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Refractory Glioblastoma

MedGen UID:
1645398
Concept ID:
C4687446
Neoplastic Process

Definition

A glioblastoma that is resistant to treatment. [from NCI]

Professional guidelines

PubMed

Palanichamy K, Patel D, Jacob JR, Litzenberg KT, Gordon N, Acus K, Noda SE, Chakravarti A
Mol Cancer Ther 2018 Feb;17(2):336-346. Epub 2017 Aug 24 doi: 10.1158/1535-7163.MCT-17-0429. PMID: 28838997
Santoni M, Paccapelo A, Burattini L, Onofri A, Cascinu S
Anticancer Res 2012 Mar;32(3):1099-101. PMID: 22399639

Recent clinical studies

Etiology

Park JH, Lee HS, Choi JW, Lim SD, Koh HK, Cho KR, Cho J, Koh YC, Yoon SY
Anticancer Res 2022 Dec;42(12):6091-6098. doi: 10.21873/anticanres.16121. PMID: 36456153
Hainsworth JD, Becker KP, Mekhail T, Chowdhary SA, Eakle JF, Wright D, Langdon RM, Yost KJ, Padula GDA, West-Osterfield K, Scarberry M, Shaifer CA, Shastry M, Burris HA 3rd, Shih K
J Neurooncol 2019 Sep;144(2):303-311. Epub 2019 Aug 7 doi: 10.1007/s11060-019-03227-7. PMID: 31392595
Brenner A, Zuniga R, Sun JD, Floyd J, Hart CP, Kroll S, Fichtel L, Cavazos D, Caflisch L, Gruslova A, Huang S, Liu Y, Lodi A, Tiziani S
Neuro Oncol 2018 Aug 2;20(9):1231-1239. doi: 10.1093/neuonc/noy015. PMID: 29415215Free PMC Article
Wen PY, Drappatz J, de Groot J, Prados MD, Reardon DA, Schiff D, Chamberlain M, Mikkelsen T, Desjardins A, Holland J, Ping J, Weitzman R, Cloughesy TF
Neuro Oncol 2018 Jan 22;20(2):249-258. doi: 10.1093/neuonc/nox154. PMID: 29016998Free PMC Article
Iwadate Y, Suganami A, Tamura Y, Matsutani T, Hirono S, Shinozaki N, Hiwasa T, Takiguchi M, Saeki N
Neurosurgery 2017 Feb 1;80(2):248-256. doi: 10.1093/neuros/nyw026. PMID: 28173571

Diagnosis

Park JH, Lee HS, Choi JW, Lim SD, Koh HK, Cho KR, Cho J, Koh YC, Yoon SY
Anticancer Res 2022 Dec;42(12):6091-6098. doi: 10.21873/anticanres.16121. PMID: 36456153
Simonds EF, Lu ED, Badillo O, Karimi S, Liu EV, Tamaki W, Rancan C, Downey KM, Stultz J, Sinha M, McHenry LK, Nasholm NM, Chuntova P, Sundström A, Genoud V, Shahani SA, Wang LD, Brown CE, Walker PR, Swartling FJ, Fong L, Okada H, Weiss WA, Hellström M
J Immunother Cancer 2021 Jun;9(6) doi: 10.1136/jitc-2020-002181. PMID: 34083417Free PMC Article
Sun J, Patel CB, Jang T, Merchant M, Chen C, Kazerounian S, Diers AR, Kiebish MA, Vishnudas VK, Gesta S, Sarangarajan R, Narain NR, Nagpal S, Recht L
Sci Rep 2020 Aug 17;10(1):13899. doi: 10.1038/s41598-020-70969-0. PMID: 32807842Free PMC Article
AlHarbi M, Ali Mobark N, AlMubarak L, Aljelaify R, AlSaeed M, Almutairi A, Alqubaishi F, Hussain ME, Balbaid AAO, Said Marie A, AlSubaie L, AlShieban S, alTassan N, Ramkissoon SH, Abedalthagafi M
Oncologist 2018 Dec;23(12):1401-1406. Epub 2018 Aug 13 doi: 10.1634/theoncologist.2018-0163. PMID: 30104292Free PMC Article
Palanichamy K, Patel D, Jacob JR, Litzenberg KT, Gordon N, Acus K, Noda SE, Chakravarti A
Mol Cancer Ther 2018 Feb;17(2):336-346. Epub 2017 Aug 24 doi: 10.1158/1535-7163.MCT-17-0429. PMID: 28838997

Therapy

Liu F, Zhou Q, Jiang HF, Zhang TT, Miao C, Xu XH, Wu JX, Yin SL, Xu SJ, Peng JY, Gao PP, Cao X, Pan F, He X, Chen XQ
J Exp Clin Cancer Res 2023 May 10;42(1):118. doi: 10.1186/s13046-023-02686-1. PMID: 37161450Free PMC Article
Park JH, Lee HS, Choi JW, Lim SD, Koh HK, Cho KR, Cho J, Koh YC, Yoon SY
Anticancer Res 2022 Dec;42(12):6091-6098. doi: 10.21873/anticanres.16121. PMID: 36456153
Simonds EF, Lu ED, Badillo O, Karimi S, Liu EV, Tamaki W, Rancan C, Downey KM, Stultz J, Sinha M, McHenry LK, Nasholm NM, Chuntova P, Sundström A, Genoud V, Shahani SA, Wang LD, Brown CE, Walker PR, Swartling FJ, Fong L, Okada H, Weiss WA, Hellström M
J Immunother Cancer 2021 Jun;9(6) doi: 10.1136/jitc-2020-002181. PMID: 34083417Free PMC Article
Cohen KA, Liu T, Bissonette R, Puri RK, Frankel AE
Curr Pharm Biotechnol 2003 Feb;4(1):39-49. doi: 10.2174/1389201033378039. PMID: 12570681
Barth S
Curr Opin Investig Drugs 2001 Sep;2(9):1309-13. PMID: 11717820

Prognosis

Park JH, Lee HS, Choi JW, Lim SD, Koh HK, Cho KR, Cho J, Koh YC, Yoon SY
Anticancer Res 2022 Dec;42(12):6091-6098. doi: 10.21873/anticanres.16121. PMID: 36456153
Hainsworth JD, Becker KP, Mekhail T, Chowdhary SA, Eakle JF, Wright D, Langdon RM, Yost KJ, Padula GDA, West-Osterfield K, Scarberry M, Shaifer CA, Shastry M, Burris HA 3rd, Shih K
J Neurooncol 2019 Sep;144(2):303-311. Epub 2019 Aug 7 doi: 10.1007/s11060-019-03227-7. PMID: 31392595
AlHarbi M, Ali Mobark N, AlMubarak L, Aljelaify R, AlSaeed M, Almutairi A, Alqubaishi F, Hussain ME, Balbaid AAO, Said Marie A, AlSubaie L, AlShieban S, alTassan N, Ramkissoon SH, Abedalthagafi M
Oncologist 2018 Dec;23(12):1401-1406. Epub 2018 Aug 13 doi: 10.1634/theoncologist.2018-0163. PMID: 30104292Free PMC Article
Brenner A, Zuniga R, Sun JD, Floyd J, Hart CP, Kroll S, Fichtel L, Cavazos D, Caflisch L, Gruslova A, Huang S, Liu Y, Lodi A, Tiziani S
Neuro Oncol 2018 Aug 2;20(9):1231-1239. doi: 10.1093/neuonc/noy015. PMID: 29415215Free PMC Article
Iwadate Y, Suganami A, Tamura Y, Matsutani T, Hirono S, Shinozaki N, Hiwasa T, Takiguchi M, Saeki N
Neurosurgery 2017 Feb 1;80(2):248-256. doi: 10.1093/neuros/nyw026. PMID: 28173571

Clinical prediction guides

Park JH, Lee HS, Choi JW, Lim SD, Koh HK, Cho KR, Cho J, Koh YC, Yoon SY
Anticancer Res 2022 Dec;42(12):6091-6098. doi: 10.21873/anticanres.16121. PMID: 36456153
Lee EQ, Muzikansky A, Duda DG, Gaffey S, Dietrich J, Nayak L, Chukwueke UN, Beroukhim R, Doherty L, Laub CK, LaFrankie D, Fontana B, Stefanik J, Ruland S, Caruso V, Bruno J, Ligon K, Reardon DA, Wen PY
Cancer Med 2019 Oct;8(13):5988-5994. Epub 2019 Aug 24 doi: 10.1002/cam4.2505. PMID: 31444999Free PMC Article
AlHarbi M, Ali Mobark N, AlMubarak L, Aljelaify R, AlSaeed M, Almutairi A, Alqubaishi F, Hussain ME, Balbaid AAO, Said Marie A, AlSubaie L, AlShieban S, alTassan N, Ramkissoon SH, Abedalthagafi M
Oncologist 2018 Dec;23(12):1401-1406. Epub 2018 Aug 13 doi: 10.1634/theoncologist.2018-0163. PMID: 30104292Free PMC Article
Brenner A, Zuniga R, Sun JD, Floyd J, Hart CP, Kroll S, Fichtel L, Cavazos D, Caflisch L, Gruslova A, Huang S, Liu Y, Lodi A, Tiziani S
Neuro Oncol 2018 Aug 2;20(9):1231-1239. doi: 10.1093/neuonc/noy015. PMID: 29415215Free PMC Article
Kesavabhotla K, Schlaff CD, Shin B, Mubita L, Kaplan R, Tsiouris AJ, Pannullo SC, Christos P, Lavi E, Scheff R, Boockvar JA
J Exp Ther Oncol 2012;10(1):71-81. PMID: 22946346

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