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Marburg acute multiple sclerosis

MedGen UID:
1641985
Concept ID:
C4707723
Disease or Syndrome
Synonyms: Acute multiple sclerosis Marburg type; Acute multiple sclerosis Marburg variant; Acute multiple sclerosis, Marburg type; acute multiple sclerosis, Marburg type; Acute multiple sclerosis, Marburg variant; acute multiple sclerosis, Marburg variant
SNOMED CT: Marburg acute multiple sclerosis (766246000); Acute multiple sclerosis Marburg type (766246000); Acute multiple sclerosis Marburg variant (766246000)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
 
Monarch Initiative: MONDO:0016429
Orphanet: ORPHA228157

Definition

A rare variant of multiple sclerosis with characteristics of a rapidly progressive, aggressive form of multiple sclerosis with numerous large multifocal demyelinating lesions in deep white matter on cerebral MRI that usually leads to severe disability or death within weeks to months without remission. A relapsing form of multiple sclerosis is observed in surviving patients. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMarburg acute multiple sclerosis

Professional guidelines

PubMed

Sánchez P, Chan F, Hardy TA
Expert Rev Neurother 2021 Sep;21(9):1005-1017. Epub 2021 Aug 31 doi: 10.1080/14737175.2021.1971077. PMID: 34424129
Pohl D, Waubant E, Banwell B, Chabas D, Chitnis T, Weinstock-Guttman B, Tenembaum S; International Pediatric MS Study Group
Neurology 2007 Apr 17;68(16 Suppl 2):S54-65. doi: 10.1212/01.wnl.0000259407.40023.ab. PMID: 17438239

Recent clinical studies

Etiology

Scholz J, Finnerup NB, Attal N, Aziz Q, Baron R, Bennett MI, Benoliel R, Cohen M, Cruccu G, Davis KD, Evers S, First M, Giamberardino MA, Hansson P, Kaasa S, Korwisi B, Kosek E, Lavand'homme P, Nicholas M, Nurmikko T, Perrot S, Raja SN, Rice ASC, Rowbotham MC, Schug S, Simpson DM, Smith BH, Svensson P, Vlaeyen JWS, Wang SJ, Barke A, Rief W, Treede RD; Classification Committee of the Neuropathic Pain Special Interest Group (NeuPSIG)
Pain 2019 Jan;160(1):53-59. doi: 10.1097/j.pain.0000000000001365. PMID: 30586071Free PMC Article
Rovira Á, Auger C, Rovira A
Handb Clin Neurol 2016;135:425-446. doi: 10.1016/B978-0-444-53485-9.00021-0. PMID: 27432677
Karussis D
J Autoimmun 2014 Feb-Mar;48-49:134-42. Epub 2014 Feb 10 doi: 10.1016/j.jaut.2014.01.022. PMID: 24524923
Zettl UK, Stüve O, Patejdl R
Autoimmun Rev 2012 Jan;11(3):167-73. Epub 2011 May 18 doi: 10.1016/j.autrev.2011.05.008. PMID: 21619943
Pohl D, Waubant E, Banwell B, Chabas D, Chitnis T, Weinstock-Guttman B, Tenembaum S; International Pediatric MS Study Group
Neurology 2007 Apr 17;68(16 Suppl 2):S54-65. doi: 10.1212/01.wnl.0000259407.40023.ab. PMID: 17438239

Diagnosis

Scholz J, Finnerup NB, Attal N, Aziz Q, Baron R, Bennett MI, Benoliel R, Cohen M, Cruccu G, Davis KD, Evers S, First M, Giamberardino MA, Hansson P, Kaasa S, Korwisi B, Kosek E, Lavand'homme P, Nicholas M, Nurmikko T, Perrot S, Raja SN, Rice ASC, Rowbotham MC, Schug S, Simpson DM, Smith BH, Svensson P, Vlaeyen JWS, Wang SJ, Barke A, Rief W, Treede RD; Classification Committee of the Neuropathic Pain Special Interest Group (NeuPSIG)
Pain 2019 Jan;160(1):53-59. doi: 10.1097/j.pain.0000000000001365. PMID: 30586071Free PMC Article
Ayrignac X, Carra-Dallière C, Labauge P
Rev Neurol (Paris) 2018 Jun;174(6):408-418. Epub 2018 Apr 16 doi: 10.1016/j.neurol.2018.03.007. PMID: 29673573
Sarbu N, Shih RY, Jones RV, Horkayne-Szakaly I, Oleaga L, Smirniotopoulos JG
Radiographics 2016 Sep-Oct;36(5):1426-47. doi: 10.1148/rg.2016160031. PMID: 27618323
Rovira Á, Auger C, Rovira A
Handb Clin Neurol 2016;135:425-446. doi: 10.1016/B978-0-444-53485-9.00021-0. PMID: 27432677
Karussis D
J Autoimmun 2014 Feb-Mar;48-49:134-42. Epub 2014 Feb 10 doi: 10.1016/j.jaut.2014.01.022. PMID: 24524923

Therapy

Gobbin F, Marangi A, Orlandi R, Richelli S, Turatti M, Calabrese M, Forgione A, Alessandrini F, Benedetti MD, Monaco S, Gajofatto A
Mult Scler Relat Disord 2017 Oct;17:9-11. Epub 2017 Jun 20 doi: 10.1016/j.msard.2017.06.007. PMID: 29055482
Pohl D, Waubant E, Banwell B, Chabas D, Chitnis T, Weinstock-Guttman B, Tenembaum S; International Pediatric MS Study Group
Neurology 2007 Apr 17;68(16 Suppl 2):S54-65. doi: 10.1212/01.wnl.0000259407.40023.ab. PMID: 17438239
Brinar VV
Clin Neurol Neurosurg 2004 Jun;106(3):197-210. doi: 10.1016/j.clineuro.2004.02.016. PMID: 15177769
Weinshenker BG
J Clin Apher 1999;14(3):144-8. doi: 10.1002/(sici)1098-1101(1999)14:3<144::aid-jca7>3.0.co;2-r. PMID: 10540370
Quast U, Herder C, Zwisler O
Vaccine 1991 Apr;9(4):228-30. doi: 10.1016/0264-410x(91)90104-e. PMID: 2058265

Prognosis

Amini Harandi A, Esfandani A, Pakdaman H, Abbasi M, Sahraian MA
Rev Neurosci 2018 Nov 27;29(8):873-882. doi: 10.1515/revneuro-2017-0096. PMID: 29768251
Ayrignac X, Carra-Dallière C, Labauge P
Rev Neurol (Paris) 2018 Jun;174(6):408-418. Epub 2018 Apr 16 doi: 10.1016/j.neurol.2018.03.007. PMID: 29673573
Frederick MC, Cameron MH
Curr Neurol Neurosci Rep 2016 Mar;16(3):26. doi: 10.1007/s11910-016-0626-9. PMID: 26847090
Karussis D
J Autoimmun 2014 Feb-Mar;48-49:134-42. Epub 2014 Feb 10 doi: 10.1016/j.jaut.2014.01.022. PMID: 24524923
Weinshenker BG
J Clin Apher 1999;14(3):144-8. doi: 10.1002/(sici)1098-1101(1999)14:3<144::aid-jca7>3.0.co;2-r. PMID: 10540370

Clinical prediction guides

Karussis D
J Autoimmun 2014 Feb-Mar;48-49:134-42. Epub 2014 Feb 10 doi: 10.1016/j.jaut.2014.01.022. PMID: 24524923
Suzuki M, Kawasaki H, Masaki K, Suzuki SO, Terada T, Tsuchida T, Tokuyama T, Kono S, Komori T, Baba S, Kira J, Miyajima H
Intern Med 2013;52(16):1825-32. Epub 2012 Mar 1 doi: 10.2169/internalmedicine.52.0425. PMID: 23955619
Turatti M, Gajofatto A, Rossi F, Vedovello M, Benedetti MD
Neurol Sci 2010 Dec;31(6):807-11. Epub 2010 May 12 doi: 10.1007/s10072-010-0287-4. PMID: 20461429
Stadelmann C, Brück W
Neurol Sci 2004 Nov;25 Suppl 4:S319-22. doi: 10.1007/s10072-004-0333-1. PMID: 15727225
Weinshenker BG
J Clin Apher 1999;14(3):144-8. doi: 10.1002/(sici)1098-1101(1999)14:3<144::aid-jca7>3.0.co;2-r. PMID: 10540370

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