Reduced bone-marrow pro-B cell count

MedGen UID:: 1644559
•Concept ID:: C4703381
•: Finding

HPO:	HP:0020048

Definition

A reduction in the numbers of pro-B cells (defined by coexpression of CD34 and CD19). Earlier B-cell precursors are defined by expressing surface CD34 and cytoplasmic TdT in the absence of CD19. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVReduced bone-marrow pro-B cell count

Phenotypic abnormality
- Abnormality of blood and blood-forming tissues
  - Abnormal bone marrow cell morphology
    - Reduced bone-marrow pro-B cell count

Recent clinical studies

Etiology

Cerebrovascular accident in a child with precursor B-cell acute lymphoblastic leukemia and coronavirus disease 2019: a case report.

Karimi H, Sarmadian R, Gilani A, Salajegheh P, Nejad Biglari H, Gholizadeh M
J Med Case Rep 2022 Dec 6;16(1):452. doi: 10.1186/s13256-022-03672-5. PMID: 36471442 Free PMC Article

Peripheral blood progenitor cell collection in pediatric patients optimized by high pre-apheresis count of circulating CD34+ cells and high blood flow.

Karow A, Wilhelm A, Ammann RA, Baerlocher GM, Pabst T, Mansouri Taleghani B, Roessler J, Leibundgut K
Bone Marrow Transplant 2019 Jun;54(6):885-893. Epub 2018 Oct 23 doi: 10.1038/s41409-018-0353-8. PMID: 30353065

See all (2)

Diagnosis

B cell homeostasis in chronic hepatitis C virus-related mixed cryoglobulinemia is maintained through naïve B cell apoptosis.

Holz LE, Yoon JC, Raghuraman S, Moir S, Sneller MC, Rehermann B
Hepatology 2012 Nov;56(5):1602-10. Epub 2012 Oct 14 doi: 10.1002/hep.25821. PMID: 22556016 Free PMC Article

See all (1)

Therapy

Cerebrovascular accident in a child with precursor B-cell acute lymphoblastic leukemia and coronavirus disease 2019: a case report.

Karimi H, Sarmadian R, Gilani A, Salajegheh P, Nejad Biglari H, Gholizadeh M
J Med Case Rep 2022 Dec 6;16(1):452. doi: 10.1186/s13256-022-03672-5. PMID: 36471442 Free PMC Article

B cell homeostasis in chronic hepatitis C virus-related mixed cryoglobulinemia is maintained through naïve B cell apoptosis.

Holz LE, Yoon JC, Raghuraman S, Moir S, Sneller MC, Rehermann B
Hepatology 2012 Nov;56(5):1602-10. Epub 2012 Oct 14 doi: 10.1002/hep.25821. PMID: 22556016 Free PMC Article

See all (2)

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Reduced bone-marrow pro-B cell count

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Therapy

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Reviews

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