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Patellofemoral pain syndrome

MedGen UID:
164080
•Concept ID:
C0877149
•
Disease or Syndrome
Synonyms: Anterior Knee Pain Syndrome; Pain Syndrome, Patellofemoral; Patellofemoral Pain Syndrome; Patellofemoral Syndrome
 
Monarch Initiative: MONDO:0006894

Definition

A syndrome characterized by retropatellar or peripatellar pain resulting from physical and biochemical changes in the patellofemoral joint. The pain is most prominent when ascending or descending stairs, squatting, or sitting with flexed knees. There is a lack of consensus on the etiology and treatment. The syndrome is often confused with (or accompanied by) chondromalacia patellae, the latter describing a pathological condition of the cartilage and not a syndrome. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPatellofemoral pain syndrome

Professional guidelines

PubMed

Common Running Injuries: Evaluation and Management.
Arnold MJ, Moody AL
Am Fam Physician 2018 Apr 15;97(8):510-516. PMID: 29671490
Effectiveness of conservative treatment for patellofemoral pain syndrome: A systematic review and meta-analysis.
Saltychev M, Dutton RA, Laimi K, Beaupré GS, Virolainen P, Fredericson M
J Rehabil Med 2018 May 8;50(5):393-401. doi: 10.2340/16501977-2295. PMID: 29392329
Management of patellofemoral pain syndrome.
Dixit S, DiFiori JP, Burton M, Mines B
Am Fam Physician 2007 Jan 15;75(2):194-202. PMID: 17263214

Recent clinical studies

Etiology

Patellofemoral Pain Syndrome Risk Associated with Squats: A Systematic Review.
Pereira PM, Baptista JS, Conceição F, Duarte J, Ferraz J, Costa JT
Int J Environ Res Public Health 2022 Jul 28;19(15) doi: 10.3390/ijerph19159241. PMID: 35954598Free PMC Article
Patellofemoral Pain Syndrome.
Gaitonde DY, Ericksen A, Robbins RC
Am Fam Physician 2019 Jan 15;99(2):88-94. PMID: 30633480
Effectiveness of conservative treatment for patellofemoral pain syndrome: A systematic review and meta-analysis.
Saltychev M, Dutton RA, Laimi K, Beaupré GS, Virolainen P, Fredericson M
J Rehabil Med 2018 May 8;50(5):393-401. doi: 10.2340/16501977-2295. PMID: 29392329
Patellofemoral Pain.
Dutton RA, Khadavi MJ, Fredericson M
Phys Med Rehabil Clin N Am 2016 Feb;27(1):31-52. doi: 10.1016/j.pmr.2015.08.002. PMID: 26616176
Exercise for treating patellofemoral pain syndrome.
van der Heijden RA, Lankhorst NE, van Linschoten R, Bierma-Zeinstra SM, van Middelkoop M
Cochrane Database Syst Rev 2015 Jan 20;1(1):CD010387. doi: 10.1002/14651858.CD010387.pub2. PMID: 25603546Free PMC Article

Diagnosis

Evaluation and Treatment of Knee Pain: A Review.
Duong V, Oo WM, Ding C, Culvenor AG, Hunter DJ
JAMA 2023 Oct 24;330(16):1568-1580. doi: 10.1001/jama.2023.19675. PMID: 37874571
Patellofemoral Pain.
Willy RW, Hoglund LT, Barton CJ, Bolgla LA, Scalzitti DA, Logerstedt DS, Lynch AD, Snyder-Mackler L, McDonough CM
J Orthop Sports Phys Ther 2019 Sep;49(9):CPG1-CPG95. doi: 10.2519/jospt.2019.0302. PMID: 31475628
Patellofemoral Pain Syndrome.
Gaitonde DY, Ericksen A, Robbins RC
Am Fam Physician 2019 Jan 15;99(2):88-94. PMID: 30633480
Patellofemoral Pain.
Dutton RA, Khadavi MJ, Fredericson M
Phys Med Rehabil Clin N Am 2016 Feb;27(1):31-52. doi: 10.1016/j.pmr.2015.08.002. PMID: 26616176
Exercise for treating patellofemoral pain syndrome.
van der Heijden RA, Lankhorst NE, van Linschoten R, Bierma-Zeinstra SM, van Middelkoop M
Cochrane Database Syst Rev 2015 Jan 20;1(1):CD010387. doi: 10.1002/14651858.CD010387.pub2. PMID: 25603546Free PMC Article

Therapy

The Effect of Valgus Control Instruction Exercises on Pain, Strength, and Functionality in Active Females With Patellofemoral Pain Syndrome.
Emamvirdi M, Letafatkar A, Khaleghi Tazji M
Sports Health 2019 May/Jun;11(3):223-237. Epub 2019 Apr 29 doi: 10.1177/1941738119837622. PMID: 31034336Free PMC Article
2018 Consensus statement on exercise therapy and physical interventions (orthoses, taping and manual therapy) to treat patellofemoral pain: recommendations from the 5th International Patellofemoral Pain Research Retreat, Gold Coast, Australia, 2017.
Collins NJ, Barton CJ, van Middelkoop M, Callaghan MJ, Rathleff MS, Vicenzino BT, Davis IS, Powers CM, Macri EM, Hart HF, de Oliveira Silva D, Crossley KM
Br J Sports Med 2018 Sep;52(18):1170-1178. Epub 2018 Jun 20 doi: 10.1136/bjsports-2018-099397. PMID: 29925502
Effectiveness of conservative treatment for patellofemoral pain syndrome: A systematic review and meta-analysis.
Saltychev M, Dutton RA, Laimi K, Beaupré GS, Virolainen P, Fredericson M
J Rehabil Med 2018 May 8;50(5):393-401. doi: 10.2340/16501977-2295. PMID: 29392329
Exercise for treating patellofemoral pain syndrome.
van der Heijden RA, Lankhorst NE, van Linschoten R, Bierma-Zeinstra SM, van Middelkoop M
Cochrane Database Syst Rev 2015 Jan 20;1(1):CD010387. doi: 10.1002/14651858.CD010387.pub2. PMID: 25603546Free PMC Article
Patellofemoral pain syndrome.
Petersen W, Ellermann A, Gösele-Koppenburg A, Best R, Rembitzki IV, Brüggemann GP, Liebau C
Knee Surg Sports Traumatol Arthrosc 2014 Oct;22(10):2264-74. Epub 2013 Nov 13 doi: 10.1007/s00167-013-2759-6. PMID: 24221245Free PMC Article

Prognosis

A systematic review of running-related musculoskeletal injuries in runners.
Kakouris N, Yener N, Fong DTP
J Sport Health Sci 2021 Sep;10(5):513-522. Epub 2021 Apr 20 doi: 10.1016/j.jshs.2021.04.001. PMID: 33862272Free PMC Article
Patellofemoral Pain Syndrome.
Gaitonde DY, Ericksen A, Robbins RC
Am Fam Physician 2019 Jan 15;99(2):88-94. PMID: 30633480
Incidence and prevalence of patellofemoral pain: A systematic review and meta-analysis.
Smith BE, Selfe J, Thacker D, Hendrick P, Bateman M, Moffatt F, Rathleff MS, Smith TO, Logan P
PLoS One 2018;13(1):e0190892. Epub 2018 Jan 11 doi: 10.1371/journal.pone.0190892. PMID: 29324820Free PMC Article
Patellofemoral pain: epidemiology, pathophysiology, and treatment options.
Rothermich MA, Glaviano NR, Li J, Hart JM
Clin Sports Med 2015 Apr;34(2):313-27. Epub 2015 Jan 27 doi: 10.1016/j.csm.2014.12.011. PMID: 25818716
Management of patellofemoral pain syndrome.
Dixit S, DiFiori JP, Burton M, Mines B
Am Fam Physician 2007 Jan 15;75(2):194-202. PMID: 17263214

Clinical prediction guides

Evaluation and Treatment of Knee Pain: A Review.
Duong V, Oo WM, Ding C, Culvenor AG, Hunter DJ
JAMA 2023 Oct 24;330(16):1568-1580. doi: 10.1001/jama.2023.19675. PMID: 37874571
Risk factors for patellofemoral pain: a systematic review and meta-analysis.
Neal BS, Lack SD, Lankhorst NE, Raye A, Morrissey D, van Middelkoop M
Br J Sports Med 2019 Mar;53(5):270-281. Epub 2018 Sep 21 doi: 10.1136/bjsports-2017-098890. PMID: 30242107
Neuromuscular electrical stimulation (NMES) for patellofemoral pain syndrome.
Martimbianco ALC, Torloni MR, Andriolo BN, Porfírio GJ, Riera R
Cochrane Database Syst Rev 2017 Dec 12;12(12):CD011289. doi: 10.1002/14651858.CD011289.pub2. PMID: 29231243Free PMC Article
Systematic Review of the Effect of Taping Techniques on Patellofemoral Pain Syndrome.
Logan CA, Bhashyam AR, Tisosky AJ, Haber DB, Jorgensen A, Roy A, Provencher MT
Sports Health 2017 Sep/Oct;9(5):456-461. Epub 2017 Jun 15 doi: 10.1177/1941738117710938. PMID: 28617653Free PMC Article
Exercise for treating patellofemoral pain syndrome.
van der Heijden RA, Lankhorst NE, van Linschoten R, Bierma-Zeinstra SM, van Middelkoop M
Cochrane Database Syst Rev 2015 Jan 20;1(1):CD010387. doi: 10.1002/14651858.CD010387.pub2. PMID: 25603546Free PMC Article

Recent systematic reviews

Patellofemoral Pain Syndrome Risk Associated with Squats: A Systematic Review.
Pereira PM, Baptista JS, Conceição F, Duarte J, Ferraz J, Costa JT
Int J Environ Res Public Health 2022 Jul 28;19(15) doi: 10.3390/ijerph19159241. PMID: 35954598Free PMC Article
A systematic review of running-related musculoskeletal injuries in runners.
Kakouris N, Yener N, Fong DTP
J Sport Health Sci 2021 Sep;10(5):513-522. Epub 2021 Apr 20 doi: 10.1016/j.jshs.2021.04.001. PMID: 33862272Free PMC Article
Incidence and prevalence of patellofemoral pain: A systematic review and meta-analysis.
Smith BE, Selfe J, Thacker D, Hendrick P, Bateman M, Moffatt F, Rathleff MS, Smith TO, Logan P
PLoS One 2018;13(1):e0190892. Epub 2018 Jan 11 doi: 10.1371/journal.pone.0190892. PMID: 29324820Free PMC Article
Systematic Review of the Effect of Taping Techniques on Patellofemoral Pain Syndrome.
Logan CA, Bhashyam AR, Tisosky AJ, Haber DB, Jorgensen A, Roy A, Provencher MT
Sports Health 2017 Sep/Oct;9(5):456-461. Epub 2017 Jun 15 doi: 10.1177/1941738117710938. PMID: 28617653Free PMC Article
Exercise for treating patellofemoral pain syndrome.
van der Heijden RA, Lankhorst NE, van Linschoten R, Bierma-Zeinstra SM, van Middelkoop M
Cochrane Database Syst Rev 2015 Jan 20;1(1):CD010387. doi: 10.1002/14651858.CD010387.pub2. PMID: 25603546Free PMC Article

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