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Increased tear production

MedGen UID:
1642181
•Concept ID:
C4703505
•
Finding
HPO: HP:0031731

Definition

Increased lacrimation owing to overproduction of tears. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased tear production

Professional guidelines

PubMed

Current trends in pharmaceutical treatment of dry eye disease: A review.
Mohamed HB, Abd El-Hamid BN, Fathalla D, Fouad EA
Eur J Pharm Sci 2022 Aug 1;175:106206. Epub 2022 May 11 doi: 10.1016/j.ejps.2022.106206. PMID: 35568107
A Meta-Analysis of the Efficacy of Hyaluronic Acid Eye Drops for the Treatment of Dry Eye Syndrome.
Yang YJ, Lee WY, Kim YJ, Hong YP
Int J Environ Res Public Health 2021 Mar 1;18(5) doi: 10.3390/ijerph18052383. PMID: 33804439Free PMC Article
Advances in dry eye disease treatment.
O'Neil EC, Henderson M, Massaro-Giordano M, Bunya VY
Curr Opin Ophthalmol 2019 May;30(3):166-178. doi: 10.1097/ICU.0000000000000569. PMID: 30883442Free PMC Article

Recent clinical studies

Etiology

Lactobacillus fermentum HY7302 Improves Dry Eye Symptoms in a Mouse Model of Benzalkonium Chloride-Induced Eye Dysfunction and Human Conjunctiva Epithelial Cells.
Lee K, Jeong JW, Shim JJ, Hong HS, Kim JY, Lee JL
Int J Mol Sci 2023 Jun 20;24(12) doi: 10.3390/ijms241210378. PMID: 37373526Free PMC Article
Extrapulmonary Manifestations COVID-19.
Nelwan EJ, Tunjungputri RN, Tetrasiwi EN, Lauditta RK, Nainggolan L
Acta Med Indones 2022 Apr;54(2):314-315. PMID: 35818654
Effects of chondrocyte-derived extracellular matrix in a dry eye mouse model.
Kim CE, Oh HN, Lee JH, Yang JW
Mol Vis 2015;21:1210-23. Epub 2015 Oct 26 PMID: 26604661Free PMC Article
Effects of phytoestrogen supplementation in postmenopausal women with dry eye syndrome: a randomized clinical trial.
Scuderi G, Contestabile MT, Gagliano C, Iacovello D, Scuderi L, Avitabile T
Can J Ophthalmol 2012 Dec;47(6):489-92. doi: 10.1016/j.jcjo.2012.08.019. PMID: 23217501
Self-reported compliance with topical cyclosporine emulsion 0.05% and onset of the effects of increased tear production as assessed through patient surveys.
Trattler W, Katsev D, Kerney D
Clin Ther 2006 Nov;28(11):1848-56. doi: 10.1016/j.clinthera.2006.11.016. PMID: 17213005

Diagnosis

Efficacy and Safety of Single-dose OC-02 (Simpinicline Solution) Nasal Spray on Signs and Symptoms of Dry Eye Disease: The PEARL Phase II Randomized Trial.
Torkildsen GL, Pattar GR, Jerkins G, Striffler K, Nau J
Clin Ther 2022 Sep;44(9):1178-1186. Epub 2022 Aug 11 doi: 10.1016/j.clinthera.2022.07.006. PMID: 35965109
Extrapulmonary Manifestations COVID-19.
Nelwan EJ, Tunjungputri RN, Tetrasiwi EN, Lauditta RK, Nainggolan L
Acta Med Indones 2022 Apr;54(2):314-315. PMID: 35818654

Therapy

Aurantio-obtusin Alleviates Dry Eye Disease by Targeting NF-κB/NLRP3 Signaling in Rodent Models.
Zhu D, Zheng N, Deng K, Li L
Biochem Genet 2024 Apr;62(2):1-14. Epub 2023 Aug 26 doi: 10.1007/s10528-023-10471-0. PMID: 37633872
A phase II randomized trial to evaluate the long-term (12-week) efficacy and safety of OC-01 (varenicline solution) nasal spray for dry eye disease: The MYSTIC study.
Quiroz-Mercado H, Hernandez-Quintela E, Chiu KH, Henry E, Nau JA
Ocul Surf 2022 Apr;24:15-21. Epub 2021 Dec 15 doi: 10.1016/j.jtos.2021.12.007. PMID: 34920097
RGN-259 (thymosin β4) improves clinically important dry eye efficacies in comparison with prescription drugs in a dry eye model.
Kim CE, Kleinman HK, Sosne G, Ousler GW, Kim K, Kang S, Yang J
Sci Rep 2018 Jul 12;8(1):10500. doi: 10.1038/s41598-018-28861-5. PMID: 30002412Free PMC Article
Effects of phytoestrogen supplementation in postmenopausal women with dry eye syndrome: a randomized clinical trial.
Scuderi G, Contestabile MT, Gagliano C, Iacovello D, Scuderi L, Avitabile T
Can J Ophthalmol 2012 Dec;47(6):489-92. doi: 10.1016/j.jcjo.2012.08.019. PMID: 23217501
Self-reported compliance with topical cyclosporine emulsion 0.05% and onset of the effects of increased tear production as assessed through patient surveys.
Trattler W, Katsev D, Kerney D
Clin Ther 2006 Nov;28(11):1848-56. doi: 10.1016/j.clinthera.2006.11.016. PMID: 17213005

Prognosis

Self-reported compliance with topical cyclosporine emulsion 0.05% and onset of the effects of increased tear production as assessed through patient surveys.
Trattler W, Katsev D, Kerney D
Clin Ther 2006 Nov;28(11):1848-56. doi: 10.1016/j.clinthera.2006.11.016. PMID: 17213005

Clinical prediction guides

Isolation and Identification of a Novel Anti-Dry Eye Peptide from Tilapia Skin Peptides Based on In Silico, In Vitro, and In Vivo Approaches.
Zeng J, Lin C, Zhang S, Yin H, Deng K, Yang Z, Zhang Y, Liu Y, Hu C, Zhao YT
Int J Mol Sci 2023 Aug 14;24(16) doi: 10.3390/ijms241612772. PMID: 37628955Free PMC Article
Lactobacillus fermentum HY7302 Improves Dry Eye Symptoms in a Mouse Model of Benzalkonium Chloride-Induced Eye Dysfunction and Human Conjunctiva Epithelial Cells.
Lee K, Jeong JW, Shim JJ, Hong HS, Kim JY, Lee JL
Int J Mol Sci 2023 Jun 20;24(12) doi: 10.3390/ijms241210378. PMID: 37373526Free PMC Article
Efficacy and Safety of Single-dose OC-02 (Simpinicline Solution) Nasal Spray on Signs and Symptoms of Dry Eye Disease: The PEARL Phase II Randomized Trial.
Torkildsen GL, Pattar GR, Jerkins G, Striffler K, Nau J
Clin Ther 2022 Sep;44(9):1178-1186. Epub 2022 Aug 11 doi: 10.1016/j.clinthera.2022.07.006. PMID: 35965109
A phase II randomized trial to evaluate the long-term (12-week) efficacy and safety of OC-01 (varenicline solution) nasal spray for dry eye disease: The MYSTIC study.
Quiroz-Mercado H, Hernandez-Quintela E, Chiu KH, Henry E, Nau JA
Ocul Surf 2022 Apr;24:15-21. Epub 2021 Dec 15 doi: 10.1016/j.jtos.2021.12.007. PMID: 34920097
Effects of chondrocyte-derived extracellular matrix in a dry eye mouse model.
Kim CE, Oh HN, Lee JH, Yang JW
Mol Vis 2015;21:1210-23. Epub 2015 Oct 26 PMID: 26604661Free PMC Article

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