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Retinopathy of prematurity prethreshold

MedGen UID:
1645380
•Concept ID:
C4703704
•
Disease or Syndrome
Synonym: ROP prethreshold
 
HPO: HP:0500065

Definition

High risk patients who were in Zone 1 (no Plus or stage 3) or Zone 2 with Plus or stage 3 but not both. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRetinopathy of prematurity prethreshold

Professional guidelines

PubMed

Does the number of laser applications for ROP treatment influence the degree of myopia?
Inoue T, Asaoka R, Hashimoto Y, Kitamoto K, Kitano M, Fujita A, Azuma K, Yamamoto K, Nagahara M, Kadonosono K, Obata R
Graefes Arch Clin Exp Ophthalmol 2021 Feb;259(2):317-322. Epub 2020 Sep 26 doi: 10.1007/s00417-020-04946-8. PMID: 32978662
The early treatment for ROP (ETROP) randomized trial: study results and nursing care adaptations.
Jones JG, MacKinnon B, Good WV, Hardy RJ, Dobson V, Palmer EA, Phelps DL, Quintos M, Tung B; Early Treatment for Retinopathy of Prematurity Cooperative Group
Insight 2005 Apr-Jun;30(2):7-13. PMID: 16134467
Supplemental oxygen for the treatment of prethreshold retinopathy of prematurity.
Lloyd J, Askie L, Smith J, Tarnow-Mordi W
Cochrane Database Syst Rev 2003;2003(2):CD003482. doi: 10.1002/14651858.CD003482. PMID: 12804470Free PMC Article

Recent clinical studies

Etiology

Prethreshold retinopathy of prematurity: VEGF inhibition without VEGF inhibitors.
Gaynon MW, Wong RJ, Stevenson DK, Sunshine P
J Perinatol 2018 Oct;38(10):1295-1300. Epub 2018 Jul 25 doi: 10.1038/s41372-018-0177-9. PMID: 30046180
Beta-blockers for prevention and treatment of retinopathy of prematurity in preterm infants.
Kaempfen S, Neumann RP, Jost K, Schulzke SM
Cochrane Database Syst Rev 2018 Mar 2;3(3):CD011893. doi: 10.1002/14651858.CD011893.pub2. PMID: 29499081Free PMC Article
Current update on retinopathy of prematurity: screening and treatment.
Chen J, Stahl A, Hellstrom A, Smith LE
Curr Opin Pediatr 2011 Apr;23(2):173-8. doi: 10.1097/MOP.0b013e3283423f35. PMID: 21150442Free PMC Article
Risk analysis of prethreshold retinopathy of prematurity.
Hardy RJ, Palmer EA, Dobson V, Summers CG, Phelps DL, Quinn GE, Good WV, Tung B; Cryotherapy for Retinopathy of Prematurity Cooperative Group
Arch Ophthalmol 2003 Dec;121(12):1697-701. doi: 10.1001/archopht.121.12.1697. PMID: 14662587
Supplemental oxygen for the treatment of prethreshold retinopathy of prematurity.
Lloyd J, Askie L, Smith J, Tarnow-Mordi W
Cochrane Database Syst Rev 2003;2003(2):CD003482. doi: 10.1002/14651858.CD003482. PMID: 12804470Free PMC Article

Diagnosis

Vision-related Quality of Life in Malaysian Children with Threshold and Prethreshold Retinopathy of Prematurity.
Wern-Yih C, Fazilawati Q, Rahmat J, Shatriah I
Korean J Ophthalmol 2022 Jun;36(3):218-225. Epub 2022 Jan 24 doi: 10.3341/kjo.2021.0116. PMID: 35067016Free PMC Article
Evolving Concepts in the Management of Retinopathy of Prematurity.
Sternberg P Jr, Durrani AK
Am J Ophthalmol 2018 Feb;186:xxiii-xxxii. Epub 2017 Nov 3 doi: 10.1016/j.ajo.2017.10.027. PMID: 29109051
Laser treatment for retinopathy of prematurity.
Houston SK, Wykoff CC, Berrocal AM, Hess DJ, Murray TG
Lasers Med Sci 2013 Feb;28(2):683-92. Epub 2011 Dec 2 doi: 10.1007/s10103-011-1021-z. PMID: 22134790
Current update on retinopathy of prematurity: screening and treatment.
Chen J, Stahl A, Hellstrom A, Smith LE
Curr Opin Pediatr 2011 Apr;23(2):173-8. doi: 10.1097/MOP.0b013e3283423f35. PMID: 21150442Free PMC Article
Risk analysis of prethreshold retinopathy of prematurity.
Hardy RJ, Palmer EA, Dobson V, Summers CG, Phelps DL, Quinn GE, Good WV, Tung B; Cryotherapy for Retinopathy of Prematurity Cooperative Group
Arch Ophthalmol 2003 Dec;121(12):1697-701. doi: 10.1001/archopht.121.12.1697. PMID: 14662587

Therapy

Update in the Treatment of Retinopathy of Prematurity.
Bancalari A, Schade R
Am J Perinatol 2022 Jan;39(1):22-30. Epub 2020 Jun 16 doi: 10.1055/s-0040-1713181. PMID: 32544962
Prethreshold retinopathy of prematurity: VEGF inhibition without VEGF inhibitors.
Gaynon MW, Wong RJ, Stevenson DK, Sunshine P
J Perinatol 2018 Oct;38(10):1295-1300. Epub 2018 Jul 25 doi: 10.1038/s41372-018-0177-9. PMID: 30046180
Beta-blockers for prevention and treatment of retinopathy of prematurity in preterm infants.
Kaempfen S, Neumann RP, Jost K, Schulzke SM
Cochrane Database Syst Rev 2018 Mar 2;3(3):CD011893. doi: 10.1002/14651858.CD011893.pub2. PMID: 29499081Free PMC Article
Management of Retinopathy of Prematurity--Use of Anti-VEGF Therapy.
Tran KD, Cernichiaro-Espinosa LA, Berrocal AM
Asia Pac J Ophthalmol (Phila) 2018 Jan-Feb;7(1):56-62. Epub 2018 Jan 26 doi: 10.22608/APO.2017436. PMID: 29376233
Evolving Concepts in the Management of Retinopathy of Prematurity.
Sternberg P Jr, Durrani AK
Am J Ophthalmol 2018 Feb;186:xxiii-xxxii. Epub 2017 Nov 3 doi: 10.1016/j.ajo.2017.10.027. PMID: 29109051

Prognosis

Prethreshold retinopathy of prematurity: VEGF inhibition without VEGF inhibitors.
Gaynon MW, Wong RJ, Stevenson DK, Sunshine P
J Perinatol 2018 Oct;38(10):1295-1300. Epub 2018 Jul 25 doi: 10.1038/s41372-018-0177-9. PMID: 30046180
Current update on retinopathy of prematurity: screening and treatment.
Chen J, Stahl A, Hellstrom A, Smith LE
Curr Opin Pediatr 2011 Apr;23(2):173-8. doi: 10.1097/MOP.0b013e3283423f35. PMID: 21150442Free PMC Article
Rethinking STOP-ROP: is it worthwhile trying to modulate excessive VEGF levels in prethreshold ROP eyes by systemic intervention? A review of the role of oxygen, light adaptation state, and anemia in prethreshold ROP.
Gaynon MW
Retina 2006 Sep;26(7 Suppl):S18-23. doi: 10.1097/01.iae.0000244292.86627.1e. PMID: 16946672
Prospective randomized evaluation of diode-laser and cryotherapy in prethreshold retinopathy of prematurity.
Azad RV, Pasumala L, Kumar H, Talwar D, Pal R, Paul VK, Chandra P
Clin Exp Ophthalmol 2004 Jun;32(3):251-4. doi: 10.1111/j.1442-9071.2004.00812.x. PMID: 15180835
Risk analysis of prethreshold retinopathy of prematurity.
Hardy RJ, Palmer EA, Dobson V, Summers CG, Phelps DL, Quinn GE, Good WV, Tung B; Cryotherapy for Retinopathy of Prematurity Cooperative Group
Arch Ophthalmol 2003 Dec;121(12):1697-701. doi: 10.1001/archopht.121.12.1697. PMID: 14662587

Clinical prediction guides

Functional results in children with retinopathy of prematurity treated with intravitreal bevacizumab.
Sanjuán Riera L, Peralta Calvo J, Hernández Rivas L, Klein Burgos C, Roca Cabau M
Arch Soc Esp Oftalmol (Engl Ed) 2023 Jul;98(7):386-390. Epub 2023 Jun 5 doi: 10.1016/j.oftale.2023.06.002. PMID: 37285960
Outcomes of near confluent laser versus combined less dense laser and bevacizumab treatment of prethreshold ROP Type 1 Zone 2: a randomized controlled trial.
Namvar E, Bolkheir A, Emadi Z, Johari M, Nowroozzadeh MH
BMC Ophthalmol 2022 Nov 28;22(1):454. doi: 10.1186/s12886-022-02689-0. PMID: 36443750Free PMC Article
Vision-related Quality of Life in Malaysian Children with Threshold and Prethreshold Retinopathy of Prematurity.
Wern-Yih C, Fazilawati Q, Rahmat J, Shatriah I
Korean J Ophthalmol 2022 Jun;36(3):218-225. Epub 2022 Jan 24 doi: 10.3341/kjo.2021.0116. PMID: 35067016Free PMC Article
Current update on retinopathy of prematurity: screening and treatment.
Chen J, Stahl A, Hellstrom A, Smith LE
Curr Opin Pediatr 2011 Apr;23(2):173-8. doi: 10.1097/MOP.0b013e3283423f35. PMID: 21150442Free PMC Article
Risk analysis of prethreshold retinopathy of prematurity.
Hardy RJ, Palmer EA, Dobson V, Summers CG, Phelps DL, Quinn GE, Good WV, Tung B; Cryotherapy for Retinopathy of Prematurity Cooperative Group
Arch Ophthalmol 2003 Dec;121(12):1697-701. doi: 10.1001/archopht.121.12.1697. PMID: 14662587

Recent systematic reviews

Beta-blockers for prevention and treatment of retinopathy of prematurity in preterm infants.
Kaempfen S, Neumann RP, Jost K, Schulzke SM
Cochrane Database Syst Rev 2018 Mar 2;3(3):CD011893. doi: 10.1002/14651858.CD011893.pub2. PMID: 29499081Free PMC Article
Supplemental oxygen for the treatment of prethreshold retinopathy of prematurity.
Lloyd J, Askie L, Smith J, Tarnow-Mordi W
Cochrane Database Syst Rev 2003;2003(2):CD003482. doi: 10.1002/14651858.CD003482. PMID: 12804470Free PMC Article

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