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Steroid Refractory Graft Versus Host Disease

MedGen UID:
1643838
•Concept ID:
C4687714
•
Disease or Syndrome
Synonyms: Steroid Refractory cGVHD; Steroid Refractory GVHD

Definition

Graft versus host disease that does not respond to steroid treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSteroid Refractory Graft Versus Host Disease

Professional guidelines

PubMed

Extracorporeal photopheresis in acute and chronic steroid‑refractory graft-versus-host disease: an evolving treatment landscape.
Greinix HT, Ayuk F, Zeiser R
Leukemia 2022 Nov;36(11):2558-2566. Epub 2022 Sep 24 doi: 10.1038/s41375-022-01701-2. PMID: 36153436Free PMC Article
Immunopathology and biology-based treatment of steroid-refractory graft-versus-host disease.
Toubai T, Magenau J
Blood 2020 Jul 23;136(4):429-440. doi: 10.1182/blood.2019000953. PMID: 32526035Free PMC Article
Graft-versus-host disease management.
Mistrik M, Bojtarova E, Sopko L, Masakova L, Roziakova L, Martinka J, Batorova A
Bratisl Lek Listy 2016;117(7):388-96. doi: 10.4149/bll_2016_077. PMID: 27546540

Recent clinical studies

Etiology

Ruxolitinib Treatment of Steroid-Refractory Graft-versus-Host Disease in Children: A Case Series and Review of the Literature.
Yan WL, Zhao FY, Gu ME, Liu N, Guo XP, Xu XJ
Paediatr Drugs 2023 Sep;25(5):577-584. Epub 2023 Jun 7 doi: 10.1007/s40272-023-00577-8. PMID: 37284944
Ruxolitinib for Treatment of Steroid-Refractory Graft-versus-Host Disease: Real-World Data from Chinese Patients.
Wei C, Zhang X, Liang D, Yang J, Du J, Yue C, Deng L
Drug Des Devel Ther 2021;15:4875-4883. Epub 2021 Nov 30 doi: 10.2147/DDDT.S338752. PMID: 34880598Free PMC Article
Ruxolitinib for chronic steroid-refractory graft versus host disease: a single center experience.
Xue E, Lorentino F, Pavesi F, Assanelli A, Peccatori J, Bernardi M, Corti C, Ciceri F, Lupo Stanghellini MT
Leuk Res 2021 Oct;109:106642. Epub 2021 Jun 11 doi: 10.1016/j.leukres.2021.106642. PMID: 34157510
Biomarker-guided preemption of steroid-refractory graft-versus-host disease with α-1-antitrypsin.
Gergoudis SC, DeFilipp Z, Özbek U, Sandhu KS, Etra AM, Choe HK, Kitko CL, Ayuk F, Aziz M, Baez J, Ben-David K, Bunworasate U, Gandhi I, Hexner EO, Hogan WJ, Holler E, Kasikis S, Kowalyk SM, Lin JY, Merli P, Morales G, Nakamura R, Reshef R, Rösler W, Srinagesh H, Young R, Chen YB, Ferrara JLM, Levine JE
Blood Adv 2020 Dec 22;4(24):6098-6105. doi: 10.1182/bloodadvances.2020003336. PMID: 33351103Free PMC Article
EASIX in patients with acute graft-versus-host disease: a retrospective cohort analysis.
Luft T, Benner A, Jodele S, Dandoy CE, Storb R, Gooley T, Sandmaier BM, Becker N, Radujkovic A, Dreger P, Penack O
Lancet Haematol 2017 Sep;4(9):e414-e423. Epub 2017 Jul 18 doi: 10.1016/S2352-3026(17)30108-4. PMID: 28733186

Diagnosis

A personalized, organ-based approach to the treatment of chronic steroid-refractory graft-versus-host disease.
Fatoum H, Zeiser R, Hashmi SK
Blood Rev 2024 Jan;63:101142. Epub 2023 Nov 11 doi: 10.1016/j.blre.2023.101142. PMID: 38087715
Ruxolitinib Treatment of Steroid-Refractory Graft-versus-Host Disease in Children: A Case Series and Review of the Literature.
Yan WL, Zhao FY, Gu ME, Liu N, Guo XP, Xu XJ
Paediatr Drugs 2023 Sep;25(5):577-584. Epub 2023 Jun 7 doi: 10.1007/s40272-023-00577-8. PMID: 37284944
Clinical Features, Treatment, and Outcome of Pediatric Steroid Refractory Acute Graft-Versus-Host Disease: A Multicenter Study.
Verbeek AB, Jansen SA, von Asmuth EGJ, Lankester AC, Bresters D, Bierings M, Mohseny AB, Lindemans CA, Buddingh EP
Transplant Cell Ther 2022 Sep;28(9):600.e1-600.e9. Epub 2022 Jun 16 doi: 10.1016/j.jtct.2022.06.008. PMID: 35717003
Ruxolitinib for chronic steroid-refractory graft versus host disease: a single center experience.
Xue E, Lorentino F, Pavesi F, Assanelli A, Peccatori J, Bernardi M, Corti C, Ciceri F, Lupo Stanghellini MT
Leuk Res 2021 Oct;109:106642. Epub 2021 Jun 11 doi: 10.1016/j.leukres.2021.106642. PMID: 34157510
Graft-versus-host disease management.
Mistrik M, Bojtarova E, Sopko L, Masakova L, Roziakova L, Martinka J, Batorova A
Bratisl Lek Listy 2016;117(7):388-96. doi: 10.4149/bll_2016_077. PMID: 27546540

Therapy

Ruxolitinib Treatment of Steroid-Refractory Graft-versus-Host Disease in Children: A Case Series and Review of the Literature.
Yan WL, Zhao FY, Gu ME, Liu N, Guo XP, Xu XJ
Paediatr Drugs 2023 Sep;25(5):577-584. Epub 2023 Jun 7 doi: 10.1007/s40272-023-00577-8. PMID: 37284944
Extracorporeal photopheresis in acute and chronic steroid‑refractory graft-versus-host disease: an evolving treatment landscape.
Greinix HT, Ayuk F, Zeiser R
Leukemia 2022 Nov;36(11):2558-2566. Epub 2022 Sep 24 doi: 10.1038/s41375-022-01701-2. PMID: 36153436Free PMC Article
Efficacy and safety of ruxolitinib in steroid-refractory graft-versus-host disease: A meta-analysis.
Fan S, Huo WX, Yang Y, Shen MZ, Mo XD
Front Immunol 2022;13:954268. Epub 2022 Aug 4 doi: 10.3389/fimmu.2022.954268. PMID: 35990629Free PMC Article
Immunopathology and biology-based treatment of steroid-refractory graft-versus-host disease.
Toubai T, Magenau J
Blood 2020 Jul 23;136(4):429-440. doi: 10.1182/blood.2019000953. PMID: 32526035Free PMC Article
Graft-versus-host disease management.
Mistrik M, Bojtarova E, Sopko L, Masakova L, Roziakova L, Martinka J, Batorova A
Bratisl Lek Listy 2016;117(7):388-96. doi: 10.4149/bll_2016_077. PMID: 27546540

Prognosis

Extracorporeal photopheresis in acute and chronic steroid‑refractory graft-versus-host disease: an evolving treatment landscape.
Greinix HT, Ayuk F, Zeiser R
Leukemia 2022 Nov;36(11):2558-2566. Epub 2022 Sep 24 doi: 10.1038/s41375-022-01701-2. PMID: 36153436Free PMC Article
Steroid-Refractory Gut Graft-Versus-Host Disease: What We Have Learned From Basic Immunology and Experimental Mouse Model.
Song Q, Nasri U, Zeng D
Front Immunol 2022;13:844271. Epub 2022 Feb 18 doi: 10.3389/fimmu.2022.844271. PMID: 35251043Free PMC Article
Biomarker-guided preemption of steroid-refractory graft-versus-host disease with α-1-antitrypsin.
Gergoudis SC, DeFilipp Z, Özbek U, Sandhu KS, Etra AM, Choe HK, Kitko CL, Ayuk F, Aziz M, Baez J, Ben-David K, Bunworasate U, Gandhi I, Hexner EO, Hogan WJ, Holler E, Kasikis S, Kowalyk SM, Lin JY, Merli P, Morales G, Nakamura R, Reshef R, Rösler W, Srinagesh H, Young R, Chen YB, Ferrara JLM, Levine JE
Blood Adv 2020 Dec 22;4(24):6098-6105. doi: 10.1182/bloodadvances.2020003336. PMID: 33351103Free PMC Article
Immunopathology and biology-based treatment of steroid-refractory graft-versus-host disease.
Toubai T, Magenau J
Blood 2020 Jul 23;136(4):429-440. doi: 10.1182/blood.2019000953. PMID: 32526035Free PMC Article
Graft-versus-host disease management.
Mistrik M, Bojtarova E, Sopko L, Masakova L, Roziakova L, Martinka J, Batorova A
Bratisl Lek Listy 2016;117(7):388-96. doi: 10.4149/bll_2016_077. PMID: 27546540

Clinical prediction guides

A personalized, organ-based approach to the treatment of chronic steroid-refractory graft-versus-host disease.
Fatoum H, Zeiser R, Hashmi SK
Blood Rev 2024 Jan;63:101142. Epub 2023 Nov 11 doi: 10.1016/j.blre.2023.101142. PMID: 38087715
Ruxolitinib Treatment of Steroid-Refractory Graft-versus-Host Disease in Children: A Case Series and Review of the Literature.
Yan WL, Zhao FY, Gu ME, Liu N, Guo XP, Xu XJ
Paediatr Drugs 2023 Sep;25(5):577-584. Epub 2023 Jun 7 doi: 10.1007/s40272-023-00577-8. PMID: 37284944
Ruxolitinib for Treatment of Steroid-Refractory Graft-versus-Host Disease: Real-World Data from Chinese Patients.
Wei C, Zhang X, Liang D, Yang J, Du J, Yue C, Deng L
Drug Des Devel Ther 2021;15:4875-4883. Epub 2021 Nov 30 doi: 10.2147/DDDT.S338752. PMID: 34880598Free PMC Article
Biomarker-guided preemption of steroid-refractory graft-versus-host disease with α-1-antitrypsin.
Gergoudis SC, DeFilipp Z, Özbek U, Sandhu KS, Etra AM, Choe HK, Kitko CL, Ayuk F, Aziz M, Baez J, Ben-David K, Bunworasate U, Gandhi I, Hexner EO, Hogan WJ, Holler E, Kasikis S, Kowalyk SM, Lin JY, Merli P, Morales G, Nakamura R, Reshef R, Rösler W, Srinagesh H, Young R, Chen YB, Ferrara JLM, Levine JE
Blood Adv 2020 Dec 22;4(24):6098-6105. doi: 10.1182/bloodadvances.2020003336. PMID: 33351103Free PMC Article
EASIX in patients with acute graft-versus-host disease: a retrospective cohort analysis.
Luft T, Benner A, Jodele S, Dandoy CE, Storb R, Gooley T, Sandmaier BM, Becker N, Radujkovic A, Dreger P, Penack O
Lancet Haematol 2017 Sep;4(9):e414-e423. Epub 2017 Jul 18 doi: 10.1016/S2352-3026(17)30108-4. PMID: 28733186

Recent systematic reviews

A personalized, organ-based approach to the treatment of chronic steroid-refractory graft-versus-host disease.
Fatoum H, Zeiser R, Hashmi SK
Blood Rev 2024 Jan;63:101142. Epub 2023 Nov 11 doi: 10.1016/j.blre.2023.101142. PMID: 38087715
Pharmacokinetics and Pharmacodynamics of Ruxolitinib: A Review.
Appeldoorn TYJ, Munnink THO, Morsink LM, Hooge MNL, Touw DJ
Clin Pharmacokinet 2023 Apr;62(4):559-571. Epub 2023 Mar 31 doi: 10.1007/s40262-023-01225-7. PMID: 37000342Free PMC Article
Efficacy and safety of ruxolitinib in steroid-refractory graft-versus-host disease: A meta-analysis.
Fan S, Huo WX, Yang Y, Shen MZ, Mo XD
Front Immunol 2022;13:954268. Epub 2022 Aug 4 doi: 10.3389/fimmu.2022.954268. PMID: 35990629Free PMC Article
Efficacy and safety of ruxolitinib for steroid-refractory graft-versus-host disease: Systematic review and meta-analysis of randomised and non-randomised studies.
Zhang MY, Zhao P, Zhang Y, Wang JS
PLoS One 2022;17(7):e0271979. Epub 2022 Jul 29 doi: 10.1371/journal.pone.0271979. PMID: 35905125Free PMC Article
Ruxolitinib for treatment of steroid-refractory graft-versus-host disease in adults: a systematic review and meta-analysis.
Hui L, Qi L, Guoyu H, Xuliang S, Meiao T
Expert Rev Hematol 2020 May;13(5):565-575. Epub 2020 Mar 21 doi: 10.1080/17474086.2020.1738214. PMID: 32178541

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