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Soft tissue sarcoma

MedGen UID:
1642116
Concept ID:
C4551687
Neoplastic Process
Synonym: Soft tissue sarcomas
SNOMED CT: Sarcoma of soft tissue (424952003)
 
HPO: HP:0030448
Monarch Initiative: MONDO:0018078
Orphanet: ORPHA3394

Definition

A type of sarcoma (A connective tissue neoplasm formed by proliferation of mesodermal cells) that develops from soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSoft tissue sarcoma

Conditions with this feature

Li-Fraumeni syndrome 1
MedGen UID:
322656
Concept ID:
C1835398
Disease or Syndrome
Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome associated with high risks for a diverse spectrum of childhood- and adult-onset malignancies. The lifetime risk of cancer in individuals with LFS is =70% for men and =90% for women. Five cancer types account for the majority of LFS tumors: adrenocortical carcinomas, breast cancer, central nervous system tumors, osteosarcomas, and soft-tissue sarcomas. LFS is associated with an increased risk of several additional cancers including leukemia, lymphoma, gastrointestinal cancers, cancers of head and neck, kidney, larynx, lung, skin (e.g., melanoma), ovary, pancreas, prostate, testis, and thyroid. Individuals with LFS are at increased risk for cancer in childhood and young adulthood; survivors are at increased risk for multiple primary cancers.

Professional guidelines

PubMed

Devaud N, Vornicova O, Abdul Razak AR, Khalili K, Demicco EG, Mitric C, Bernardini MQ, Gladdy RA
Surg Oncol Clin N Am 2022 Jul;31(3):527-546. doi: 10.1016/j.soc.2022.03.011. PMID: 35715148
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Grünewald TG, Alonso M, Avnet S, Banito A, Burdach S, Cidre-Aranaz F, Di Pompo G, Distel M, Dorado-Garcia H, Garcia-Castro J, González-González L, Grigoriadis AE, Kasan M, Koelsche C, Krumbholz M, Lecanda F, Lemma S, Longo DL, Madrigal-Esquivel C, Morales-Molina Á, Musa J, Ohmura S, Ory B, Pereira-Silva M, Perut F, Rodriguez R, Seeling C, Al Shaaili N, Shaabani S, Shiavone K, Sinha S, Tomazou EM, Trautmann M, Vela M, Versleijen-Jonkers YM, Visgauss J, Zalacain M, Schober SJ, Lissat A, English WR, Baldini N, Heymann D
EMBO Mol Med 2020 Nov 6;12(11):e11131. Epub 2020 Oct 13 doi: 10.15252/emmm.201911131. PMID: 33047515Free PMC Article

Recent clinical studies

Etiology

Kunisada T, Nakata E, Fujiwara T, Hosono A, Takihira S, Kondo H, Ozaki T
Int J Clin Oncol 2023 Jan;28(1):1-11. Epub 2022 Jan 27 doi: 10.1007/s10147-022-02119-7. PMID: 35084598
Milgrom SA, Million L, Mandeville H, Safwat A, Ermoian RP, Terezakis S
Pediatr Blood Cancer 2021 May;68 Suppl 2:e28279. doi: 10.1002/pbc.28279. PMID: 33818885
Rogers TN, Dasgupta R
Surg Oncol Clin N Am 2021 Apr;30(2):339-353. Epub 2021 Jan 27 doi: 10.1016/j.soc.2020.11.003. PMID: 33706904
Ratan R, Patel SR
Cancer 2016 Oct;122(19):2952-60. Epub 2016 Jul 19 doi: 10.1002/cncr.30191. PMID: 27434055
O'Sullivan B, Davis AM, Turcotte R, Bell R, Catton C, Chabot P, Wunder J, Kandel R, Goddard K, Sadura A, Pater J, Zee B
Lancet 2002 Jun 29;359(9325):2235-41. doi: 10.1016/S0140-6736(02)09292-9. PMID: 12103287

Diagnosis

Rogers TN, Dasgupta R
Surg Oncol Clin N Am 2021 Apr;30(2):339-353. Epub 2021 Jan 27 doi: 10.1016/j.soc.2020.11.003. PMID: 33706904
Bourcier K, Le Cesne A, Tselikas L, Adam J, Mir O, Honore C, de Baere T
Cardiovasc Intervent Radiol 2019 Sep;42(9):1255-1261. Epub 2019 Jun 24 doi: 10.1007/s00270-019-02259-w. PMID: 31236647
Ray-Coquard I, Serre D, Reichardt P, Martín-Broto J, Bauer S
Future Oncol 2018 May;14(10s):25-49. doi: 10.2217/fon-2018-0076. PMID: 29768052
Córdoba Rovira SM, Inarejos Clemente EJ
Radiologia 2016 Nov-Dec;58(6):481-490. Epub 2016 Nov 1 doi: 10.1016/j.rx.2016.09.003. PMID: 27810092
Gilbert NF, Cannon CP, Lin PP, Lewis VO
J Am Acad Orthop Surg 2009 Jan;17(1):40-7. doi: 10.5435/00124635-200901000-00006. PMID: 19136426

Therapy

Roulleaux Dugage M, Jones RL, Trent J, Champiat S, Dumont S
Front Immunol 2021;12:715727. Epub 2021 Aug 20 doi: 10.3389/fimmu.2021.715727. PMID: 34489967Free PMC Article
Meyer M, Seetharam M
Curr Treat Options Oncol 2019 Jan 24;20(1):6. doi: 10.1007/s11864-019-0606-9. PMID: 30675651
Shen G, Zheng F, Ren D, Du F, Dong Q, Wang Z, Zhao F, Ahmad R, Zhao J
J Hematol Oncol 2018 Sep 19;11(1):120. doi: 10.1186/s13045-018-0664-7. PMID: 30231931Free PMC Article
Miyamoto S, Kakutani S, Sato Y, Hanashi A, Kinoshita Y, Ishikawa A
Jpn J Clin Oncol 2018 Jun 1;48(6):503-513. doi: 10.1093/jjco/hyy053. PMID: 29684209
O'Sullivan B, Davis AM, Turcotte R, Bell R, Catton C, Chabot P, Wunder J, Kandel R, Goddard K, Sadura A, Pater J, Zee B
Lancet 2002 Jun 29;359(9325):2235-41. doi: 10.1016/S0140-6736(02)09292-9. PMID: 12103287

Prognosis

Milgrom SA, Million L, Mandeville H, Safwat A, Ermoian RP, Terezakis S
Pediatr Blood Cancer 2021 May;68 Suppl 2:e28279. doi: 10.1002/pbc.28279. PMID: 33818885
Groeneveld CS, Fontugne J, Cabel L, Bernard-Pierrot I, Radvanyi F, Allory Y, de Reyniès A
Eur J Cancer 2021 May;148:181-189. Epub 2021 Mar 18 doi: 10.1016/j.ejca.2021.01.036. PMID: 33743486
Spunt SL, Million L, Chi YY, Anderson J, Tian J, Hibbitts E, Coffin C, McCarville MB, Randall RL, Parham DM, Black JO, Kao SC, Hayes-Jordan A, Wolden S, Laurie F, Speights R, Kawashima E, Skapek SX, Meyer W, Pappo AS, Hawkins DS
Lancet Oncol 2020 Jan;21(1):145-161. Epub 2019 Nov 27 doi: 10.1016/S1470-2045(19)30672-2. PMID: 31786124Free PMC Article
Meyer M, Seetharam M
Curr Treat Options Oncol 2019 Jan 24;20(1):6. doi: 10.1007/s11864-019-0606-9. PMID: 30675651
O'Sullivan B, Davis AM, Turcotte R, Bell R, Catton C, Chabot P, Wunder J, Kandel R, Goddard K, Sadura A, Pater J, Zee B
Lancet 2002 Jun 29;359(9325):2235-41. doi: 10.1016/S0140-6736(02)09292-9. PMID: 12103287

Clinical prediction guides

Qi L, Zhang W, Ren X, Xu R, Yang Z, Chen R, Tu C, Li Z
Front Immunol 2022;13:921223. Epub 2022 Jul 4 doi: 10.3389/fimmu.2022.921223. PMID: 35860263Free PMC Article
Shern JF, Selfe J, Izquierdo E, Patidar R, Chou HC, Song YK, Yohe ME, Sindiri S, Wei J, Wen X, Rudzinski ER, Barkauskas DA, Lo T, Hall D, Linardic CM, Hughes D, Jamal S, Jenney M, Chisholm J, Brown R, Jones K, Hicks B, Angelini P, George S, Chesler L, Hubank M, Kelsey A, Gatz SA, Skapek SX, Hawkins DS, Shipley JM, Khan J
J Clin Oncol 2021 Sep 10;39(26):2859-2871. Epub 2021 Jun 24 doi: 10.1200/JCO.20.03060. PMID: 34166060Free PMC Article
Foersch S, Eckstein M, Wagner DC, Gach F, Woerl AC, Geiger J, Glasner C, Schelbert S, Schulz S, Porubsky S, Kreft A, Hartmann A, Agaimy A, Roth W
Ann Oncol 2021 Sep;32(9):1178-1187. Epub 2021 Jun 15 doi: 10.1016/j.annonc.2021.06.007. PMID: 34139273
Winchester D, Lehman J, Tello T, Chimato N, Hocker T, Kim S, Chang J, Markey J, Yom SS, Ryan W, Mully T, Hodge D, Otley C, Arron ST
J Am Acad Dermatol 2018 Nov;79(5):853-859. Epub 2018 May 19 doi: 10.1016/j.jaad.2018.05.022. PMID: 29787841
Bray JP
J Small Anim Pract 2016 Oct;57(10):510-519. Epub 2016 Sep 14 doi: 10.1111/jsap.12556. PMID: 27624929

Recent systematic reviews

Roohani S, Ehret F, Kobus M, Flörcken A, Märdian S, Striefler JK, Rau D, Öllinger R, Jarosch A, Budach V, Kaul D
Radiat Oncol 2022 Sep 14;17(1):159. doi: 10.1186/s13014-022-02072-9. PMID: 36104789Free PMC Article
de Graaf L, Boulanger M, Bureau M, Bouvier G, Meryet-Figuiere M, Tual S, Lebailly P, Baldi I
Environ Res 2022 Jan;203:111822. Epub 2021 Aug 2 doi: 10.1016/j.envres.2021.111822. PMID: 34352232
Saerens M, Brusselaers N, Rottey S, Decruyenaere A, Creytens D, Lapeire L
Eur J Cancer 2021 Jul;152:165-182. Epub 2021 Jun 6 doi: 10.1016/j.ejca.2021.04.034. PMID: 34107450
Cupp MA, Cariolou M, Tzoulaki I, Aune D, Evangelou E, Berlanga-Taylor AJ
BMC Med 2020 Nov 20;18(1):360. doi: 10.1186/s12916-020-01817-1. PMID: 33213430Free PMC Article
Pervaiz N, Colterjohn N, Farrokhyar F, Tozer R, Figueredo A, Ghert M
Cancer 2008 Aug 1;113(3):573-81. doi: 10.1002/cncr.23592. PMID: 18521899

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