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Grade 3 Pharyngeal Mucositis, CTCAE

MedGen UID:
1644277
•Concept ID:
C4686438
•
Finding

Definition

Severe pain; unable to adequately aliment or hydrate orally; limiting self care ADL [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Pharyngeal Mucositis, CTCAE

Recent clinical studies

Etiology

Patterns of dysphagia and acute toxicities in patients with head and neck cancer undergoing helical IMRT±concurrent chemotherapy.
Moroney LB, Helios J, Ward EC, Crombie J, Wockner LF, Burns CL, Spurgin AL, Blake C, Kenny L, Hughes BG
Oral Oncol 2017 Jan;64:1-8. Epub 2016 Nov 25 doi: 10.1016/j.oraloncology.2016.11.009. PMID: 28024718
A randomised controlled trial of Caphosol mouthwash in management of radiation-induced mucositis in head and neck cancer.
Wong KH, Kuciejewska A, Sharabiani MTA, Ng-Cheng-Hin B, Hoy S, Hurley T, Rydon J, Grove L, Santos A, Ryugenji M, Bhide SA, Nutting CM, Harrington KJ, Newbold KL
Radiother Oncol 2017 Feb;122(2):207-211. Epub 2016 Jul 5 doi: 10.1016/j.radonc.2016.06.015. PMID: 27393218Free PMC Article
Excellent local control and survival after postoperative or definitive radiation therapy for sarcomas of the head and neck.
Andrä C, Rauch J, Li M, Ganswindt U, Belka C, Saleh-Ebrahimi L, Ballhausen H, Nachbichler SB, Roeder F
Radiat Oncol 2015 Jul 10;10:140. doi: 10.1186/s13014-015-0449-x. PMID: 26156022Free PMC Article
Efficacy and safety of combined radiotherapy with EGFR inhibitors and chemotherapy for laryngeal organ preservation in patients with locally advanced hypopharyngeal carcinomas.
Zhang X, Wang J, Wu W, Liu M, Zhao F, Du L, Huang D, Yang S, Ma L
Curr Cancer Drug Targets 2014;14(6):589-98. doi: 10.2174/1568009614666140716115349. PMID: 25039274
Characteristics of response of oral and pharyngeal mucosa in patients receiving chemo-IMRT for head and neck cancer using hypofractionated accelerated radiotherapy.
Bhide SA, Gulliford S, Fowler J, Rosenfelder N, Newbold K, Harrington KJ, Nutting CM
Radiother Oncol 2010 Oct;97(1):86-91. Epub 2010 Sep 7 doi: 10.1016/j.radonc.2010.08.013. PMID: 20826031

Therapy

Patterns of dysphagia and acute toxicities in patients with head and neck cancer undergoing helical IMRT±concurrent chemotherapy.
Moroney LB, Helios J, Ward EC, Crombie J, Wockner LF, Burns CL, Spurgin AL, Blake C, Kenny L, Hughes BG
Oral Oncol 2017 Jan;64:1-8. Epub 2016 Nov 25 doi: 10.1016/j.oraloncology.2016.11.009. PMID: 28024718
A randomised controlled trial of Caphosol mouthwash in management of radiation-induced mucositis in head and neck cancer.
Wong KH, Kuciejewska A, Sharabiani MTA, Ng-Cheng-Hin B, Hoy S, Hurley T, Rydon J, Grove L, Santos A, Ryugenji M, Bhide SA, Nutting CM, Harrington KJ, Newbold KL
Radiother Oncol 2017 Feb;122(2):207-211. Epub 2016 Jul 5 doi: 10.1016/j.radonc.2016.06.015. PMID: 27393218Free PMC Article
Excellent local control and survival after postoperative or definitive radiation therapy for sarcomas of the head and neck.
Andrä C, Rauch J, Li M, Ganswindt U, Belka C, Saleh-Ebrahimi L, Ballhausen H, Nachbichler SB, Roeder F
Radiat Oncol 2015 Jul 10;10:140. doi: 10.1186/s13014-015-0449-x. PMID: 26156022Free PMC Article
Efficacy and safety of combined radiotherapy with EGFR inhibitors and chemotherapy for laryngeal organ preservation in patients with locally advanced hypopharyngeal carcinomas.
Zhang X, Wang J, Wu W, Liu M, Zhao F, Du L, Huang D, Yang S, Ma L
Curr Cancer Drug Targets 2014;14(6):589-98. doi: 10.2174/1568009614666140716115349. PMID: 25039274
Characteristics of response of oral and pharyngeal mucosa in patients receiving chemo-IMRT for head and neck cancer using hypofractionated accelerated radiotherapy.
Bhide SA, Gulliford S, Fowler J, Rosenfelder N, Newbold K, Harrington KJ, Nutting CM
Radiother Oncol 2010 Oct;97(1):86-91. Epub 2010 Sep 7 doi: 10.1016/j.radonc.2010.08.013. PMID: 20826031

Prognosis

Excellent local control and survival after postoperative or definitive radiation therapy for sarcomas of the head and neck.
Andrä C, Rauch J, Li M, Ganswindt U, Belka C, Saleh-Ebrahimi L, Ballhausen H, Nachbichler SB, Roeder F
Radiat Oncol 2015 Jul 10;10:140. doi: 10.1186/s13014-015-0449-x. PMID: 26156022Free PMC Article

Clinical prediction guides

Patterns of dysphagia and acute toxicities in patients with head and neck cancer undergoing helical IMRT±concurrent chemotherapy.
Moroney LB, Helios J, Ward EC, Crombie J, Wockner LF, Burns CL, Spurgin AL, Blake C, Kenny L, Hughes BG
Oral Oncol 2017 Jan;64:1-8. Epub 2016 Nov 25 doi: 10.1016/j.oraloncology.2016.11.009. PMID: 28024718
A randomised controlled trial of Caphosol mouthwash in management of radiation-induced mucositis in head and neck cancer.
Wong KH, Kuciejewska A, Sharabiani MTA, Ng-Cheng-Hin B, Hoy S, Hurley T, Rydon J, Grove L, Santos A, Ryugenji M, Bhide SA, Nutting CM, Harrington KJ, Newbold KL
Radiother Oncol 2017 Feb;122(2):207-211. Epub 2016 Jul 5 doi: 10.1016/j.radonc.2016.06.015. PMID: 27393218Free PMC Article
Excellent local control and survival after postoperative or definitive radiation therapy for sarcomas of the head and neck.
Andrä C, Rauch J, Li M, Ganswindt U, Belka C, Saleh-Ebrahimi L, Ballhausen H, Nachbichler SB, Roeder F
Radiat Oncol 2015 Jul 10;10:140. doi: 10.1186/s13014-015-0449-x. PMID: 26156022Free PMC Article
Characteristics of response of oral and pharyngeal mucosa in patients receiving chemo-IMRT for head and neck cancer using hypofractionated accelerated radiotherapy.
Bhide SA, Gulliford S, Fowler J, Rosenfelder N, Newbold K, Harrington KJ, Nutting CM
Radiother Oncol 2010 Oct;97(1):86-91. Epub 2010 Sep 7 doi: 10.1016/j.radonc.2010.08.013. PMID: 20826031

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