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RISS Stage III Plasma Cell Myeloma

MedGen UID:
1641034
•Concept ID:
C4683785
•
Neoplastic Process
Synonym: Revised International Staging System Stage IIII Plasma Cell Myeloma

Definition

Serum beta-2-microglobulin 5.5 mg/L or more and high-risk cytogenetics and/or high LDH. High risk cytogenetics consist of one or more of the following: del17p, t(4;14), or t(14;16). (from AJCC 8th Ed.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRISS Stage III Plasma Cell Myeloma

Professional guidelines

PubMed

Comparison of clinical characteristics, treatment efficacy and survival in patients with newly diagnosed multiple myeloma with single- versus multi-site extramedullary invasion.
Zhao Y, Zhou F
J Cancer Res Clin Oncol 2023 Mar;149(3):995-1006. Epub 2022 Feb 25 doi: 10.1007/s00432-022-03948-9. PMID: 35212816
Diagnosis and treatment of multiple myeloma in Hunan Province.
Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345
Clinical utility of the Revised International Staging System in unselected patients with newly diagnosed and relapsed multiple myeloma.
Tandon N, Rajkumar SV, LaPlant B, Pettinger A, Lacy MQ, Dispenzieri A, Buadi FK, Gertz MA, Hayman SR, Leung N, Go RS, Dingli D, Kapoor P, Lin Y, Hwa YL, Fonder AL, Hobbs MA, Zeldenrust SR, Lust JA, Gonsalves WI, Russell SJ, Kumar SK
Blood Cancer J 2017 Feb 17;7(2):e528. doi: 10.1038/bcj.2017.13. PMID: 28211889Free PMC Article

Recent clinical studies

Etiology

Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma (MM).
Zhong L, Hao P, Zhang Q, Jiang T, Li H, Xiao J, Li C, Luo L, Xie C, Hu J, Wang L, Liu Y, Shi Y, Zhang W, Gong B
Elife 2022 Oct 31;11 doi: 10.7554/eLife.75340. PMID: 36315425Free PMC Article
Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Characteristics and clinical outcome of high-risk multiple myeloma patients in Korea (KMM 1805).
Kim K, Kim JS, Yoon SS, Yoon DH, Eom HS, Lee JJ, Yim HW, Park M, Lee H, Min CK; Korean Multiple Myeloma Working Party (KMMWP)
Int J Hematol 2022 Jul;116(1):110-121. Epub 2022 May 11 doi: 10.1007/s12185-022-03332-w. PMID: 35543899
Exploring the R-ISS stage-specific regular networks in the progression of multiple myeloma at single-cell resolution.
Zhong L, Yang X, Zhou Y, Xiao J, Li H, Tao J, Xi Q, Chu C, Li C, Yang X, Yang C, Zhang Y, Shuai P, Liu Y, Yu M, Shi Y, Hu J, Zhang W, Gong B, Yang Z
Sci China Life Sci 2022 Sep;65(9):1811-1823. Epub 2022 Apr 7 doi: 10.1007/s11427-021-2097-1. PMID: 35437648
Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P
J Clin Oncol 2015 Sep 10;33(26):2863-9. Epub 2015 Aug 3 doi: 10.1200/JCO.2015.61.2267. PMID: 26240224Free PMC Article

Diagnosis

Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma (MM).
Zhong L, Hao P, Zhang Q, Jiang T, Li H, Xiao J, Li C, Luo L, Xie C, Hu J, Wang L, Liu Y, Shi Y, Zhang W, Gong B
Elife 2022 Oct 31;11 doi: 10.7554/eLife.75340. PMID: 36315425Free PMC Article
Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Diagnosis and treatment of multiple myeloma in Hunan Province.
Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345
Characteristics and clinical outcome of high-risk multiple myeloma patients in Korea (KMM 1805).
Kim K, Kim JS, Yoon SS, Yoon DH, Eom HS, Lee JJ, Yim HW, Park M, Lee H, Min CK; Korean Multiple Myeloma Working Party (KMMWP)
Int J Hematol 2022 Jul;116(1):110-121. Epub 2022 May 11 doi: 10.1007/s12185-022-03332-w. PMID: 35543899
Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P
J Clin Oncol 2015 Sep 10;33(26):2863-9. Epub 2015 Aug 3 doi: 10.1200/JCO.2015.61.2267. PMID: 26240224Free PMC Article

Therapy

Isatuximab Plus Carfilzomib and Dexamethasone Versus Carfilzomib and Dexamethasone in Patients with Relapsed Multiple Myeloma: IKEMA Subgroup Analysis by Prior Transplantation.
Martin TG, Capra M, Mohty M, Suzuki K, Quach H, Cavo M, Moreau P, Dimopoulos M, Yong K, Tekle C, Foster MC, Barnes Y, Risse ML, Mikhael J
Transplant Cell Ther 2023 Feb;29(2):134.e1-134.e7. Epub 2022 Nov 11 doi: 10.1016/j.jtct.2022.11.005. PMID: 36372355
Belantamab in Combination with Dexamethasone in Patients with Triple-class Relapsed/Refractory Multiple Myeloma.
Atieh T, Atrash S, Ahmed N, Mohan M, Cui W, Shune L, Hajjar S, Mahmoudjafari Z, Quick J, Wishna A, Riffel J, McGuirk J, Mohyuddin GR, Abdallah AO
Clin Lymphoma Myeloma Leuk 2022 Dec;22(12):912-919. Epub 2022 Aug 15 doi: 10.1016/j.clml.2022.08.003. PMID: 36127271
Diagnosis and treatment of multiple myeloma in Hunan Province.
Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345
Prognostic and predictive performance of R-ISS with SKY92 in older patients with multiple myeloma: the HOVON-87/NMSG-18 trial.
Kuiper R, Zweegman S, van Duin M, van Vliet MH, van Beers EH, Dumee B, Vermeulen M, Koenders J, van der Holt B, Visser-Wisselaar H, Hansson M, van der Velden AWG, Beverloo HB, Stevens-Kroef M, Levin MD, Broijl A, Waage A, Sonneveld P
Blood Adv 2020 Dec 22;4(24):6298-6309. doi: 10.1182/bloodadvances.2020002838. PMID: 33351127Free PMC Article
Efficacy of VDT PACE-like regimens in treatment of relapsed/refractory multiple myeloma.
Lakshman A, Singh PP, Rajkumar SV, Dispenzieri A, Lacy MQ, Gertz MA, Buadi FK, Dingli D, Hwa YL, Fonder AL, Hobbs M, Hayman SR, Zeldenrust SR, Lust JA, Russell SJ, Leung N, Kapoor P, Go RS, Lin Y, Gonsalves WI, Kourelis T, Warsame R, Kyle RA, Kumar SK
Am J Hematol 2018 Feb;93(2):179-186. Epub 2017 Nov 10 doi: 10.1002/ajh.24954. PMID: 29067723

Prognosis

Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma (MM).
Zhong L, Hao P, Zhang Q, Jiang T, Li H, Xiao J, Li C, Luo L, Xie C, Hu J, Wang L, Liu Y, Shi Y, Zhang W, Gong B
Elife 2022 Oct 31;11 doi: 10.7554/eLife.75340. PMID: 36315425Free PMC Article
Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Exploring the R-ISS stage-specific regular networks in the progression of multiple myeloma at single-cell resolution.
Zhong L, Yang X, Zhou Y, Xiao J, Li H, Tao J, Xi Q, Chu C, Li C, Yang X, Yang C, Zhang Y, Shuai P, Liu Y, Yu M, Shi Y, Hu J, Zhang W, Gong B, Yang Z
Sci China Life Sci 2022 Sep;65(9):1811-1823. Epub 2022 Apr 7 doi: 10.1007/s11427-021-2097-1. PMID: 35437648
Clinical characteristics and prognosis of immunoglobulin D myeloma in the novel agent era.
Chen L, Fan F, Deng J, Xu J, Xu A, Sun C, Hu Y
Ann Hematol 2019 Apr;98(4):963-970. Epub 2019 Jan 4 doi: 10.1007/s00277-018-3582-4. PMID: 30610280
Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P
J Clin Oncol 2015 Sep 10;33(26):2863-9. Epub 2015 Aug 3 doi: 10.1200/JCO.2015.61.2267. PMID: 26240224Free PMC Article

Clinical prediction guides

Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Histogram Analysis Based on Apparent Diffusion Coefficient Maps of Bone Marrow in Multiple Myeloma: An Independent Predictor for High-risk Patients Classified by the Revised International Staging System.
Wang Q, Zhang L, Li S, Sun Z, Wu X, Zhao A, Benkert T, Zhou D, Xue H, Jin Z, Li J
Acad Radiol 2022 Jun;29(6):e98-e107. Epub 2021 Aug 24 doi: 10.1016/j.acra.2021.07.010. PMID: 34452820
Correlations between apparent diffusion coefficient values of WB-DWI and clinical parameters in multiple myeloma.
Zhang B, Bian B, Zhao Z, Lin F, Zhu Z, Lou M
BMC Med Imaging 2021 Jun 8;21(1):98. doi: 10.1186/s12880-021-00631-2. PMID: 34103001Free PMC Article
Prognostic and predictive performance of R-ISS with SKY92 in older patients with multiple myeloma: the HOVON-87/NMSG-18 trial.
Kuiper R, Zweegman S, van Duin M, van Vliet MH, van Beers EH, Dumee B, Vermeulen M, Koenders J, van der Holt B, Visser-Wisselaar H, Hansson M, van der Velden AWG, Beverloo HB, Stevens-Kroef M, Levin MD, Broijl A, Waage A, Sonneveld P
Blood Adv 2020 Dec 22;4(24):6298-6309. doi: 10.1182/bloodadvances.2020002838. PMID: 33351127Free PMC Article
Clinical characteristics and prognosis of immunoglobulin D myeloma in the novel agent era.
Chen L, Fan F, Deng J, Xu J, Xu A, Sun C, Hu Y
Ann Hematol 2019 Apr;98(4):963-970. Epub 2019 Jan 4 doi: 10.1007/s00277-018-3582-4. PMID: 30610280

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