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EGFR Gene Rearrangement

MedGen UID:
1642205
Concept ID:
C4688368
Cell or Molecular Dysfunction
Synonyms: c-erbB1 Gene Rearrangement; Epidermal Growth Factor Receptor Gene Rearrangement; ERBB Gene Rearrangement; ERBB1 Gene Rearrangement; HER1 Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the EGFR gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEGFR Gene Rearrangement

Professional guidelines

PubMed

Rybarczyk-Kasiuchnicz A, Ramlau R, Stencel K
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020593. PMID: 33435596Free PMC Article
Pavlakis N, Cooper C, John T, Kao S, Klebe S, Lee CK, Leong T, Millward M, O'Byrne K, Russell PA, Solomon B, Cooper WA, Fox S
Pathology 2019 Dec;51(7):673-680. Epub 2019 Oct 24 doi: 10.1016/j.pathol.2019.08.006. PMID: 31668406
Cheng L, Zhang S, Alexander R, Yao Y, MacLennan GT, Pan CX, Huang J, Wang M, Montironi R, Lopez-Beltran A
Future Oncol 2011 Apr;7(4):519-41. doi: 10.2217/fon.11.25. PMID: 21463141

Recent clinical studies

Etiology

Shi Y, Lei Y, Liu L, Zhang S, Wang W, Zhao J, Zhao S, Dong X, Yao M, Wang K, Zhou Q
Cancer Med 2021 Apr;10(7):2216-2231. Epub 2021 Mar 2 doi: 10.1002/cam4.3649. PMID: 33655698Free PMC Article
Rybarczyk-Kasiuchnicz A, Ramlau R, Stencel K
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020593. PMID: 33435596Free PMC Article
Barlesi F, Mazieres J, Merlio JP, Debieuvre D, Mosser J, Lena H, Ouafik L, Besse B, Rouquette I, Westeel V, Escande F, Monnet I, Lemoine A, Veillon R, Blons H, Audigier-Valette C, Bringuier PP, Lamy R, Beau-Faller M, Pujol JL, Sabourin JC, Penault-Llorca F, Denis MG, Lantuejoul S, Morin F, Tran Q, Missy P, Langlais A, Milleron B, Cadranel J, Soria JC, Zalcman G; Biomarkers France contributors
Lancet 2016 Apr 2;387(10026):1415-1426. Epub 2016 Jan 15 doi: 10.1016/S0140-6736(16)00004-0. PMID: 26777916
Devarakonda S, Morgensztern D, Govindan R
Lancet Oncol 2015 Jul;16(7):e342-51. doi: 10.1016/S1470-2045(15)00077-7. PMID: 26149886
Imielinski M, Berger AH, Hammerman PS, Hernandez B, Pugh TJ, Hodis E, Cho J, Suh J, Capelletti M, Sivachenko A, Sougnez C, Auclair D, Lawrence MS, Stojanov P, Cibulskis K, Choi K, de Waal L, Sharifnia T, Brooks A, Greulich H, Banerji S, Zander T, Seidel D, Leenders F, Ansén S, Ludwig C, Engel-Riedel W, Stoelben E, Wolf J, Goparju C, Thompson K, Winckler W, Kwiatkowski D, Johnson BE, Jänne PA, Miller VA, Pao W, Travis WD, Pass HI, Gabriel SB, Lander ES, Thomas RK, Garraway LA, Getz G, Meyerson M
Cell 2012 Sep 14;150(6):1107-20. doi: 10.1016/j.cell.2012.08.029. PMID: 22980975Free PMC Article

Diagnosis

Ozcan G, Singh M, Vredenburgh JJ
Clin Cancer Res 2023 Jan 4;29(1):11-29. doi: 10.1158/1078-0432.CCR-22-1585. PMID: 35972437
Tan AC, Tan DSW
J Clin Oncol 2022 Feb 20;40(6):611-625. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01626. PMID: 34985916
Imyanitov EN, Iyevleva AG, Levchenko EV
Crit Rev Oncol Hematol 2021 Jan;157:103194. Epub 2020 Dec 11 doi: 10.1016/j.critrevonc.2020.103194. PMID: 33316418
Jain D, Nambirajan A, Borczuk A, Chen G, Minami Y, Moreira AL, Motoi N, Papotti M, Rekhtman N, Russell PA, Savic Prince S, Yatabe Y, Bubendorf L; IASLC Pathology Committee
Cancer Cytopathol 2019 May;127(5):325-339. Epub 2019 May 3 doi: 10.1002/cncy.22137. PMID: 31050216Free PMC Article
Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, Zheng S, Chakravarty D, Sanborn JZ, Berman SH, Beroukhim R, Bernard B, Wu CJ, Genovese G, Shmulevich I, Barnholtz-Sloan J, Zou L, Vegesna R, Shukla SA, Ciriello G, Yung WK, Zhang W, Sougnez C, Mikkelsen T, Aldape K, Bigner DD, Van Meir EG, Prados M, Sloan A, Black KL, Eschbacher J, Finocchiaro G, Friedman W, Andrews DW, Guha A, Iacocca M, O'Neill BP, Foltz G, Myers J, Weisenberger DJ, Penny R, Kucherlapati R, Perou CM, Hayes DN, Gibbs R, Marra M, Mills GB, Lander E, Spellman P, Wilson R, Sander C, Weinstein J, Meyerson M, Gabriel S, Laird PW, Haussler D, Getz G, Chin L; TCGA Research Network
Cell 2013 Oct 10;155(2):462-77. doi: 10.1016/j.cell.2013.09.034. PMID: 24120142Free PMC Article

Therapy

Tan AC, Tan DSW
J Clin Oncol 2022 Feb 20;40(6):611-625. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01626. PMID: 34985916
Rybarczyk-Kasiuchnicz A, Ramlau R, Stencel K
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020593. PMID: 33435596Free PMC Article
Arbour KC, Riely GJ
JAMA 2019 Aug 27;322(8):764-774. doi: 10.1001/jama.2019.11058. PMID: 31454018
Du Z, Lovly CM
Mol Cancer 2018 Feb 19;17(1):58. doi: 10.1186/s12943-018-0782-4. PMID: 29455648Free PMC Article
Kris MG, Johnson BE, Berry LD, Kwiatkowski DJ, Iafrate AJ, Wistuba II, Varella-Garcia M, Franklin WA, Aronson SL, Su PF, Shyr Y, Camidge DR, Sequist LV, Glisson BS, Khuri FR, Garon EB, Pao W, Rudin C, Schiller J, Haura EB, Socinski M, Shirai K, Chen H, Giaccone G, Ladanyi M, Kugler K, Minna JD, Bunn PA
JAMA 2014 May 21;311(19):1998-2006. doi: 10.1001/jama.2014.3741. PMID: 24846037Free PMC Article

Prognosis

Tan AC, Tan DSW
J Clin Oncol 2022 Feb 20;40(6):611-625. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01626. PMID: 34985916
Imyanitov EN, Iyevleva AG, Levchenko EV
Crit Rev Oncol Hematol 2021 Jan;157:103194. Epub 2020 Dec 11 doi: 10.1016/j.critrevonc.2020.103194. PMID: 33316418
Skoulidis F, Heymach JV
Nat Rev Cancer 2019 Sep;19(9):495-509. Epub 2019 Aug 12 doi: 10.1038/s41568-019-0179-8. PMID: 31406302Free PMC Article
Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, Zheng S, Chakravarty D, Sanborn JZ, Berman SH, Beroukhim R, Bernard B, Wu CJ, Genovese G, Shmulevich I, Barnholtz-Sloan J, Zou L, Vegesna R, Shukla SA, Ciriello G, Yung WK, Zhang W, Sougnez C, Mikkelsen T, Aldape K, Bigner DD, Van Meir EG, Prados M, Sloan A, Black KL, Eschbacher J, Finocchiaro G, Friedman W, Andrews DW, Guha A, Iacocca M, O'Neill BP, Foltz G, Myers J, Weisenberger DJ, Penny R, Kucherlapati R, Perou CM, Hayes DN, Gibbs R, Marra M, Mills GB, Lander E, Spellman P, Wilson R, Sander C, Weinstein J, Meyerson M, Gabriel S, Laird PW, Haussler D, Getz G, Chin L; TCGA Research Network
Cell 2013 Oct 10;155(2):462-77. doi: 10.1016/j.cell.2013.09.034. PMID: 24120142Free PMC Article
Gan HK, Cvrljevic AN, Johns TG
FEBS J 2013 Nov;280(21):5350-70. Epub 2013 Jul 8 doi: 10.1111/febs.12393. PMID: 23777544

Clinical prediction guides

Tan AC, Tan DSW
J Clin Oncol 2022 Feb 20;40(6):611-625. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01626. PMID: 34985916
Imyanitov EN, Iyevleva AG, Levchenko EV
Crit Rev Oncol Hematol 2021 Jan;157:103194. Epub 2020 Dec 11 doi: 10.1016/j.critrevonc.2020.103194. PMID: 33316418
Arbour KC, Riely GJ
JAMA 2019 Aug 27;322(8):764-774. doi: 10.1001/jama.2019.11058. PMID: 31454018
Jain D, Nambirajan A, Borczuk A, Chen G, Minami Y, Moreira AL, Motoi N, Papotti M, Rekhtman N, Russell PA, Savic Prince S, Yatabe Y, Bubendorf L; IASLC Pathology Committee
Cancer Cytopathol 2019 May;127(5):325-339. Epub 2019 May 3 doi: 10.1002/cncy.22137. PMID: 31050216Free PMC Article
Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, Zheng S, Chakravarty D, Sanborn JZ, Berman SH, Beroukhim R, Bernard B, Wu CJ, Genovese G, Shmulevich I, Barnholtz-Sloan J, Zou L, Vegesna R, Shukla SA, Ciriello G, Yung WK, Zhang W, Sougnez C, Mikkelsen T, Aldape K, Bigner DD, Van Meir EG, Prados M, Sloan A, Black KL, Eschbacher J, Finocchiaro G, Friedman W, Andrews DW, Guha A, Iacocca M, O'Neill BP, Foltz G, Myers J, Weisenberger DJ, Penny R, Kucherlapati R, Perou CM, Hayes DN, Gibbs R, Marra M, Mills GB, Lander E, Spellman P, Wilson R, Sander C, Weinstein J, Meyerson M, Gabriel S, Laird PW, Haussler D, Getz G, Chin L; TCGA Research Network
Cell 2013 Oct 10;155(2):462-77. doi: 10.1016/j.cell.2013.09.034. PMID: 24120142Free PMC Article

Recent systematic reviews

Parra-Medina R, Castañeda-González JP, Montoya L, Paula Gómez-Gómez M, Clavijo Cabezas D, Plazas Vargas M
Lung Cancer 2023 Nov;185:107378. Epub 2023 Sep 15 doi: 10.1016/j.lungcan.2023.107378. PMID: 37729688
White VA, Hyrcza MD, Lennerz JK, Thierauf J, Lokuhetty D, Cree IA, Indave BI
Mod Pathol 2022 Oct;35(10):1484-1493. Epub 2022 Jul 23 doi: 10.1038/s41379-022-01100-z. PMID: 35871081Free PMC Article
Zhu VW, Zhao JJ, Gao Y, Syn NL, Zhang SS, Ou SI, Bauer KA, Nagasaka M
Lung Cancer 2021 Jul;157:147-155. Epub 2021 May 20 doi: 10.1016/j.lungcan.2021.05.019. PMID: 34049720
Malapelle U, Muscarella LA, Pisapia P, Rossi A
Expert Opin Investig Drugs 2020 Apr;29(4):363-372. Epub 2020 Feb 26 doi: 10.1080/13543784.2020.1732922. PMID: 32073317
Mendoza DP, Stowell J, Muzikansky A, Shepard JO, Shaw AT, Digumarthy SR
Clin Lung Cancer 2019 Sep;20(5):339-349. Epub 2019 May 11 doi: 10.1016/j.cllc.2019.05.006. PMID: 31164317

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