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Presence of xenobiotic

MedGen UID:
1643655
•Concept ID:
C4703568
•
Finding
HPO: HP:0031838

Definition

Presence of a chemical substance found within an individual that is not naturally produced or expected to be present in human tissues or bodily fluids. [from HPO]

Professional guidelines

PubMed

The effect of topical minoxidil treatment on follicular sulfotransferase enzymatic activity.
Goren A, Mccoy J, Kovacevic M, Situm M, Chitalia J, Dhurat R, Naccarato T, Lotti T
J Biol Regul Homeost Agents 2018 Jul-Aug;32(4):937-940. PMID: 30043580

Recent clinical studies

Etiology

An introduction to human microbiome.
Das B
Prog Mol Biol Transl Sci 2022;191(1):1-28. Epub 2022 Jul 30 doi: 10.1016/bs.pmbts.2022.06.026. PMID: 36270674
Cancer Risk and Nullity of Glutathione-S-Transferase Mu and Theta 1 in Occupational Pesticide Workers.
Usman MB, Priya K, Pandit S, Gupta PK
Curr Pharm Biotechnol 2022;23(7):932-945. doi: 10.2174/1389201022666210810092342. PMID: 34375184
N-vinyl compounds: studies on metabolism, genotoxicity, carcinogenicity.
Oesch F, Honarvar N, Fabian E, Berger FI, Landsiedel R
Arch Toxicol 2021 Oct;95(10):3143-3159. Epub 2021 Jun 6 doi: 10.1007/s00204-021-03081-5. PMID: 34091723
Toxicity and remediation of pharmaceuticals and pesticides using metal oxides and carbon nanomaterials.
Fallah Z, Zare EN, Ghomi M, Ahmadijokani F, Amini M, Tajbakhsh M, Arjmand M, Sharma G, Ali H, Ahmad A, Makvandi P, Lichtfouse E, Sillanpää M, Varma RS
Chemosphere 2021 Jul;275:130055. Epub 2021 Feb 22 doi: 10.1016/j.chemosphere.2021.130055. PMID: 33984903Free PMC Article
The beneficial effects of Brassica vegetables on human health.
Kapusta-Duch J, Kopeć A, Piatkowska E, Borczak B, Leszczyńska T
Rocz Panstw Zakl Hig 2012;63(4):389-95. PMID: 23631258

Diagnosis

Associations of dietary factors and xenobiotic intake with faecal microbiota composition according to the presence of intestinal mucosa damage.
Ruiz-Saavedra S, González Del Rey C, Suárez A, Díaz Y, Zapico A, Arboleya S, Salazar N, Gueimonde M, de Los Reyes-Gavilán CG, González S
Food Funct 2023 Oct 30;14(21):9591-9605. doi: 10.1039/d3fo01356a. PMID: 37740374
Expression of the endocannabinoid system and response to cannabinoid components by the human fetal testis.
Dochez-Arnault J, Desdoits-Lethimonier C, Matias I, Evrard B, Lagarrigue M, Toupin M, Lardenois A, Chalmel F, Mazaud-Guittot S, Dejucq-Rainsford N, Gely-Pernot A
BMC Med 2023 Jul 11;21(1):219. doi: 10.1186/s12916-023-02916-5. PMID: 37430350Free PMC Article
Eryptosis: An Erythrocyte's Suicidal Type of Cell Death.
Repsold L, Joubert AM
Biomed Res Int 2018;2018:9405617. Epub 2018 Jan 3 doi: 10.1155/2018/9405617. PMID: 29516014Free PMC Article
Transdermal immunotherapy: Past, present and future.
Szczepanik M, Majewska-Szczepanik M
Pharmacol Rep 2016 Aug;68(4):773-81. Epub 2016 Apr 25 doi: 10.1016/j.pharep.2016.04.004. PMID: 27236747
Bioluminescent assays for ADMET.
Cali JJ, Niles A, Valley MP, O'Brien MA, Riss TL, Shultz J
Expert Opin Drug Metab Toxicol 2008 Jan;4(1):103-20. doi: 10.1517/17425255.4.1.103. PMID: 18370862

Therapy

Exploring the influence of the microbiome on the pharmacology of anti-asthmatic drugs.
Chan M, Ghadieh C, Irfan I, Khair E, Padilla N, Rebeiro S, Sidgreaves A, Patravale V, Disouza J, Catanzariti R, Pont L, Williams K, De Rubis G, Mehndiratta S, Dhanasekaran M, Dua K
Naunyn Schmiedebergs Arch Pharmacol 2024 Feb;397(2):751-762. Epub 2023 Aug 31 doi: 10.1007/s00210-023-02681-5. PMID: 37650889Free PMC Article
Sympathomimetic Toxidromes and Other Pharmacological Causes of Acute Hypertension.
King A, Dimovska M, Bisoski L
Curr Hypertens Rep 2018 Feb 24;20(1):8. doi: 10.1007/s11906-018-0807-9. PMID: 29478133
Clinical Pharmacokinetics and Pharmacodynamics of Antihyperglycemic Medications in Children and Adolescents with Type 2 Diabetes Mellitus.
Akhlaghi F, Matson KL, Mohammadpour AH, Kelly M, Karimani A
Clin Pharmacokinet 2017 Jun;56(6):561-571. doi: 10.1007/s40262-016-0472-6. PMID: 27832452Free PMC Article
Xenobiotics and loss of tolerance in primary biliary cholangitis.
Wang J, Yang G, Dubrovsky AM, Choi J, Leung PS
World J Gastroenterol 2016 Jan 7;22(1):338-48. doi: 10.3748/wjg.v22.i1.338. PMID: 26755880Free PMC Article
Antioxidants and cataract.
Thiagarajan R, Manikandan R
Free Radic Res 2013 May;47(5):337-45. Epub 2013 Mar 11 doi: 10.3109/10715762.2013.777155. PMID: 23438873

Prognosis

Associations of dietary factors and xenobiotic intake with faecal microbiota composition according to the presence of intestinal mucosa damage.
Ruiz-Saavedra S, González Del Rey C, Suárez A, Díaz Y, Zapico A, Arboleya S, Salazar N, Gueimonde M, de Los Reyes-Gavilán CG, González S
Food Funct 2023 Oct 30;14(21):9591-9605. doi: 10.1039/d3fo01356a. PMID: 37740374
N-vinyl compounds: studies on metabolism, genotoxicity, carcinogenicity.
Oesch F, Honarvar N, Fabian E, Berger FI, Landsiedel R
Arch Toxicol 2021 Oct;95(10):3143-3159. Epub 2021 Jun 6 doi: 10.1007/s00204-021-03081-5. PMID: 34091723
Atypical Michaelis-Menten kinetics in cytochrome P450 enzymes: A focus on substrate inhibition.
Leow JWH, Chan ECY
Biochem Pharmacol 2019 Nov;169:113615. Epub 2019 Aug 21 doi: 10.1016/j.bcp.2019.08.017. PMID: 31445022
Clinical Pharmacokinetics and Pharmacodynamics of Antihyperglycemic Medications in Children and Adolescents with Type 2 Diabetes Mellitus.
Akhlaghi F, Matson KL, Mohammadpour AH, Kelly M, Karimani A
Clin Pharmacokinet 2017 Jun;56(6):561-571. doi: 10.1007/s40262-016-0472-6. PMID: 27832452Free PMC Article
Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach.
Hernández LG, van Steeg H, Luijten M, van Benthem J
Mutat Res 2009 Sep-Dec;682(2-3):94-109. Epub 2009 Jul 22 doi: 10.1016/j.mrrev.2009.07.002. PMID: 19631282

Clinical prediction guides

Pesticides analysis in alternative biological matrices.
Crocoli LC, Menck RA, Moura S
Drug Chem Toxicol 2023 Nov;46(4):809-824. Epub 2022 Jun 23 doi: 10.1080/01480545.2022.2090574. PMID: 35734890
N-vinyl compounds: studies on metabolism, genotoxicity, carcinogenicity.
Oesch F, Honarvar N, Fabian E, Berger FI, Landsiedel R
Arch Toxicol 2021 Oct;95(10):3143-3159. Epub 2021 Jun 6 doi: 10.1007/s00204-021-03081-5. PMID: 34091723
Mycotoxin: Its Impact on Gut Health and Microbiota.
Liew WP, Mohd-Redzwan S
Front Cell Infect Microbiol 2018;8:60. Epub 2018 Feb 26 doi: 10.3389/fcimb.2018.00060. PMID: 29535978Free PMC Article
Clinical Pharmacokinetics and Pharmacodynamics of Antihyperglycemic Medications in Children and Adolescents with Type 2 Diabetes Mellitus.
Akhlaghi F, Matson KL, Mohammadpour AH, Kelly M, Karimani A
Clin Pharmacokinet 2017 Jun;56(6):561-571. doi: 10.1007/s40262-016-0472-6. PMID: 27832452Free PMC Article
NRH:quinone oxidoreductase2 (NQO2).
Long DJ 2nd, Jaiswal AK
Chem Biol Interact 2000 Dec 1;129(1-2):99-112. doi: 10.1016/s0009-2797(00)00200-3. PMID: 11154737

Recent systematic reviews

Polymorphisms in GSTT1 and GSTM1 genes as possible risk factors for susceptibility to breast cancer development and their influence in chemotherapy response: a systematic review.
Pacholak LM, Amarante MK, Guembarovski RL, Watanabe MAE, Panis C
Mol Biol Rep 2020 Jul;47(7):5495-5501. Epub 2020 Jun 3 doi: 10.1007/s11033-020-05555-8. PMID: 32494978
Antioxidant and Antimicrobial Activities of Crude Extracts and Fractions of Cashew (Anacardium occidentale L.), Cajui (Anacardium microcarpum), and Pequi (Caryocar brasiliense C.): A Systematic Review.
Baptista A, Gonçalves RV, Bressan J, Pelúzio MDCG
Oxid Med Cell Longev 2018;2018:3753562. Epub 2018 Apr 18 doi: 10.1155/2018/3753562. PMID: 29849888Free PMC Article

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