U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Multifocal hypointensity of cerebral white matter on MRI

MedGen UID:
1643542
•Concept ID:
C4703614
•
Finding
HPO: HP:0040332

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultifocal hypointensity of cerebral white matter on MRI

Recent clinical studies

Etiology

Susceptibility-Weighted MR Imaging Hypointense Rim in Progressive Multifocal Leukoencephalopathy: The End Point of Neuroinflammation and a Potential Outcome Predictor.
Thurnher MM, Boban J, Rieger A, Gelpi E
AJNR Am J Neuroradiol 2019 Jun;40(6):994-1000. Epub 2019 May 23 doi: 10.3174/ajnr.A6072. PMID: 31122919Free PMC Article
High b-value diffusion-weighted imaging in progressive multifocal leukoencephalopathy in HIV patients.
Godi C, De Vita E, Tombetti E, Davagnanam I, Haddow L, Jäger HR
Eur Radiol 2017 Sep;27(9):3593-3599. Epub 2017 Feb 6 doi: 10.1007/s00330-017-4761-8. PMID: 28168372Free PMC Article
Use of quantitative susceptibility mapping (QSM) in progressive multifocal leukoencephalopathy.
Carra-Dalliere C, Menjot de Champfleur N, Deverdun J, Ayrignac X, Nerrant E, Makinson A, Casanova ML, Labauge P
J Neuroradiol 2016 Feb;43(1):6-10. Epub 2015 Oct 23 doi: 10.1016/j.neurad.2015.08.001. PMID: 26475668
Clinical and MRI characteristics of levamisole-induced leukoencephalopathy in 16 patients.
Xu N, Zhou W, Li S, Zhou G, Zhang N, Liang J
J Neuroimaging 2009 Oct;19(4):326-31. Epub 2009 Jan 29 doi: 10.1111/j.1552-6569.2008.00344.x. PMID: 19187474
Patterns of MRI lesions in CADASIL.
Chabriat H, Levy C, Taillia H, Iba-Zizen MT, Vahedi K, Joutel A, Tournier-Lasserve E, Bousser MG
Neurology 1998 Aug;51(2):452-7. doi: 10.1212/wnl.51.2.452. PMID: 9710018

Diagnosis

MRI Shrimp Sign in Cerebellar Progressive Multifocal Leukoencephalopathy: Description and Validation of a Novel Observation.
Adra N, Goodheart AE, Rapalino O, Caruso P, Mukerji SS, González RG, Venna N, Schmahmann JD
AJNR Am J Neuroradiol 2021 Jun;42(6):1073-1079. Epub 2021 May 13 doi: 10.3174/ajnr.A7145. PMID: 33985948Free PMC Article
White matter abnormalities and iron deposition in prenatal mucolipidosis IV- fetal imaging and pathology.
Zerem A, Ben-Sira L, Vigdorovich N, Leibovitz Z, Fisher Y, Schiffmann R, Grishchuk Y, Misko AL, Orenstein N, Lev D, Lerman-Sagie T, Kidron D
Metab Brain Dis 2021 Oct;36(7):2155-2167. Epub 2021 May 8 doi: 10.1007/s11011-021-00742-3. PMID: 33963976
Cortical hypointensity in T2-weighted gradient-echo sequences in patients with progressive multifocal leukoencephalopathy.
López Sala P, Alberdi Aldasoro N, Zelaya Huerta MV, Bacaicoa Saralegui MC, Cabada Giadás T
Radiologia (Engl Ed) 2020 Jan-Feb;62(1):59-66. Epub 2019 Jul 30 doi: 10.1016/j.rx.2019.06.003. PMID: 31375267
Neuroimaging Applications in Chronic Ataxias.
Mascalchi M, Vella A
Int Rev Neurobiol 2018;143:109-162. Epub 2018 Oct 29 doi: 10.1016/bs.irn.2018.09.011. PMID: 30473193
MR imaging, apparent diffusion coefficient and histopathological features of desmoplastic infantile tumors-own experience and review of the literature.
Jurkiewicz E, Grajkowska W, Nowak K, Kowalczyk P, Walecka A, Dembowska-Bagińska B
Childs Nerv Syst 2015 Feb;31(2):251-9. Epub 2014 Nov 22 doi: 10.1007/s00381-014-2593-2. PMID: 25416471

Therapy

Cortical hypointensity in T2-weighted gradient-echo sequences in patients with progressive multifocal leukoencephalopathy.
López Sala P, Alberdi Aldasoro N, Zelaya Huerta MV, Bacaicoa Saralegui MC, Cabada Giadás T
Radiologia (Engl Ed) 2020 Jan-Feb;62(1):59-66. Epub 2019 Jul 30 doi: 10.1016/j.rx.2019.06.003. PMID: 31375267
Magnetic resonance imaging pattern in natalizumab-associated progressive multifocal leukoencephalopathy.
Yousry TA, Pelletier D, Cadavid D, Gass A, Richert ND, Radue EW, Filippi M
Ann Neurol 2012 Nov;72(5):779-87. doi: 10.1002/ana.23676. PMID: 23280794
A rational approach to PML for the clinician.
Calabrese L
Cleve Clin J Med 2011 Nov;78 Suppl 2:S38-41. doi: 10.3949/ccjm.78.s2.09. PMID: 22123934
Clinical and MRI characteristics of levamisole-induced leukoencephalopathy in 16 patients.
Xu N, Zhou W, Li S, Zhou G, Zhang N, Liang J
J Neuroimaging 2009 Oct;19(4):326-31. Epub 2009 Jan 29 doi: 10.1111/j.1552-6569.2008.00344.x. PMID: 19187474
Patterns of MRI lesions in CADASIL.
Chabriat H, Levy C, Taillia H, Iba-Zizen MT, Vahedi K, Joutel A, Tournier-Lasserve E, Bousser MG
Neurology 1998 Aug;51(2):452-7. doi: 10.1212/wnl.51.2.452. PMID: 9710018

Prognosis

MRI of fatal course of acute hemorrhagic leukoencephalitis in a child with SARS-CoV-2 omicron BA 2.0 infection.
Wong AM, Lin JJ, Hsia SH, Lin KL
Neuroradiology 2023 Jul;65(7):1179-1181. Epub 2023 May 18 doi: 10.1007/s00234-023-03160-7. PMID: 37199765Free PMC Article
MRI Shrimp Sign in Cerebellar Progressive Multifocal Leukoencephalopathy: Description and Validation of a Novel Observation.
Adra N, Goodheart AE, Rapalino O, Caruso P, Mukerji SS, González RG, Venna N, Schmahmann JD
AJNR Am J Neuroradiol 2021 Jun;42(6):1073-1079. Epub 2021 May 13 doi: 10.3174/ajnr.A7145. PMID: 33985948Free PMC Article
Cortical hypointensity in T2-weighted gradient-echo sequences in patients with progressive multifocal leukoencephalopathy.
López Sala P, Alberdi Aldasoro N, Zelaya Huerta MV, Bacaicoa Saralegui MC, Cabada Giadás T
Radiologia (Engl Ed) 2020 Jan-Feb;62(1):59-66. Epub 2019 Jul 30 doi: 10.1016/j.rx.2019.06.003. PMID: 31375267
Susceptibility-Weighted MR Imaging Hypointense Rim in Progressive Multifocal Leukoencephalopathy: The End Point of Neuroinflammation and a Potential Outcome Predictor.
Thurnher MM, Boban J, Rieger A, Gelpi E
AJNR Am J Neuroradiol 2019 Jun;40(6):994-1000. Epub 2019 May 23 doi: 10.3174/ajnr.A6072. PMID: 31122919Free PMC Article
A rational approach to PML for the clinician.
Calabrese L
Cleve Clin J Med 2011 Nov;78 Suppl 2:S38-41. doi: 10.3949/ccjm.78.s2.09. PMID: 22123934

Clinical prediction guides

MRI Shrimp Sign in Cerebellar Progressive Multifocal Leukoencephalopathy: Description and Validation of a Novel Observation.
Adra N, Goodheart AE, Rapalino O, Caruso P, Mukerji SS, González RG, Venna N, Schmahmann JD
AJNR Am J Neuroradiol 2021 Jun;42(6):1073-1079. Epub 2021 May 13 doi: 10.3174/ajnr.A7145. PMID: 33985948Free PMC Article
A case of disseminated microscopic demyelination with multifocal dystrophic calcification.
Abdollahi M, Gao AF, Munoz DG
Neuropathology 2020 Jun;40(3):308-314. Epub 2020 Mar 3 doi: 10.1111/neup.12642. PMID: 32128889
Susceptibility-Weighted MR Imaging Hypointense Rim in Progressive Multifocal Leukoencephalopathy: The End Point of Neuroinflammation and a Potential Outcome Predictor.
Thurnher MM, Boban J, Rieger A, Gelpi E
AJNR Am J Neuroradiol 2019 Jun;40(6):994-1000. Epub 2019 May 23 doi: 10.3174/ajnr.A6072. PMID: 31122919Free PMC Article
Neuroimaging Applications in Chronic Ataxias.
Mascalchi M, Vella A
Int Rev Neurobiol 2018;143:109-162. Epub 2018 Oct 29 doi: 10.1016/bs.irn.2018.09.011. PMID: 30473193
MR imaging, apparent diffusion coefficient and histopathological features of desmoplastic infantile tumors-own experience and review of the literature.
Jurkiewicz E, Grajkowska W, Nowak K, Kowalczyk P, Walecka A, Dembowska-Bagińska B
Childs Nerv Syst 2015 Feb;31(2):251-9. Epub 2014 Nov 22 doi: 10.1007/s00381-014-2593-2. PMID: 25416471

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...