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Blood xenobiotic

MedGen UID:
1641496
•Concept ID:
C4703659
•
Finding
HPO: HP:0410172

Definition

The presence of a xenobiotic in blood. [from HPO]

Professional guidelines

PubMed

The blood-brain barrier and cancer: transporters, treatment, and Trojan horses.
Deeken JF, Löscher W
Clin Cancer Res 2007 Mar 15;13(6):1663-74. doi: 10.1158/1078-0432.CCR-06-2854. PMID: 17363519
Antituberculosis drug-induced hepatitis: risk factors, prevention and management.
Hussain Z, Kar P, Husain SA
Indian J Exp Biol 2003 Nov;41(11):1226-32. PMID: 15332488
Drug-induced methaemoglobinaemia. Treatment issues.
Coleman MD, Coleman NA
Drug Saf 1996 Jun;14(6):394-405. doi: 10.2165/00002018-199614060-00005. PMID: 8828017

Recent clinical studies

Etiology

The aging lung: Physiology, disease, and immunity.
Schneider JL, Rowe JH, Garcia-de-Alba C, Kim CF, Sharpe AH, Haigis MC
Cell 2021 Apr 15;184(8):1990-2019. Epub 2021 Apr 2 doi: 10.1016/j.cell.2021.03.005. PMID: 33811810Free PMC Article
Vitamin K Nutrition and Bone Health.
Tsugawa N, Shiraki M
Nutrients 2020 Jun 27;12(7) doi: 10.3390/nu12071909. PMID: 32605143Free PMC Article
Bystander activation and autoimmunity.
Pacheco Y, Acosta-Ampudia Y, Monsalve DM, Chang C, Gershwin ME, Anaya JM
J Autoimmun 2019 Sep;103:102301. Epub 2019 Jul 17 doi: 10.1016/j.jaut.2019.06.012. PMID: 31326230
Kidney Pathophysiology, Toxicology, and Drug-Induced Injury in Drug Development.
Radi ZA
Int J Toxicol 2019 May/Jun;38(3):215-227. Epub 2019 Mar 7 doi: 10.1177/1091581819831701. PMID: 30845865
Toxico-/biokinetics of nanomaterials.
Landsiedel R, Fabian E, Ma-Hock L, van Ravenzwaay B, Wohlleben W, Wiench K, Oesch F
Arch Toxicol 2012 Jul;86(7):1021-60. Epub 2012 May 11 doi: 10.1007/s00204-012-0858-7. PMID: 22576463

Diagnosis

Vitamin K Nutrition and Bone Health.
Tsugawa N, Shiraki M
Nutrients 2020 Jun 27;12(7) doi: 10.3390/nu12071909. PMID: 32605143Free PMC Article
Revisited: Therapeutic and toxic blood concentrations of more than 1100 drugs and other xenobiotics.
Schulz M, Schmoldt A, Andresen-Streichert H, Iwersen-Bergmann S
Crit Care 2020 May 6;24(1):195. doi: 10.1186/s13054-020-02915-5. PMID: 32375836Free PMC Article
Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis.
Furue M, Hashimoto-Hachiya A, Tsuji G
Int J Mol Sci 2019 Oct 31;20(21) doi: 10.3390/ijms20215424. PMID: 31683543Free PMC Article
Drug-induced liver injury.
Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, Merz M, Lucena MI, Kaplowitz N, Aithal GP
Nat Rev Dis Primers 2019 Aug 22;5(1):58. doi: 10.1038/s41572-019-0105-0. PMID: 31439850
Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics.
Schulz M, Iwersen-Bergmann S, Andresen H, Schmoldt A
Crit Care 2012 Jul 26;16(4):R136. doi: 10.1186/cc11441. PMID: 22835221Free PMC Article

Therapy

The shared biomarkers and pathways of systemic lupus erythematosus and metabolic syndrome analyzed by bioinformatics combining machine learning algorithm and single-cell sequencing analysis.
Wang Y, Huang Z, Xiao Y, Wan W, Yang X
Front Immunol 2022;13:1015882. Epub 2022 Oct 19 doi: 10.3389/fimmu.2022.1015882. PMID: 36341378Free PMC Article
Vitamin K and Osteoporosis.
Fusaro M, Cianciolo G, Brandi ML, Ferrari S, Nickolas TL, Tripepi G, Plebani M, Zaninotto M, Iervasi G, La Manna G, Gallieni M, Vettor R, Aghi A, Gasperoni L, Giannini S, Sella S, M Cheung A
Nutrients 2020 Nov 25;12(12) doi: 10.3390/nu12123625. PMID: 33255760Free PMC Article
Drug-induced liver injury.
Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, Merz M, Lucena MI, Kaplowitz N, Aithal GP
Nat Rev Dis Primers 2019 Aug 22;5(1):58. doi: 10.1038/s41572-019-0105-0. PMID: 31439850
Gut microbiome and type 2 diabetes: where we are and where to go?
Sharma S, Tripathi P
J Nutr Biochem 2019 Jan;63:101-108. Epub 2018 Oct 11 doi: 10.1016/j.jnutbio.2018.10.003. PMID: 30366260
Metabolic alterations in multiple sclerosis and the impact of vitamin D supplementation.
Bhargava P, Fitzgerald KC, Calabresi PA, Mowry EM
JCI Insight 2017 Oct 5;2(19) doi: 10.1172/jci.insight.95302. PMID: 28978801Free PMC Article

Prognosis

The shared biomarkers and pathways of systemic lupus erythematosus and metabolic syndrome analyzed by bioinformatics combining machine learning algorithm and single-cell sequencing analysis.
Wang Y, Huang Z, Xiao Y, Wan W, Yang X
Front Immunol 2022;13:1015882. Epub 2022 Oct 19 doi: 10.3389/fimmu.2022.1015882. PMID: 36341378Free PMC Article
Revisited: Therapeutic and toxic blood concentrations of more than 1100 drugs and other xenobiotics.
Schulz M, Schmoldt A, Andresen-Streichert H, Iwersen-Bergmann S
Crit Care 2020 May 6;24(1):195. doi: 10.1186/s13054-020-02915-5. PMID: 32375836Free PMC Article
Drug-induced liver injury.
Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, Merz M, Lucena MI, Kaplowitz N, Aithal GP
Nat Rev Dis Primers 2019 Aug 22;5(1):58. doi: 10.1038/s41572-019-0105-0. PMID: 31439850
The liver.
Trefts E, Gannon M, Wasserman DH
Curr Biol 2017 Nov 6;27(21):R1147-R1151. doi: 10.1016/j.cub.2017.09.019. PMID: 29112863Free PMC Article
Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics.
Schulz M, Iwersen-Bergmann S, Andresen H, Schmoldt A
Crit Care 2012 Jul 26;16(4):R136. doi: 10.1186/cc11441. PMID: 22835221Free PMC Article

Clinical prediction guides

Revisited: Therapeutic and toxic blood concentrations of more than 1100 drugs and other xenobiotics.
Schulz M, Schmoldt A, Andresen-Streichert H, Iwersen-Bergmann S
Crit Care 2020 May 6;24(1):195. doi: 10.1186/s13054-020-02915-5. PMID: 32375836Free PMC Article
Drug-induced liver injury.
Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, Merz M, Lucena MI, Kaplowitz N, Aithal GP
Nat Rev Dis Primers 2019 Aug 22;5(1):58. doi: 10.1038/s41572-019-0105-0. PMID: 31439850
Metabolic alterations in multiple sclerosis and the impact of vitamin D supplementation.
Bhargava P, Fitzgerald KC, Calabresi PA, Mowry EM
JCI Insight 2017 Oct 5;2(19) doi: 10.1172/jci.insight.95302. PMID: 28978801Free PMC Article
Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics.
Schulz M, Iwersen-Bergmann S, Andresen H, Schmoldt A
Crit Care 2012 Jul 26;16(4):R136. doi: 10.1186/cc11441. PMID: 22835221Free PMC Article
Toxico-/biokinetics of nanomaterials.
Landsiedel R, Fabian E, Ma-Hock L, van Ravenzwaay B, Wohlleben W, Wiench K, Oesch F
Arch Toxicol 2012 Jul;86(7):1021-60. Epub 2012 May 11 doi: 10.1007/s00204-012-0858-7. PMID: 22576463

Recent systematic reviews

Toxic implications of silver nanoparticles on the central nervous system: A systematic literature review.
Suthar JK, Vaidya A, Ravindran S
J Appl Toxicol 2023 Jan;43(1):4-21. Epub 2022 Mar 23 doi: 10.1002/jat.4317. PMID: 35285037
Nephrotoxicity: Topical issue.
Gabelova A, Kozics K, Kapka-Skrzypczak L, Kruszewski M, Sramkova M
Mutat Res Genet Toxicol Environ Mutagen 2019 Sep;845:402988. Epub 2018 Dec 6 doi: 10.1016/j.mrgentox.2018.11.012. PMID: 31561894
The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders: a systematic review and meta-analysis.
Bonde JP, Flachs EM, Rimborg S, Glazer CH, Giwercman A, Ramlau-Hansen CH, Hougaard KS, Høyer BB, Hærvig KK, Petersen SB, Rylander L, Specht IO, Toft G, Bräuner EV
Hum Reprod Update 2016 Dec;23(1):104-125. Epub 2016 Sep 21 doi: 10.1093/humupd/dmw036. PMID: 27655588Free PMC Article
Exposure to Agrochemicals and Cardiovascular Disease: A Review.
Sekhotha MM, Monyeki KD, Sibuyi ME
Int J Environ Res Public Health 2016 Feb 18;13(2):229. doi: 10.3390/ijerph13020229. PMID: 26901215Free PMC Article
GSTT1 and GSTM1 polymorphisms predict treatment outcome for acute myeloid leukemia: a systematic review and meta-analysis.
Xiao Q, Deng D, Li H, Ye F, Huang L, Zhang B, Ye B, Mo Z, Yang X, Liu Z
Ann Hematol 2014 Aug;93(8):1381-90. Epub 2014 Mar 29 doi: 10.1007/s00277-014-2050-z. PMID: 24994605

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