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Focal hyperintensity of cerebral white matter on MRI

MedGen UID:
1644331
Concept ID:
C4703610
Finding
HPO: HP:0040328

Definition

An abnormal area of increased brightness (hyperintensity) that is limited to one particular area. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal hyperintensity of cerebral white matter on MRI

Professional guidelines

PubMed

Lebrun-Frénay C, Okuda DT, Siva A, Landes-Chateau C, Azevedo CJ, Mondot L, Carra-Dallière C, Zephir H, Louapre C, Durand-Dubief F, Le Page E, Bensa C, Ruet A, Ciron J, Laplaud DA, Casez O, Mathey G, de Seze J, Zeydan B, Makhani N, Tutuncu M, Levraut M, Cohen M, Thouvenot E, Pelletier D, Kantarci OH
Brain 2023 Aug 1;146(8):3431-3443. doi: 10.1093/brain/awad073. PMID: 36864688
Charidimou A, Boulouis G, Frosch MP, Baron JC, Pasi M, Albucher JF, Banerjee G, Barbato C, Bonneville F, Brandner S, Calviere L, Caparros F, Casolla B, Cordonnier C, Delisle MB, Deramecourt V, Dichgans M, Gokcal E, Herms J, Hernandez-Guillamon M, Jäger HR, Jaunmuktane Z, Linn J, Martinez-Ramirez S, Martínez-Sáez E, Mawrin C, Montaner J, Moulin S, Olivot JM, Piazza F, Puy L, Raposo N, Rodrigues MA, Roeber S, Romero JR, Samarasekera N, Schneider JA, Schreiber S, Schreiber F, Schwall C, Smith C, Szalardy L, Varlet P, Viguier A, Wardlaw JM, Warren A, Wollenweber FA, Zedde M, van Buchem MA, Gurol ME, Viswanathan A, Al-Shahi Salman R, Smith EE, Werring DJ, Greenberg SM
Lancet Neurol 2022 Aug;21(8):714-725. doi: 10.1016/S1474-4422(22)00208-3. PMID: 35841910Free PMC Article
Ingala S, Mazzai L, Sudre CH, Salvadó G, Brugulat-Serrat A, Wottschel V, Falcon C, Operto G, Tijms B, Gispert JD, Molinuevo JL, Barkhof F; ALFA Study
Neurobiol Aging 2020 Nov;95:104-114. Epub 2020 Jun 29 doi: 10.1016/j.neurobiolaging.2020.06.015. PMID: 32791423

Recent clinical studies

Etiology

Lebrun-Frénay C, Okuda DT, Siva A, Landes-Chateau C, Azevedo CJ, Mondot L, Carra-Dallière C, Zephir H, Louapre C, Durand-Dubief F, Le Page E, Bensa C, Ruet A, Ciron J, Laplaud DA, Casez O, Mathey G, de Seze J, Zeydan B, Makhani N, Tutuncu M, Levraut M, Cohen M, Thouvenot E, Pelletier D, Kantarci OH
Brain 2023 Aug 1;146(8):3431-3443. doi: 10.1093/brain/awad073. PMID: 36864688
Theodorou A, Palaiodimou L, Malhotra K, Zompola C, Katsanos AH, Shoamanesh A, Boviatsis E, Dardiotis E, Spilioti M, Sacco S, Werring DJ, Cordonnier C, Alexandrov AV, Paraskevas GP, Tsivgoulis G
Stroke 2023 Jan;54(1):178-188. Epub 2022 Dec 1 doi: 10.1161/STROKEAHA.122.040671. PMID: 36453271
Seyedsalehi A, Warrier V, Bethlehem RAI, Perry BI, Burgess S, Murray GK
Brain 2023 May 2;146(5):2059-2074. doi: 10.1093/brain/awac392. PMID: 36310536Free PMC Article
Yang Y, Knol MJ, Wang R, Mishra A, Liu D, Luciano M, Teumer A, Armstrong N, Bis JC, Jhun MA, Li S, Adams HHH, Aziz NA, Bastin ME, Bourgey M, Brody JA, Frenzel S, Gottesman RF, Hosten N, Hou L, Kardia SLR, Lohner V, Marquis P, Maniega SM, Satizabal CL, Sorond FA, Valdés Hernández MC, van Duijn CM, Vernooij MW, Wittfeld K, Yang Q, Zhao W, Boerwinkle E, Levy D, Deary IJ, Jiang J, Mather KA, Mosley TH, Psaty BM, Sachdev PS, Smith JA, Sotoodehnia N, DeCarli CS, Breteler MMB, Ikram MA, Grabe HJ, Wardlaw J, Longstreth WT, Launer LJ, Seshadri S, Debette S, Fornage M
Brain 2023 Feb 13;146(2):492-506. doi: 10.1093/brain/awac290. PMID: 35943854Free PMC Article
Charidimou A, Boulouis G, Frosch MP, Baron JC, Pasi M, Albucher JF, Banerjee G, Barbato C, Bonneville F, Brandner S, Calviere L, Caparros F, Casolla B, Cordonnier C, Delisle MB, Deramecourt V, Dichgans M, Gokcal E, Herms J, Hernandez-Guillamon M, Jäger HR, Jaunmuktane Z, Linn J, Martinez-Ramirez S, Martínez-Sáez E, Mawrin C, Montaner J, Moulin S, Olivot JM, Piazza F, Puy L, Raposo N, Rodrigues MA, Roeber S, Romero JR, Samarasekera N, Schneider JA, Schreiber S, Schreiber F, Schwall C, Smith C, Szalardy L, Varlet P, Viguier A, Wardlaw JM, Warren A, Wollenweber FA, Zedde M, van Buchem MA, Gurol ME, Viswanathan A, Al-Shahi Salman R, Smith EE, Werring DJ, Greenberg SM
Lancet Neurol 2022 Aug;21(8):714-725. doi: 10.1016/S1474-4422(22)00208-3. PMID: 35841910Free PMC Article

Diagnosis

Lebrun-Frénay C, Okuda DT, Siva A, Landes-Chateau C, Azevedo CJ, Mondot L, Carra-Dallière C, Zephir H, Louapre C, Durand-Dubief F, Le Page E, Bensa C, Ruet A, Ciron J, Laplaud DA, Casez O, Mathey G, de Seze J, Zeydan B, Makhani N, Tutuncu M, Levraut M, Cohen M, Thouvenot E, Pelletier D, Kantarci OH
Brain 2023 Aug 1;146(8):3431-3443. doi: 10.1093/brain/awad073. PMID: 36864688
Charidimou A, Boulouis G, Frosch MP, Baron JC, Pasi M, Albucher JF, Banerjee G, Barbato C, Bonneville F, Brandner S, Calviere L, Caparros F, Casolla B, Cordonnier C, Delisle MB, Deramecourt V, Dichgans M, Gokcal E, Herms J, Hernandez-Guillamon M, Jäger HR, Jaunmuktane Z, Linn J, Martinez-Ramirez S, Martínez-Sáez E, Mawrin C, Montaner J, Moulin S, Olivot JM, Piazza F, Puy L, Raposo N, Rodrigues MA, Roeber S, Romero JR, Samarasekera N, Schneider JA, Schreiber S, Schreiber F, Schwall C, Smith C, Szalardy L, Varlet P, Viguier A, Wardlaw JM, Warren A, Wollenweber FA, Zedde M, van Buchem MA, Gurol ME, Viswanathan A, Al-Shahi Salman R, Smith EE, Werring DJ, Greenberg SM
Lancet Neurol 2022 Aug;21(8):714-725. doi: 10.1016/S1474-4422(22)00208-3. PMID: 35841910Free PMC Article
Raji CA, Benzinger TLS
Continuum (Minneap Minn) 2022 Jun 1;28(3):800-821. doi: 10.1212/CON.0000000000001133. PMID: 35678403Free PMC Article
Liu YH, Chou YT, Chang FP, Lee WJ, Guo YC, Chou CT, Huang HC, Mizuguchi T, Chou CC, Yu HY, Yu KW, Wu HM, Tsai PC, Matsumoto N, Lee YC, Liao YC
Brain 2022 Sep 14;145(9):3010-3021. doi: 10.1093/brain/awac135. PMID: 35411397
Charidimou A, Boulouis G, Gurol ME, Ayata C, Bacskai BJ, Frosch MP, Viswanathan A, Greenberg SM
Brain 2017 Jul 1;140(7):1829-1850. doi: 10.1093/brain/awx047. PMID: 28334869Free PMC Article

Therapy

Theodorou A, Palaiodimou L, Malhotra K, Zompola C, Katsanos AH, Shoamanesh A, Boviatsis E, Dardiotis E, Spilioti M, Sacco S, Werring DJ, Cordonnier C, Alexandrov AV, Paraskevas GP, Tsivgoulis G
Stroke 2023 Jan;54(1):178-188. Epub 2022 Dec 1 doi: 10.1161/STROKEAHA.122.040671. PMID: 36453271
Seyedsalehi A, Warrier V, Bethlehem RAI, Perry BI, Burgess S, Murray GK
Brain 2023 May 2;146(5):2059-2074. doi: 10.1093/brain/awac392. PMID: 36310536Free PMC Article
Yang Y, Knol MJ, Wang R, Mishra A, Liu D, Luciano M, Teumer A, Armstrong N, Bis JC, Jhun MA, Li S, Adams HHH, Aziz NA, Bastin ME, Bourgey M, Brody JA, Frenzel S, Gottesman RF, Hosten N, Hou L, Kardia SLR, Lohner V, Marquis P, Maniega SM, Satizabal CL, Sorond FA, Valdés Hernández MC, van Duijn CM, Vernooij MW, Wittfeld K, Yang Q, Zhao W, Boerwinkle E, Levy D, Deary IJ, Jiang J, Mather KA, Mosley TH, Psaty BM, Sachdev PS, Smith JA, Sotoodehnia N, DeCarli CS, Breteler MMB, Ikram MA, Grabe HJ, Wardlaw J, Longstreth WT, Launer LJ, Seshadri S, Debette S, Fornage M
Brain 2023 Feb 13;146(2):492-506. doi: 10.1093/brain/awac290. PMID: 35943854Free PMC Article
Malhotra K, Theodorou A, Katsanos AH, Zompola C, Shoamanesh A, Boviatsis E, Paraskevas GP, Spilioti M, Cordonnier C, Werring DJ, Alexandrov AV, Tsivgoulis G
Stroke 2022 Jun;53(6):1944-1953. Epub 2022 Mar 10 doi: 10.1161/STROKEAHA.121.035836. PMID: 35264008
Mastrangelo A, Turrini F, de Zan V, Caccia R, Gerevini S, Cinque P
AIDS 2019 Dec 1;33 Suppl 2:S159-S169. doi: 10.1097/QAD.0000000000002266. PMID: 31789816

Prognosis

Lebrun-Frénay C, Okuda DT, Siva A, Landes-Chateau C, Azevedo CJ, Mondot L, Carra-Dallière C, Zephir H, Louapre C, Durand-Dubief F, Le Page E, Bensa C, Ruet A, Ciron J, Laplaud DA, Casez O, Mathey G, de Seze J, Zeydan B, Makhani N, Tutuncu M, Levraut M, Cohen M, Thouvenot E, Pelletier D, Kantarci OH
Brain 2023 Aug 1;146(8):3431-3443. doi: 10.1093/brain/awad073. PMID: 36864688
Seyedsalehi A, Warrier V, Bethlehem RAI, Perry BI, Burgess S, Murray GK
Brain 2023 May 2;146(5):2059-2074. doi: 10.1093/brain/awac392. PMID: 36310536Free PMC Article
Grosset L, Jouvent E
Cerebrovasc Dis 2022;51(2):131-137. Epub 2022 Feb 21 doi: 10.1159/000522213. PMID: 35189622
Moroni F, Ammirati E, Hainsworth AH, Camici PG
Circ Cardiovasc Imaging 2020 Aug;13(8):e010460. Epub 2020 Jul 28 doi: 10.1161/CIRCIMAGING.120.010460. PMID: 33232175
Jokinen H, Koikkalainen J, Laakso HM, Melkas S, Nieminen T, Brander A, Korvenoja A, Rueckert D, Barkhof F, Scheltens P, Schmidt R, Fazekas F, Madureira S, Verdelho A, Wallin A, Wahlund LO, Waldemar G, Chabriat H, Hennerici M, O'Brien J, Inzitari D, Lötjönen J, Pantoni L, Erkinjuntti T
Stroke 2020 Jan;51(1):170-178. Epub 2019 Nov 8 doi: 10.1161/STROKEAHA.119.026170. PMID: 31699021Free PMC Article

Clinical prediction guides

Lebrun-Frénay C, Okuda DT, Siva A, Landes-Chateau C, Azevedo CJ, Mondot L, Carra-Dallière C, Zephir H, Louapre C, Durand-Dubief F, Le Page E, Bensa C, Ruet A, Ciron J, Laplaud DA, Casez O, Mathey G, de Seze J, Zeydan B, Makhani N, Tutuncu M, Levraut M, Cohen M, Thouvenot E, Pelletier D, Kantarci OH
Brain 2023 Aug 1;146(8):3431-3443. doi: 10.1093/brain/awad073. PMID: 36864688
Seyedsalehi A, Warrier V, Bethlehem RAI, Perry BI, Burgess S, Murray GK
Brain 2023 May 2;146(5):2059-2074. doi: 10.1093/brain/awac392. PMID: 36310536Free PMC Article
Malhotra K, Theodorou A, Katsanos AH, Zompola C, Shoamanesh A, Boviatsis E, Paraskevas GP, Spilioti M, Cordonnier C, Werring DJ, Alexandrov AV, Tsivgoulis G
Stroke 2022 Jun;53(6):1944-1953. Epub 2022 Mar 10 doi: 10.1161/STROKEAHA.121.035836. PMID: 35264008
Baril AA, Martineau-Dussault MÈ, Sanchez E, André C, Thompson C, Legault J, Gosselin N
Curr Neurol Neurosci Rep 2021 Feb 14;21(3):11. doi: 10.1007/s11910-021-01094-2. PMID: 33586028
Jokinen H, Koikkalainen J, Laakso HM, Melkas S, Nieminen T, Brander A, Korvenoja A, Rueckert D, Barkhof F, Scheltens P, Schmidt R, Fazekas F, Madureira S, Verdelho A, Wallin A, Wahlund LO, Waldemar G, Chabriat H, Hennerici M, O'Brien J, Inzitari D, Lötjönen J, Pantoni L, Erkinjuntti T
Stroke 2020 Jan;51(1):170-178. Epub 2019 Nov 8 doi: 10.1161/STROKEAHA.119.026170. PMID: 31699021Free PMC Article

Recent systematic reviews

Theodorou A, Palaiodimou L, Malhotra K, Zompola C, Katsanos AH, Shoamanesh A, Boviatsis E, Dardiotis E, Spilioti M, Sacco S, Werring DJ, Cordonnier C, Alexandrov AV, Paraskevas GP, Tsivgoulis G
Stroke 2023 Jan;54(1):178-188. Epub 2022 Dec 1 doi: 10.1161/STROKEAHA.122.040671. PMID: 36453271
Malhotra K, Theodorou A, Katsanos AH, Zompola C, Shoamanesh A, Boviatsis E, Paraskevas GP, Spilioti M, Cordonnier C, Werring DJ, Alexandrov AV, Tsivgoulis G
Stroke 2022 Jun;53(6):1944-1953. Epub 2022 Mar 10 doi: 10.1161/STROKEAHA.121.035836. PMID: 35264008
Di Stadio A, Ralli M, Roccamatisi D, Scarpa A, Della Volpe A, Cassandro C, Ricci G, Greco A, Bernitsas E
Neurol Sci 2021 Feb;42(2):579-588. Epub 2021 Jan 7 doi: 10.1007/s10072-020-04948-8. PMID: 33409831
Almutairi B, Langley C, Crawley E, Thai NJ
BMJ Open 2020 Aug 30;10(8):e031672. doi: 10.1136/bmjopen-2019-031672. PMID: 32868345Free PMC Article

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