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Side Effect

MedGen UID:: 163994
•Concept ID:: C0879626
•: Pathologic Function

Definition

The term was used in various ways in the past, to describe unintended effects of medical intervention, usually negative (unfavourable), but also positive (favourable) ones. It is recommended that this term no longer be used and particularly should not be regarded as synonymous with adverse event or adverse reaction. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSide Effect

Pathological Conditions, Signs and Symptoms
- Clinical finding
  - Finding by Cause
    - Side Effect

Professional guidelines

PubMed

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants.

Bousman CA, Stevenson JM, Ramsey LB, Sangkuhl K, Hicks JK, Strawn JR, Singh AB, Ruaño G, Mueller DJ, Tsermpini EE, Brown JT, Bell GC, Leeder JS, Gaedigk A, Scott SA, Klein TE, Caudle KE, Bishop JR
Clin Pharmacol Ther 2023 Jul;114(1):51-68. Epub 2023 May 30 doi: 10.1002/cpt.2903. PMID: 37032427 Free PMC Article

Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders.

Katzman MA, Bleau P, Blier P, Chokka P, Kjernisted K, Van Ameringen M; Canadian Anxiety Guidelines Initiative Group on behalf of the Anxiety Disorders Association of Canada/Association Canadienne des troubles anxieux and McGill University, Antony MM, Bouchard S, Brunet A, Flament M, Grigoriadis S, Mendlowitz S, O'Connor K, Rabheru K, Richter PM, Robichaud M, Walker JR
BMC Psychiatry 2014;14 Suppl 1(Suppl 1):S1. Epub 2014 Jul 2 doi: 10.1186/1471-244X-14-S1-S1. PMID: 25081580 Free PMC Article

Infusion reactions: diagnosis, assessment, and management.

Vogel WH
Clin J Oncol Nurs 2010 Apr;14(2):E10-21. doi: 10.1188/10.CJON.E10-E21. PMID: 20350882

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Recent clinical studies

Etiology

Antidepressant and antipsychotic side-effects and personalised prescribing: a systematic review and digital tool development.

Pillinger T, Howes OD, Correll CU, Leucht S, Huhn M, Schneider-Thoma J, Gaughran F, Jauhar S, McGuire PK, Taylor DM, Young AH, McCutcheon RA
Lancet Psychiatry 2023 Nov;10(11):860-876. Epub 2023 Sep 26 doi: 10.1016/S2215-0366(23)00262-6. PMID: 37774723 Free PMC Article

Adverse Events and Androgen Receptor Signaling Inhibitors in the Treatment of Prostate Cancer: A Systematic Review and Multivariate Network Meta-analysis.

Cao B, Kim M, Reizine NM, Moreira DM
Eur Urol Oncol 2023 Jun;6(3):237-250. Epub 2023 Jan 20 doi: 10.1016/j.euo.2023.01.001. PMID: 36682938

Pharmacological Management of Insomnia.

Madari S, Golebiowski R, Mansukhani MP, Kolla BP
Neurotherapeutics 2021 Jan;18(1):44-52. Epub 2021 Feb 1 doi: 10.1007/s13311-021-01010-z. PMID: 33527255 Free PMC Article

Antiepileptic Drug Treatment of Epilepsy in Children.

Moosa ANV
Continuum (Minneap Minn) 2019 Apr;25(2):381-407. doi: 10.1212/CON.0000000000000712. PMID: 30921015

Are Probiotic Really Safe for Humans?

Zawistowska-Rojek A, Tyski S
Pol J Microbiol 2018;67(3):251-258. doi: 10.21307/pjm-2018-044. PMID: 30451441 Free PMC Article

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Diagnosis

Adverse Events and Androgen Receptor Signaling Inhibitors in the Treatment of Prostate Cancer: A Systematic Review and Multivariate Network Meta-analysis.

Cao B, Kim M, Reizine NM, Moreira DM
Eur Urol Oncol 2023 Jun;6(3):237-250. Epub 2023 Jan 20 doi: 10.1016/j.euo.2023.01.001. PMID: 36682938

Melasma.

Doolan BJ, Gupta M
Aust J Gen Pract 2021 Dec;50(12):880-885. doi: 10.31128/AJGP-05-21-6002. PMID: 34845463

Approach to the adult patient with chronic diarrhea: A literature review.

Gómez-Escudero O, Remes-Troche JM
Rev Gastroenterol Mex (Engl Ed) 2021 Oct-Dec;86(4):387-402. Epub 2021 Aug 11 doi: 10.1016/j.rgmxen.2021.08.007. PMID: 34389290

Side Effect Profiles of Selective Serotonin Reuptake Inhibitors: A Cross-Sectional Study in a Naturalistic Setting.

Anagha K, Shihabudheen P, Uvais NA
Prim Care Companion CNS Disord 2021 Jul 29;23(4) doi: 10.4088/PCC.20m02747. PMID: 34324797

Ocular surface squamous neoplasia: management and outcomes.

Hӧllhumer R, Williams S, Michelow P
Eye (Lond) 2021 Jun;35(6):1562-1573. Epub 2021 Feb 9 doi: 10.1038/s41433-021-01422-3. PMID: 33564137 Free PMC Article

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Therapy

New and emerging treatments for schizophrenia: a narrative review of their pharmacology, efficacy and side effect profile relative to established antipsychotics.

Lobo MC, Whitehurst TS, Kaar SJ, Howes OD
Neurosci Biobehav Rev 2022 Jan;132:324-361. Epub 2021 Nov 24 doi: 10.1016/j.neubiorev.2021.11.032. PMID: 34838528

Comparative effects of furosemide and other diuretics in the treatment of heart failure: a systematic review and combined meta-analysis of randomized controlled trials.

Eid PS, Ibrahim DA, Zayan AH, Elrahman MMA, Shehata MAA, Kandil H, Abouibrahim MA, Duy LM, Shinkar A, Elfaituri MK, Minh LHN, Fahmy MM, Tam DNH, Vuong NL, Shah J, Do VBD, Hirayama K, Huy NT
Heart Fail Rev 2021 Jan;26(1):127-136. doi: 10.1007/s10741-020-10003-7. PMID: 32783109

A Comparative Effectiveness Meta-Analysis of Drugs for the Prophylaxis of Migraine Headache.

Jackson JL, Cogbill E, Santana-Davila R, Eldredge C, Collier W, Gradall A, Sehgal N, Kuester J
PLoS One 2015;10(7):e0130733. Epub 2015 Jul 14 doi: 10.1371/journal.pone.0130733. PMID: 26172390 Free PMC Article

Saline nasal irrigation for acute upper respiratory tract infections.

King D, Mitchell B, Williams CP, Spurling GK
Cochrane Database Syst Rev 2015 Apr 20;2015(4):CD006821. doi: 10.1002/14651858.CD006821.pub3. PMID: 25892369 Free PMC Article

Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS).

CONSENSUS Trial Study Group
N Engl J Med 1987 Jun 4;316(23):1429-35. doi: 10.1056/NEJM198706043162301. PMID: 2883575

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Prognosis

Systematic review of low-dose isotretinoin for treatment of acne vulgaris: Focus on indication, dosage, regimen, efficacy, safety, satisfaction, and follow up, based on clinical studies.

Sadeghzadeh-Bazargan A, Ghassemi M, Goodarzi A, Roohaninasab M, Najar Nobari N, Behrangi E
Dermatol Ther 2021 Jan;34(1):e14438. Epub 2020 Dec 6 doi: 10.1111/dth.14438. PMID: 33085149

European S2k Guideline on Chronic Pruritus.

Weisshaar E, Szepietowski JC, Dalgard FJ, Garcovich S, Gieler U, Giménez-Arnau AM, Lambert J, Leslie T, Mettang T, Misery L, Şavk E, Streit M, Tschachler E, Wallengren J, Ständer S
Acta Derm Venereol 2019 Apr 1;99(5):469-506. doi: 10.2340/00015555-3164. PMID: 30931482

Neuroleptic Malignant Syndrome: A Review from a Clinically Oriented Perspective.

Tse L, Barr AM, Scarapicchia V, Vila-Rodriguez F
Curr Neuropharmacol 2015;13(3):395-406. doi: 10.2174/1570159x13999150424113345. PMID: 26411967 Free PMC Article

Drug-induced pancreatitis.

Nitsche C, Maertin S, Scheiber J, Ritter CA, Lerch MM, Mayerle J
Curr Gastroenterol Rep 2012 Apr;14(2):131-8. doi: 10.1007/s11894-012-0245-9. PMID: 22314811

Chemotherapy-induced hair loss.

Trüeb RM
Skin Therapy Lett 2010 Jul-Aug;15(7):5-7. PMID: 20700552

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Clinical prediction guides

CMR findings after COVID-19 and after COVID-19-vaccination-same but different?

Doeblin P, Jahnke C, Schneider M, Al-Tabatabaee S, Goetze C, Weiss KJ, Tanacli R, Faragli A, Witt U, Stehning C, Seidel F, Elsanhoury A, Kühne T, Tschöpe C, Pieske B, Kelle S
Int J Cardiovasc Imaging 2022 Sep;38(9):2057-2071. Epub 2022 May 12 doi: 10.1007/s10554-022-02623-x. PMID: 37726611 Free PMC Article

European S2k Guideline on Chronic Pruritus.

Drug-induced hair colour changes.

Ricci F, De Simone C, Del Regno L, Peris K
Eur J Dermatol 2016 Dec 1;26(6):531-536. doi: 10.1684/ejd.2016.2844. PMID: 27545142

Haloperidol, risperidone, olanzapine and aripiprazole in the management of delirium: A comparison of efficacy, safety, and side effects.

Boettger S, Jenewein J, Breitbart W
Palliat Support Care 2015 Aug;13(4):1079-85. Epub 2014 Sep 5 doi: 10.1017/S1478951514001059. PMID: 25191793

Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives.

Fontana RJ
Gastroenterology 2014 Apr;146(4):914-28. Epub 2013 Dec 31 doi: 10.1053/j.gastro.2013.12.032. PMID: 24389305 Free PMC Article

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Recent systematic reviews

Comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults: a systematic review and network meta-analysis.

Yildiz A, Siafis S, Mavridis D, Vieta E, Leucht S
Lancet Psychiatry 2023 Sep;10(9):693-705. doi: 10.1016/S2215-0366(23)00199-2. PMID: 37595997

Impact of physical exercise in advanced-stage cancer patients: Systematic review and meta-analysis.

Rodríguez-Cañamero S, Cobo-Cuenca AI, Carmona-Torres JM, Pozuelo-Carrascosa DP, Santacruz-Salas E, Rabanales-Sotos JA, Cuesta-Mateos T, Laredo-Aguilera JA
Cancer Med 2022 Oct;11(19):3714-3727. Epub 2022 Apr 11 doi: 10.1002/cam4.4746. PMID: 35411694 Free PMC Article

Current application of mesotherapy in pattern hair loss: A systematic review.

Tang Z, Hu Y, Wang J, Fan Z, Qu Q, Miao Y
J Cosmet Dermatol 2022 Oct;21(10):4184-4193. Epub 2022 Mar 14 doi: 10.1111/jocd.14900. PMID: 35253335

Safety and side effects of apple vinegar intake and its effect on metabolic parameters and body weight: a systematic review.

Launholt TL, Kristiansen CB, Hjorth P
Eur J Nutr 2020 Sep;59(6):2273-2289. Epub 2020 Mar 13 doi: 10.1007/s00394-020-02214-3. PMID: 32170375

Mortazavi H, Shafiei S, Sadr S, Safiaghdam H
Oral Health Prev Dent 2018;16(6):499-507. doi: 10.3290/j.ohpd.a41655. PMID: 30574604

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MedGen

National Center for Biotechnology Information