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Gastric Hyperplastic Polyp

MedGen UID:
164209
•Concept ID:
C0878649
•
Disease or Syndrome
Synonym: Gastric Metaplastic Polyp

Definition

A non-neoplastic polyp that arises from the stomach and is characterized by the presence of dilated gastric foveoli, edematous changes, and inflammation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric Hyperplastic Polyp

Professional guidelines

PubMed

Endoscopic differential diagnosis between foveolar-type gastric adenoma and gastric hyperplastic polyps in Helicobacter pylori-naïve patients.
Shibagaki K, Ishimura N, Kotani S, Fukuyama C, Takahashi Y, Kishimoto K, Yazaki T, Kataoka M, Omachi T, Kinoshita Y, Hasegawa N, Oka A, Mishima Y, Mishiro T, Oshima N, Kawashima K, Nagase M, Araki A, Kadota K, Ishihara S
Gastric Cancer 2023 Nov;26(6):1002-1011. Epub 2023 Aug 6 doi: 10.1007/s10120-023-01420-2. PMID: 37543537
Management of Non-neoplastic Gastric Lesions.
Schmocker RK, Lidor AO
Surg Clin North Am 2017 Apr;97(2):387-403. doi: 10.1016/j.suc.2016.11.011. PMID: 28325193
Guidelines for the management of Helicobacter pylori infection in Japan: current status and future prospects.
Fujioka T, Yoshiiwa A, Okimoto T, Kodama M, Murakami K
J Gastroenterol 2007 Jan;42 Suppl 17:3-6. doi: 10.1007/s00535-006-1938-3. PMID: 17238017

Recent clinical studies

Etiology

Endoscopic differential diagnosis between foveolar-type gastric adenoma and gastric hyperplastic polyps in Helicobacter pylori-naïve patients.
Shibagaki K, Ishimura N, Kotani S, Fukuyama C, Takahashi Y, Kishimoto K, Yazaki T, Kataoka M, Omachi T, Kinoshita Y, Hasegawa N, Oka A, Mishima Y, Mishiro T, Oshima N, Kawashima K, Nagase M, Araki A, Kadota K, Ishihara S
Gastric Cancer 2023 Nov;26(6):1002-1011. Epub 2023 Aug 6 doi: 10.1007/s10120-023-01420-2. PMID: 37543537
BRAF Mutation Is Associated with Hyperplastic Polyp-Associated Gastric Cancer.
Fujiwara-Tani R, Okamoto A, Katsuragawa H, Ohmori H, Fujii K, Mori S, Kishi S, Sasaki T, Nakashima C, Kawahara I, Hojo Y, Nishiguchi Y, Mori T, Mizumoto T, Nagai K, Luo Y, Kuniyasu H
Int J Mol Sci 2021 Nov 25;22(23) doi: 10.3390/ijms222312724. PMID: 34884530Free PMC Article
Changes of Gastric Juice Microenvironment in Patients with Fundic Gland Polyp and Hyperplastic Polyp.
Gao H, Chang L, Wang L, Zhou X, Wang N
Pathobiology 2021;88(6):383-391. Epub 2021 Sep 9 doi: 10.1159/000516855. PMID: 34500447
Helicobacter pylori Eradication Regressed Gastric Hyperplastic Polyp: A Randomized Controlled Trial.
Nam SY, Lee SW, Jeon SW, Kwon YH, Lee HS
Dig Dis Sci 2020 Dec;65(12):3652-3659. Epub 2020 Jan 23 doi: 10.1007/s10620-020-06065-0. PMID: 31974914
Pathophysiological and clinical aspects of gastric hyperplastic polyps.
Markowski AR, Markowska A, Guzinska-Ustymowicz K
World J Gastroenterol 2016 Oct 28;22(40):8883-8891. doi: 10.3748/wjg.v22.i40.8883. PMID: 27833379Free PMC Article

Diagnosis

Endoscopic differential diagnosis between foveolar-type gastric adenoma and gastric hyperplastic polyps in Helicobacter pylori-naïve patients.
Shibagaki K, Ishimura N, Kotani S, Fukuyama C, Takahashi Y, Kishimoto K, Yazaki T, Kataoka M, Omachi T, Kinoshita Y, Hasegawa N, Oka A, Mishima Y, Mishiro T, Oshima N, Kawashima K, Nagase M, Araki A, Kadota K, Ishihara S
Gastric Cancer 2023 Nov;26(6):1002-1011. Epub 2023 Aug 6 doi: 10.1007/s10120-023-01420-2. PMID: 37543537
Helicobacter pylori eradication reduces risk for recurrence of gastric hyperplastic polyp after endoscopic resection.
Cho YS, Nam SY, Moon HS, Kim TH, Kim SE, Jung JT
Korean J Intern Med 2023 Mar;38(2):167-175. Epub 2022 Nov 28 doi: 10.3904/kjim.2022.111. PMID: 36437035Free PMC Article
Adenocarcinoma and Neuroendocrine Collision Tumor in a Giant Gastric Hyperplastic Polyp.
Park YM, Na K, Sung JY, Jang JY, Kim YW
J Nippon Med Sch 2020;87(3):157-161. doi: 10.1272/jnms.JNMS.2020_87-306. PMID: 32655092
Helicobacter pylori Eradication Regressed Gastric Hyperplastic Polyp: A Randomized Controlled Trial.
Nam SY, Lee SW, Jeon SW, Kwon YH, Lee HS
Dig Dis Sci 2020 Dec;65(12):3652-3659. Epub 2020 Jan 23 doi: 10.1007/s10620-020-06065-0. PMID: 31974914
Pathophysiological and clinical aspects of gastric hyperplastic polyps.
Markowski AR, Markowska A, Guzinska-Ustymowicz K
World J Gastroenterol 2016 Oct 28;22(40):8883-8891. doi: 10.3748/wjg.v22.i40.8883. PMID: 27833379Free PMC Article

Therapy

Severe Anemia from Multiple Gastric Hyperplastic Polyps in a Hemodialysis Patient after Long-term Use of a Proton-pump Inhibitor.
Ikeda S, Takahashi T, Tandoh T, Ushiyama K, Kida Y
Intern Med 2024;63(5):649-657. doi: 10.2169/internalmedicine.2091-23. PMID: 38432892Free PMC Article
Helicobacter pylori Eradication Regressed Gastric Hyperplastic Polyp: A Randomized Controlled Trial.
Nam SY, Lee SW, Jeon SW, Kwon YH, Lee HS
Dig Dis Sci 2020 Dec;65(12):3652-3659. Epub 2020 Jan 23 doi: 10.1007/s10620-020-06065-0. PMID: 31974914
Bleeding from a gastric hyperplastic polyp during anticoagulation therapy.
Okano H, Saitou T, Sase T
Intern Med 2011;50(12):1349. Epub 2011 Jun 15 doi: 10.2169/internalmedicine.50.5365. PMID: 21673475
Incidence and risk factor of fundic gland polyp and hyperplastic polyp in long-term proton pump inhibitor therapy: a prospective study in Japan.
Hongo M, Fujimoto K; Gastric Polyps Study Group
J Gastroenterol 2010 Jun;45(6):618-24. Epub 2010 Feb 23 doi: 10.1007/s00535-010-0207-7. PMID: 20177714
Guidelines for the management of Helicobacter pylori infection in Japan: current status and future prospects.
Fujioka T, Yoshiiwa A, Okimoto T, Kodama M, Murakami K
J Gastroenterol 2007 Jan;42 Suppl 17:3-6. doi: 10.1007/s00535-006-1938-3. PMID: 17238017

Prognosis

BRAF Mutation Is Associated with Hyperplastic Polyp-Associated Gastric Cancer.
Fujiwara-Tani R, Okamoto A, Katsuragawa H, Ohmori H, Fujii K, Mori S, Kishi S, Sasaki T, Nakashima C, Kawahara I, Hojo Y, Nishiguchi Y, Mori T, Mizumoto T, Nagai K, Luo Y, Kuniyasu H
Int J Mol Sci 2021 Nov 25;22(23) doi: 10.3390/ijms222312724. PMID: 34884530Free PMC Article
Gastric adenocarcinoma coexisting with a reddish semipedunculated polyp arising from Helicobacter pylori-negative normal gastric mucosa: a report of two cases.
Isono Y, Baba Y, Mukai K, Asakawa H, Nose K, Tsuruga S, Tochio T, Kumazawa H, Tanaka H, Matsusaki S, Sase T, Saito T, Okano H, Toyoda H
Clin J Gastroenterol 2018 Dec;11(6):481-486. Epub 2018 Jul 18 doi: 10.1007/s12328-018-0887-8. PMID: 30022297
A white opaque substance-positive gastric hyperplastic polyp with dysplasia.
Ueyama H, Matsumoto K, Nagahara A, Gushima R, Hayashi T, Yao T, Watanabe S
World J Gastroenterol 2013 Jul 14;19(26):4262-6. doi: 10.3748/wjg.v19.i26.4262. PMID: 23864793Free PMC Article
Incidence and risk factor of fundic gland polyp and hyperplastic polyp in long-term proton pump inhibitor therapy: a prospective study in Japan.
Hongo M, Fujimoto K; Gastric Polyps Study Group
J Gastroenterol 2010 Jun;45(6):618-24. Epub 2010 Feb 23 doi: 10.1007/s00535-010-0207-7. PMID: 20177714
H. pylori infection and the development of gastric cancer.
Uemura N, Okamoto S, Yamamoto S
Keio J Med 2002 Dec;51 Suppl 2:63-8. doi: 10.2302/kjm.51.supplement2_63. PMID: 12528941

Clinical prediction guides

BRAF Mutation Is Associated with Hyperplastic Polyp-Associated Gastric Cancer.
Fujiwara-Tani R, Okamoto A, Katsuragawa H, Ohmori H, Fujii K, Mori S, Kishi S, Sasaki T, Nakashima C, Kawahara I, Hojo Y, Nishiguchi Y, Mori T, Mizumoto T, Nagai K, Luo Y, Kuniyasu H
Int J Mol Sci 2021 Nov 25;22(23) doi: 10.3390/ijms222312724. PMID: 34884530Free PMC Article
Helicobacter pylori Eradication Regressed Gastric Hyperplastic Polyp: A Randomized Controlled Trial.
Nam SY, Lee SW, Jeon SW, Kwon YH, Lee HS
Dig Dis Sci 2020 Dec;65(12):3652-3659. Epub 2020 Jan 23 doi: 10.1007/s10620-020-06065-0. PMID: 31974914
Hyperplastic polyps arising in autoimmune metaplastic atrophic gastritis patients: is this a distinct clinicopathological entity?
Zhang H, Nie X, Song Z, Cui R, Jin Z
Scand J Gastroenterol 2018 Oct-Nov;53(10-11):1186-1193. Epub 2018 Oct 24 doi: 10.1080/00365521.2018.1514420. PMID: 30353753
Gastric Hyperplastic Polyp with Xanthoma Observed by Magnification Narrow-Band Imaging Endoscopy and Endoscopic Ultrasonography : Report of a Case.
Fukuda S, Akahoshi K, Fushimi F, Oya M
Fukuoka Igaku Zasshi 2015 Apr;106(4):77-82. PMID: 26117951
Cyclooxygenase-2 expression and angiogenesis in gastric hyperplastic polyp--association with polyp size.
Kawada M, Seno H, Wada M, Suzuki K, Kanda N, Kayahara T, Fukui H, Sawada M, Kajiyama T, Sakai M, Chiba T
Digestion 2003;67(1-2):20-4. doi: 10.1159/000069708. PMID: 12743436

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