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Abnormal HDL cholesterol concentration

MedGen UID:
1640068
•Concept ID:
C4703600
•
Finding
HPO: HP:0031888

Definition

Any deviation from the normal concentration of high-density lipoprotein cholesterol (HDL) in the blood. [from HPO]

Professional guidelines

PubMed

Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine.
Nordestgaard BG, Langsted A, Mora S, Kolovou G, Baum H, Bruckert E, Watts GF, Sypniewska G, Wiklund O, Borén J, Chapman MJ, Cobbaert C, Descamps OS, von Eckardstein A, Kamstrup PR, Pulkki K, Kronenberg F, Remaley AT, Rifai N, Ros E, Langlois M; European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) joint consensus initiative
Eur Heart J 2016 Jul 1;37(25):1944-58. Epub 2016 Apr 26 doi: 10.1093/eurheartj/ehw152. PMID: 27122601Free PMC Article
Treatment approaches for diabetes and dyslipidemia.
Wu M, Lyons TJ
Horm Res Paediatr 2011;76 Suppl 1(Suppl 1):76-80. Epub 2011 Jul 21 doi: 10.1159/000329180. PMID: 21778754Free PMC Article
Fenofibrate: treatment of hyperlipidemia and beyond.
Rosenson RS
Expert Rev Cardiovasc Ther 2008 Nov;6(10):1319-30. doi: 10.1586/14779072.6.10.1319. PMID: 19018684

Recent clinical studies

Etiology

Sport as Medicine for Dyslipidemia (and Other Risk Factors).
Mosteoru S, Gaiţă L, Gaiţă D
Curr Atheroscler Rep 2023 Sep;25(9):613-617. Epub 2023 Aug 7 doi: 10.1007/s11883-023-01133-y. PMID: 37548846
Pathophysiology of Diabetic Dyslipidemia.
Hirano T
J Atheroscler Thromb 2018 Sep 1;25(9):771-782. Epub 2018 Jul 12 doi: 10.5551/jat.RV17023. PMID: 29998913Free PMC Article
HDL functionality in type 1 diabetes.
Ganjali S, Dallinga-Thie GM, Simental-Mendía LE, Banach M, Pirro M, Sahebkar A
Atherosclerosis 2017 Dec;267:99-109. Epub 2017 Oct 21 doi: 10.1016/j.atherosclerosis.2017.10.018. PMID: 29102899
Could high-density lipoprotein cholesterol predict increased cardiovascular risk?
Chang TI, Streja E, Moradi H
Curr Opin Endocrinol Diabetes Obes 2017 Apr;24(2):140-147. doi: 10.1097/MED.0000000000000318. PMID: 28099207
Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine.
Nordestgaard BG, Langsted A, Mora S, Kolovou G, Baum H, Bruckert E, Watts GF, Sypniewska G, Wiklund O, Borén J, Chapman MJ, Cobbaert C, Descamps OS, von Eckardstein A, Kamstrup PR, Pulkki K, Kronenberg F, Remaley AT, Rifai N, Ros E, Langlois M; European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) joint consensus initiative
Eur Heart J 2016 Jul 1;37(25):1944-58. Epub 2016 Apr 26 doi: 10.1093/eurheartj/ehw152. PMID: 27122601Free PMC Article

Diagnosis

Sport as Medicine for Dyslipidemia (and Other Risk Factors).
Mosteoru S, Gaiţă L, Gaiţă D
Curr Atheroscler Rep 2023 Sep;25(9):613-617. Epub 2023 Aug 7 doi: 10.1007/s11883-023-01133-y. PMID: 37548846
PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Growth, body composition, and cardiovascular and nutritional risk of 5- to 10-y-old children consuming vegetarian, vegan, or omnivore diets.
Desmond MA, Sobiecki JG, Jaworski M, Płudowski P, Antoniewicz J, Shirley MK, Eaton S, Książyk J, Cortina-Borja M, De Stavola B, Fewtrell M, Wells JCK
Am J Clin Nutr 2021 Jun 1;113(6):1565-1577. doi: 10.1093/ajcn/nqaa445. PMID: 33740036Free PMC Article
Could high-density lipoprotein cholesterol predict increased cardiovascular risk?
Chang TI, Streja E, Moradi H
Curr Opin Endocrinol Diabetes Obes 2017 Apr;24(2):140-147. doi: 10.1097/MED.0000000000000318. PMID: 28099207
The Evidence for Saturated Fat and for Sugar Related to Coronary Heart Disease.
DiNicolantonio JJ, Lucan SC, O'Keefe JH
Prog Cardiovasc Dis 2016 Mar-Apr;58(5):464-72. Epub 2015 Nov 14 doi: 10.1016/j.pcad.2015.11.006. PMID: 26586275Free PMC Article

Therapy

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Current and future therapies for addressing the effects of inflammation on HDL cholesterol metabolism.
Iqbal F, Baker WS, Khan MI, Thukuntla S, McKinney KH, Abate N, Tuvdendorj D
Br J Pharmacol 2017 Nov;174(22):3986-4006. Epub 2017 Mar 23 doi: 10.1111/bph.13743. PMID: 28326542Free PMC Article
Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine.
Nordestgaard BG, Langsted A, Mora S, Kolovou G, Baum H, Bruckert E, Watts GF, Sypniewska G, Wiklund O, Borén J, Chapman MJ, Cobbaert C, Descamps OS, von Eckardstein A, Kamstrup PR, Pulkki K, Kronenberg F, Remaley AT, Rifai N, Ros E, Langlois M; European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) joint consensus initiative
Eur Heart J 2016 Jul 1;37(25):1944-58. Epub 2016 Apr 26 doi: 10.1093/eurheartj/ehw152. PMID: 27122601Free PMC Article
The Evidence for Saturated Fat and for Sugar Related to Coronary Heart Disease.
DiNicolantonio JJ, Lucan SC, O'Keefe JH
Prog Cardiovasc Dis 2016 Mar-Apr;58(5):464-72. Epub 2015 Nov 14 doi: 10.1016/j.pcad.2015.11.006. PMID: 26586275Free PMC Article
The Role of Dietary Cholesterol in Lipoprotein Metabolism and Related Metabolic Abnormalities: A Mini-review.
Kapourchali FR, Surendiran G, Goulet A, Moghadasian MH
Crit Rev Food Sci Nutr 2016 Oct 25;56(14):2408-15. doi: 10.1080/10408398.2013.842887. PMID: 26055276

Prognosis

High-Density Lipoproteins and the Kidney.
Strazzella A, Ossoli A, Calabresi L
Cells 2021 Mar 31;10(4) doi: 10.3390/cells10040764. PMID: 33807271Free PMC Article
Pathophysiology of Diabetic Dyslipidemia.
Hirano T
J Atheroscler Thromb 2018 Sep 1;25(9):771-782. Epub 2018 Jul 12 doi: 10.5551/jat.RV17023. PMID: 29998913Free PMC Article
Could high-density lipoprotein cholesterol predict increased cardiovascular risk?
Chang TI, Streja E, Moradi H
Curr Opin Endocrinol Diabetes Obes 2017 Apr;24(2):140-147. doi: 10.1097/MED.0000000000000318. PMID: 28099207
Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine.
Nordestgaard BG, Langsted A, Mora S, Kolovou G, Baum H, Bruckert E, Watts GF, Sypniewska G, Wiklund O, Borén J, Chapman MJ, Cobbaert C, Descamps OS, von Eckardstein A, Kamstrup PR, Pulkki K, Kronenberg F, Remaley AT, Rifai N, Ros E, Langlois M; European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) joint consensus initiative
Eur Heart J 2016 Jul 1;37(25):1944-58. Epub 2016 Apr 26 doi: 10.1093/eurheartj/ehw152. PMID: 27122601Free PMC Article
The Evidence for Saturated Fat and for Sugar Related to Coronary Heart Disease.
DiNicolantonio JJ, Lucan SC, O'Keefe JH
Prog Cardiovasc Dis 2016 Mar-Apr;58(5):464-72. Epub 2015 Nov 14 doi: 10.1016/j.pcad.2015.11.006. PMID: 26586275Free PMC Article

Clinical prediction guides

The association between tooth loss and cognitive decline in the aged population: The mediating role of HDL-cholesterol.
Chen HM, Li KY, Li TL, Kwong E, Wong GHY, McGrath C, Chen H
J Dent 2023 Aug;135:104570. Epub 2023 May 30 doi: 10.1016/j.jdent.2023.104570. PMID: 37263408
High-Density Lipoproteins and the Kidney.
Strazzella A, Ossoli A, Calabresi L
Cells 2021 Mar 31;10(4) doi: 10.3390/cells10040764. PMID: 33807271Free PMC Article
Pathophysiology of Diabetic Dyslipidemia.
Hirano T
J Atheroscler Thromb 2018 Sep 1;25(9):771-782. Epub 2018 Jul 12 doi: 10.5551/jat.RV17023. PMID: 29998913Free PMC Article
Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine.
Nordestgaard BG, Langsted A, Mora S, Kolovou G, Baum H, Bruckert E, Watts GF, Sypniewska G, Wiklund O, Borén J, Chapman MJ, Cobbaert C, Descamps OS, von Eckardstein A, Kamstrup PR, Pulkki K, Kronenberg F, Remaley AT, Rifai N, Ros E, Langlois M; European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) joint consensus initiative
Eur Heart J 2016 Jul 1;37(25):1944-58. Epub 2016 Apr 26 doi: 10.1093/eurheartj/ehw152. PMID: 27122601Free PMC Article
The Evidence for Saturated Fat and for Sugar Related to Coronary Heart Disease.
DiNicolantonio JJ, Lucan SC, O'Keefe JH
Prog Cardiovasc Dis 2016 Mar-Apr;58(5):464-72. Epub 2015 Nov 14 doi: 10.1016/j.pcad.2015.11.006. PMID: 26586275Free PMC Article

Recent systematic reviews

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
The impact of Emblica Officinalis (Amla) on lipid profile, glucose, and C-reactive protein: A systematic review and meta-analysis of randomized controlled trials.
Setayesh L, Haghighat N, Rasaei N, Rezaei M, Casazza K, Nadery M, Yamrali I, Zamani M, Asbaghi O
Diabetes Metab Syndr 2023 Mar;17(3):102729. Epub 2023 Mar 11 doi: 10.1016/j.dsx.2023.102729. PMID: 36934568
The effects of phytosterol and phytostanol supplementation on the lipid profile in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials.
Xia W, Xiang S, Gaman MA, Jamilian P, Prabahar K, Du G, Gao D
Phytother Res 2022 Dec;36(12):4398-4408. Epub 2022 Sep 30 doi: 10.1002/ptr.7646. PMID: 36180973
Effect of inulin-type fructans on blood lipid profile and glucose level: a systematic review and meta-analysis of randomized controlled trials.
Liu F, Prabhakar M, Ju J, Long H, Zhou HW
Eur J Clin Nutr 2017 Jan;71(1):9-20. Epub 2016 Sep 14 doi: 10.1038/ejcn.2016.156. PMID: 27623982
Lipid levels in polycystic ovary syndrome: systematic review and meta-analysis.
Wild RA, Rizzo M, Clifton S, Carmina E
Fertil Steril 2011 Mar 1;95(3):1073-9.e1-11. Epub 2011 Jan 17 doi: 10.1016/j.fertnstert.2010.12.027. PMID: 21247558

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