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Abnormal libido

MedGen UID:
1644032
•Concept ID:
C4703571
•
Pathologic Function
HPO: HP:0031845

Definition

Any deviation from the normal sexual drive or desire for sexual activity. [from HPO]

Professional guidelines

PubMed

Long-term treatment of acromegaly with bromocriptine.
Wass JA, Thorner MO, Morris DV, Rees LH, Mason AS, Jones AE, Besser GM
Br Med J 1977 Apr 2;1(6065):875-8. doi: 10.1136/bmj.1.6065.875. PMID: 576843Free PMC Article

Recent clinical studies

Etiology

Erectile Dysfunction and Decreased Libido in Klinefelter Syndrome: A Prevalence Meta-Analysis and Meta-Regression Study.
Barbonetti A, D'Andrea S, Vena W, Pizzocaro A, Rastrelli G, Pallotti F, Condorelli R, Calogero AE, Pasquali D, Ferlin A, Foresta C, Jannini EA, Maggi M, Lenzi A, Pivonello R, Isidori A, Garolla A, Francavilla S, Corona G; KING, Klinefelter ItaliaN Group
J Sex Med 2021 Jun;18(6):1053-1064. Epub 2021 May 20 doi: 10.1016/j.jsxm.2021.03.078. PMID: 34023236
Male sexual dysfunction: A review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention.
Chen L, Shi GR, Huang DD, Li Y, Ma CC, Shi M, Su BX, Shi GJ
Biomed Pharmacother 2019 Apr;112:108585. Epub 2019 Feb 21 doi: 10.1016/j.biopha.2019.01.046. PMID: 30798136
Adverse effects of bisphenol A on male reproductive function.
Manfo FP, Jubendradass R, Nantia EA, Moundipa PF, Mathur PP
Rev Environ Contam Toxicol 2014;228:57-82. doi: 10.1007/978-3-319-01619-1_3. PMID: 24162092
Sexual dysfunction in uremia.
Palmer BF
J Am Soc Nephrol 1999 Jun;10(6):1381-8. doi: 10.1681/ASN.V1061381. PMID: 10361878
Possible physiological bases for contraceptive techniques in the male.
Setchell BP
Hum Reprod 1994 Jun;9(6):1081-7. doi: 10.1093/oxfordjournals.humrep.a138637. PMID: 7962380

Diagnosis

Erectile Dysfunction and Decreased Libido in Klinefelter Syndrome: A Prevalence Meta-Analysis and Meta-Regression Study.
Barbonetti A, D'Andrea S, Vena W, Pizzocaro A, Rastrelli G, Pallotti F, Condorelli R, Calogero AE, Pasquali D, Ferlin A, Foresta C, Jannini EA, Maggi M, Lenzi A, Pivonello R, Isidori A, Garolla A, Francavilla S, Corona G; KING, Klinefelter ItaliaN Group
J Sex Med 2021 Jun;18(6):1053-1064. Epub 2021 May 20 doi: 10.1016/j.jsxm.2021.03.078. PMID: 34023236
Male sexual dysfunction: A review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention.
Chen L, Shi GR, Huang DD, Li Y, Ma CC, Shi M, Su BX, Shi GJ
Biomed Pharmacother 2019 Apr;112:108585. Epub 2019 Feb 21 doi: 10.1016/j.biopha.2019.01.046. PMID: 30798136
New Biomarkers to Evaluate Hyperandrogenemic Women and Hypogonadal Men.
Karakas SE, Surampudi P
Adv Clin Chem 2018;86:71-125. Epub 2018 Aug 18 doi: 10.1016/bs.acc.2018.06.001. PMID: 30144842
Sexual dysfunction in diabetes.
Tamás V, Kempler P
Handb Clin Neurol 2014;126:223-32. doi: 10.1016/B978-0-444-53480-4.00017-5. PMID: 25410225
Neuroimaging in posttraumatic hypopituitarism.
Makulski DD, Taber KH, Chiou-Tan FY
J Comput Assist Tomogr 2008 Mar-Apr;32(2):324-8. doi: 10.1097/RCT.0b013e3181636ed4. PMID: 18379326

Therapy

Erectile Dysfunction and Decreased Libido in Klinefelter Syndrome: A Prevalence Meta-Analysis and Meta-Regression Study.
Barbonetti A, D'Andrea S, Vena W, Pizzocaro A, Rastrelli G, Pallotti F, Condorelli R, Calogero AE, Pasquali D, Ferlin A, Foresta C, Jannini EA, Maggi M, Lenzi A, Pivonello R, Isidori A, Garolla A, Francavilla S, Corona G; KING, Klinefelter ItaliaN Group
J Sex Med 2021 Jun;18(6):1053-1064. Epub 2021 May 20 doi: 10.1016/j.jsxm.2021.03.078. PMID: 34023236
Cannabis and Male Fertility: A Systematic Review.
Payne KS, Mazur DJ, Hotaling JM, Pastuszak AW
J Urol 2019 Oct;202(4):674-681. Epub 2019 Sep 6 doi: 10.1097/JU.0000000000000248. PMID: 30916627Free PMC Article
Male sexual dysfunction: A review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention.
Chen L, Shi GR, Huang DD, Li Y, Ma CC, Shi M, Su BX, Shi GJ
Biomed Pharmacother 2019 Apr;112:108585. Epub 2019 Feb 21 doi: 10.1016/j.biopha.2019.01.046. PMID: 30798136
Sexual dysfunction in diabetes.
Tamás V, Kempler P
Handb Clin Neurol 2014;126:223-32. doi: 10.1016/B978-0-444-53480-4.00017-5. PMID: 25410225
The effect of cancer and its therapy upon fertility.
Barber HR
Int J Fertil 1981;26(4):250-9. PMID: 6120905

Prognosis

Testosterone in men with advanced liver disease: abnormalities and implications.
Sinclair M, Grossmann M, Gow PJ, Angus PW
J Gastroenterol Hepatol 2015 Feb;30(2):244-51. doi: 10.1111/jgh.12695. PMID: 25087838
Bicalutamide-associated fulminant hepatotoxicity.
O'Bryant CL, Flaig TW, Utz KJ
Pharmacotherapy 2008 Aug;28(8):1071-5. doi: 10.1592/phco.28.8.1071. PMID: 18657023
Diabetes and the impairment of reproductive function: possible role of mitochondria and reactive oxygen species.
Amaral S, Oliveira PJ, Ramalho-Santos J
Curr Diabetes Rev 2008 Feb;4(1):46-54. doi: 10.2174/157339908783502398. PMID: 18220695
Safety and tolerability of the dual 5alpha-reductase inhibitor dutasteride in the treatment of benign prostatic hyperplasia.
Andriole GL, Kirby R
Eur Urol 2003 Jul;44(1):82-8. doi: 10.1016/s0302-2838(03)00198-2. PMID: 12814679
Sexual dysfunction in uremia.
Palmer BF
J Am Soc Nephrol 1999 Jun;10(6):1381-8. doi: 10.1681/ASN.V1061381. PMID: 10361878

Clinical prediction guides

Prevalence and reproductive manifestations of macroprolactinemia.
Kalsi AK, Halder A, Jain M, Chaturvedi PK, Sharma JB
Endocrine 2019 Feb;63(2):332-340. Epub 2018 Sep 29 doi: 10.1007/s12020-018-1770-6. PMID: 30269265
Other Antidepressants.
Schwasinger-Schmidt TE, Macaluso M
Handb Exp Pharmacol 2019;250:325-355. doi: 10.1007/164_2018_167. PMID: 30194544
New Biomarkers to Evaluate Hyperandrogenemic Women and Hypogonadal Men.
Karakas SE, Surampudi P
Adv Clin Chem 2018;86:71-125. Epub 2018 Aug 18 doi: 10.1016/bs.acc.2018.06.001. PMID: 30144842
Sexuality after hysterectomy.
Farrell SA, Kieser K
Obstet Gynecol 2000 Jun;95(6 Pt 2):1045-51. doi: 10.1016/s0029-7844(00)00784-5. PMID: 10808032
Androgen antagonists in androgen target tissues.
Tindall DJ, Chang CH, Lobl TJ, Cunningham GR
Pharmacol Ther 1984;24(3):367-400. doi: 10.1016/0163-7258(84)90010-x. PMID: 6205409

Recent systematic reviews

46,XX Testicular Disorder of Sex Development (DSD): A Case Report and Systematic Review.
Terribile M, Stizzo M, Manfredi C, Quattrone C, Bottone F, Giordano DR, Bellastella G, Arcaniolo D, De Sio M
Medicina (Kaunas) 2019 Jul 12;55(7) doi: 10.3390/medicina55070371. PMID: 31336995Free PMC Article
Cannabis and Male Fertility: A Systematic Review.
Payne KS, Mazur DJ, Hotaling JM, Pastuszak AW
J Urol 2019 Oct;202(4):674-681. Epub 2019 Sep 6 doi: 10.1097/JU.0000000000000248. PMID: 30916627Free PMC Article
Pharmacological interventions for those who have sexually offended or are at risk of offending.
Khan O, Ferriter M, Huband N, Powney MJ, Dennis JA, Duggan C
Cochrane Database Syst Rev 2015 Feb 18;2015(2):CD007989. doi: 10.1002/14651858.CD007989.pub2. PMID: 25692326Free PMC Article
The impact of opioids on the endocrine system.
Katz N, Mazer NA
Clin J Pain 2009 Feb;25(2):170-5. doi: 10.1097/AJP.0b013e3181850df6. PMID: 19333165
Sexuality after hysterectomy.
Farrell SA, Kieser K
Obstet Gynecol 2000 Jun;95(6 Pt 2):1045-51. doi: 10.1016/s0029-7844(00)00784-5. PMID: 10808032

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