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Impaired nasal mucociliary clearance

MedGen UID:
1640666
Concept ID:
C4703436
Finding
Synonym: Abnormal saccharine test
 
HPO: HP:0031603

Definition

An abnormally increased amount of time required to clear mucus (and substances contained in the mucus) from the nasal mucosa. The nasal mucociliary clearance (NMC) system functions to transport the mucous layer lining the nasal epithelium towards the naso pharynx by ciliary beating in a metachronous fashion at a frequency of 7-16 Hz. NMC depends upon two principal components [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpaired nasal mucociliary clearance

Conditions with this feature

Ciliary dyskinesia, primary, 41
MedGen UID:
1680404
Concept ID:
C5193103
Disease or Syndrome
Ciliary dyskinesia-41 (CILD41) is an autosomal recessive disorder characterized by chronic sinusitis, otitis media, and bronchiectasis (Bustamante-Marin et al., 2019). For a phenotypic description and a discussion of genetic heterogeneity of primary ciliary dyskinesia, see CILD1 (244400).

Professional guidelines

PubMed

Huang ZQ, Liu J, Sun LY, Ong HH, Ye J, Xu Y, Wang DY
Allergy 2024 May;79(5):1146-1165. Epub 2024 Feb 19 doi: 10.1111/all.16064. PMID: 38372149
Alanin MC
Dan Med J 2017 May;64(5) PMID: 28552099
Lie H, Ferkol T
Drugs 2007;67(13):1883-92. doi: 10.2165/00003495-200767130-00006. PMID: 17722956

Recent clinical studies

Etiology

Cavalcante de Sá M, Nakagawa NK, Saldiva de André CD, Carvalho-Oliveira R, de Santana Carvalho T, Nicola ML, de André PA, Nascimento Saldiva PH, Vaisberg M
J Breath Res 2016 Dec 21;10(4):046018. doi: 10.1088/1752-7163/10/4/046018. PMID: 28000620
Utiyama DM, Yoshida CT, Goto DM, de Santana Carvalho T, de Paula Santos U, Koczulla AR, Saldiva PH, Nakagawa NK
Clinics (Sao Paulo) 2016 Jul;71(6):344-50. doi: 10.6061/clinics/2016(06)10. PMID: 27438569Free PMC Article
Ramos EM, De Toledo AC, Xavier RF, Fosco LC, Vieira RP, Ramos D, Jardim JR
Respirology 2011 Jul;16(5):849-55. doi: 10.1111/j.1440-1843.2011.01985.x. PMID: 21545372
Müns G, Singer P, Wolf F, Rubinstein I
Int J Sports Med 1995 May;16(4):209-13. doi: 10.1055/s-2007-972993. PMID: 7657412

Diagnosis

Bashi S, Khan MA, Guirjis A, Joharjy IA, Abid MA
Br J Dis Chest 1988 Apr;82(2):194-6. doi: 10.1016/0007-0971(88)90043-5. PMID: 3048367

Therapy

Cavalcante de Sá M, Nakagawa NK, Saldiva de André CD, Carvalho-Oliveira R, de Santana Carvalho T, Nicola ML, de André PA, Nascimento Saldiva PH, Vaisberg M
J Breath Res 2016 Dec 21;10(4):046018. doi: 10.1088/1752-7163/10/4/046018. PMID: 28000620
Utiyama DM, Yoshida CT, Goto DM, de Santana Carvalho T, de Paula Santos U, Koczulla AR, Saldiva PH, Nakagawa NK
Clinics (Sao Paulo) 2016 Jul;71(6):344-50. doi: 10.6061/clinics/2016(06)10. PMID: 27438569Free PMC Article
Ramos EM, De Toledo AC, Xavier RF, Fosco LC, Vieira RP, Ramos D, Jardim JR
Respirology 2011 Jul;16(5):849-55. doi: 10.1111/j.1440-1843.2011.01985.x. PMID: 21545372
Ahman M, Holmström M, Cynkier I, Söderman E
Occup Environ Med 1996 Feb;53(2):112-7. doi: 10.1136/oem.53.2.112. PMID: 8777447Free PMC Article
Corbo GM, Foresi A, Bonfitto P, Mugnano A, Agabiti N, Cole PJ
Arch Dis Child 1989 Apr;64(4):546-50. doi: 10.1136/adc.64.4.546. PMID: 2751328Free PMC Article

Prognosis

Ramos EM, De Toledo AC, Xavier RF, Fosco LC, Vieira RP, Ramos D, Jardim JR
Respirology 2011 Jul;16(5):849-55. doi: 10.1111/j.1440-1843.2011.01985.x. PMID: 21545372

Clinical prediction guides

Utiyama DM, Yoshida CT, Goto DM, de Santana Carvalho T, de Paula Santos U, Koczulla AR, Saldiva PH, Nakagawa NK
Clinics (Sao Paulo) 2016 Jul;71(6):344-50. doi: 10.6061/clinics/2016(06)10. PMID: 27438569Free PMC Article
Müns G, Singer P, Wolf F, Rubinstein I
Int J Sports Med 1995 May;16(4):209-13. doi: 10.1055/s-2007-972993. PMID: 7657412

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