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Refractory Childhood Malignant Solid Neoplasm

MedGen UID:
1644994
Concept ID:
C4688334
Neoplastic Process
Synonyms: Childhood Refractory Malignant Solid Neoplasm; Childhood Refractory Malignant Solid Tumor

Definition

A childhood malignant solid neoplasm that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Childhood Malignant Solid Neoplasm

Professional guidelines

PubMed

Al-Jilaihawi S, Spreafico F, Mavinkurve-Groothuis A, Drost J, Perotti D, Koenig C, Brok J
Expert Rev Anticancer Ther 2024 Sep;24(9):837-843. Epub 2024 Jul 23 doi: 10.1080/14737140.2024.2381537. PMID: 39016020
Gros SJ, Holland-Cunz SG, Supuran CT, Braissant O
Int J Mol Sci 2019 Oct 9;20(20) doi: 10.3390/ijms20204984. PMID: 31600976Free PMC Article
Rivera GK, Pui CH, Santana VM, Pratt CB, Crist WM
Cancer Chemother Pharmacol 1994;34 Suppl:S89-95. doi: 10.1007/BF00684870. PMID: 8070034

Recent clinical studies

Etiology

Davis KL, Fox E, Isikwei E, Reid JM, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Clin Cancer Res 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164. PMID: 36190525Free PMC Article
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Bayoumy AB, Simsek M, Seinen ML, Mulder CJJ, Ansari A, Peters GJ, De Boer NK
Expert Opin Drug Metab Toxicol 2020 Feb;16(2):111-123. Epub 2020 Feb 24 doi: 10.1080/17425255.2020.1719996. PMID: 32090622
Fletcher JI, Ziegler DS, Trahair TN, Marshall GM, Haber M, Norris MD
Nat Rev Cancer 2018 Jun;18(6):389-400. doi: 10.1038/s41568-018-0003-x. PMID: 29632319
Davis KL, Agarwal AM, Verma AR
Pediatr Hematol Oncol 2017 Sep-Oct;34(6-7):379-394. Epub 2017 Nov 30 doi: 10.1080/08880018.2017.1383542. PMID: 29190182

Diagnosis

Byron SA, Hendricks WPD, Nagulapally AB, Kraveka JM, Ferguson WS, Brown VI, Eslin DE, Mitchell D, Cornelius A, Roberts W, Isakoff MS, Oesterheld JE, Wada RK, Rawwas J, Neville K, Zage PE, Harrod VL, Bergendahl G, VanSickle E, Dykema K, Bond J, Chou HC, Wei JS, Wen X, Reardon HV, Roos A, Nasser S, Izatt T, Enriquez D, Hegde AM, Cisneros F, Christofferson A, Turner B, Szelinger S, Keats JJ, Halperin RF, Khan J, Saulnier Sholler GL, Trent JM
Cancer Res 2021 Dec 1;81(23):5818-5832. Epub 2021 Oct 5 doi: 10.1158/0008-5472.CAN-21-1033. PMID: 34610968Free PMC Article
Fletcher JI, Ziegler DS, Trahair TN, Marshall GM, Haber M, Norris MD
Nat Rev Cancer 2018 Jun;18(6):389-400. doi: 10.1038/s41568-018-0003-x. PMID: 29632319
Kayano D, Kinuya S
ScientificWorldJournal 2015;2015:189135. Epub 2015 Mar 22 doi: 10.1155/2015/189135. PMID: 25874239Free PMC Article
Howman-Giles R, Shaw PJ, Uren RF, Chung DK
Semin Nucl Med 2007 Jul;37(4):286-302. doi: 10.1053/j.semnuclmed.2007.02.009. PMID: 17544628
Rivera GK, Pui CH, Santana VM, Pratt CB, Crist WM
Cancer Chemother Pharmacol 1994;34 Suppl:S89-95. doi: 10.1007/BF00684870. PMID: 8070034

Therapy

Marques Da Costa ME, Zaidi S, Scoazec JY, Droit R, Lim WC, Marchais A, Salmon J, Cherkaoui S, Morscher RJ, Laurent A, Malinge S, Mercher T, Tabone-Eglinger S, Goddard I, Pflumio F, Calvo J, Redini F, Entz-Werlé N, Soriano A, Villanueva A, Cairo S, Chastagner P, Moro M, Owens C, Casanova M, Hladun-Alvaro R, Berlanga P, Daudigeos-Dubus E, Dessen P, Zitvogel L, Lacroix L, Pierron G, Delattre O, Schleiermacher G, Surdez D, Geoerger B
Commun Biol 2023 Sep 18;6(1):949. doi: 10.1038/s42003-023-05320-0. PMID: 37723198Free PMC Article
Davis KL, Fox E, Isikwei E, Reid JM, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Clin Cancer Res 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164. PMID: 36190525Free PMC Article
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Fletcher JI, Ziegler DS, Trahair TN, Marshall GM, Haber M, Norris MD
Nat Rev Cancer 2018 Jun;18(6):389-400. doi: 10.1038/s41568-018-0003-x. PMID: 29632319
Davis KL, Agarwal AM, Verma AR
Pediatr Hematol Oncol 2017 Sep-Oct;34(6-7):379-394. Epub 2017 Nov 30 doi: 10.1080/08880018.2017.1383542. PMID: 29190182

Prognosis

Al-Jilaihawi S, Spreafico F, Mavinkurve-Groothuis A, Drost J, Perotti D, Koenig C, Brok J
Expert Rev Anticancer Ther 2024 Sep;24(9):837-843. Epub 2024 Jul 23 doi: 10.1080/14737140.2024.2381537. PMID: 39016020
Tang XX, Shimada H, Ikegaki N
Genes Immun 2022 Jun;23(3-4):129-140. Epub 2022 May 7 doi: 10.1038/s41435-022-00172-w. PMID: 35525858Free PMC Article
Obu S, Umeda K, Ueno H, Sonoda M, Tasaka K, Ogata H, Kouzuki K, Nodomi S, Saida S, Kato I, Hiramatsu H, Okamoto T, Ogawa E, Okajima H, Morita K, Kamikubo Y, Kawaguchi K, Watanabe K, Iwafuchi H, Yagyu S, Iehara T, Hosoi H, Nakahata T, Adachi S, Uemoto S, Heike T, Takita J
Cancer Sci 2021 Nov;112(11):4617-4626. Epub 2021 Sep 30 doi: 10.1111/cas.15124. PMID: 34464480Free PMC Article
Lucchesi M, Sardi I, Puppo G, Chella A, Favre C
Cancer Chemother Pharmacol 2017 Dec;80(6):1047-1053. Epub 2017 Oct 24 doi: 10.1007/s00280-017-3450-2. PMID: 29067473
Harel M, Ferrer FA, Shapiro LH, Makari JH
Urol Oncol 2016 Feb;34(2):103-15. Epub 2015 Oct 28 doi: 10.1016/j.urolonc.2015.09.013. PMID: 26519985

Clinical prediction guides

Mangum R, Reuther J, Sen Baksi K, Gandhi I, Zabriskie RC, Recinos A, Raesz-Martinez R, Lin FY, Potter SL, Sher AC, Kralik SF, Mohila CA, Chintagumpala MM, Muzny D, Hu J, Gibbs RA, Fisher KE, Bernini JC, Gill J, Griffin TC, Tomlinson GE, Vallance KL, Plon SE, Roy A, Parsons DW
Pediatr Hematol Oncol 2023;40(8):719-738. Epub 2023 Jun 27 doi: 10.1080/08880018.2023.2228837. PMID: 37366551Free PMC Article
Davis KL, Fox E, Isikwei E, Reid JM, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Clin Cancer Res 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164. PMID: 36190525Free PMC Article
Takagi M, Ogawa C, Iehara T, Aoki-Nogami Y, Ishibashi E, Imai M, Kimura T, Nagata M, Yasuhara M, Masutani M, Yoshimura K, Tomizawa D, Ogawa A, Yonemori K, Morishita A, Miyamoto S, Takita J, Kihara T, Nobori K, Hasebe K, Miya F, Ikeda S, Shioda Y, Matsumoto K, Fujimura J, Mizutani S, Morio T, Hosoi H, Koike R
Cancer 2022 Aug 1;128(15):2949-2957. Epub 2022 May 20 doi: 10.1002/cncr.34270. PMID: 35593736
Gaspar N, Venkatramani R, Hecker-Nolting S, Melcon SG, Locatelli F, Bautista F, Longhi A, Lervat C, Entz-Werle N, Casanova M, Aerts I, Strauss SJ, Thebaud E, Morland B, Nieto AC, Marec-Berard P, Gambart M, Rossig C, Okpara CE, He C, Dutta L, Campbell-Hewson Q
Lancet Oncol 2021 Sep;22(9):1312-1321. Epub 2021 Aug 17 doi: 10.1016/S1470-2045(21)00387-9. PMID: 34416158
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article

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