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Opioid-induced constipation

MedGen UID:
1641995
Concept ID:
C3160897
Sign or Symptom
Synonyms: Constipation, Opiate-Induced; Constipation, Opioid-Induced; Opiate Induced Constipation; Opiate-Induced Constipation; Opiate-Induced Constipations; Opioid Induced Constipation; Opioid-Induced Constipation; Opioid-Induced Constipations
 
Monarch Initiative: MONDO:0100187

Definition

Constipation that results from, or follows, treatment with an opioid or opioid-containing medication. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOpioid-induced constipation

Professional guidelines

PubMed

Bharucha AE, Lacy BE
Gastroenterology 2020 Apr;158(5):1232-1249.e3. Epub 2020 Jan 13 doi: 10.1053/j.gastro.2019.12.034. PMID: 31945360Free PMC Article
Aziz I, Whitehead WE, Palsson OS, Törnblom H, Simrén M
Expert Rev Gastroenterol Hepatol 2020 Jan;14(1):39-46. Epub 2020 Jan 2 doi: 10.1080/17474124.2020.1708718. PMID: 31893959
Prichard D, Norton C, Bharucha AE
Br J Nurs 2016 May 26-Jun 8;25(10):S4-5, S8-11. doi: 10.12968/bjon.2016.25.10.S4. PMID: 27231750

Recent clinical studies

Etiology

De Giorgio R, Zucco FM, Chiarioni G, Mercadante S, Corazziari ES, Caraceni A, Odetti P, Giusti R, Marinangeli F, Pinto C
Adv Ther 2021 Jul;38(7):3589-3621. Epub 2021 Jun 4 doi: 10.1007/s12325-021-01766-y. PMID: 34086265Free PMC Article
Deb B, Prichard DO, Bharucha AE
Curr Gastroenterol Rep 2020 Aug 24;22(11):54. doi: 10.1007/s11894-020-00791-1. PMID: 32839874
Serra J, Pohl D, Azpiroz F, Chiarioni G, Ducrotté P, Gourcerol G, Hungin APS, Layer P, Mendive JM, Pfeifer J, Rogler G, Scott SM, Simrén M, Whorwell P; Functional Constipation Guidelines Working Group
Neurogastroenterol Motil 2020 Feb;32(2):e13762. Epub 2019 Nov 22 doi: 10.1111/nmo.13762. PMID: 31756783
Bharucha AE, Wald A
Mayo Clin Proc 2019 Nov;94(11):2340-2357. Epub 2019 May 1 doi: 10.1016/j.mayocp.2019.01.031. PMID: 31054770Free PMC Article
Rao SS, Rattanakovit K, Patcharatrakul T
Nat Rev Gastroenterol Hepatol 2016 May;13(5):295-305. Epub 2016 Apr 1 doi: 10.1038/nrgastro.2016.53. PMID: 27033126

Diagnosis

Deb B, Prichard DO, Bharucha AE
Curr Gastroenterol Rep 2020 Aug 24;22(11):54. doi: 10.1007/s11894-020-00791-1. PMID: 32839874
Bharucha AE, Lacy BE
Gastroenterology 2020 Apr;158(5):1232-1249.e3. Epub 2020 Jan 13 doi: 10.1053/j.gastro.2019.12.034. PMID: 31945360Free PMC Article
Aziz I, Whitehead WE, Palsson OS, Törnblom H, Simrén M
Expert Rev Gastroenterol Hepatol 2020 Jan;14(1):39-46. Epub 2020 Jan 2 doi: 10.1080/17474124.2020.1708718. PMID: 31893959
Bharucha AE, Wald A
Mayo Clin Proc 2019 Nov;94(11):2340-2357. Epub 2019 May 1 doi: 10.1016/j.mayocp.2019.01.031. PMID: 31054770Free PMC Article
Farmer AD, Holt CB, Downes TJ, Ruggeri E, Del Vecchio S, De Giorgio R
Lancet Gastroenterol Hepatol 2018 Mar;3(3):203-212. doi: 10.1016/S2468-1253(18)30008-6. PMID: 29870734

Therapy

Bharucha AE, Lacy BE
Gastroenterology 2020 Apr;158(5):1232-1249.e3. Epub 2020 Jan 13 doi: 10.1053/j.gastro.2019.12.034. PMID: 31945360Free PMC Article
Aziz I, Whitehead WE, Palsson OS, Törnblom H, Simrén M
Expert Rev Gastroenterol Hepatol 2020 Jan;14(1):39-46. Epub 2020 Jan 2 doi: 10.1080/17474124.2020.1708718. PMID: 31893959
Bharucha AE, Wald A
Mayo Clin Proc 2019 Nov;94(11):2340-2357. Epub 2019 May 1 doi: 10.1016/j.mayocp.2019.01.031. PMID: 31054770Free PMC Article
Müller-Lissner S, Bassotti G, Coffin B, Drewes AM, Breivik H, Eisenberg E, Emmanuel A, Laroche F, Meissner W, Morlion B
Pain Med 2017 Oct 1;18(10):1837-1863. doi: 10.1093/pm/pnw255. PMID: 28034973Free PMC Article
Prichard D, Norton C, Bharucha AE
Br J Nurs 2016 May 26-Jun 8;25(10):S4-5, S8-11. doi: 10.12968/bjon.2016.25.10.S4. PMID: 27231750

Prognosis

Engle AL, Winans ARM
J Pain Palliat Care Pharmacother 2021 Mar;35(1):63-72. Epub 2021 Feb 17 doi: 10.1080/15360288.2020.1828529. PMID: 33596159
Olson EA, Metzger AK, Mallory MJ, Mackey RM
J Pain Symptom Manage 2021 Oct;62(4):876-880. Epub 2021 Feb 5 doi: 10.1016/j.jpainsymman.2021.01.135. PMID: 33556492
Samolsky Dekel BG, Sorella MC, Vasarri A, Gori A, Melotti RM
J Opioid Manag 2019 Sep/Oct;15(5):375-387. doi: 10.5055/jom.2019.0527. PMID: 31849029
Murphy JE, Wo JY, Ryan DP, Clark JW, Jiang W, Yeap BY, Drapek LC, Ly L, Baglini CV, Blaszkowsky LS, Ferrone CR, Parikh AR, Weekes CD, Nipp RD, Kwak EL, Allen JN, Corcoran RB, Ting DT, Faris JE, Zhu AX, Goyal L, Berger DL, Qadan M, Lillemoe KD, Talele N, Jain RK, DeLaney TF, Duda DG, Boucher Y, Fernández-Del Castillo C, Hong TS
JAMA Oncol 2019 Jul 1;5(7):1020-1027. doi: 10.1001/jamaoncol.2019.0892. PMID: 31145418Free PMC Article
Drugs R D 2006;7(6):374-8. doi: 10.2165/00126839-200607060-00006. PMID: 17073520

Clinical prediction guides

Engle AL, Winans ARM
J Pain Palliat Care Pharmacother 2021 Mar;35(1):63-72. Epub 2021 Feb 17 doi: 10.1080/15360288.2020.1828529. PMID: 33596159
Song X, Wang D, Qu X, Dong N, Teng S
Expert Rev Clin Pharmacol 2019 Feb;12(2):121-128. Epub 2019 Jan 24 doi: 10.1080/17512433.2019.1570845. PMID: 30652502
Wald A
JAMA 2016 Jan 12;315(2):185-91. doi: 10.1001/jama.2015.16994. PMID: 26757467
Garnock-Jones KP, McKeage K
Drugs 2010 May 7;70(7):919-28. doi: 10.2165/11204520-000000000-00000. PMID: 20426500
Drugs R D 2006;7(6):374-8. doi: 10.2165/00126839-200607060-00006. PMID: 17073520

Recent systematic reviews

Candy B, Jones L, Vickerstaff V, Larkin PJ, Stone P
Cochrane Database Syst Rev 2022 Sep 15;9(9):CD006332. doi: 10.1002/14651858.CD006332.pub4. PMID: 36106667Free PMC Article
Nee J, Zakari M, Sugarman MA, Whelan J, Hirsch W, Sultan S, Ballou S, Iturrino J, Lembo A
Clin Gastroenterol Hepatol 2018 Oct;16(10):1569-1584.e2. Epub 2018 Jan 31 doi: 10.1016/j.cgh.2018.01.021. PMID: 29374616
Mehta N, O'Connell K, Giambrone GP, Baqai A, Diwan S
Postgrad Med 2016;128(3):282-9. Epub 2016 Feb 23 doi: 10.1080/00325481.2016.1149017. PMID: 26839023
Siemens W, Gaertner J, Becker G
Expert Opin Pharmacother 2015 Mar;16(4):515-32. Epub 2014 Dec 24 doi: 10.1517/14656566.2015.995625. PMID: 25539282
Gaertner J, Siemens W, Camilleri M, Davies A, Drossman DA, Webster LR, Becker G
J Clin Gastroenterol 2015 Jan;49(1):9-16. doi: 10.1097/MCG.0000000000000246. PMID: 25356996

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