Epub 2020 Feb 18 doi: 10.1007/s11060-020-03434-7. PMID: 32072441
Leksell Radiosurgery for Ependymomas and Oligodendrogliomas.
Kano H, Lunsford LD
Prog Neurol Surg 2019;34:200-206. Epub 2019 May 16 doi: 10.1159/000493065. PMID: 31096227
mTORC1 activation in childhood ependymoma and response to sirolimus.
Bowers DC, Kucejova B, Margraf L, Gargan L, Brugarolas J
J Neurooncol 2011 Jul;103(3):797-801. Epub 2010 Nov 13 doi: 10.1007/s11060-010-0455-7. PMID: 21076853
Stepwise accumulation of distinct genomic aberrations in a patient with progressively metastasizing ependymoma.
Milde T, Pfister S, Korshunov A, Deubzer HE, Oehme I, Ernst A, Starzinski-Powitz A, Seitz A, Lichter P, von Deimling A, Witt O
Genes Chromosomes Cancer 2009 Mar;48(3):229-38. doi: 10.1002/gcc.20635. PMID: 19025795

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